Literature summary for 2.1.1.77 extracted from

Dung, T.T.; Yi, Y.S.; Heo, J.; Yang, W.S.; Kim, J.H.; Kim, H.G.; Park, J.G.; Yoo, B.C.; Cho, J.Y.; Hong, S.
Critical role of protein L-isoaspartyl methyltransferase in basic fibroblast growth factor-mediated neuronal cell differentiation (2016), BMB Rep., 49, 437-442 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
adenosine dialdehyde	-	Rattus norvegicus
S-adenosylhomocysteine	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + protein L-isoaspartate	Rattus norvegicus	-	S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
PC-12 cell	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + protein L-isoaspartate	-	Rattus norvegicus	S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester	-	?

Synonyms

Synonyms	Comment	Organism
PIMT	-	Rattus norvegicus
protein L-isoaspartyl methyltransferase	-	Rattus norvegicus

General Information

General Information	Comment	Organism
malfunction	enzyme inhibition suppresses basic fibroblast growth factor-mediated neuronal differentiation of PC-12 cells. Enzyme deficiency inhibits neuronal differentiation of PC-12 cells by suppressing phosphorylation of MEK1/2 and ERK1/2 in the MAPK signaling pathway and Akt and mTOR in the PI3K/Akt signaling pathway	Rattus norvegicus
physiological function	the enzyme is critical for basic fibroblast growth factor-mediated neuronal differentiation of PC-12 cells and regulates the MAPK and Akt signaling pathways	Rattus norvegicus

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Release 2023.1 (January 2023)