Inhibitors | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-homocysteine | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.055 | - |
7-nitro-2,1,3-benzoxadiazole-labeled delta sleep-inducing peptide L-isoaspartate | pH not specified in the publication, at 37°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein D-aspartate | Homo sapiens | - |
S-adenosyl-L-homocysteine + protein D-aspartate methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | Homo sapiens | - |
S-adenosyl-L-homocysteine + protein L-isoaspartate methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 7-nitro-2,1,3-benzoxadiazole-labeled delta sleep-inducing peptide L-isoaspartate | - |
Homo sapiens | S-adenosyl-L-homocysteine + 7-nitro-2,1,3-benzoxadiazole-labeled delta sleep-inducing peptide L-isoaspartate methyl ester | - |
? | |
S-adenosyl-L-methionine + protein D-aspartate | - |
Homo sapiens | S-adenosyl-L-homocysteine + protein D-aspartate methyl ester | - |
? | |
S-adenosyl-L-methionine + protein L-isoaspartate | - |
Homo sapiens | S-adenosyl-L-homocysteine + protein L-isoaspartate methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
L-isoaspartyl/D-aspartyl O-methyltransferase | - |
Homo sapiens |
PIMT | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme activity and expression are 50% lower in the hippocampus of epileptic patients | down |
General Information | Comment | Organism |
---|---|---|
malfunction | silencing enzym expression results in the accumulation of proteins with racemized or isomerized Asp residues. Suppression of enzyme expression leads to epidermal growth factor-stimulated hyperactivation of the MAP-kinase | Homo sapiens |
physiological function | protein L-isoaspartyl/D-aspartyl O-methyltransferase is a repair enzyme that initiates the conversion of L-isoaspartyl (or D-Asp) residues to L-aspartyl residues. Isomerization of Asn or Asp residues, and the repair of atypical residues by PIMT plays a role in the posttranslational regulation of protein activity. The repair of abnormal residues by the enzyme is essential for maintenance of the central nervous system | Homo sapiens |