Literature summary for 2.1.1.77 extracted from

Lee, J.C.; Kang, S.U.; Jeon, Y.; Park, J.W.; You, J.S.; Ha, S.W.; Bae, N.; Lubec, G.; Kwon, S.H.; Lee, J.S.; Cho, E.J.; Han, J.W.
Protein L-isoaspartyl methyltransferase regulates p53 activity (2012), Nat. Commun., 3, 927.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + protein p53	the enzyme mediates methylation of protein p53 at isoaspartate residues 29 and 30	Homo sapiens	S-adenosyl-L-homocysteine + ?	-	?

Synonyms

Synonyms	Comment	Organism
PIMT	-	Homo sapiens
protein L-isoaspartyl methyltransferase	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	enzyme depletion upregulates the proapoptotic and checkpoint activation functions of p53	Homo sapiens
physiological function	the enzyme negatively regulates the tumour suppressor protein p53 by reducing p53 protein levels, thereby suppressing the p53-mediated transcription of target genes. The enzyme destabilizes p53 by enhancing the p53-HDM2 interaction	Homo sapiens

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Release 2023.1 (January 2023)