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Literature summary for 3.4.24.64 extracted from

  • Nagayama, K.; Ohmachi, T.
    Mitochondrial processing peptidase activity is controlled by the processing of alpha-MPP during development in Dictyostelium discoideum (2010), Microbiology, 156, 978-989.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene mppA, encoding subunit alpha-MPP, located on chromosome 2, DNA and amino acid sequence determination and analysis, sequence comparisons, expression of alphaMPP237-GFP, a fusion protein in which the N-terminal 237 amino acids of alpha-MPP are fused to GFP. Expression of mppA is developmentally regulated. Overexpression in Dictyostelium, Development of an alpha-mpp antisense strain is delayed, disruption of the mppA gene is lethal in Dictyostelium Dictyostelium discoideum

Protein Variants

Protein Variants Comment Organism
additional information construction of alphaMPP237-GFP, a fusion protein in which the N-terminal 237 amino acids of alpha-MPP are fused to GFP for subcellular localization study Dictyostelium discoideum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion subcellular localization study, overview Dictyostelium discoideum 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
COX IV precursor + H2O Dictyostelium discoideum
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processed COX IV + mitochondrial targeting sequence of COX IV
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?

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum Q86A84 gene mppA encoding alpha-MPP
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the larger form of the alpha-subunit alpha-MPPH is cleaved, removing its N-terminal region, to produce the functional alpha-MPPL form Dictyostelium discoideum

Source Tissue

Source Tissue Comment Organism Textmining
additional information expression analysis of the alpha-subunit of MPP during development, highest levels in vegetatively growing cells and during early development, marked downregulation after 10 h, alpha-MPPL and MPP activities completely disappear around the slug stage, overview Dictyostelium discoideum
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
COX IV precursor + H2O
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Dictyostelium discoideum processed COX IV + mitochondrial targeting sequence of COX IV
-
?
COX IV precursor + H2O recombinant C-terminally His-tagged substrate Dictyostelium discoideum processed COX IV + mitochondrial targeting sequence of COX IV
-
?

Synonyms

Synonyms Comment Organism
MPP
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Dictyostelium discoideum

General Information

General Information Comment Organism
additional information expression of mppA is developmentally regulated Dictyostelium discoideum
physiological function MPP plays an essential role in mitochondrial biogenesis and cell proliferation Dictyostelium discoideum