Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence analysis, expression analysis and regulation | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | determination and analysis of naturally occuring mutant enzyme variants and their phenotypes, construction of chimeric enzymes with 21-hydroxylase, gene CYP11B2, detailed overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | deficiency of 11beta-hydroxylase results in decreased synthesis of cortisol and glucocorticoids, and thus causes weakened depressive feedback ofACTH and increased synthesis of ACTH in pituitary, which leads to production of more cortisol precursor in zona fasciculata, enzyme regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | zona glomerulosa | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | deficiency of 11beta-hydroxylase results in decreased synthesis of cortisol and glucocorticoids, and thus causes weakened depressive feedback ofACTH and increased synthesis of ACTH in pituitary, which leads to production of more cortisol precursor in zona fasciculata, enzyme regulation, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-hydroxylase | - |
Homo sapiens |
cytochrome P45011beta | - |
Homo sapiens |