Reference on EC 3.4.24.64 - mitochondrial processing peptidase
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Rawlings, N.D.; Barrett, A.J.
Homologues of insulinase, a new superfamily of metalloendopeptidases
Biochem. J.
275
389-391
1991
Saccharomyces cerevisiae, Neurospora crassa
Kalousek, F.; Neupert, W.; Omura, T.; Schatz, G.; Schmitz, U.K.
Uniform nomenclature for the mitochondrial peptidases cleaving precursors of mitochondrial proteins
Trends Biochem. Sci.
18
249
1993
Saccharomyces cerevisiae, Neurospora crassa, Rattus norvegicus, Solanum tuberosum
Bhni, P.C.; Daum, G.
Processing of mitochondrial polypeptide precursors in yeast
Methods Enzymol.
97
311-323
1983
Saccharomyces cerevisiae, Saccharomyces cerevisiae D-273-10B
McAda, P.C.; Douglas, M.G.
A yeast mitochondrial chelator-sensitive protease that processes cytoplasmically synthesized protein precursors: isolation from yeast and assay
Methods Enzymol.
97
337-344
1983
Saccharomyces cerevisiae
Bhni, P.C.; Daum, G.; Schatz, G.
Import of proteins into mitochondria. Partial purification of a matrix-located protease involved in cleavage of mitochondrial precursor polypeptides
J. Biol. Chem.
258
4937-4943
1983
Saccharomyces cerevisiae, Saccharomyces cerevisiae D-273-10B
Miura, S.; Amaya, Y.; Mori, M.
A metalloprotease involved in the processing of mitochondrial precursor proteins
Biochem. Biophys. Res. Commun.
134
1151-1159
1986
Rattus norvegicus
Kumamoto, T.; Omura, T.
Characterization of a mitochondrial matrix protease catalyzing the processing of adrenodoxin precursor
J. Biochem.
100
247-254
1986
Bos taurus, Rattus norvegicus
Hawlitschek, G.; Schneider, H.; Schmidt, B.; Tropschug, M.; Hartl, F.U.; Neupert, W.
Mitochondrial protein import: identification of processing peptidase and of PEP, a processing enhancing protein
Cell
53
795-806
1988
Neurospora crassa
Yang, M.; Jensen, R.E.; Yaffe, M.P.; Oppliger, W.; Schatz, G.
Import of proteins into yeast mitochondria: the purified matrix processing protease contains two subunits which are encoded by the nuclear MAS1 and MAS2 genes
EMBO J.
7
3857-3862
1988
Saccharomyces cerevisiae, Saccharomyces cerevisiae D-273-10B
Jensen, R.E.; Yaffe, M.P.
Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit
EMBO J.
7
3863-3871
1988
Saccharomyces cerevisiae
Witte, C.; Jensen, R.E.; Yaffe, M.P.; Schatz, G.
MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease
EMBO J.
7
1439-1447
1988
Saccharomyces cerevisiae, More
Kleiber, J.; Kalousek, F.; Swaroop, M.; Rosenberg, L.E.
The general mitochondrial matrix processing protease from rat liver: structural characterization of the catalytic subunit
Proc. Natl. Acad. Sci. USA
87
7978-7982
1990
More, Rattus norvegicus
Geli, V.; Yang, M.; Suda, K.; Lustig, A.; Schatz, G.
The MAS-encoded processing protease of yeast mitochondria. Overproduction and characterization of its two nonidentical subunits
J. Biol. Chem.
265
19216-19222
1990
Saccharomyces cerevisiae
Schneider, H.; Arretz, M.; Wachter, E.; Neupert, W.
Matrix processing peptidase of mitochondria. Structure-function relationships
J. Biol. Chem.
265
9881-9887
1990
More, Neurospora crassa
Isaya, G.; Kalousek, F.; Fenton, W.A.; Rosenberg, L.E.
Cleavage of precursors by the mitochondrial processing peptidase requires a compatible mature protein or an intermediate octapeptide
J. Cell Biol.
113
65-76
1991
Rattus norvegicus
Yang, M.; Geli, V.; Oppliger, W.; Suda, K.; James, P.; Schatz, G.
The MAS-encoded processing protease of yeast mitochondria. Interaction of the purified enzyme with signal peptides and a purified precursor protein
J. Biol. Chem.
266
6416-6423
1991
Saccharomyces cerevisiae
Eriksson, A.C.; Glaser, E.
Mitochondrial processing proteinase: a general processing proteinase of spinach leaf mitochondria is a membrane-bound enzyme
Biochim. Biophys. Acta
1140
208-214
1992
More, Solanum tuberosum, Spinacia oleracea
-
Emmermann, M.; Schmitz, U.K.
The cytochrome c reductase integrated processing peptidase from potato mitochondria belongs to a new class of metalloendoproteases
Plant Physiol.
103
615-620
1993
Solanum tuberosum
Emmermann, M.; Braun, H.P.; Arretz, M.; Schmitz, U.K.
Characterization of the bifunctional cytochrome c reductase-processing peptidase complex from potato mitochondria
J. Biol. Chem.
268
18936-18942
1993
More, Solanum tuberosum
Saavedra-Alanis, V.M.; Rysavy, P.; Rosenberg, L.E.; Kalousek, F.
Rat liver mitochondrial processing peptidase. Both alpha- and beta-subunits are required for activity
J. Biol. Chem.
269
9284-9288
1994
Rattus norvegicus
Arretz, M.; Schneider, H.; Guiard, B.; Brunner, M.; Neupert, W.
Characterization of the mitochondrial processing peptidase of Neurospora crassa
J. Biol. Chem.
269
4959-4967
1994
Neurospora crassa
Geli, V.
Functional reconstitution in Escherichia coli of the yeast mitochondrial matrix peptidase from its two inactive subunits
Proc. Natl. Acad. Sci. USA
90
6247-6251
1993
Saccharomyces cerevisiae
Sjling, S.; Eriksson, A.C.; Glaaser, E.
A helical element in the C-terminal domain of the N. plumbaginifolia F1 beta presequence is important for recognition by the mitochondrial processing peptidase
J. Biol. Chem.
269
32059-32062
1994
Spinacia oleracea
Bassham, D.C.; Creighton, A.M.; Arretz, M.; Brunner, M.; Robinson, C.
Efficient but aberrant cleavage of mitochondrial precursor proteins by the chloroplast stromal processing peptidase
Eur. J. Biochem.
221
523-528
1994
Neurospora crassa
Brunner, M.; Neupert, W.
Purification and characterization of mitochondrial processing peptidase of Neurospora crassa
Methods Enzymol.
248
717-728
1995
Neurospora crassa
Braun, H.P.; Schmitz, U.K.
The bifunctional cytochrome c reductase/processing peptidase complex from plant mitochondria
J. Bioenerg. Biomembr.
27
423-436
1995
Solanum tuberosum, Spinacia oleracea, Triticum aestivum
Waltner, M.; Weiner, H.
Conversion of a nonprocessed mitochondrial precursor protein into one that is processed by the mitochondrial processing peptidase
J. Biol. Chem.
270
26311-26317
1995
Rattus norvegicus
Gakh, O.; Obsil, T.; Adamec, J.; Spizek, J.; Amler, E.; Janata, J.; Kalousek, F.
Substrate binding changes conformation of the alpha-, but not the beta-subunit of mitochondrial processing peptidase
Arch. Biochem. Biophys.
385
392-396
2001
Saccharomyces cerevisiae
Kitada, S.; Kojima, K.; Ito, A.
Glu191 and Asp195 in rat mitochondrial processing peptidase beta subunit are involved in effective cleavage of precursor protein through interaction with the proximal arginine
Biochem. Biophys. Res. Commun.
287
594-599
2001
Rattus norvegicus
Braun, H.P.; Schmitz, U.K.
The mitochondrial processing peptidase
Int. J. Biochem. Cell Biol.
29
1043-1045
1997
Neurospora sp., Rattus norvegicus, Saccharomyces cerevisiae, Solanum tuberosum, Triticum aestivum
Song, M.C.; Ogishima, T.; Ito, A.
Importance of residues carboxyl terminal relative to the cleavage site in substrates of mitochondrial processing peptidase for their specific recognition and cleavage
J. Biochem.
124
1045-1049
1998
Bos taurus
Deng, K.; Zhang, L.; Kachurin, A.M.; Yu, L.; Xia, D.; Kim, H.; Deisenhofer, J.; Yu, C.A.
Activation of a matrix processing peptidase from the crystalline cytochrome bc1 complex of bovine heart mitochondria
J. Biol. Chem.
273
20752-20757
1998
Bos taurus
Shimokata, K.; Kitada, S.; Ogishima, T.; Ito, A.
Role of alpha-subunit of mitochondrial processing peptidase in substrate recognition
J. Biol. Chem.
273
25158-25163
1998
Saccharomyces cerevisiae
Kojima, K.; Kitada, S.; Shimokata, K.; Ogishima, T.; Ito, A.
Cooperative formation of a substrate binding pocket by alpha- and beta-subunits of mitochondrial processing peptidase
J. Biol. Chem.
273
32542-32546
1998
Saccharomyces cerevisiae
Kitada, S.; Kojima, K.; Shimokata, K.; Ogishima, T.; Ito, A.
Glutamate residues required for substrate binding and cleavage activity in mitochondrial processing peptidase
J. Biol. Chem.
273
32547-32553
1998
Saccharomyces cerevisiae, Rattus norvegicus
Kojima, K.; Kitada, S.; Ogishima, T.; Ito, A.
A proposed common structure of substrates bound to mitochondrial processing peptidase
J. Biol. Chem.
276
2115-2121
2001
Saccharomyces cerevisiae
Kitada, S.; Yamasaki, E.; Kojima, K.; Ito, A.
Determination of the cleavage site of the presequence by mitochondrial processing peptidase on the substrate binding scaffold and the multiple subsites inside a molecular cavity
J. Biol. Chem.
278
1879-1885
2003
Saccharomyces cerevisiae, Rattus norvegicus
Taylor, A.B.; Smith, B.S.; Kitada, S.; Kojima, K.; Miyaura, H.; Otwinowski, Z.; Ito, A.; Deisenhofer, J.
Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences
Structure
9
615-625
2001
Saccharomyces cerevisiae
Janata, J.; Hola, K.; Kubala, M.; Gakh, O.; Parkhomenko, N.; Matuskova, A.; Kutejova, E.; Amler, E.
Substrate evokes translocation of both domains in the mitochondrial processing peptidase alpha-subunit during which the C-terminus acts as a stabilizing element
Biochem. Biophys. Res. Commun.
316
211-217
2004
Saccharomyces cerevisiae
Oshima, T.; Yamasaki, E.; Ogishima, T.; Kadowaki, K.; Ito, A.; Kitada, S.
Recognition and processing of a nuclear-encoded polyprotein precursor by mitochondrial processing peptidase
Biochem. J.
385
755-761
2005
Saccharomyces cerevisiae
Nomura, H.; Athauda, S.B.; Wada, H.; Maruyama, Y.; Takahashi, K.; Inoue, H.
Identification and reverse genetic analysis of mitochondrial processing peptidase and the core protein of the cytochrome bc1 complex of Caenorhabditis elegans, a model parasitic nematode
J. Biochem.
139
967-979
2006
Brugia malayi, Caenorhabditis elegans
Rudhe, C.; Clifton, R.; Chew, O.; Zemam, K.; Richter, S.; Lamppa, G.; Whelan, J.; Glaser, E.
Processing of the dual targeted precursor protein of glutathione reductase in mitochondria and chloroplasts
J. Mol. Biol.
343
639-647
2004
Solanum tuberosum
Murcha, M.W.; Elhafez, D.; Millar, A.H.; Whelan, J.
The N-terminal extension of plant mitochondrial carrier proteins is removed by two-step processing: the first cleavage is by the mitochondrial processing peptidase
J. Mol. Biol.
344
443-454
2004
Saccharomyces cerevisiae, Saccharomyces cerevisiae MY111-2, Solanum tuberosum
Nishino, T.G.; Kitano, K.; Kojima, K.; Ogishima, T.; Ito, A.; Kitada, S.
Spatial orientation of mitochondrial processing peptidase and a preprotein revealed by fluorescence resonance energy transfer
J. Biochem.
141
889-895
2007
Saccharomyces cerevisiae
Mukhopadhyay, A.; Yang, C.S.; Wei, B.; Weiner, H.
Precursor protein is readily degraded in mitochondrial matrix space if the leader is not processed by mitochondrial processing peptidase
J. Biol. Chem.
282
37266-37275
2007
Homo sapiens, Saccharomyces cerevisiae
Yoon, T.; Dizin, E.; Cowan, J.A.
N-terminal iron-mediated self-cleavage of human frataxin: regulation of iron binding and complex formation with target proteins
J. Biol. Inorg. Chem.
12
535-542
2007
Homo sapiens
Osman, C.; Wilmes, C.; Tatsuta, T.; Langer, T.
Prohibitins interact genetically with Atp23, a novel processing peptidase and chaperone for the F1Fo-ATP synthase
Mol. Biol. Cell
18
627-635
2007
Saccharomyces cerevisiae
Burri, L.; Williams, B.A.; Bursac, D.; Lithgow, T.; Keeling, P.J.
Microsporidian mitosomes retain elements of the general mitochondrial targeting system
Proc. Natl. Acad. Sci. USA
103
15916-15920
2006
Antonospora locustae, no activity in Encephalitozoon cuniculi
Nagayama, K.; Itono, S.; Yoshida, T.; Ishiguro, S.; Ochiai, H.; Ohmachi, T.
Antisense RNA inhibition of the beta subunit of the Dictyostelium discoideum mitochondrial processing peptidase induces the expression of mitochondrial proteins
Biosci. Biotechnol. Biochem.
72
1836-1846
2008
Dictyostelium discoideum
Smid, O.; Matuskova, A.; Harris, S.R.; Kucera, T.; Novotny, M.; Horvathova, L.; Hrdy, I.; Kutejova, E.; Hirt, R.P.; Embley, T.M.; Janata, J.; Tachezy, J.
Reductive evolution of the mitochondrial processing peptidases of the unicellular parasites trichomonas vaginalis and giardia intestinalis
PLoS Pathog.
4
e1000243
2008
Giardia intestinalis, Trichomonas vaginalis
Voegtle, F.N.; Wortelkamp, S.; Zahedi, R.P.; Becker, D.; Leidhold, C.; Gevaert, K.; Kellermann, J.; Voos, W.; Sickmann, A.; Pfanner, N.; Meisinger, C.
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability
Cell
139
428-439
2009
Saccharomyces cerevisiae
Naamati, A.; Regev-Rudzki, N.; Galperin, S.; Lill, R.; Pines, O.
Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55
J. BIOL. CHEM.
284
30200-30208
2009
Saccharomyces cerevisiae
Nagayama, K.; Ohmachi, T.
Mitochondrial processing peptidase activity is controlled by the processing of alpha-MPP during development in Dictyostelium discoideum
Microbiology
156
978-989
2010
Dictyostelium discoideum (Q86A84), Dictyostelium discoideum
Ohtsuka, J.; Ichihara, Y.; Ebihara, A.; Nagata, K.; Tanokura, M.
Crystal structure of TTHA1264, a putative M16-family zinc peptidase from Thermus thermophilus HB8 that is homologous to the β subunit of mitochondrial processing peptidase
Proteins
75
774-780
2009
Thermus thermophilus (Q5SIV0), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SIV0)
Mossmann, D.; Meisinger, C.; Voegtle, F.
Processing of mitochondrial presequences
Biochim. Biophys. Acta
1819
1098-1106
2012
Saccharomyces cerevisiae
Teixeira, P.; Glaser, E.
Processing peptidases in mitochondria and chloroplasts
Biochim. Biophys. Acta
1833
360-370
2013
Homo sapiens
Greene, A.; Grenier, K.; Aguileta, M.; Muise, S.; Farazifard, R.; Haque, M.; McBride, H.; Park, D.; Fon, E.
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
EMBO Rep.
13
378-385
2012
Homo sapiens
Endow, J.; Inoue, K.
Stable complex formation of thylakoidal processing peptidase and PGRL1
FEBS Lett.
587
2226-2231
2013
Arabidopsis thaliana
Mach, J.; Poliak, P.; Matuskova, A.; Zarsky V.; Janata, J.; Lukes, J.; Tachezy, J.
An advanced system of the mitochondrial processing peptidase and core protein family in Trypanosoma bruceiand multiple origins of the Core I subunit in eukaryotes
Genome Biol. Evol.
5
860-875
2013
Trypanosoma brucei
Desy, S.; Schneider, A.; Mani, J.
Trypanosoma brucei has a canonical mitochondrial processing peptidase
Mol. Biochem. Parasitol.
185
161-164
2012
Trypanosoma brucei
Kwasniak, M.; Pogorzelec, L.; Migdal, I.; Smakowska, E.; Janska, H.
Proteolytic system of plant mitochondria
Physiol. Plant.
145
187-195
2012
Arabidopsis thaliana
Jobling, R.K.; Assoum, M.; Gakh, O.; Blaser, S.; Raiman, J.A.; Mignot, C.; Roze, E.; Duerr, A.; Brice, A.; Levy, N.; Prasad, C.; Paton, T.; Paterson, A.D.; Roslin, N.M.; Marshall, C.R.; Desvignes, J.P.; Roeckel-Trevisiol, N.; Scherer, S.W.; Rouleau, G.A.; Megarbane, A.; Isaya, G.; Delague, V.; Yoon, G.
PMPCA mutations cause abnormal mitochondrial protein processing in patients with non-progressive cerebellar ataxia
Brain
138
1505-1517
2015
Homo sapiens (Q10713 AND O75439), Homo sapiens
Joshi, M.; Anselm, I.; Shi, J.; Bale, T.A.; Towne, M.; Schmitz-Abe, K.; Crowley, L.; Giani, F.C.; Kazerounian, S.; Markianos, K.; Lidov, H.G.; Folkerth, R.; Sankaran, V.G.; Agrawal, P.B.
Mutations in the substrate binding glycine-rich loop of the mitochondrial processing peptidase-alpha protein (PMPCA) cause a severe mitochondrial disease
Cold Spring Harb. Mol. Case Stud.
2
a000786
2016
Homo sapiens (Q10713), Homo sapiens
Marcondes, M.F.; Alves, F.M.; Assis, D.M.; Hirata, I.Y.; Juliano, L.; Oliveira, V.; Juliano, M.A.
Substrate specificity of mitochondrial intermediate peptidase analysed by a support-bound peptide library
FEBS open bio
5
429-436
2015
Homo sapiens (Q10713 AND O75439)
Burkhart, J.M.; Taskin, A.A.; Zahedi, R.P.; Voegtle, F.N.
Quantitative profiling for substrates of the mitochondrial presequence processing protease reveals a set of nonsubstrate proteins increased upon proteotoxic stress
J. Proteome Res.
14
4550-4563
2015
Saccharomyces cerevisiae (P10507 AND P11914), Saccharomyces cerevisiae ATCC 204508 (P10507 AND P11914)
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