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Literature summary for 1.2.1.88 extracted from
- Hydroxyproline metabolism. IV. Enzymatic synthesis of gamma-hydroxyglutamate from DELTA1-pyrroline-3-hydroxy-5-carboxylate (1960), J. Biol. Chem., 235, 3504-3512.
General Stability
| General Stability | Organism |
|---|---|
| glutathione stabilizes | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| arsenate | - |
Bos taurus |  |
| arsenite | - |
Bos taurus | |
| Borate | - |
Bos taurus | |
| DELTA1-pyrroline-2-carboxylate | - |
Bos taurus | |
| EDTA | - |
Bos taurus | |
| fluoride | - |
Bos taurus | |
| imidazole | - |
Bos taurus | |
| L-hydroxyproline | - |
Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-pyrroline-5-carboxylate + NAD+ + H2O | - |
Bos taurus | L-glutamate + NADH | - |
? | |
| DELTA1-pyrroline-3-hydroxy-5-carboxylate + NAD+ + H2O | - |
Bos taurus | 4-hydroxyglutamate + NADH | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
1-pyrroline-3-hydroxy-5-carboxylate | Bos taurus |
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Release 2023.1 (January 2023)
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