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Literature summary for 2.6.1.43 extracted from
- Purification and characterization of rat kidney L-alanine: 4,5-dioxovalerate transaminase and inhibition by hemin (1985), Biochim. Biophys. Acta, 827, 305-309.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hemin | - |
Rattus norvegicus |  |
| protoporphyrin | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.25 | - |
4,5-Dioxopentanoate | pH 7.6, 37°C | Rattus norvegicus | |
| 2.9 | - |
L-alanine | pH 7.6, 37°C | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 37000 | - |
6 * 37000, SDS-PAGE | Rattus norvegicus |
| 225000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-alanine + 4,5-dioxopentanoate | Rattus norvegicus | - |
5-aminolevulinate + pyruvate | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.05 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-alanine + 4,5-dioxopentanoate | - |
Rattus norvegicus | 5-aminolevulinate + pyruvate | - |
ir | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | 6 * 37000, SDS-PAGE | Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 65 | - |
- |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.6 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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