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Literature summary for 3.4.24.64 extracted from

  • Naamati, A.; Regev-Rudzki, N.; Galperin, S.; Lill, R.; Pines, O.
    Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55 (2009), J. BIOL. CHEM., 284, 30200-30208.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Saccharomyces cerevisiae 5739
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additional information Nfs1 needs to be processed by MPP to be functional in the mitochondrion and the nucleus, the latter case requires a mechanism that involves reverse translocation of processed Nfs1, i.e. the retrograde movement of Nfs1 Saccharomyces cerevisiae
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Nfs1 + H2O Saccharomyces cerevisiae MPP cleaves the precursor between Phe33 and Tyr34, Nfs1 processing, overview processed Nfs1
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 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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 several strains, overview
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information construction of a mutant MPP recognition sequence in substrate Nfs1 by replacing the two arginine codons at positions -2 and -3 prevents cleavage by MPP Saccharomyces cerevisiae ?
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 ?
Nfs1 + H2O MPP cleaves the precursor between Phe33 and Tyr34, Nfs1 processing, overview Saccharomyces cerevisiae processed Nfs1
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 ?
Nfs1 + H2O recombinant His-tagged substrate. Nfs1 is a highly conserved mitochondrial cysteine desulfurase with dual localization in mitochondria and nuclei, mechanism of Nfs1 distribution, overview Saccharomyces cerevisiae processed Nfs1
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 ?

Synonyms

Synonyms Comment Organism
MPP
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
metabolism yeast Nfs1 undergoes two steps of proteolytic processing: first it is cleaved by the mitochondrial processing peptidase, MPP, which removes its mitochondrial targeting sequence, and then it is cleaved by a peptidase, designated Icp55, which removes three amino acids from its N-terminus Saccharomyces cerevisiae