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Literature summary for 1.14.15.4 extracted from

  • Vecchiola, A.; Lagos, C.F.; Fuentes, C.A.; Allende, F.; Campino, C.; Valdivia, C.; Tapia-Castillo, A.; Ogishima, T.; Mukai, K.; Owen, G.; Solari, S.; Carvajal, C.A.; Fardella, C.E.
    Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro (2013), Reprod. Biol. Endocrinol., 11, 76.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type CYP11B1 and of chimeric mutant CYP11B1/B2 in HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of a chimeric mutant from 11beta-hydroxylase CYP11B1 and aldosterone synthase CYP11B2 genes analogously to the naturally occuring mutant resulting from an unequal crossover break point Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information estradiol has no effect on aldosterone production by wild-type CYP11B1 and chimeric mutant CYP11B1/B2 in HEK-293 cells Homo sapiens
progesterone progesterone acts as a competitive inhibitor for 11beta-hydroxylase and aldosterone synthase, inhibits aldosterone production by wild-type CYP11B1 and chimeric mutant CYP11B1/B2 in HEK-293 cells. The wild-type is more strongly inhibited than the chimera Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
11beta-hydroxylase
-
Homo sapiens
Aldosterone synthase
-
Homo sapiens
CYP11B1
-
Homo sapiens
CYP11B2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
adrenodoxin
-
Homo sapiens

General Information

General Information Comment Organism
malfunction familial hyperaldosteronism type I is caused by the unequal recombination between the 11beta-hydroxylase CYP11B1 and aldosterone synthase CYP11B2 genes, resulting in the generation of a CYP11B1/B2 chimeric gene and abnormal adrenal aldosterone production, which leads to severe hypertension and an elevated frequency of stroke at a young age Homo sapiens
additional information molecular modelling of CYP11B1 and CYP11B1/B2 chimeric proteins and steroids docking, overview Homo sapiens
physiological function progesterone might regulate the 11beta-hydroxylase CYP11B1 and aldosterone synthase CYP11B2 enzymatic activities and contribute to the decay of aldosterone synthase activity in CYP11B1/B2 chimeric gene-positive patients. This regulatory mechanism of progesterone action might be involved in protecting pregnant women with FH-1 against hypertension Homo sapiens