Reference on EC 2.1.1.77 - protein-L-isoaspartate(D-aspartate) O-methyltransferase
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Johnson, B.A.; Aswad, D.W.
Enzymatic protein carboxyl methylation at physiological pH: cyclic imide formation explains rapid methyl turnover
Biochemistry
24
2581-2586
1985
Bos taurus, Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Aswad, D.W.; Johnson, B.A.
The unusual substrate specificity of eukaryotic protein carboxyl methyltranferases
Trends Biochem. Sci.
12
155-158
1987
Bos taurus, Mus musculus, Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium, Xenopus laevis
-
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Ota, I.M.; Ding, L.; Clarke, S.
Methylation at specific altered aspartyl and asparaginyl residues in glucagon by the erythrocyte protein carboxyl methyltransferase
J. Biol. Chem.
262
8522-8531
1987
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Gilbert, J.M.; Fowler, A.; Bleibaum, J.; Clarke, S.
Purification of homologous protein carboxyl methyltransferase isozymes from human and bovine erythrocytes
Biochemistry
27
5227-5233
1988
Bos taurus, Escherichia coli, Homo sapiens, Salmonella enterica subsp. enterica serovar Typhimurium
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Ota, I.M.; Gilbert, J.M.; Clarke, S.
Two major isozymes of the protein D-aspartyl/L-isoaspartyl methyltransferase from human erythrocytes
Biochem. Biophys. Res. Commun.
151
1136-1143
1988
Bos taurus, Oryctolagus cuniculus, Equus sp., Homo sapiens, Rattus norvegicus, Torpedo ocellata, Xenopus laevis
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Ingrosso, D.; Fowler, A.V.; Bleibaum, J.; Clarke, S.
Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases
J. Biol. Chem.
264
20131-20139
1989
Bos taurus, Escherichia coli, Homo sapiens, Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Lowenson, J.D.; Clarke, S.
Identification of isoaspartyl-containing sequences in peptides and proteins that are usually poor substrates for the class II protein carboxyl methyltransferase
J. Biol. Chem.
265
3106-3110
1990
Bos taurus, Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Fu, J.C.; Ding, L.; Clarke, S.
Purification, gene cloning, and sequence analysis of an L-isoaspartyl protein carboxyl methyltransferase from Escherichia coli [published erratum appears in J Biol Chem 1992 Jun 5;267(16):11660]
J. Biol. Chem.
266
14562-14572
1991
Bos taurus, Escherichia coli, Homo sapiens, Salmonella enterica subsp. enterica serovar Typhimurium
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Gingras, D.; Menard, P.; Beliveau, R.
Protein carboxyl methylation in kidney brush-border membranes
Biochim. Biophys. Acta
1066
261-267
1991
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Ingrosso, D.; Kagan, R.M.; Clarke, S.
Distinct C-terminal sequences of isozymes I and II of the human erythrocyte L-isoaspartyl/D-aspartyl protein methyltransferase [published erratum appears in Biochem Biophys Res Commun 1991 Apr 15;176(1):549]
Biochem. Biophys. Res. Commun.
175
351-358
1991
Bos taurus, Oryctolagus cuniculus, Drosophila melanogaster, Escherichia coli, Homo sapiens, Mus musculus, Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Johnson, B.A.; Ngo, S.Q.; Aswad, D.W.
Widespread phylogenetic distribution of a protein methyltransferase that modifies L-isoaspartyl residues
Biochem. Int.
24
841-847
1991
Agaricus bisporus, Armadillidium pulchellum, Limax maximus, Triticum aestivum
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Brennan, T.V.; Anderson, J.W.; Jia, Z.; Waygood, E.B.; Clarke, S.
Repair of spontaneously deamidated HPr phosphocarrier protein catalyzed by the L-isoaspartate-(D-aspartate) O-methyltransferase
J. Biol. Chem.
269
24586-24595
1994
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Boivin, D.; Bilodeau, D.; Beliveau, R.
Immunochemical characterization of L-isoaspartyl-protein carboxyl methyltransferase from mammalian tissues
Biochem. J.
309
993-998
1995
Bos taurus, Gallus gallus, Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley, Torpedo ocellata, Triticum aestivum, Xenopus laevis
-
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
David, C.L.; Aswad, D.W.
Cloning, expression, and purification of rat brain protein L-isoaspartyl methyltransferase
Protein Expr. Purif.
6
312-318
1995
Bos taurus, Escherichia coli, Rattus norvegicus
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Mudgett, M.B.; Clarke, S.
A distinctly regulated protein repair L-isoaspartylmethyltransferase from Arabidopsis thaliana
Plant Mol. Biol.
30
723-737
1996
Arabidopsis thaliana, Escherichia coli, Homo sapiens, Mus musculus, Triticum aestivum
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Ingrosso, D.; Perna, A.F.; D'Angelo, S.; Buro, M.D.; Malanga, P.; Galletti, P.; De Rosa, M.; Zappia, V.
Enzymic detection of L-isoaspartyl residues in food proteins and the protective properties of trehalose
J. Nutr. Biochem.
8
535-540
1997
Gallus gallus
-
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Weber, D.J.; McFadden, P.N.
Detection and characterization of a protein isoaspartyl methyltransferase which becomes trapped in the extracellular space during blood vessel injury
J. Protein Chem.
16
257-267
1997
Rattus norvegicus
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Ichikawa, J.K.; Clarke, S.
A highly active protein repair enzyme from an extreme thermophile: the L-isoaspartyl methyltransferase from Thermotoga maritima
Arch. Biochem. Biophys.
358
222-231
1998
Archaeoglobus fulgidus, Caenorhabditis elegans, Escherichia coli, Homo sapiens, Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii, Mus musculus, no activity in Aquifex aeolicus, no activity in Bacillus subtilis, no activity in Borrelia burgdorferi, no activity in Haemophilus influenzae, no activity in Mycoplasma genitalium, no activity in Mycoplasma pneumoniae, no activity in Sinorhizobium meliloti, no activity in Treponema pallidum, Rattus norvegicus, Thermotoga maritima, Triticum aestivum
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
O'Connor, M.B.; O'Connor, C.M.
Complex interactions of the protein L-isoaspartyl methyltransferase and calmodulin revealed with the yeast two-hybrid system
J. Biol. Chem.
273
12909-12913
1998
Escherichia coli, Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
David, C.L.; Pierce, V.A.; Aswad, D.W.; Gibbs, A.G.
The effect of urea exposure on isoaspartyl content and protein L-isoaspartate methyltransferase activity in Drosophila melanogaster
Comp. Biochem. Physiol. B
124B
423-427
1999
Drosophila melanogaster, Rattus norvegicus
-
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
DeVry, C.G.; Clarke, S.
Polymorphic forms of the protein L-isoaspartate (D-aspartate) O-methyltransferase involved in the repair of age-damaged proteins
J. Hum. Genet.
44
275-288
1999
Homo sapiens, Mus musculus
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Niewmierzycka, A.; Clarke, S.
Do damaged proteins accumulate in Caenorhabditis elegans L-isoaspartate methyltransferase (pcm-1) deletion mutants?
Arch. Biochem. Biophys.
364
209-218
1999
Caenorhabditis elegans, Escherichia coli, Homo sapiens, Mus musculus
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Thapar, N.; Clarke, S.
Expression, Purification, and Characterization of the Protein Repair L-Isoaspartyl Methyltransferase from Arabidopsis thaliana
Protein Expr. Purif.
20
237-251
2000
Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Escherichia coli, Homo sapiens, Solanum lycopersicum, Oryza sativa, Rattus norvegicus, Thermotoga maritima, Triticum aestivum, Xenopus laevis, Zea mays
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Griffith, S.C.; Sawaya, M.R.; Boutz, D.R.; Thapar, N.; Katz, J.E.; Clarke, S.; Yeates, T.O.
Crystal Structure of a Protein Repair Methyltransferase from Pyrococcus furiosus with its L-Isoaspartyl Peptide Substrate
J. Mol. Biol.
313
1103-1116
2001
Pyrococcus furiosus (Q8TZR3), Pyrococcus furiosus
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Lowenson, J.D.; Kim, E.; Young, S.G.; Clarke, S.
Limited accumulation of damaged proteins in L-isoaspartyl (D-aspartyl) O-methyltransferase-deficient mice
J. Biol. Chem.
276
20695-20702
2001
Homo sapiens, Mus musculus, Xenopus laevis
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Thapar, N.; Kim, A.K.; Clarke, S.
Distinct patterns of expression but similar biochemical properties of protein L-isoaspartyl methyltransferase in higher plants
Plant Physiol.
125
1023-1035
2001
Arabidopsis thaliana, Caenorhabditis elegans, Daucus carota, Escherichia coli, Homo sapiens, Oryza sativa, Triticum aestivum, Zea mays, Caenorhabditis elegans N2, Oryza sativa M-101
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Young, A.L.; Carter, W.G.; Doyle, H.A.; Mamula, M.J.; Aswad, D.W.
Structural integrity of histone H2B in vivo requires the activity of protein L-isoaspartate O-methyltransferase, a putative protein repair enzyme
J. Biol. Chem.
276
37161-37165
2001
Mus musculus, Rattus norvegicus
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Ryttersgaard, C.; Griffith, S.C.; Sawaya, M.R.; MacLaren, D.C.; Clarke, S.; Yeates, T.O.
Crystal structure of human L-isoaspartyl methyltransferase
J. Biol. Chem.
277
10642-10646
2002
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Smith, C.D.; Carson, M.; Friedman, A.M.; Skinner, M.M.; Delucas, L.; Chantalat, L.; Weise, L.; Shirasawa, T.; Chattopadhyay, D.
Crystal structure of human L-isoaspartyl-O-methyltransferase with S-adenosyl homocysteine at 1.6-.ANG. resolution and modeling of an isoaspartyl-containing peptide at the active site
Protein Sci.
11
625-635
2002
Homo sapiens, Thermotoga maritima
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Thapar, N.; Griffith, S.C.; Yeates, T.O.; Clarke, S.
Protein repair methyltransferase from the hyperthermophilic archaeon Pyrococcus furiosus: unusual methyl-accepting affinity for D-aspartyl and N-succinyl-containing peptides
J. Biol. Chem.
277
1058-1065
2002
Arabidopsis thaliana, Caenorhabditis elegans, Escherichia coli, Homo sapiens, Mus musculus, Pyrococcus furiosus, Thermotoga maritima
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Bennett, E.J.; Bjerregaard, J.; Knapp, J.E.; Chavous, D.A.; Friedman, A.M.; Royer, W.E., Jr.; O'Connor, C.M.
Catalytic implications from the Drosophila protein L-isoaspartyl methyltransferase structure and site-directed mutagenesis
Biochemistry
42
12844-12853
2003
Drosophila melanogaster (Q27869), Drosophila melanogaster
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Lanthier, J.; Desrosiers, R.R.
Protein L-isoaspartyl methyltransferase repairs abnormal aspartyl residues accumulated in vivo in type-I collagen and restores cell migration
Exp. Cell Res.
293
96-105
2004
Drosophila sp. (in: flies)
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Kern, R.; Malki, A.; Abdallah, J.; Liebart, J.C.; Dubucs, C.; Yu, M.H.; Richarme, G.
Protein isoaspartate methyltransferase is a multicopy suppressor of protein aggregation in Escherichia coli
J. Bacteriol.
187
1377-1383
2005
Escherichia coli
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Kindrachuk, J.; Parent, J.; Davies, G.F.; Dinsmore, M.; Attah-Poku, S.; Napper, S.
Overexpression of L-isoaspartate O-methyltransferase in Escherichia coli increases heat shock survival by a mechanism independent of methyltransferase activity
J. Biol. Chem.
278
50880-50886
2003
Escherichia coli
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Tanaka, Y.; Tsumoto, K.; Yasutake, Y.; Umetsu, M.; Yao, M.; Fukada, H.; Tanaka, I.; Kumagai, I.
How oligomerization contributes to the thermostability of an archaeon protein: protein L-isoaspartyl-O-methyltransferase from Sulfolobus tokodaii
J. Biol. Chem.
279
32957-32967
2004
Sulfurisphaera tokodaii
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Hicks, W.M.; Kotlajich, M.V.; Visick, J.E.
Recovery from long-term stationary phase and stress survival in Escherichia coli require the L-isoaspartyl protein carboxyl methyltransferase at alkaline pH
Microbiology
151
2151-2158
2005
Escherichia coli
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Lapointe, M.; Lanthier, J.; Moumdjian, R.; Regina, A.; Desrosiers, R.R.
Expression and activity of L-isoaspartyl methyltransferase decrease in stage progression of human astrocytic tumors
Mol. Brain Res.
135
93-103
2005
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Xu, Q.; Belcastro, M.P.; Villa, S.T.; Dinkins, R.D.; Clarke, S.G.; Downie, A.B.
A second protein L-isoaspartyl methyltransferase gene in Arabidopsis produces two transcripts whose products are sequestered in the nucleus
Plant Physiol.
136
2652-2664
2004
Arabidopsis thaliana (Q64J17), Arabidopsis thaliana Heynh. (Q64J17)
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Lanthier, J.; Desrosiers, R.R.
Regulation of protein L-isoaspartyl methyltransferase by cell-matrix interactions: involvement of integrin alphavbeta3, PI 3-kinase, and the proteasome
Biochem. Cell Biol.
84
684-694
2006
Bos taurus
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Kharbanda, K.K.; Mailliard, M.E.; Baldwin, C.R.; Sorrell, M.F.; Tuma, D.J.
Accumulation of proteins bearing atypical isoaspartyl residues in livers of alcohol-fed rats is prevented by betaine administration: effects on protein-L-isoaspartyl methyltransferase activity
J. Hepatol.
46
1119-1125
2007
Rattus norvegicus
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Lamarre, M.; Desrosiers, R.R.
Up-regulation of protein L-isoaspartyl methyltransferase expression by lithium is mediated by glycogen synthase kinase-3 inactivation and beta-catenin stabilization
Neuropharmacology
55
669-676
2008
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Furuchi, T.; Kosugi, S.; Ohno, K.; Egawa, T.; Sekine, M.; Katane, M.; Homma, H.
High-performance liquid chromatographic method to measure protein L-isoaspartyl/D-aspartyl O-methyltransferase activity in cell lysates
Anal. Biochem.
384
207-212
2009
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Alfaro, J.F.; Gillies, L.A.; Sun, H.G.; Dai, S.; Zang, T.; Klaene, J.J.; Kim, B.J.; Lowenson, J.D.; Clarke, S.G.; Karger, B.L.; Zhou, Z.S.
Chemo-enzymatic detection of protein isoaspartate using protein isoaspartate methyltransferase and hydrazine trapping
Anal. Chem.
80
3882-3889
2008
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Fanelus, I.; Desrosiers, R.R.
Reactive oxygen species generated by thiol-modifying phenylarsine oxide stimulate the expression of protein L-isoaspartyl methyltransferase
Biochem. Biophys. Res. Commun.
371
203-208
2008
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Kosugi, S.; Furuchi, T.; Katane, M.; Sekine, M.; Shirasawa, T.; Homma, H.
Suppression of protein L-isoaspartyl (D-aspartyl) methyltransferase results in hyperactivation of EGF-stimulated MEK-ERK signaling in cultured mammalian cells
Biochem. Biophys. Res. Commun.
371
22-27
2008
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Carter, W.G.; Aswad, D.W.
Formation, localization, and repair of L-isoaspartyl sites in histones H2A and H2B in nucleosomes from rat liver and chicken erythrocytes
Biochemistry
47
10757-10764
2008
Gallus gallus, Rattus norvegicus
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Pyun, J.A.; Kang, H.; Lee, S.K.; Kim, M.H.; Kwack, K.
Association between polymorphisms in the protein L-isoaspartate (D-aspartate) O-methyltransferase gene and premature ovarian failure
Fertil. Steril.
91
1362-1365
2009
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Gomez, T.A.; Banfield, K.L.; Clarke, S.G.
The protein L-isoaspartyl-O-methyltransferase functions in the Caenorhabditis elegans stress response
Mech. Ageing Dev.
129
752-758
2008
Caenorhabditis elegans
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Cournoyer, P.; Desrosiers, R.R.
Valproic acid enhances protein L-isoaspartyl methyltransferase expression by stimulating extracellular signal-regulated kinase signaling pathway
Neuropharmacology
56
839-848
2009
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Oge, L.; Bourdais, G.; Bove, J.; Collet, B.; Godin, B.; Granier, F.; Boutin, J.P.; Job, D.; Jullien, M.; Grappin, P.
Protein repair L-isoaspartyl methyltransferase 1 is involved in both seed longevity and germination vigor in Arabidopsis
Plant Cell
20
3022-3037
2008
Arabidopsis thaliana
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Dinkins, R.D.; Majee, S.M.; Nayak, N.R.; Martin, D.; Xu, Q.; Belcastro, M.P.; Houtz, R.L.; Beach, C.M.; Downie, A.B.
Changing transcriptional initiation sites and alternative 5'- and 3'-splice site selection of the first intron deploys Arabidopsis protein isoaspartyl methyltransferase2 variants to different subcellular compartments
Plant J.
55
1-13
2008
Arabidopsis thaliana
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Verma, P.; Singh, A.; Kaur, H.; Majee, M.
Protein L-isoaspartyl methyltransferase1 (CaPIMT1) from chickpea mitigates oxidative stress-induced growth inhibition of Escherichia coli
Planta
231
329-336
2010
Cicer arietinum (D2IWA7), Cicer arietinum
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Cimmino, A.; Capasso, R.; Muller, F.; Sambri, I.; Masella, L.; Raimo, M.; De Bonis, M.L.; DAngelo, S.; Zappia, V.; Galletti, P.; Ingrosso, D.
Protein isoaspartate methyltransferase prevents apoptosis induced by oxidative stress in endothelial cells: role of Bcl-Xl deamidation and methylation
PLoS ONE
3
e3258
2008
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Rutherford, K.; Daggett, V.
The V119I polymorphism in protein L-isoaspartate O-methyltransferase alters the substrate-binding interface
Protein Eng. Des. Sel.
22
713-721
2009
Homo sapiens (P22061)
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Waegner, A.M.; Cloos, P.; Bergholdt, R.; Eising, S.; Brorsson, C.; Stalhut, M.; Christgau, S.; Nerup, J.; Pociot, F.
Posttranslational protein modifications in type 1 diabetes - Genetic studies with PCMT1, the repair enzyme protein isoaspartate methyltransferase (PIMT) encoding gene
Rev. Diabet. Stud.
5
225-231
2008
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Liu, M.; Cheetham, J.; Cauchon, N.; Ostovic, J.; Ni, W.; Ren, D.; Zhou, Z.S.
Protein isoaspartate methyltransferase-mediated 18O-labeling of isoaspartic acid for mass spectrometry analysis
Anal. Chem.
84
1056-1062
2012
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Fang, P.; Li, X.; Wang, J.; Xing, L.; Gao, Y.; Niu, L.; Teng, M.
Crystal structure of the protein L-isoaspartyl methyltransferase from Escherichia coli
Cell Biochem. Biophys.
58
163-167
2010
Escherichia coli (P0A7A5), Escherichia coli
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Furuchi, T.; Sakurako, K.; Katane, M.; Sekine, M.; Homma, H.
The role of protein L-isoaspartyl/D-aspartyl O-methyltransferase (PIMT) in intracellular signal transduction
Chem. Biodivers.
7
1337-1348
2010
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Chen, T.; Nayak, N.; Majee, S.M.; Lowenson, J.; Schaefermeyer, K.R.; Eliopoulos, A.C.; Lloyd, T.D.; Dinkins, R.; Perry, S.E.; Forsthoefel, N.R.; Clarke, S.G.; Vernon, D.M.; Zhou, Z.S.; Rejtar, T.; Downie, A.B.
Substrates of the Arabidopsis thaliana protein isoaspartyl methyltransferase 1 identified using phage display and biopanning
J. Biol. Chem.
285
37281-37292
2010
Arabidopsis thaliana
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Ayyappan, V.; Andy, G.; Natesan, S.; Choi, C.; Markandan, M.
Changes in L-isoaspartyl methyltransferase, storage components and anti-oxidant enzymes activities during accelerated ageing in cucumber (Cucumis sativus L.) seeds
J. Plant Sci.
5
309-320
2010
Cucumis sativus
-
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Lee, J.C.; Kang, S.U.; Jeon, Y.; Park, J.W.; You, J.S.; Ha, S.W.; Bae, N.; Lubec, G.; Kwon, S.H.; Lee, J.S.; Cho, E.J.; Han, J.W.
Protein L-isoaspartyl methyltransferase regulates p53 activity
Nat. Commun.
3
927
2012
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Khare, S.; Linster, C.L.; Clarke, S.G.
The interplay between protein L-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in Caenorhabditis elegans
PLoS ONE
6
e20850
2011
Caenorhabditis elegans, Caenorhabditis elegans N2, Caenorhabditis elegans PL51
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Dutta, T.; Banerjee, S.; Soren, D.; Lahiri, S.; Sengupta, S.; Rasquinha, J.A.; Ghosh, A.K.
Regulation of enzymatic activity by deamidation and their subsequent repair by protein L-isoaspartyl methyl transferase
Appl. Biochem. Biotechnol.
168
2358-2375
2012
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Banerjee, S.; Dutta, T.; Lahiri, S.; Sengupta, S.; Gangopadhyay, A.; Kumar Karri, S.; Chakraborty, S.; Bhattacharya, D.; Ghosh, A.
Enzymatic attributes of an l-isoaspartyl methyltransferase from
Biochem. Biophys. Rep.
4
59-75
2015
Cyberlindnera jadinii
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Park, J.W.; Lee, J.C.; Ha, S.W.; Bang, S.Y.; Park, E.K.; Yi, S.A.; Lee, M.G.; Kim, D.S.; Nam, K.H.; Yoo, J.H.; Kwon, S.H.; Han, J.W.
Requirement of protein L-isoaspartyl O-methyltransferase for transcriptional activation of trefoil factor 1 (TFF1) gene by estrogen receptor alpha
Biochem. Biophys. Res. Commun.
420
223-229
2012
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Chatterjee, T.; Pal, A.; Chakravarty, D.; Dey, S.; Saha, R.P.; Chakrabarti, P.
Protein L-isoaspartyl-O-methyltransferase of Vibrio cholerae: interaction with cofactors and effect of osmolytes on unfolding
Biochimie
95
912-921
2013
Vibrio cholerae serotype O1
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Yan, G.; Qin, Q.; Yi, B.; Chuprun, K.; Sun, H.; Huang, S.; Sun, J.
Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1
Int. J. Cardiol.
168
3291-3299
2013
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Oda, A.; Noji, I.; Fukuyoshi, S.; Takahashi, O.
Prediction of binding modes between protein L-isoaspartyl (D-aspartyl) O-methyltransferase and peptide substrates including isomerized aspartic acid residues using in silico analytic methods for the substrate screening
J. Pharm. Biomed. Anal.
116
116-122
2015
Homo sapiens (P22061), Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Nayak, N.R.; Putnam, A.A.; Addepalli, B.; Lowenson, J.D.; Chen, T.; Jankowsky, E.; Perry, S.E.; Dinkins, R.D.; Limbach, P.A.; Clarke, S.G.; Downie, A.B.
An Arabidopsis ATP-dependent, DEAD-box RNA helicase loses activity upon IsoAsp formation but is restored by protein isoaspartyl methyltransferase
Plant Cell
25
2573-2586
2013
Arabidopsis thaliana
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Wei, Y.; Xu, H.; Diao, L.; Zhu, Y.; Xie, H.; Cai, Q.; Wu, F.; Wang, Z.; Zhang, J.; Xie, H.
Protein repair L-isoaspartyl methyltransferase 1 (PIMT1) in rice improves seed longevity by preserving embryo vigor and viability
Plant Mol. Biol.
89
475-492
2015
Oryza sativa
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Verma, P.; Kaur, H.; Petla, B.P.; Rao, V.; Saxena, S.C.; Majee, M.
Protein L-isoaspartyl methyltransferase2 is differentially expressed in chickpea and enhances seed vigor and longevity by reducing abnormal isoaspartyl accumulation predominantly in seed nuclear proteins
Plant Physiol.
161
1141-1157
2013
Cicer arietinum, Cicer arietinum (M4I6P1), Cicer arietinum (M4I787)
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Morrison, G.J.; Ganesan, R.; Qin, Z.; Aswad, D.W.
Considerations in the identification of endogenous substrates for protein L-isoaspartyl methyltransferase: the case of synuclein
PLoS ONE
7
e43288
2012
Mus musculus
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Biterge, B.; Richter, F.; Mittler, G.; Schneider, R.
Methylation of histone H4 at aspartate 24 by protein L-isoaspartate O-methyltransferase (PCMT1) links histone modifications with protein homeostasis
Sci. Rep.
4
6674
2014
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Kimura, Y.; Komatsu, T.; Yanagi, K.; Hanaoka, K.; Ueno, T.; Terai, T.; Kojima, H.; Okabe, T.; Nagano, T.; Urano, Y.
Development of chemical tools to monitor and control isoaspartyl peptide methyltransferase activity
Angew. Chem. Int. Ed. Engl.
56
153-157
2017
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Chatterjee, T.; Mukherjee, D.; Banerjee, M.; Chatterjee, B.K.; Chakrabarti, P.
Crystal structure and activity of protein L-isoaspartyl-O-methyltransferase from Vibrio cholerae, and the effect of AdoHcy binding
Arch. Biochem. Biophys.
583
140-149
2015
Vibrio cholerae serotype O1 (A5F9C1), Vibrio cholerae serotype O1 ATCC 39541 (A5F9C1)
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Chatterjee, T.; Das, G.; Chatterjee, B.K.; Dhar, J.; Ghosh, S.; Chakrabarti, P.
The role of isoaspartate in fibrillation and its prevention by protein-L-isoaspartyl methyltransferase
Biochim. Biophys. Acta
1864
129500
2019
Rattus norvegicus
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Dung, T.T.; Yi, Y.S.; Heo, J.; Yang, W.S.; Kim, J.H.; Kim, H.G.; Park, J.G.; Yoo, B.C.; Cho, J.Y.; Hong, S.
Critical role of protein L-isoaspartyl methyltransferase in basic fibroblast growth factor-mediated neuronal cell differentiation
BMB Rep.
49
437-442
2016
Rattus norvegicus
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Mishra, P.K.K.; Gattani, A.; Mahawar, M.
Isolation and identification of protein L-isoaspartate-O-methyltransferase (PIMT) interacting proteins in Salmonella Typhimurium
Curr. Microbiol.
77
695-701
2020
Salmonella enterica subsp. enterica
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Lyon, Y.A.; Sabbah, G.M.; Julian, R.R.
Differences in alpha-crystallin isomerization reveal the activity of protein isoaspartyl methyltransferase (PIMT) in the nucleus and cortex of human lenses
Exp. Eye Res.
171
131-141
2018
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Ogasawara, M.; Otani, M.; Takano, M.; Shudou, M.; Inaba, Y.; Nirasawa, S.; Takahashi, S.; Kiyoi, T.; Tanaka, Y.; Kameda, K.; Kunugita, N.; Maeyama, K.; Sano, K.; Yamashita, M.; Yamauchi, K.
The protective role of protein L-isoaspartyl (D-aspartate) O-methyltransferase for maintenance of mitochondrial morphology in A549 cell
Exp. Lung Res.
42
245-262
2016
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Pesingi, P.K.; Kumawat, M.; Behera, P.; Dixit, S.K.; Agarwal, R.K.; Goswami, T.K.; Mahawar, M.
Protein-L-isoaspartyl methyltransferase (PIMT) is required for survival of Salmonella Typhimurium at 42C and contributes to the virulence in poultry
Front. Microbiol.
8
361
2017
Salmonella enterica subsp. enterica, Salmonella enterica subsp. enterica E-5591
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Saito, H.; Yamashita, M.; Ogasawara, M.; Yamada, N.; Niisato, M.; Tomoyasu, M.; Deguchi, H.; Tanita, T.; Ishida, K.; Sugai, T.; Yamauchi, K.
Chaperone protein L-isoaspartate (D-aspartyl) O-methyltransferase as a novel predictor of poor prognosis in lung adenocarcinoma
Hum. Pathol.
50
1-10
2016
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Kumawat, M.; Pesingi, P.K.; Agarwal, R.K.; Goswami, T.K.; Mahawar, M.
Contribution of protein isoaspartate methyl transferase (PIMT) in the survival of Salmonella Typhimurium under oxidative stress and virulence
Int. J. Med. Microbiol.
306
222-230
2016
Salmonella enterica subsp. enterica, Salmonella enterica subsp. enterica E-2375
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Yin, L.; Harwood, C.S.
Functional divergence of annotated L-isoaspartate O-methyltransferases in an alpha-proteobacterium
J. Biol. Chem.
294
2854-2861
2019
Rhodopseudomonas palustris
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Ghosh, S.; Kamble, N.U.; Verma, P.; Salvi, P.; Petla, B.P.; Roy, S.; Rao, V.; Hazra, A.; Varshney, V.; Kaur, H.; Majee, M.
Arabidopsis protein L-isoaspartyl methyltransferaserepairs isoaspartyl damage to antioxidant enzymes and increases heat and oxidative stress tolerance
J. Biol. Chem.
295
783-799
2019
Arabidopsis thaliana
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Ouanouki, A.; Desrosiers, R.R.
The enzyme L-isoaspartyl (D-aspartyl) methyltransferase is required for VEGF-dependent endothelial cell migration and tubulogenesis
Mol. Cell. Biochem.
413
37-46
2016
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Ouazia, D.; Levros, L.C.; Rassart, E.; Desrosiers, R.R.
The protein L-isoaspartyl (D-aspartyl) methyltransferase protects against dopamine-induced apoptosis in neuroblastoma SH-SY5Y cells
Neuroscience
295
139-150
2015
Homo sapiens
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
Petla, B.P.; Kamble, N.U.; Kumar, M.; Verma, P.; Ghosh, S.; Singh, A.; Rao, V.; Salvi, P.; Kaur, H.; Saxena, S.C.; Majee, M.
Rice protein L-isoaspartyl methyltransferase isoforms differentially accumulate during seed maturation to restrict deleterious isoAsp and reactive oxygen species accumulation and are implicated in seed vigor and longevity
New Phytol.
211
627-645
2016
Oryza sativa
![Manually annotated by BRENDA team Manually annotated by BRENDA team](./images/brenda_logo_8.gif)
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