Literature summary for 1.2.1.88 extracted from

Li, B.; Cai, D.; Hu, S.; Zhu, A.; He, Z.; Chen, S.
Enhanced synthesis of poly gamma glutamic acid by increasing the intracellular reactive oxygen species in the Bacillus licheniformis delta1-pyrroline-5-carboxylate dehydrogenase gene ycgN-deficient strain (2018), Appl. Microbiol. Biotechnol., 102, 10127-10137 .

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Organism

Organism	UniProt	Comment	Textmining
Bacillus licheniformis	-	-	-

Synonyms

Synonyms	Comment	Organism
YcgN	-	Bacillus licheniformis

General Information

General Information	Comment	Organism
physiological function	deletion of delta1-pyrroline-5-carboxylate dehydrogenase gene ycgN increases poly-gamma glutamic acid yield to 13.91 g/l, 85.22% higher than that of the wild type. Deletion of proline dehydrogenase gene ycgM has no effect on poly-gamma glutamic acid synthesis. A 2.92fold higher delta1-pyrroline-5-carboxylate content (19.24 micromol per g dry cell weight) is detected in the ycgN deficient strain. The ROS level of of the deletion strain is increased by 1.18fold, and addition of N-acetylcysteine (antioxidant) decreases its ROS level	Bacillus licheniformis

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Release 2023.1 (January 2023)