General Stability | Organism |
---|---|
purified enzyme is stable in 50 mM potassium buffer, pH 6.9, containing 10% glycerol, freezing and thawing does not affect activity significantly | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxoglutarate | - |
Rattus norvegicus | |
4,5-Dioxopentanoate | - |
Rattus norvegicus | |
hemin | uncompetitive inhibitor | Rattus norvegicus | |
iodoacetate | - |
Rattus norvegicus | |
methylglyoxal | - |
Rattus norvegicus | |
p-chloromercuric benzene sulfonate | - |
Rattus norvegicus | |
pyruvate | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.28 | - |
4,5-Dioxopentanoate | pH 6.9, 37°C | Rattus norvegicus | |
3.3 | - |
L-alanine | pH 6.9, 37°C | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
41000 | - |
6 * 41000 | Rattus norvegicus |
232000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + 4,5-dioxopentanoate | Rattus norvegicus | - |
5-aminolevulinate + pyruvate | - |
ir | |
L-alanine + 4,5-dioxopentanoate | Rattus norvegicus Wistar | - |
5-aminolevulinate + pyruvate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Wistar | - |
Rattus norvegicus Wistar | - |
Wistar | - |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.171 | - |
- |
Rattus norvegicus |
Storage Stability | Organism |
---|---|
-20°C, remains stable for at least 1 month | Rattus norvegicus |
-70°C, stable for at least 2-3 months | Rattus norvegicus |
4°C, can be stored for at least 1 week without any significant loss of activity | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + 4,5-dioxopentanoate | - |
Rattus norvegicus | 5-aminolevulinate + pyruvate | - |
ir | |
L-alanine + 4,5-dioxopentanoate | - |
Rattus norvegicus Wistar | 5-aminolevulinate + pyruvate | - |
ir | |
additional information | DL-alanine, D-alanine, ammonium sulfate, L-glutamate, glycine and phenylalanine cannot replace L-alanine | Rattus norvegicus | ? | - |
? | |
additional information | DL-alanine, D-alanine, ammonium sulfate, L-glutamate, glycine and phenylalanine cannot replace L-alanine | Rattus norvegicus Wistar | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
hexamer | 6 * 41000 | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Rattus norvegicus |