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Information on EC 1.13.11.2 - catechol 2,3-dioxygenase
for references in articles please use BRENDA:EC1.13.11.2
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EC Tree 1 Oxidoreductases
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.13.11 With incorporation of two atoms of oxygen
1.13.11.2 catechol 2,3-dioxygenase
IUBMB Comments
Requires FeII. The enzyme initiates the meta-cleavage pathway of catechol degradation.
The enzyme appears in viruses and cellular organisms
- 1.13.11.2
- heme
- putida
- carboxylase
- hydroxylase
- rubisco
- ferredoxins
- ribulose-1,5-bisphosphate
- l-arginine
-
non-heme
-
rieske
- tetrahydrobiopterin
-
dioxygenation
- ribulose
- toluene
- 2-oxoglutarate
- naphthalene
- biphenyls
- rhodococcus
- fmn
- nnos
-
bioremediation
-
mixed-function
-
nitric-oxide
- phenanthrene
-
photorespiration
-
photorespiratory
-
1,5-bisphosphate
- biliverdin
- bh4
- l-citrulline
- sphingomonas
-
ring-hydroxylating
- comamonas
-
dihydroxylation
- carbazole
- xylene
- l-arg
-
2-oxoglutarate-dependent
-
heme-heme
-
diiron
-
ironii
- 4-methylcatechol
-
monooxygenation
- rubp
- testosteroni
- sphingobium
- ethylbenzene
-
4.1.1.39
- degradation
- environmental protection
- fluoranthene
- rhodochrous
showSynonyms
oxygenase, catechol 2,3-dioxygenase, catechol-2,3-dioxygenase, metapyrocatechase, catechol 2,3-oxygenase, meta-cleavage dioxygenase, catechol 2,3 dioxygenase, c23os, c2,3o, 3sc23o, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
A23O
AtdB
BupB
C2,3O
C23D
C23o
C23O1
C23O2
C23Os
CatE
catechol 2,3-di-2,3-pyrocatechase
-
-
-
-
catechol 2,3-dioxygenase
catechol 2,3-oxygenase
-
-
-
-
catechol oxygenase
-
-
-
-
catechol-2,3-dioxygenase
CD-2,3
EC 1.13.1.2
-
-
formerly
-
ECDO
Extradiol-cleaving catecholic dioxygenase
meta-cleavage dioxygenase
metapyrocatechase
oxygenase
-
-
-
-
PheB
pyrocatechol 2,3-dioxygenase
-
-
-
-
Saci_2295
SSO1223
SsoC2,3O
ssol_2912
tbuE
TdnC
XylE
additional information
-
-
Pseudomonas stutzeri NA1 has the nahH gene encoding extradiol catechol 2,3-dioxygenase
C23o
-
C23Os
Halalkalibacterium ligniniphilum L1
WP_017726464.1
-
-
metapyrocatechase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
catechol + O2 = 2-hydroxymuconate-6-semialdehyde
ordered bi uni mechanism
-
catechol + O2 = 2-hydroxymuconate-6-semialdehyde
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
-
-
-
-
reduction
-
-
-
-
oxidation
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
MetaCyc
2-nitrotoluene degradation, catechol degradation to 2-hydroxypentadienoate I, catechol degradation to 2-hydroxypentadienoate II, toluene degradation II (aerobic) (via 4-methylcatechol), toluene degradation to 2-hydroxypentadienoate (via toluene-cis-diol), toluene degradation to 2-hydroxypentadienoate I (via o-cresol)
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SYSTEMATIC NAME
IUBMB Comments
catechol:oxygen 2,3-oxidoreductase (decyclizing)
Requires FeII. The enzyme initiates the meta-cleavage pathway of catechol degradation.
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CAS REGISTRY NUMBER
COMMENTARY
9029-46-3
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,2',3-trihydroxybiphenylether + O2
?
Substrates: -
Products: -
Products: -
?
2,3-dihydroxybiphenylcatechol + O2
?
Halalkalibacterium ligniniphilum
WP_017726464.1
Substrates: % of the activity as compared to 3-ethylcatechol
Products: -
Products: -
?
3,5-dichlorocatechol + O2
2-hydroxy-3,5-dimethyl-6-oxohexa-2,4-dienoic acid
Substrates: 30.8% of the activity as compared to catechol
Products: -
Products: -
?
3-ethylcatechol + O2
?
Halalkalibacterium ligniniphilum
WP_017726464.1
Substrates: best substrate. The enzyme can cleave the catechol ring when substitutions occur at C3 more efficiently than C4 substitutes. The enzyme can cleave aromatic compounds with two 6-carbon ring structures
Products: -
Products: -
?
3-methoxycatechol + O2
2-hydroxy-3-methoxy-6-oxohexa-2,4-dienoate
-
Substrates: -
Products: -
Products: -
?
3-methylcatechol + O2
2-hydroxy-3-methoxymuconate semialdehyde
Substrates: 211.7% compared to the activity with catechol
Products: -
Products: -
?
3-methylcatechol + O2
2-hydroxy-3-methylmuconate-6-semialdehyde
-
Substrates: -
Products: -
Products: -
?
3-phenylcatechol + O2
2-hydroxy-3-phenylmuconate semialdehyde
Substrates: -
Products: -
Products: -
?
3-sulfocatechol + O2 + H2O
(2E,4Z)-2-hydroxymuconate + bisulfite + H+
-
Substrates: -
Products: -
Products: -
?
4-bromocatechol + O2
4-bromo-2-hydroxymuconate semialdehyde
Substrates: -
Products: -
Products: -
?
4-fluorocatechol + O2
3-fluoro-2-hydroxy-6-oxohexa-2,4-dienoate
-
Substrates: -
Products: -
Products: -
?
4-hydroxymethylcatechol + O2
2-hydroxy-4-hydroxymethylmuconate semialdehyde
Substrates: rapid inactivation of enzyme during turnover
Products: -
Products: -
?
4-n-butylcatechol + O2
?
Substrates: activity is 1.85fold higher than with catechol
Products: -
Products: -
?
4-n-heptylcatechol + O2
?
Substrates: 45% of the activity with catechol
Products: -
Products: -
?
4-n-hexylcatechol + O2
?
Substrates: 53% of the activity with catechol
Products: -
Products: -
?
4-n-nonylcatechol + O2
?
Substrates: 10% of the activity with catechol
Products: -
Products: -
?
alkylcatechol + O2
?
Substrates: degradation of aromatic compounds
Products: -
Products: -
?
tetrachlorohydroquinone + O2
?
-
Substrates: immobilized enzyme, no activity with the free enzyme
Products: -
Products: -
?
2,3-dihydroxybiphenyl + O2
?
-
Substrates: 5% of the activity with catechol
Products: -
Products: -
?
2,3-dihydroxybiphenyl + O2
?
-
Substrates: 5% of the activity with catechol
Products: -
Products: -
?
2,3-dihydroxybiphenyl + O2
?
Substrates: 1.3% of the activity with 2,3-dihydroxybiphenyl
Products: -
Products: -
?
2,3-dihydroxybiphenyl + O2
?
Substrates: 1.3% of the activity with 2,3-dihydroxybiphenyl
Products: -
Products: -
?
2,3-dihydroxybiphenyl + O2
?
Substrates: poor substrate
Products: -
Products: -
?
2,3-dihydroxybiphenyl + O2
?
Substrates: 9.47% compared to the activity with catechol
Products: -
Products: -
?
2,3-dihydroxybiphenyl + O2
?
Sphingobium scionense DSM 19371
Substrates: 9.47% compared to the activity with catechol
Products: -
Products: -
?
2,4-dichlorophenol + O2
?
-
Substrates: -
Products: -
Products: -
?
3,4-dimethylcatechol + O2
2-hydroxy-5-methyl-6-oxo-hepta-2,4-dienoate
-
Substrates: -
Products: -
Products: -
?
3,4-dimethylcatechol + O2
2-hydroxy-5-methyl-6-oxo-hepta-2,4-dienoate
-
Substrates: -
Products: -
Products: -
?
3,5-dichlorocatechol + O2
?
-
Substrates: immobilized enzyme, no activity with the free enzyme
Products: -
Products: -
?
3,5-dichlorocatechol + O2
?
-
Substrates: immobilized enzyme, no activity with the free enzyme
Products: -
Products: -
?
3,5-dimethylcatechol + O2
2-hydroxy-3,5-dimethyl-6-oxohexa-2,4-dienoic acid
-
Substrates: -
Products: -
Products: -
?
3,5-dimethylcatechol + O2
2-hydroxy-3,5-dimethyl-6-oxohexa-2,4-dienoic acid
-
Substrates: -
Products: -
Products: -
?
3-chlorocatechol + O2
2-chloro-2-hydroxy-6-oxohexa-2,4-dienoate
-
Substrates: weak
Products: -
Products: -
?
3-chlorocatechol + O2
2-chloro-2-hydroxy-6-oxohexa-2,4-dienoate
-
Substrates: weak
Products: -
Products: -
?
3-chlorocatechol + O2
2-chloro-2-hydroxy-6-oxohexa-2,4-dienoate
-
Substrates: weak
Products: -
Products: -
?
3-chlorocatechol + O2
2-chloro-2-hydroxy-6-oxohexa-2,4-dienoate
-
Substrates: -
Products: -
Products: -
?
3-chlorocatechol + O2
2-chloro-2-hydroxy-6-oxohexa-2,4-dienoate
-
Substrates: weak
Products: -
Products: -
?
3-chlorocatechol + O2
2-chloro-2-hydroxy-6-oxohexa-2,4-dienoate
-
Substrates: weak
Products: -
Products: -
?
3-chlorocatechol + O2
2-hydroxy-6-oxohepta-2,4-dienoate
-
Substrates: -
Products: -
Products: -
?
3-chlorocatechol + O2
2-hydroxy-6-oxohepta-2,4-dienoate
Oceanimonas marisflavi 102-Na3
-
Substrates: -
Products: -
Products: -
?
3-chlorocatechol + O2
2-hydroxy-6-oxohepta-2,4-dienoate
Substrates: 82.3% of the activity as compared to catechol
Products: -
Products: -
?
3-chlorocatechol + O2
3-chloro-2-hydroxymuco