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Information on EC 2.3.1.8 - phosphate acetyltransferase
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EC Tree
2.3.1.8 phosphate acetyltransferaseIUBMB Comments
Also acts with other short-chain acyl-CoAs.
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Word Map
- 2.3.1.8
-
acetyl-coenzyme
- methanosarcina
- thermophila
- formate-lyase
- acetobutylicum
-
pta-ack
-
acetogenic
- coash
-
acka-pta
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2.7.2.1
- phosphoketolase
- acetoin
-
acetate-activating
- butyryl-coa
- tyrobutyricum
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substrate-level
- 2,3-butanediol
-
acetate-grown
- acetylphosphate
- sulfoacetaldehyde
- synthesis
- biotechnology
- biofuel production
The enzyme appears in viruses and cellular organisms
Synonyms
phosphotransacetylase, phosphate acetyltransferase, pta-1, pta-2, aywb-pdul, pdul1, pdul2, moth_0864, moth_1181, phosphotransacetylase pta, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acetyl-S-CoA: orthophosphate acetyltransferase
acetyltransferase, phosphate
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-
-
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PGN_1179
phosphate acetyltransferase
phosphoacylase
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-
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phosphotransacetylase
PTA
phosphotransacetylase
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-
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PTA
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-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + phosphate = CoA + acetyl phosphate
reaction mechanism
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acetyl-CoA + phosphate = CoA + acetyl phosphate
evidence against an acyl-enzyme intermediate
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acetyl-CoA + phosphate = CoA + acetyl phosphate
rapid equilibrium random bi-bi reaction mechanism
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acetyl-CoA + phosphate = CoA + acetyl phosphate
rapid equilibrium random bi-bi reaction mechanism
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acetyl-CoA + phosphate = CoA + acetyl phosphate
ternary complex kinetic echanism rather than a ping-pong kinetic mechanism. Sustrates bind to the enzyme in a random order
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acetyl-CoA + phosphate = CoA + acetyl phosphate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
Acyl group transfer
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-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
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, , acetate fermentation, Carbon fixation pathways in prokaryotes, Carbon fixation pathways in prokaryotes, Carbon fixation pathways in prokaryotes, Carbon fixation pathways in prokaryotes, Carbon fixation pathways in prokaryotes, Methane metabolism, Microbial metabolism in diverse environments, purine metabolism, purine metabolism, purine metabolism, Pyruvate metabolism, Pyruvate metabolism, Pyruvate metabolism
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:phosphate acetyltransferase
Also acts with other short-chain acyl-CoAs.
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CAS REGISTRY NUMBER
COMMENTARY
9029-91-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3'-dephospho-CoA + acetyl phosphate
acetyl-3'-dephospho-CoA + phosphate
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rate is about one tenth of the activity with CoA
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-
?
3'-dephospho-CoA + acetyl phosphate
acetyl-3'-dephospho-CoA + phosphate
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rate is about one tenth of the activity with CoA
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-
?
acetyl phosphate + CoA
acetyl-CoA + phosphate
with isoform Pta-2, reaction is irreversible, no acetyl phosphate forming reaction can be detected
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r
acetyl-CoA + carnitine
CoA + O-acetylcarnitine
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-
?
acetyl-CoA + phosphate
CoA + acetyl phosphate
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formation of acetyl-CoA is favored
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r
acetyl-CoA + phosphate
CoA + acetyl phosphate
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in reverse reaction specific for CoA
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-
?
acetyl-CoA + phosphate
CoA + acetyl phosphate
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in reverse reaction specific for CoA
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r
acetyl-CoA + phosphate
CoA + acetyl phosphate
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r
acetyl-CoA + phosphate
CoA + acetyl phosphate
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-
r
acetyl-CoA + phosphate
CoA + acetyl phosphate
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rate of acetyl-CoA synthesis is 10times greater than rate of acetyl phosphate synthesis
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r
acetyl-CoA + phosphate
CoA + acetyl phosphate
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integral role in acetate metabolism
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r
acetyl-CoA + phosphate
CoA + acetyl phosphate
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enables growth on acetate as carbon and energy source, required for ethanolamine catabolism
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r
acetyl-CoA + phosphate
CoA + acetyl phosphate
acetate excretion during growth of Salmonella enterica on ethanolamine requires phosphotransacetylase (EutD) activity, and acetate recapture requires acetyl-CoA synthetase (Acs) and phosphotransacetylase (Pta) activities
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-
?
acetyl-CoA + phosphate
CoA + acetyl phosphate
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rate of acetyl-CoA synthesis is 6.5times greater than rate of acetyl phosphate synthesis
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r
acetyl-phosphate + CoA
acetyl-CoA + phosphate
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ternary complex kinetic echanism rather than a ping-pong kinetic mechanism. Sustrates bind to the enzyme in a random order
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r
butyryl-CoA + phosphate
CoA + butyryl phosphate
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at a rate 0.01 as rapid as acetyl-CoA
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-
?
CoA + acetyl phosphate
acetyl-CoA + phosphate
involved in taurine catabolism
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-
?
CoA + acetyl phosphate
acetyl-CoA + phosphate
acetate excretion during growth of Salmonella enterica on ethanolamine requires phosphotransacetylase (EutD) activity, and acetate recapture requires acetyl-CoA synthetase (Acs) and phosphotransacetylase (Pta) activities
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-
?
propionyl-CoA + phosphate
CoA + propionyl phosphate
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at a rate 0.1 to 0.5 as rapid as acetyl-CoA
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?
propionyl-CoA + phosphate
CoA + propionyl phosphate
reaction of EC 2.3.1.222
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?
additional information
?
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enzymes is confirmed by total proteome analysis of glycerol-grown cells
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?
additional information
?
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physiological function in anaerobic metabolism of eukaryotic green algae rather than in aerobic acetate activation
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?
additional information
?
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enzyme additionally catalyzes reaction with propionyl-CoA, reaction of EC 2.3.1.222, and with butanoyl-CoA, reaction of EC 2.3.1.19
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additional information
?
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enzyme additionally catalyzes reaction with propionyl-CoA, reaction of EC 2.3.1.222, and with butanoyl-CoA, reaction of EC 2.3.1.19
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additional information
?
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enzyme additionally catalyzes reaction with propionyl-CoA, reaction of EC 2.3.1.222, and with butanoyl-CoA, reaction of EC 2.3.1.19
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additional information
?
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no substrates: butanoyl-CoA, acetyl phosphate
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additional information
?
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no substrates: butanoyl-CoA, acetyl phosphate
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additional information
?
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no substrates: butanoyl-CoA, acetyl phosphate
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additional information
?
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mutation of phosphotransacetylase reduces the virulence of Salmonella enterica serovar typhimurium in mice
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + phosphate
CoA + acetyl phosphate
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-
r
acetyl-CoA + phosphate
CoA + acetyl phosphate
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-
r
acetyl-CoA + phosphate
CoA + acetyl phosphate
-
integral role in acetate metabolism
-
-
r
acetyl-CoA + phosphate
CoA + acetyl phosphate
-
enables growth on acetate as carbon and energy source, required for ethanolamine catabolism
-
-
r
acetyl-CoA + phosphate
CoA + acetyl phosphate
acetate excretion during growth of Salmonella enterica on ethanolamine requires phosphotransacetylase (EutD) activity, and acetate recapture requires acetyl-CoA synthetase (Acs) and phosphotransacetylase (Pta) activities
-
-
?
CoA + acetyl phosphate
acetyl-CoA + phosphate
involved in taurine catabolism
-
-
?
CoA + acetyl phosphate
acetyl-CoA + phosphate
acetate excretion during growth of Salmonella enterica on ethanolamine requires phosphotransacetylase (EutD) activity, and acetate recapture requires acetyl-CoA synthetase (Acs) and phosphotransacetylase (Pta) activities
-
-
?
additional information
?
-
-
physiological function in anaerobic metabolism of eukaryotic green algae rather than in aerobic acetate activation
-
-
?
additional information
?
-
-
mutation of phosphotransacetylase reduces the virulence of Salmonella enterica serovar typhimurium in mice
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
K+
KCl