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Information on EC 1.14.15.4 - steroid 11beta-monooxygenase
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1.14.15.4 steroid 11beta-monooxygenaseIUBMB Comments
A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone.
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Word Map
- 1.14.15.4
- hypertension
- cortisol
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adrenocortical
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steroidogenic
- corticosterone
- angiotensin
- acth
- hyperplasia
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mineralocorticoid
- glucocorticoid
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steroidogenesis
- zona
- glomerulosa
- 21-hydroxylase
- adenoma
- renin
- 11-deoxycortisol
- fasciculata
- deoxycorticosterone
- metyrapone
- 11-deoxycorticosterone
- angiotensinogen
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beta-hydroxysteroid
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cushing
- pregnenolone
- androstenedione
-
virilization
- 18-hydroxycorticosterone
- 17-hydroxyprogesterone
- cyp21
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beta-hydroxylation
- spironolactone
- adrenodoxin
- p450scc
- hsd3b2
- hirsutism
-
cortisol-producing
- 11-ketotestosterone
- 17alpha-hydroxylase
- hypokalemia
- atp1a1
- etomidate
-
acth-stimulated
- cyp19a1a
- trilostane
- analysis
-
salt-wasting
-
low-renin
- medicine
-
apccs
- drug development
-
liddle
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extra-adrenal
The enzyme appears in viruses and cellular organisms
Synonyms
11-hydroxylase, 11 beta-hydroxylase, 11-beta hydroxylase, 11-beta-hydroxylase, 11-hydroxylase, 11beta hydroxylase, 11beta-hydroxylase, ALDOS, Aldosterone synthase, Aldosterone-synthesizing enzyme, 
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topREACTION 
REACTION DIAGRAM
COMMENTARY 
ORGANISM
UNIPROT
LITERATURE
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
superfamily of heme-containing enzyme, 11-/18-/19-hydroxylations of 11-deoxycorticosterone, 11-deoxycortisol and androstenedione
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
one bifunctional cytochrome P-450, 11beta-/14alpha-hydroxylation
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
cytochrome P45011beta is implicated in mineralocorticoid, synthesized and secreted from zona glomerulosa, as well as glucocorticoid, secreted primarily in zonae fasciculate and reticularis, biosynthesis with multiple catalytic activities, 11beta-/18-/19-hydroxylase and 18-/19-hydroxysteroid oxidase activities
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
for synthesis of aldosterone 3 molecules P450 must be reduced or one molecule must be reduced 3 times
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
P-45011beta responsible for two hydroxylase reactions
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
single enzyme, 11beta-/18-hydroxylation and aldosterone synthetic activities
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
11beta-/18-hydroxylation and aldosterone synthesis are catalyzed by 2 distinct forms of cytochrome P-45011beta
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
11beta-/18-hydroxylation and aldosterone synthesis are catalyzed by 2 distinct forms of cytochrome P-45011beta
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone. Formerly EC 1.14.1.6 and 1.99.1.7
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
2 step reduction: reduction of P-450 with non-specific donor and reduction which is specifically dependent on reduced iron-sulfur protein
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
ferric cytochrome P-45011beta-deoxycorticosterone complex classified as a pentacoordinated species, H2O molecule binds ferric heme iron
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
both hydroxylation activities seem to occur in a single enzyme
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
both hydroxylation activities seem to occur in a single enzyme
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a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
heme protein of so-called P-450 family
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