Literature summary for 2.1.1.77 extracted from

Kimura, Y.; Komatsu, T.; Yanagi, K.; Hanaoka, K.; Ueno, T.; Terai, T.; Kojima, H.; Okabe, T.; Nagano, T.; Urano, Y.
Development of chemical tools to monitor and control isoaspartyl peptide methyltransferase activity (2017), Angew. Chem. Int. Ed. Engl., 56, 153-157 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
Nalpha-benzyloxycarbonyl-O-benzyl-L-Asp-Nepsilon-L-Lys-L-Tyr-L-Ala-amide	-	Homo sapiens
S-adenosyl-L-homocysteine	-	Homo sapiens
sinefungin	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + protein L-isoaspartate	Homo sapiens	-	S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + DR-Oct-VYPisoDHA	-	Homo sapiens	S-adenosyl-L-homocysteine + DR-Oct-VYPisoD(Me)HA	-	-
S-adenosyl-L-methionine + protein L-isoaspartate	-	Homo sapiens	S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester	-	?

Synonyms

Synonyms	Comment	Organism
isoaspartyl peptide methyltransferase	-	Homo sapiens
PIMT	-	Homo sapiens
protein L-isoaspartyl methyltransferase	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00023	-	pH and temperature not specified in the publication	Homo sapiens	sinefungin
0.0026	-	pH and temperature not specified in the publication	Homo sapiens	Nalpha-benzyloxycarbonyl-O-benzyl-L-Asp-Nepsilon-L-Lys-L-Tyr-L-Ala-amide

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Release 2023.1 (January 2023)