Ligand acetyl phosphate

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Basic Ligand Information

Molecular Structure
Picture of acetyl phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H5O5P
acetyl phosphate
LIPOUNRJVLNBCD-UHFFFAOYSA-N
Synonyms:
acetyl-phosphate, Acetylphosphate


Show all pahtways known for Show all BRENDA pathways known for acetyl phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl phosphate + NH3 + thioredoxin disulfide + H2O = glycine + phosphate + thioredoxin
show the reaction diagram
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CoA + acetyl phosphate = acetyl-CoA + phosphate
show the reaction diagram
D-glucose + acetyl phosphate = D-glucose 6-phosphate + acetate
show the reaction diagram
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ADP + acetyl phosphate = ATP + acetate
show the reaction diagram
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acetylphosphate + H2O = acetate + phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glycine + phosphate + thioredoxin = acetyl phosphate + NH3 + thioredoxin disulfide + H2O
show the reaction diagram
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N-methylglycine + phosphate + thioredoxin = acetyl phosphate + methylamine + thioredoxin disulfide
show the reaction diagram
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N,N,N-trimethylglycine + phosphate + thioredoxin = acetyl phosphate + trimethylamine + thioredoxin disulfide
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2-sulfoacetaldehyde + phosphate = acetyl phosphate + sulfite
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Substrate in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl phosphate + NH3 + thioredoxin disulfide + H2O = glycine + phosphate + thioredoxin
show the reaction diagram
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CoA + acetyl phosphate = acetyl-CoA + phosphate
show the reaction diagram
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acetyl-phosphate + D-fructose 6-phosphate = acetate + D-fructose 1,6-bisphosphate
show the reaction diagram
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acetyl-phosphate + N-acetyl-alpha-D-galactosamine = acetate + N-acetyl-alpha-D-galactosamine 1-phosphate
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acetylphosphate + inosine = acetate + IMP
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acetylphosphate + H2O = acetate + phosphate
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ADP + acetyl phosphate = ?
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acetyl phosphate + H2O = acetate + phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (44 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-hydroxyethylphosphonate + O2 = acetylphosphate
show the reaction diagram
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acetaldehyde + phosphate + NAD+ = acetyl phosphate + NADH
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glycine + phosphate + thioredoxin = acetyl phosphate + NH3 + thioredoxin disulfide + H2O
show the reaction diagram
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N,N,N-trimethylglycine + phosphate + thioredoxin = acetyl phosphate + trimethylamine + thioredoxin disulfide
show the reaction diagram
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acetate + ATP = acetyl phosphate + ADP
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acetyl-CoA + phosphate = CoA + acetyl phosphate
show the reaction diagram
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pyruvate + phosphate = acetylphosphate + formate
show the reaction diagram
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2-sulfoacetaldehyde + phosphate = acetyl phosphate + sulfite
show the reaction diagram
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ATP + acetate = ADP + acetyl phosphate
show the reaction diagram
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ATP + acetate = ADP + acetyl phosphate
show the reaction diagram
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ATP + acetate = ADP + acetyl phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulates
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10 mM, activity is stimulated more than 10fold
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Inhibitor in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slight inhibition at 2 mM
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inhibits protein C activity, although a substrate
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inhibits ATP synthesis reaction from carbamoyl phosphate and ADP, and synthesis of 10-formyltetrahydrofolate
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3D Structure of Enzyme-Ligand-Complex (PDB) (7 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (71 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (121 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
11.9
-
pH 6.5, 50°C
0.4
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carbamoyl phosphate, D-mannose 6-phosphate, pH 7.5, 25°C
0.48
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recombinant enzyme, pH 8.0, 25°C, reaction with ADP

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for acetyl phosphate

ChEBI
PubChem
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PubChem