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Information on EC - L-glutamate gamma-semialdehyde dehydrogenase

for references in articles please use BRENDA:EC1.2.1.88
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IUBMB Comments
This enzyme catalyses the irreversible oxidation of glutamate-gamma-semialdehyde to glutamate as part of the proline degradation pathway. (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC, proline dehydrogenase) is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde. In many bacterial species, both activities are carried out by a single bifunctional enzyme [3,4].The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)-1-pyrroline-5-carboxylate is converted into D-glutamate. NADP+ can also act as acceptor, but with lower activity .
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The enzyme appears in viruses and cellular organisms
1-pyrroline dehydrogenase, Aldh4a1, dehydrogenase, 1-pyrroline-5-carboxylate, DELTA1-pyrroline-5-carboxylate dehydrogenase, delta1-pyrroline-5-carboxylate synthetase, DR_0813, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, LRRP Ba1-651, OsALDH12, OsALDH18-2, more
L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH + H+
show the reaction diagram
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