Application | Comment | Organism |
---|---|---|
medicine | results show that PIMT expression is up-regulated by GSK-3 inhibition and beta-catenin stabilization upon treatments with lithium and valproic acid suggesting a possible therapeutic role for PIMT in certain brain diseases including epilepsy | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocytoma cell line | treatment of astrocytoma cells (U-87) with direct pharmacological GSK-3 inhibitors stimulate PIMT expression (2fold). Results demonstrate regulation of PIMT expression by GSK-3 inhibitor lithium at both the transcriptional and the translational levels. Inhibition by siRNA of GSK-3 and beta-catenin modulates expression of the PIMT in accordance with GSK-3 pharmacological inhibition. Valproic acid up-regulates phospho-GSK-3b (Ser9), beta-catenin and PIMT levels similarly to lithium | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PIMT | - |
Homo sapiens |
protein L-isoaspartyl methyltransferase | - |
Homo sapiens |