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Information on EC 1.14.15.4 - steroid 11beta-monooxygenase
for references in articles please use BRENDA:EC1.14.15.4
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EC Tree 1 Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.15.4 steroid 11beta-monooxygenase
IUBMB Comments
A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone.
The enzyme appears in viruses and cellular organisms
- 1.14.15.4
- hypertension
- cortisol
-
adrenocortical
-
steroidogenic
- corticosterone
- angiotensin
- hyperplasia
- acth
- zona
- glucocorticoid
-
steroidogenesis
-
mineralocorticoid
- glomerulosa
- adenoma
- 21-hydroxylase
- renin
- 11-deoxycortisol
- deoxycorticosterone
- fasciculata
- metyrapone
- 11-deoxycorticosterone
-
beta-hydroxysteroid
- pregnenolone
- angiotensinogen
- cushing
- cyp11a1
-
virilization
- androstenedione
- cyp21
- spironolactone
- 18-hydroxycorticosterone
- p450scc
- adrenodoxin
- 17-hydroxyprogesterone
- hirsutism
-
beta-hydroxylation
- atp1a1
-
acth-stimulated
- 17alpha-hydroxylase
-
cortisol-producing
- etomidate
- hsd3b2
- hypokalemia
- medicine
- trilostane
-
apccs
-
salt-wasting
- 11-ketotestosterone
-
low-renin
- drug development
-
liddle
-
extra-adrenal
- analysis
Synonyms
cyp11b2, cyp11b1, aldosterone synthase, 11 beta-hydroxylase, 11beta-hydroxylase, 11-hydroxylase, p450c11, 11-beta-hydroxylase, p45011beta, steroid 11beta-hydroxylase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
11beta-hydroxylase
ALDOS
-
-
-
-
Aldosterone synthase
Aldosterone-synthesizing enzyme
-
-
-
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C450XIB2
-
-
-
-
CYP11B1
CYP11B2
CYPXIB
-
-
-
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CYPXIB1
-
-
-
-
CYPXIB2
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-
-
-
CYPXIB3
-
-
-
-
EC 1.14.1.6
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-
formerly
-
EC 1.99.1.7
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-
formerly
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P-450(11 beta,aldo)
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-
-
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P-450Aldo
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-
-
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P-450c11
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-
-
-
P-450C18
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-
-
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P450(11 beta)-DS
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-
-
-
P45011beta
P450C11
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-
-
-
Steroid 11-beta-hydroxylase
steroid 11beta-hydroxylase
steroid 11beta-monooxygenase
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-
-
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steroid 11beta/18-hydroxylase
-
-
-
-
Steroid 18-hydroxylase
-
-
-
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11beta-hydroxylase
-
-
Aldosterone synthase
-
-
-
-
Aldosterone synthase
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-
CYP11B1
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-
CYP11B2
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-
Steroid 11-beta-hydroxylase
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-
-
-
steroid 11beta-hydroxylase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
superfamily of heme-containing enzyme, 11-/18-/19-hydroxylations of 11-deoxycorticosterone, 11-deoxycortisol and androstenedione
-
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
one bifunctional cytochrome P-450, 11beta-/14alpha-hydroxylation
-
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
cytochrome P45011beta is implicated in mineralocorticoid, synthesized and secreted from zona glomerulosa, as well as glucocorticoid, secreted primarily in zonae fasciculate and reticularis, biosynthesis with multiple catalytic activities, 11beta-/18-/19-hydroxylase and 18-/19-hydroxysteroid oxidase activities
-
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
for synthesis of aldosterone 3 molecules P450 must be reduced or one molecule must be reduced 3 times
-
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
P-45011beta responsible for two hydroxylase reactions
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
single enzyme, 11beta-/18-hydroxylation and aldosterone synthetic activities
-
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
11beta-/18-hydroxylation and aldosterone synthesis are catalyzed by 2 distinct forms of cytochrome P-45011beta
-
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
11beta-/18-hydroxylation and aldosterone synthesis are catalyzed by 2 distinct forms of cytochrome P-45011beta
-
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone. Formerly EC 1.14.1.6 and 1.99.1.7
-
-
-
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
2 step reduction: reduction of P-450 with non-specific donor and reduction which is specifically dependent on reduced iron-sulfur protein
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
ferric cytochrome P-45011beta-deoxycorticosterone complex classified as a pentacoordinated species, H2O molecule binds ferric heme iron
-
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
both hydroxylation activities seem to occur in a single enzyme
-
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
both hydroxylation activities seem to occur in a single enzyme
-
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
heme protein of so-called P-450 family
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydroxylation
-
-
-
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oxidation
-
-
-
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redox reaction
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-
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reduction
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-
-
-
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PATHWAY SOURCE
PATHWAYS
MetaCyc
11-oxyandrogens biosynthesis, glucocorticoid biosynthesis, mineralocorticoid biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)
A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone.
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CAS REGISTRY NUMBER
COMMENTARY
9029-66-7
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
11-deoxy-cortisol + reduced ferredoxin + O2
cortisol + ferredoxin + H2O
-
Substrates: -
Products: -
Products: -
?
11-deoxycorticosterone + adrenal ferredoxin + H2O
corticosterone + reduced adrenal ferredoxin + O2
-
Substrates: -
Products: -
Products: -
?
11-deoxycorticosterone + NADPH + O2
18-hydroxycorticosterone + NADP+ + H2O
-
Substrates: -
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2
aldosterone + oxidized adrenal ferredoxin + 2 H2O
11-deoxycorticosterone + reduced adrenal ferredoxin + O2
?
Substrates: -
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + O2
corticosterone + oxidized adrenal ferredoxin + H2O
11-deoxycorticosterone + reduced adrenodoxin + O2
corticosterone + oxidized adrenodoxin + H2O
11-deoxycortisol + adrenal ferredoxin + H2O
cortisol + reduced adrenal ferredoxin + O2
-
Substrates: -
Products: -
Products: -
?
11-deoxycortisol + NADPH + O2
cortisol + NADP+ + H2O
-
Substrates: -
Products: -
Products: -
?
11-deoxycortisol + oxidized adrenodoxin + H2O
cortisol + reduced adrenodoxin + O2
Substrates: -
Products: -
Products: -
?
11-deoxycortisol + reduced adrenal ferredoxin + O2
14alpha-hydroxy-11-deoxycortisol + oxidized adrenal ferredoxin + H2O
-
Substrates: 14alpha-hydroxylase activity
Products: -
Products: -
?
11-deoxycortisol + reduced adrenal ferredoxin + O2
cortisol + oxidized adrenal ferredoxin + H2O
11-deoxycortisol + reduced adrenodoxin + O2
cortisol + oxidized adrenodoxin + H2O
Substrates: -
Products: -
Products: -
?
16,17alpha-epoxyprogesterone + reduced adrenal ferredoxin + O2
11beta-hydroxy-16,17alpha-epoxyprogesterone + adrenal ferredoxin + H2O
17alpha,21-dihydroxy-pregn-4-ene-3,20-dione + reduced adrenal ferredoxin + O2
11beta,17alpha,21-trihydroxy-pregn-4-ene-3,20-dione + oxidized adrenal ferredoxin + H2O
-
Substrates: i.e. Reichstein's compound, inducer
Products: hydrocortisone, 60%, 11beta hydroxylation
Products: hydrocortisone, 60%, 11beta hydroxylation
?
17alpha,21-dihydroxy-pregn-4-ene-3,20-dione + reduced adrenal ferredoxin + O2
14alpha,17alpha,21-trihydroxy-pregn-4-ene-3,20-dione + oxidized adrenal ferredoxin + H2O
-
Substrates: i.e. Reichstein's compound, inducer
Products: 25%, 14alpha hydroxylation
Products: 25%, 14alpha hydroxylation
?
18-hydroxy-corticosterone + reduced adrenal ferredoxin + O2
aldosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: 18-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis
Products: -
Products: -
?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
aldosterone + oxidized adrenal ferredoxin + H2O
18-hydroxycorticosterone + reduced adrenodoxin + O2
aldosterone + oxidized adrenodoxin + H2O
Substrates: -
Products: -
Products: -
?
19-hydroxy-11-deoxycorticosterone + reduced adrenal ferredoxin + O2
19-oxo-11-deoxycorticosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: -
Products: -
Products: -
?
4-androstene-3,17-dione + reduced adrenal ferredoxin + O2
11beta-hydroxy-4-androstene-3,17-dione + oxidized adrenal ferredoxin + H2O
-
Substrates: i.e. testosterone, 11beta-/19-hydroxylase activity, good sustrate
Products: -
Products: -
?
4-androstene-3,17-dione + reduced adrenal ferredoxin + O2
19-hydroxy-4-androstene-3,17-dione + oxidized adrenal ferredoxin + H2O
-
Substrates: i.e. testosterone, 11beta-/19-hydroxylase activity, good sustrate
Products: -
Products: -
?
4-pregnen-21-ol-3,20-dione + reduced adrenal ferredoxin + O2
4-pregnene-11,21-diol-3,20-dione + oxidized adrenal ferredoxin + H2O
4-pregnene-17,21-diol-3,20-dione + reduced adrenal ferredoxin + O2
4-pregnene-11,17,21-triol-3,20-dione + oxidized adrenal ferredoxin + H2O
a steroid + reduced adrenodoxin + O2
an 11beta-hydroxysteroid + oxidized adrenodoxin + H2O
-
Substrates: -
Products: -
Products: -
?
corticosterone + reduced adrenal ferredoxin + O2
11-deoxycorticosterone + adrenal ferredoxin + ?
corticosterone + reduced adrenal ferredoxin + O2
18-hydroxy-11-deoxycorticosterone + oxidized adrenal ferredoxin + ?
-
Substrates: addition of adrenodoxin and adrenodoxin reductase
Products: -
Products: -
?
corticosterone + reduced adrenal ferredoxin + O2
18-hydroxy-corticosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: 18-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis
Products: -
Products: -
?
corticosterone + reduced adrenal ferredoxin + O2
18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
corticosterone + reduced adrenal ferredoxin + O2
aldosterone + oxidized adrenal ferredoxin + H2O
corticosterone + reduced adrenodoxin + O2
18-hydroxycorticosterone + oxidized adrenodoxin + H2O
cortisol + reduced adrenal ferredoxin + O2
cortisone + oxidized adrenal ferredoxin + ?
-
Substrates: -
Products: -
Products: -
?
deoxycorticosterone + oxidized adrenodoxin + H2O
corticosterone + reduced adrenodoxin + O2
Substrates: -
Products: -
Products: -
?
metyrapone + ?
metyrapol + ?
-
Substrates: plasma, product-stereoselective reductive metabolism
Products: enantiomers
Products: enantiomers
r
progesterone + reduced adrenodoxin + O2
11beta-hydroxyprogesterone + oxidized adrenodoxin + H2O
testosterone + reduced adrenal ferredoxin + O2
11beta-hydroxytestosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: at low rate
Products: -
Products: -
?
testosterone + reduced adrenodoxin + O2
11-hydroxytestosterone + oxidized adrenodoxin + H2O
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2
aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
Substrates: -
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2
aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
Substrates: 11beta-hydroxylase and 18-hydroxylase activities, after replacement of Tween 20 by phosphatidylcholine catalytic activity for aldosterone activity is exhibited, form 1 higher active in aldosterone and 18-hydroxycorticosterone production and less active in the production of corticosterone and 18-hydroxydeoxycorticosterone from deoxycorticosterone as form 2
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2
aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
Substrates: 11beta-/18-hydroxylation
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2
aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
Substrates: 3 steps in glomerulosa catalysed by one enzyme, 11beta-hydroxylation to corticosterone, 18-hydroxylation to 18-hydroxycorticosterone and aldehyde synthesis to aldosterone
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2
aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
Substrates: 3 step 11beta-/18-hydroxylation to aldosterone
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2
aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
Substrates: 49 kDa protein, exclusively in zona glomerulosa, 11beta -hydroxylation, as well as 18-hydroxylation and 18-hydroxydehydrogenation of corticosterone with 18-hydroxydeoxycorticosterone and 18-hydroxycorticosterone as intermediates
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2
aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
Substrates: 49 kDa protein, exclusively in zona glomerulosa, 11beta -hydroxylation, as well as 18-hydroxylation and 18-hydroxydehydrogenation of corticosterone with 18-hydroxydeoxycorticosterone and 18-hydroxycorticosterone as intermediates
Products: product of 49 kDa protein
Products: product of 49 kDa protein
?
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2
aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
Substrates: 51 kDa protein, zona fasciculata and glomerulosa, high sodium and low potassium, 11beta-/18-hydroxylation
Products: product of 49 kDa protein
Products: product of 49 kDa protein
?
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2
aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
Substrates: by 49.5 kDa protein from capsular portion, 11beta-/18-hydroxylation by 51.5 kDa protein
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2
aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
Substrates: supported by adrenodoxin and adrenodoxin reductase, 3 step-hydroxylation with corticosterone and 18-hydroxycorticosterone as intermediates, 11beta-/18-hydroxylase
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + O2
corticosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: containing adrenal ferredoxin, adrenal ferredoxin reductase and P-45011beta, highly active hydroxylation, 11beta-/18-hydroxylase activity
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + O2
corticosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: 11beta-hydroxylation
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + O2
corticosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: addition of adrenodoxin and adrenodoxin reductase
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + O2
corticosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: 11beta-hydroxylation
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + O2
corticosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: 11beta-hydroxylation
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + O2
corticosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: 11beta-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + O2
corticosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: by 49.5 kDa protein from capsular portion, 11beta-/18-hydroxylation by 51.5 kDa protein
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + O2
corticosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: by 49.5 kDa protein from capsular portion, 11beta-/18-hydroxylation by 51.5 kDa protein
Products: 51.5 kDa protein
Products: 51.5 kDa protein
?
11-deoxycorticosterone + reduced adrenal ferredoxin + O2
corticosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: 18-/11beta-hydroxylation
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenal ferredoxin + O2
corticosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: adrenal
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenodoxin + O2
corticosterone + oxidized adrenodoxin + H2O
Substrates: -
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenodoxin + O2
corticosterone + oxidized adrenodoxin + H2O
Substrates: -
Products: -
Products: -
?
11-deoxycorticosterone + reduced adrenodoxin + O2
corticosterone + oxidized adrenodoxin + H2O
Substrates: i.e. 21-hydroxyprogesterone
Products: -
Products: -
?
11-deoxycortisol + reduced adrenal ferredoxin + O2
cortisol + oxidized adrenal ferredoxin + H2O
-
Substrates: cytochrome P-45011beta-linked monoxygenase
Products: -
Products: -
?
11-deoxycortisol + reduced adrenal ferredoxin + O2
cortisol + oxidized adrenal ferredoxin + H2O
-
Substrates: 11beta-hydroxylase activity
Products: -
Products: -
?
11-deoxycortisol + reduced adrenal ferredoxin + O2
cortisol + oxidized adrenal ferredoxin + H2O
-
Substrates: -
Products: -
Products: -
?
11-deoxycortisol + reduced adrenal ferredoxin + O2
cortisol + oxidized adrenal ferredoxin + H2O
Substrates: -
Products: -
Products: -
?
11-deoxycortisol + reduced adrenal ferredoxin + O2
cortisol + oxidized adrenal ferredoxin + H2O
-
Substrates: 11beta-hydroxylation
Products: -
Products: -
?
11-deoxycortisol + reduced adrenal ferredoxin + O2
cortisol + oxidized adrenal ferredoxin + H2O
-
Substrates: CYP11B1
Products: -
Products: -
?
11-deoxycortisol + reduced adrenal ferredoxin + O2
cortisol + oxidized adrenal ferredoxin + H2O
Substrates: CYP11B1
Products: -
Products: -
?
11-deoxycortisol + reduced adrenal ferredoxin + O2
cortisol + oxidized adrenal ferredoxin + H2O
-
Substrates: deficiency of steroid 11-hydroxylase CYP11B1 due to mutations in the CYP11B1 gene causes congenital adrenal hyperplasia, a group of autosomal recessive disorders, overview
Products: -
Products: -
?
16,17alpha-epoxyprogesterone + reduced adrenal ferredoxin + O2
11beta-hydroxy-16,17alpha-epoxyprogesterone + adrenal ferredoxin + H2O
-
Substrates: -
Products: the product is an important intermediate for many anti-inflammatory drugs
Products: the product is an important intermediate for many anti-inflammatory drugs
?
16,17alpha-epoxyprogesterone + reduced adrenal ferredoxin + O2
11beta-hydroxy-16,17alpha-epoxyprogesterone + adrenal ferredoxin + H2O
-
Substrates: assay optimization
Products: -
Products: -
?
16,17alpha-epoxyprogesterone + reduced adrenal ferredoxin + O2
11beta-hydroxy-16,17alpha-epoxyprogesterone + adrenal ferredoxin + H2O
-
Substrates: -
Products: the product is an important intermediate for many anti-inflammatory drugs
Products: the product is an important intermediate for many anti-inflammatory drugs
?
16,17alpha-epoxyprogesterone + reduced adrenal ferredoxin + O2
11beta-hydroxy-16,17alpha-epoxyprogesterone + adrenal ferredoxin + H2O
-
Substrates: assay optimization
Products: -
Products: -
?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
aldosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: -
Products: -
Products: -
?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
aldosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: -
Products: 18-hydroxylation
Products: 18-hydroxylation
?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
aldosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: -
Products: -
Products: -
?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
aldosterone + oxidized adrenal ferredoxin + H2O
Substrates: -
Products: -
Products: -
?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
aldosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: CYP11B2
Products: -
Products: -
?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
aldosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: -
Products: 18-hydroxylation
Products: 18-hydroxylation
?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
aldosterone + oxidized adrenal ferredoxin + H2O
-
Substrates: -
Products: aldosterone production exclusively in the zona glomerulosa
Products: aldosterone production exclusively in the zona glomerulosa
?
18-hydroxycorticosterone + reduced ferredoxin + O2
aldosterone + ferredoxin + H2O
-
Substrates: -
Products: -
Products: -
?
18-hydroxycorticosterone + reduced ferredoxin + O2
aldosterone + ferredoxin + H2O
-
Substrates: aldosterone is one of the main effectors of the reninĀangiotensinĀaldosterone system, RAAS, regulating salt and water homeostasis and thereby also blood pressure
Products: -
Products: -
?
18-hydroxycorticosterone + reduced ferredoxin + O2
aldosterone + ferredoxin + H2O
-
Substrates: -
Products: -
Products: -
?
4-pregnen-21-ol-3,20-dione + reduced adrenal ferredoxin + O2
4-pregnene-11,21-diol-3,20-dione + oxidized adrenal ferredoxin + H2O
-
Substrates: 11-deoxycorticosterone, fumarate required in mitochondria treated with hypotonic solutions of electrolytes
Products: -
Products: -
?
4-pregnen-21-ol-3,20-dione + reduced adrenal ferredoxin + O2
4-pregnene-11,21-diol-3,20-dione + oxidized adrenal ferredoxin + H2O
-
Substrates: 11-hydroxylation
Products: -
Products: -
?
4-pregnen-21-ol-3,20-dione + reduced adrenal ferredoxin + O2
4-pregnene-11,21-diol-3,20-dione + oxidized adrenal ferredoxin + H2O
-
Substrates: 11-hydroxylation
Products: -
Products: -
?
4-pregnene-17,21-diol-3,20-dione + reduced adrenal ferredoxin + O2
4-pregnene-11,17,21-triol-3,20-dione + oxidized adrenal ferredoxin + H2O
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Substrates: 11-hydroxylation
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4-pregnene-17,21-diol-3,20-dione + reduced adrenal ferredoxin + O2
4-pregnene-11,17,21-triol-3,20-dione + oxidized adrenal ferredoxin + H2O
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Substrates: 11-hydroxylation
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androstendione + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
Substrates: low activity with isozyme CYP11B1
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androstendione + reduced adrenodoxin + O2
? + oxidized adrenodoxin + H2O
Substrates: low activity with isozyme CYP11B2
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corticosterone + reduced adrenal ferredoxin + O2
11-deoxycorticosterone + adrenal ferredoxin + ?
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corticosterone + reduced adrenal ferredoxin + O2
11-deoxycorticosterone + adrenal ferredoxin + ?
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Substrates: -
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corticosterone + reduced adrenal ferredoxin + O2
18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
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Substrates: addition of adrenodoxin and adrenodoxin reductase
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corticosterone + reduced adrenal ferredoxin + O2
18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
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Substrates: 18-hydroxylation
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corticosterone + reduced adrenal ferredoxin + O2
18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
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Substrates: 18-hydroxylation
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corticosterone + reduced adrenal ferredoxin + O2
aldosterone + oxidized adrenal ferredoxin + H2O
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Substrates: 18-hydroxylation
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corticosterone + reduced adrenal ferredoxin + O2
aldosterone + oxidized adrenal ferredoxin + H2O
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Substrates: 18-hydroxycorticosterone as intermediate of 11beta-hydroxylation
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corticosterone + reduced adrenodoxin + O2
18-hydroxycorticosterone + oxidized adrenodoxin + H2O
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corticosterone + reduced adrenodoxin + O2
18-hydroxycorticosterone + oxidized adrenodoxin + H2O
Substrates: -
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cortisol + reduced adrenal ferredoxin + O2
11-deoxycortisol + adrenal ferredoxin + ?
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Substrates: -
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cortisol + reduced adrenal ferredoxin + O2
11-deoxycortisol + adrenal ferredoxin + ?
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Substrates: in the adrenal zona fasciculata
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progesterone + reduced adrenodoxin + O2
11beta-hydroxyprogesterone + oxidized adrenodoxin + H2O
Substrates: low activity with isozyme CYP11B1
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progesterone + reduced adrenodoxin + O2
11beta-hydroxyprogesterone + oxidized adrenodoxin + H2O
Substrates: low activity with isozyme CYP11B2
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testosterone + reduced adrenodoxin + O2
11-hydroxytestosterone + oxidized adrenodoxin + H2O
Substrates: low activity with isozyme CYP11B1
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testosterone + reduced adrenodoxin + O2
11-hydroxytestosterone + oxidized adrenodoxin + H2O
Substrates: low activity with isozyme CYP11B2
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additional information
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Substrates: the enzyme is involved in sex differentiation in the protandrous anemonefish, overview
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additional information
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Substrates: corticosterone generally believed to be preferred substrate for 18-hydroxylase
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additional information
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Substrates: corticosterone normal substrate in vivo
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additional information
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Substrates: the enzyme is involved in gonadal transformation in the zebrafish, enzyme expression regulation, overview
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additional information
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Substrates: the enzyme is involved in gonadal transformation in the zebrafish, enzyme expression regulation, overview
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additional information
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Substrates: a key mitochondrial enzyme for the production of 11-oxygenated androgens, which have been shown to be potent masculinising steroids in several fish species, it plays a role in testicular development
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additional information
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Substrates: -344T/C polymorphism is associated with a clinically relevant phenotype for diabetic nephropathy such as hypertension
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additional information
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Substrates: CYP11B2-CYP11B1 haplotypes associate with decreased 11beta-hydroxylase activity, overview
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additional information
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Substrates: effects of enzyme inhibition of steroid biosynthesis and mineralcorticoid formation, overview
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additional information
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Substrates: enzyme deficiency is a cause for congenital adrenal hyperplasia, overview
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additional information
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Substrates: genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor 11-deoxycortisol urinary metabolite excretion, overview
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additional information
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Substrates: non-classical enzyme deficiency causes mild androgen excess, hirsutism, precocious adrenarche and accelerated growth in children, missense mutations are responsible for non-classical adrenal hyperplasia in children, overview
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additional information
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Substrates: variation of 344 C/T and intron 2 in the CYP11B2 gene, encoding aldosterone synthase, is associated with CYP11B1 deficiency due to variations of gene CYP11B1 at positions 1889 and 1859 and disequiliibrium with CYP11B2, overview
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additional information
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Substrates: 11-beta-hydroxylase deficiency, i.e. 11betaOHD is caused by CYP11B1 gene defects and leads to congenital adrenal hyperplasia associated with hypertension, overview
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additional information
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Substrates: 11beta-hydroxylase deficiency is the second most common form of congenital adrenal hyperplasia after 21-hydroxylase deficiency, overview
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additional information
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Substrates: congenital adrenal hyperplasia due to steroid 11beta-hydroxylase deficiency is a genetic disorder of steroidogenesis, transmitted as an autosomal recessive trait. It is associated with low renin hypertension, hypokalemia, hyperandrogenemia and genital ambiguity in affected females, overview
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additional information
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Substrates: deficiency of 11beta-hydroxylase results in decreased synthesis of cortisol and glucocorticoids, and thus causes weakened depressive feedback ofACTH and increased synthesis of ACTH in pituitary, which leads to production of more cortisol precursor in zona fasciculata, enzyme regulation, overview
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additional information
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Substrates: enzyme deficiency leads to hypokalemia and further, when under-treated, to rhabdomyolysis, overview
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additional information
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Substrates: the enzyme is regulated by adrenocorticotrophic hormone, ACTH
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additional information
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Substrates: the polymorphism genotype of gene CYP11B2, encoding aldosterone synthase, affects the activity of the 11beta-hydroxylase, encoded by gene CYP11B1, overview
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additional information
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Substrates: the recombinant enzyme is capable of hydroxylating its substrates at position 11-beta
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additional information
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Substrates: enzyme is responsible for the final step of aldosterone synthesis. It requires electron transfer from the adrenodoxin/adrenodoxin reductase system to catalyze the production of aldosterone
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additional information
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Substrates: enzyme is responsible for the final step of aldosterone synthesis. It requires electron transfer from the adrenodoxin/adrenodoxin reductase system to catalyze the production of aldosterone
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additional information
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Substrates: enzyme is responsible for the final step of aldosterone synthesis. It requires electron transfer from the adrenodoxin/adrenodoxin reductase system to catalyze the production of aldosterone
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additional information
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Substrates: CYP11B2 hydroxylates 18-hydroxycorticosterone
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additional information
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Substrates: steroid 11beta-hydroxylase converts 11-deoxycortisol and 11-deoxycorticosterone to cortisol and corticosterone, respectively
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additional information
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Substrates: bifunctional enzyme catalyzing the biosynthesis of aldosterone by successive 11beta- and 18-hydroxylation followed by an 18-oxidation of 11-deoxycorticosterone
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additional information
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Substrates: bifunctional enzyme catalyzing the biosynthesis of aldosterone by successive 11beta- and 18-hydroxylation followed by an 18-oxidation of 11-deoxycorticosterone
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additional information
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Substrates: N-terminally unprocessed enzyme has 2fold more activity than the mature physiological enzyme
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additional information
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Substrates: aldosterone synthase shows high 11beta-hydroxylase activity toward both gluco- and mineralocorticoid formation, and additional 18-oxidase activity, substrate specificties of isozymes CYP11B2 and CYP11B1, overview. No oxidation activity of CYP11B2 with 18-hydroxycorticosterone, 11-dehydrocorticosterone, 21-hydroxypregnenolone, and poor activity with cortisol
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additional information
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Substrates: aldosterone synthase shows high 11beta-hydroxylase activity toward both gluco- and mineralocorticoid formation, and additional 18-oxidase activity, substrate specificties of isozymes CYP11B2 and CYP11B1, overview. No oxidation activity of CYP11B2 with 18-hydroxycorticosterone, 11-dehydrocorticosterone, 21-hydroxypregnenolone, and poor activity with cortisol
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additional information
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Substrates: aldosterone synthase shows high 11beta-hydroxylase activity toward both gluco- and mineralocorticoid formation, and additional 18-oxidase activity, substrate specificties of isozymes CYP11B2 and CYP11B1, overview. No oxidation activity of CYP11B2 with 18-hydroxycorticosterone, 11-dehydrocorticosterone, 21-hydroxypregnenolone, and poor activity with cortisol
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additional information
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Substrates: substrate specificties of isozymes CYP11B2 and CYP11B1, overview. No or poor activity of CYP11B1 with cortisol, 18-hydroxycorticosterone, 11-dehydrocorticosterone, 21-hydroxypregnenolone, and 11beta-hydroxyprogesterone
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additional information
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Substrates: substrate specificties of isozymes CYP11B2 and CYP11B1, overview. No or poor activity of CYP11B1 with cortisol, 18-hydroxycorticosterone, 11-dehydrocorticosterone, 21-hydroxypregnenolone, and 11beta-hydroxyprogesterone
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additional information
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Substrates: substrate specificties of isozymes CYP11B2 and CYP11B1, overview. No or poor activity of CYP11B1 with cortisol, 18-hydroxycorticosterone, 11-dehydrocorticosterone, 21-hydroxypregnenolone, and 11beta-hydroxyprogesterone
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additional information
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Substrates: the concomitant down-regulation of P450arom and up-regulation of P45011beta are of pivotal importance to the sex change
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additional information
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Substrates: the concomitant down-regulation of P450arom and up-regulation of P45011beta are of pivotal importance to the sex change
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additional information
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Substrates: prolactin regulatory element-binding (PREB) protein. It regulates the transcription of the CYP11B1 gene via cAMP. PREB can function as a transcriptional regulator of the CYP11B1 promoter. PREB binds to the CYP11B1 promoter, and in cells expressing PREB, it increases CYP11B1 expression. Knockdown of PREB expression attenuated the effects of cAMP on CYP11B1 expression. CYP11B1 promoter activity is increased in the cells treated with the scrambled siRNA and cAMP, while the CYP11B1 promoter activity is markedly reduced in the cells treated with the PREB-specific siRNA. Enzyme is regulated by cAMP, which stimulates the expression of PREB. Knockdown of PREB expression attenuates the effects of cAMP on CYP11B1 expression
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additional information
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Substrates: responsible for the last step of glucocorticoid biosynthesis in the adrenal cortices of many kinds of animals
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additional information
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Substrates: androgen production of male animal is partially regulated by changes in abundance of enzyme mRNA
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
11-deoxy-cortisol + reduced ferredoxin + O2
cortisol + ferredoxin + H2O
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Substrates: -
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11-deoxycorticosterone + reduced adrenal ferredoxin + O2
corticosterone + oxidized adrenal ferredoxin + H2O
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Substrates: 11beta-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis
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11-deoxycorticosterone + reduced adrenodoxin + O2
corticosterone + oxidized adrenodoxin + H2O