Ligand L-glutamate 5-semialdehyde

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Basic Ligand Information

Molecular Structure
Picture of L-glutamate 5-semialdehyde (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H9NO3
L-glutamate 5-semialdehyde
KABXUUFDPUOJMW-BYPYZUCNSA-N
Synonyms:
(2S)-2-amino-5-oxopentanoate, (S)-2-amino-5-oxopentanoate, 5-oxo-L-norvaline, glutamate-gamma-semialdehyde, glutamate gamma-semialdehyde, glutamic gamma-semialdehyde, L-glutamate-5-semialdehyde, L-glutamate-gamma-semialdehyde


Show all pahtways known for Show all BRENDA pathways known for L-glutamate 5-semialdehyde

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH + H+
show the reaction diagram
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malonyl-CoA + L-glutamate-gamma-semialdehyde = CoA + (2S,5S)-5-carboxymethylproline + CO2
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
malonyl-CoA + L-glutamate-gamma-semialdehyde = CoA + (2S,5S)-5-carboxymethylproline + CO2
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(2S)-5-hydroxy-2-aminovaleric acid + NAD+ + H2O = (2S)-2-amino-5-oxopentanoate + NADH
show the reaction diagram
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L-ornithine + O2 + H2O = 5-oxo-L-norvaline + H2O2 + NH3
show the reaction diagram
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L-ornithine + 2-oxoglutarate = L-glutamate-gamma-semialdehyde + L-glutamate
show the reaction diagram
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L-ornithine + 2-oxoglutarate = L-glutamate + (S)-2-amino-5-oxopentanoate
show the reaction diagram
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L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
potent linear mixed-type inhibitor, competitive with respect to ammonia, no inhibition of the mutant enzyme C379A
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
7
-
pH 7.2, 28°C

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
97
-
pH 7.2, 28°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.39
-
-

References & Links

Links to other databases for L-glutamate 5-semialdehyde

ChEBI
PubChem
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PubChem