Cloned (Comment) | Organism |
---|---|
gene mppA, encoding subunit alpha-MPP, located on chromosome 2, DNA and amino acid sequence determination and analysis, sequence comparisons, expression of alphaMPP237-GFP, a fusion protein in which the N-terminal 237 amino acids of alpha-MPP are fused to GFP. Expression of mppA is developmentally regulated. Overexpression in Dictyostelium, Development of an alpha-mpp antisense strain is delayed, disruption of the mppA gene is lethal in Dictyostelium | Dictyostelium discoideum |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of alphaMPP237-GFP, a fusion protein in which the N-terminal 237 amino acids of alpha-MPP are fused to GFP for subcellular localization study | Dictyostelium discoideum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | subcellular localization study, overview | Dictyostelium discoideum | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
COX IV precursor + H2O | Dictyostelium discoideum | - |
processed COX IV + mitochondrial targeting sequence of COX IV | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dictyostelium discoideum | Q86A84 | gene mppA encoding alpha-MPP | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the larger form of the alpha-subunit alpha-MPPH is cleaved, removing its N-terminal region, to produce the functional alpha-MPPL form | Dictyostelium discoideum |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | expression analysis of the alpha-subunit of MPP during development, highest levels in vegetatively growing cells and during early development, marked downregulation after 10 h, alpha-MPPL and MPP activities completely disappear around the slug stage, overview | Dictyostelium discoideum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
COX IV precursor + H2O | - |
Dictyostelium discoideum | processed COX IV + mitochondrial targeting sequence of COX IV | - |
? | |
COX IV precursor + H2O | recombinant C-terminally His-tagged substrate | Dictyostelium discoideum | processed COX IV + mitochondrial targeting sequence of COX IV | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MPP | - |
Dictyostelium discoideum |
General Information | Comment | Organism |
---|---|---|
additional information | expression of mppA is developmentally regulated | Dictyostelium discoideum |
physiological function | MPP plays an essential role in mitochondrial biogenesis and cell proliferation | Dictyostelium discoideum |