BRENDA - Enzyme Database show
show all sequences of 1.14.15.4

Cytochrome P-450 for 11beta- and 18-hydroxylase activities of bovine adrenocortical mitochondria: one enzyme or two?

Watanuki, M.; Tilley, B.E.; Hall, P.F.; Biochemistry 17, 127-130 (1978)

Data extracted from this reference:

General Stability
General Stability
Organism
deoxycorticosterone stabilizes
Bos taurus
Inhibitors
Inhibitors
Commentary
Organism
Structure
acetone
10%, v/v, complete inhibition of hydroxylation
Bos taurus
antiserum
produced by rabbits
Bos taurus
CO
-
Bos taurus
deoxycorticosterone
competitive substrate inhibition
Bos taurus
ethanol
10%, v/v, complete inhibition of hydroxylation
Bos taurus
KCl
total inactivation
Bos taurus
methanol
10%, v/v, complete inhibition of hydroxylation
Bos taurus
Metyrapone
competitive substrate inhibition
Bos taurus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Bos taurus
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Bos taurus
corticosterone normal substrate in vivo
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Reaction
Reaction
Commentary
Organism
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O
both hydroxylation activities seem to occur in a single enzyme; heme protein of so-called P-450 family
Bos taurus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adrenal cortex
-
Bos taurus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.000171
-
18-hydroxylation activity, 4% O2, 96% N2
Bos taurus
0.000211
-
18-hydroxylation activity, 21% O2, 79% N2
Bos taurus
0.00205
-
11beta-hydroxylation activity, 4% O2, 96% N2
Bos taurus
0.00278
-
11beta-hydroxylation activity, 21% O2, 79% N2
Bos taurus
Storage Stability
Storage Stability
Organism
4°C, 11 days, both activities decrease considerably in a similar way, deoxycorticosterone delays decline
Bos taurus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
11-deoxycorticosterone + reduced adrenal ferredoxin + O2
addition of adrenodoxin and adrenodoxin reductase
285390
Bos taurus
corticosterone + oxidized adrenal ferredoxin + H2O
-
285390
Bos taurus
?
corticosterone + reduced adrenal ferredoxin + O2
addition of adrenodoxin and adrenodoxin reductase
285390
Bos taurus
18-hydroxy-11-deoxycorticosterone + oxidized adrenal ferredoxin + H2O
-
285390
Bos taurus
?
additional information
corticosterone normal substrate in vivo
285390
Bos taurus
?
-
-
-
-
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
20
-
-
Bos taurus
Temperature Range [°C]
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
2
50
at 50°C almost no activity
Bos taurus
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
2
-
14% residual activity of 11beta- and 18-hydroxylation
Bos taurus
30
-
after preincubation for 20 min, 27% residual activity, after 60 min 5.7%
Bos taurus
50
-
complete inactivation
Bos taurus
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Bos taurus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Bos taurus
General Stability (protein specific)
General Stability
Organism
deoxycorticosterone stabilizes
Bos taurus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
acetone
10%, v/v, complete inhibition of hydroxylation
Bos taurus
antiserum
produced by rabbits
Bos taurus
CO
-
Bos taurus
deoxycorticosterone
competitive substrate inhibition
Bos taurus
ethanol
10%, v/v, complete inhibition of hydroxylation
Bos taurus
KCl
total inactivation
Bos taurus
methanol
10%, v/v, complete inhibition of hydroxylation
Bos taurus
Metyrapone
competitive substrate inhibition
Bos taurus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Bos taurus
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Bos taurus
corticosterone normal substrate in vivo
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adrenal cortex
-
Bos taurus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.000171
-
18-hydroxylation activity, 4% O2, 96% N2
Bos taurus
0.000211
-
18-hydroxylation activity, 21% O2, 79% N2
Bos taurus
0.00205
-
11beta-hydroxylation activity, 4% O2, 96% N2
Bos taurus
0.00278
-
11beta-hydroxylation activity, 21% O2, 79% N2
Bos taurus
Storage Stability (protein specific)
Storage Stability
Organism
4°C, 11 days, both activities decrease considerably in a similar way, deoxycorticosterone delays decline
Bos taurus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
11-deoxycorticosterone + reduced adrenal ferredoxin + O2
addition of adrenodoxin and adrenodoxin reductase
285390
Bos taurus
corticosterone + oxidized adrenal ferredoxin + H2O
-
285390
Bos taurus
?
corticosterone + reduced adrenal ferredoxin + O2
addition of adrenodoxin and adrenodoxin reductase
285390
Bos taurus
18-hydroxy-11-deoxycorticosterone + oxidized adrenal ferredoxin + H2O
-
285390
Bos taurus
?
additional information
corticosterone normal substrate in vivo
285390
Bos taurus
?
-
-
-
-
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
20
-
-
Bos taurus
Temperature Range [°C] (protein specific)
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
2
50
at 50°C almost no activity
Bos taurus
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
2
-
14% residual activity of 11beta- and 18-hydroxylation
Bos taurus
30
-
after preincubation for 20 min, 27% residual activity, after 60 min 5.7%
Bos taurus
50
-
complete inactivation
Bos taurus
Other publictions for EC 1.14.15.4
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744791
Neunzig
The impact of the clinical CY ...
Homo sapiens
Endocr. J.
64
457-461
2017
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1
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1
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725981
Strushkevich
Structural insights into aldos ...
Homo sapiens
Mol. Endocrinol.
27
315-324
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-
2
1
1
-
-
2
-
-
-
-
4
-
3
-
-
1
-
-
-
-
-
16
-
1
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1
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1
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2
2
2
1
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-
2
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4
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2
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16
-
2
-
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-
2
-
-
-
-
3
5
-
-
-
726468
Vecchiola
Different effects of progester ...
Homo sapiens
Reprod. Biol. Endocrinol.
11
76
2013
-
-
1
-
1
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2
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-
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2
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1
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1
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1
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3
3
-
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-
724701
Saha
Very-low-density lipoprotein m ...
Homo sapiens
Cell Tissue Res.
348
71-80
2012
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-
-
-
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-
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2
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3
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1
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1
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1
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3
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1
-
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-
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-
-
-
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-
1
1
1
1
-
-
725828
Hobler
Human aldosterone synthase: re ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
132
57-65
2012
-
-
1
-
-
-
1
1
1
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2
4
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3
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1
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4
2
1
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1
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1
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1
1
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1
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1
1
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2
4
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1
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4
2
1
-
-
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1
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-
2
2
-
-
-
726012
Adams
Alteration in accumulated aldo ...
Homo sapiens
Mol. Pharmacol.
81
465-474
2012
-
-
1
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1
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-
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3
-
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1
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1
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3
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1
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1
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1
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1
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3
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1
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3
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1
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1
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1
-
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1
3
3
1
-
-
711434
Zimmer
N-(Pyridin-3-yl)benzamides as ...
Homo sapiens
Bioorg. Med. Chem. Lett.
21
186-190
2011
-
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1
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24
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2
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18
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1
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18
24
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712715
Lucas
Fine-tuning the selectivity of ...
Homo sapiens
J. Med. Chem.
54
2307-2319
2011
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1
1
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-
30
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1
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-
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1
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2
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54
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1
1
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54
30
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1
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2
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1
1
-
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698085
Zhang
Molecular cloning of two isofo ...
Oreochromis niloticus
Gen. Comp. Endocrinol.
165
34-41
2010
-
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1
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2
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5
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3
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3
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711420
Adams
The discovery of potent inhibi ...
Homo sapiens
Bioorg. Med. Chem. Lett.
20
4324-4327
2010
-
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19
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1
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1
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14
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14
19
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1
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1
1
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712572
Parajes
Functional consequences of sev ...
Homo sapiens
J. Clin. Endocrinol. Metab.
95
779-788
2010
-
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1
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8
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1
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2
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1
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8
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1
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2
2
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712695
Roumen
Synthesis, biological evaluati ...
Homo sapiens
J. Med. Chem.
53
1712-1725
2010
-
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47
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1
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1
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1
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92
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92
47
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1
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695555
LaSala
Coexpression of CYP11B2 or CYP ...
Homo sapiens
Anal. Biochem.
394
56-61
2009
-
1
1
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1
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2
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4
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1
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4
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1
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2
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2
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2
2
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2
2
2
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2
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2
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4
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2
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698017
Liu
Aromatase (P450arom) and 11bet ...
Monopterus albus
Fish Physiol. Biochem.
35
511-518
2009
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1
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1
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4
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4
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686170
Freel
Effect of variation in CYP11B1 ...
Homo sapiens
Clin. Endocrinol. (Oxf.)
68
700-706
2008
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1
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1
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1
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1
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686714
Zoellner
Purification and functional ch ...
Homo sapiens
FEBS J.
275
799-810
2008
-
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1
-
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-
5
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1
2
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4
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1
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1
1
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4
2
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4
1
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1
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1
1
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5
-
-
1
2
-
-
-
1
-
1
1
-
4
2
-
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-
4
1
-
-
-
-
-
-
-
-
-
687020
Peter
A case of 11beta-hydroxylase d ...
Homo sapiens
Horm. Res.
69
253-256
2008
-
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1
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1
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-
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1
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1
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1
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-
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-
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687021
Riedl
A homozygous L299P mutation in ...
Homo sapiens
Horm. Res.
70
145-149
2008
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1
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1
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1
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2
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1
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1
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1
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1
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1
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1
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1
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688009
Ye
Effects of ACTH, dexamethasone ...
Rattus norvegicus
J. Endocrinol.
196
305-311
2008
1
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1
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4
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-
10
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1
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-
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-
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-
1
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688587
Tonetto-Fernandes
21-hydroxylase deficiency tran ...
Homo sapiens
J. Pediatr. Endocrinol. Metab.
21
487-494
2008
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
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-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688588
Atabek
Hypokalemic rhabdomyolysis in ...
Homo sapiens
J. Pediatr. Endocrinol. Metab.
21
93-96
2008
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690171
Nimkarn
Steroid 11beta-hydroxylase def ...
Homo sapiens
Trends Endocrinol. Metab.
19
96-99
2008
-
-
-
-
1
-
-
-
-
-
-
3
-
1
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690201
Zhao
Progress in molecular-genetic ...
Homo sapiens
World J. Pediatr.
4
85-90
2008
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690218
Miura
Immunohistochemical evidence f ...
Amphiprion clarkii
Zool. Sci.
25
212-219
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696010
Imachi
The prolactin regulatory eleme ...
Mus musculus
Biochem. Biophys. Res. Commun.
376
531-535
2008
-
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673925
Peters
Cosegregation of a novel homoz ...
Homo sapiens
Horm. Res.
67
189-193
2007
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686286
Wang
Anti-Muellerian hormone and 11 ...
Danio rerio
Dev. Dyn.
236
1329-1338
2007
1
-
1
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
13
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
13
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686458
Chen
-
The 11beta-hydroxylation of 16 ...
Absidia caerulea, Absidia caerulea IBL02
Enzyme Microb. Technol.
41
71-79
2007
1
-
-
-
-
-
4
-
-
2
1
2
-
2
-
-
1
-
-
1
-
1
4
1
1
-
1
-
1
-
-
2
-
-
-
1
-
-
2
-
-
-
-
4
-
-
-
2
1
2
-
-
-
1
-
1
-
1
4
1
1
-
1
-
1
-
-
-
-
-
-
-
-
-
686928
Socorro
A cDNA for European sea bass ( ...
Dicentrarchus labrax
Gen. Comp. Endocrinol.
150
164-173
2007
-
-
1
-
-
-
-
-
2
-
-
1
-
3
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687019
Simm
Successful pregnancy in a pati ...
Homo sapiens
Horm. Res.
68
294-297
2007
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688012
Cingoez
Familial pericentric inversion ...
Homo sapiens
J. Endocrinol. Invest.
30
285-291
2007
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672590
Ulmschneider
Development and evaluation of ...
Homo sapiens
Bioorg. Med. Chem. Lett.
16
25-30
2006
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
1
-
-
-
1
1
1
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673258
Lajer
Aldosterone synthase (CYP11B2) ...
Homo sapiens
Diabet. Med.
23
675-680
2006
-
-
1
-
1
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673348
Lin
Mechanistic study of polychlor ...
Homo sapiens
Endocrinology
147
1536-1544
2006
1
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673954
Barr
Polymorphic variation in the 1 ...
Homo sapiens
Hypertension
49
113-119
2006
-
-
1
-
2
-
-
-
-
-
-
3
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675058
Imrie
Association between aldosteron ...
Homo sapiens
J. Clin. Endocrinol. Metab.
91
5051-5056
2006
-
-
-
-
1
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675295
Voets
Synthesis and evaluation of he ...
Homo sapiens
J. Med. Chem.
49
2222-2231
2006
-
-
1
-
-
-
22
-
-
-
-
2
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
1
-
30
-
-
1
1
-
-
-
30
22
1
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659682
Ulmschneider
Synthesis and evaluation of (p ...
Homo sapiens
J. Med. Chem.
48
1563-1575
2005
-
-
-
-
-
-
8
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659683
Ulmschneider
Synthesis and evaluation of im ...
Homo sapiens
J. Med. Chem.
48
1796-1805
2005
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673345
Ye
The aldosterone synthase (CYP1 ...
Rattus norvegicus
Endocrinology
146
5287-5293
2005
1
-
-
-
-
-
-
-
-
-
-
2
-
6
-
-
-
-
-
5
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
5
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673923
Kuribayashi
Steroid 11-beta-hydroxylase de ...
Homo sapiens
Horm. Res.
63
284-293
2005
-
-
1
-
1
-
-
-
1
-
-
2
-
1
-
-
-
-
-
3
1
-
2
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
3
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
675052
Keavney
Genetic variation at the locus ...
Homo sapiens
J. Clin. Endocrinol. Metab.
90
1072-1077
2005
-
-
1
-
1
-
-
-
-
-
-
3
-
1
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675053
Ganapathipillai
CYP11B2-CYP11B1 haplotypes ass ...
Homo sapiens
J. Clin. Endocrinol. Metab.
90
1220-1225
2005
-
-
1
-
1
-
-
-
-
-
-
3
-
1
-
-
-
-
-
1
1
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675054
Krone
Congenital adrenal hyperplasia ...
Homo sapiens
J. Clin. Endocrinol. Metab.
90
3724-3730
2005
-
-
1
-
3
-
-
-
-
1
-
1
-
2
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
3
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
675055
Paperna
Mutations in CYP11B1 and conge ...
Homo sapiens
J. Clin. Endocrinol. Metab.
90
5463-5465
2005
-
-
-
-
3
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675684
Mueller-Vieira
The adrenocortical tumor cell ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
96
259-270
2005
-
-
-
-
-
-
2
-
-
-
-
3
-
1
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
3
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655347
Wang
Expression of 11beta-hydroxyla ...
Rattus norvegicus
Endocrinology
143
621-626
2002
-
-
-
-
-
-
3
1
-
-
1
-
-
3
-
-
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
1
-
-
1
-
-
-
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657511
Lloyd-MacGilp
Mutations in aldosterone synth ...
Rattus norvegicus
Am. J. Physiol.
282
E608-617
2002
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659746
MacKenzie
11beta-hydroxylase and aldoste ...
Rattus norvegicus
J. Mol. Endocrinol.
29
319-325
2002
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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4
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659974
Kusakabe
Molecular cloning and expressi ...
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Mol. Reprod. Dev.
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456-469
2002
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285404
Davioud
18-Vinyldeoxycorticosterone: a ...
Bos taurus
Bioorg. Med. Chem.
6
1781-1788
1998
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1
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285401
Boon
Functional and expression anal ...
Ovis aries
Endocr. Res.
23
325-347
1997
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285403
Delorme
Mechanism-based inactivation o ...
Bos taurus
Eur. J. Biochem.
248
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1997
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285406
Nagamine
Stereoselective reductive meta ...
Rattus norvegicus
Biol. Pharm. Bull.
20
188-192
1997
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2
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285402
Delorme
Inhibition of bovine cytochrom ...
Bos taurus
Eur. J. Biochem.
232
247-256
1995
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3
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285407
Denner
Cloning and stable expression ...
Homo sapiens
Pharmacogenetics
5
89-96
1995
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285408
Nonaka
Frog cytochrome P-450 (11beta, ...
Rana catesbeiana
Eur. J. Biochem.
229
249-256
1995
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285410
Zhou
Cloning and expression of the ...
Rattus norvegicus
Mol. Cell. Endocrinol.
114
137-145
1995
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285405
Ohnishi
Photoaffinity labeling of cyto ...
Bos taurus
Biochim. Biophys. Acta
1161
257-264
1993
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285409
Suzuki
Purification and properties of ...
Curvularia lunata
Biochim. Biophys. Acta
1203
215-223
1993
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8
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1
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1
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285411
Kuhn-Velten
Norharman (beta-carboline) as ...
Rattus norvegicus
Eur. J. Pharmacol.
250
R1-3
1993
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285398
Seybert
Lipid regulation of bovine cyt ...
Bos taurus
Arch. Biochem. Biophys.
279
188-194
1990
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285399
Tsubaki
Active site of bovine adrenoco ...
Bos taurus
Biochemistry
29
8805-8812
1990
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285400
Yanigabashi
Ascorbate as a source of reduc ...
Bos taurus
Biochem. Biophys. Res. Commun.
170
1256-1262
1990
1
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285392
Ogishima
Isolation of aldosterone synth ...
Rattus norvegicus
J. Biol. Chem.
264
10935-10938
1989
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285396
Ogishima
Isolation of two distinct cyto ...
Bos taurus
J. Biochem.
105
497-499
1989
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2
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1
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285397
Lauber
Purification and characterizat ...
Rattus norvegicus
Arch. Biochem. Biophys.
274
109-119
1989
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8
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285395
Yanigabashi
The synthesis of aldosterone b ...
Bos taurus, Sus scrofa
J. Biol. Chem.
261
3556-3562
1986
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4
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2
2
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285394
Lombardo
Integration of purified adreno ...
Bos taurus
Biochem. Biophys. Res. Commun.
104
1638-1645
1982
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285390
Watanuki
Cytochrome P-450 for 11beta- a ...
Bos taurus
Biochemistry
17
127-130
1978
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1
8
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1
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1
3
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285391
Sato
Properties of an adrenal cytoc ...
Bos taurus
Arch. Biochem. Biophys.
190
307-314
1978
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2
2
1
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285389
Watanuki
Purification and properties of ...
Bos taurus
Biochim. Biophys. Acta
483
236-247
1977
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3
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2
1
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285393
Cooper
Studies on the partially purif ...
Bos taurus
Ann. N. Y. Acad. Sci.
212
227-242
1973
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285388
Zuidweg
Hydroxylation of Reichstein's ...
Curvularia lunata
Biochim. Biophys. Acta
152
144-158
1968
3
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3
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2
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1
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1
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285386
Tomkins
Studies on the nature of stero ...
Bos taurus, Oryctolagus cuniculus
Biochim. Biophys. Acta
23
655-656
1957
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1
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285387
Grant
The role of fumarate and TPN i ...
Bos taurus
Biochim. Biophys. Acta
18
433-434
1955
3
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