Literature summary for 2.1.1.77 extracted from

Chatterjee, T.; Das, G.; Chatterjee, B.K.; Dhar, J.; Ghosh, S.; Chakrabarti, P.
The role of isoaspartate in fibrillation and its prevention by protein-L-isoaspartyl methyltransferase (2019), Biochim. Biophys. Acta, 1864, 129500 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
stiripentol	stabilizes the enzyme, binds close to the cofactor binding site, and increases the enzymatic activity	Rattus norvegicus
Valproic acid	stabilizes the enzyme, binds close to the cofactor binding site, and increases the enzymatic activity	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + protein L-isoaspartate	Rattus norvegicus	-	S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
PC-12 cell	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + protein L-isoaspartate	-	Rattus norvegicus	S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester	-	?
S-adenosyl-L-methionine + Val-Tyr-Pro-(isoAsp)-His-Ala	-	Rattus norvegicus	S-adenosyl-L-homocysteine + Val-Tyr-Pro-(isoAsp-alpha-methyl ester)-His-Ala	-	?

Synonyms

Synonyms	Comment	Organism
PIMT	-	Rattus norvegicus
protein-L-isoaspartyl methyltransferase	-	Rattus norvegicus

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Release 2023.1 (January 2023)