Any feedback?
Literature summary for 1.2.1.88 extracted from
- Structural basis of substrate selectivity of delta(1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): semialdehyde chain length (2013), Arch. Biochem. Biophys., 538, 34-40.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mus musculus |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| complexed with glutarate, succinate, malonate, glyoxylate, and acetate | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glyoxylate | - |
Mus musculus |  |
| L-glutamate | - |
Mus musculus | |
| L-glutarate | - |
Mus musculus | |
| additional information | not inhibitory: malonate | Mus musculus | |
| succinate | - |
Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q8CHT0 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate semialdehyde + NAD+ + H2O | - |
Mus musculus | succinate + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Aldh4a1 | - |
Mus musculus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.27 | - |
glyoxylate | pH 7.0, 20°C | Mus musculus | |
| 12 | - |
L-glutamate | pH 7.0, 20°C | Mus musculus | |
| 30 | - |
L-glutarate | pH 7.0, 20°C | Mus musculus | |
| 58 | - |
succinate | pH 7.0, 20°C | Mus musculus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
