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Literature summary for 3.4.24.64 extracted from

  • Hawlitschek, G.; Schneider, H.; Schmidt, B.; Tropschug, M.; Hartl, F.U.; Neupert, W.
    Mitochondrial protein import: identification of processing peptidase and of PEP, a processing enhancing protein (1988), Cell, 53, 795-806.
    View publication on PubMed
Search for more literature for 3.4.24.64

Activating Compound

Activating Compound Comment Organism Structure
Processing enhancing protein activation, stimulates MPP protein to full processing activity Neurospora crassa

Cloned(Commentary)

Cloned (Comment) Organism
Neurospora crassa and processing enhancing protein subunit Neurospora crassa

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion matrix Neurospora crassa 5739
-
mitochondrion 2 components, proteolytic activity bearing, matrix-soluble MPP protein and activating processing enhancing protein which is partly associated with the inner surface of the inner membrane Neurospora crassa 5739
-
soluble MPP protein Neurospora crassa
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
 Neurospora crassa, processing enhancing protein (i.e. PEP), gel filtration at 50 and 300 mM NaCl Neurospora crassa
57000
-
 Neurospora crassa, MPP, gel filtration at 50 and 300 mM NaCl Neurospora crassa

Organism

Organism UniProt Comment Textmining
Neurospora crassa
-
 wild-type strain 74A
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000298
-
 ATP synthase subunits 2 and 9 Neurospora crassa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP synthase subunit 2 precursor + H2O
-
 Neurospora crassa ATP synthase subunit 2
-
 ?
ATP synthase subunit 9 precursor + H2O
-
 Neurospora crassa ATP synthase subunit 9
-
 ?
additional information MPP alone has a low processing activity, processing enhancing protein alone has none, upon recombining both, full processing activity is restored, both proteins cooperate in binding precursor substrates and proteolytic activity, the latter is associated with the MPP protein (MW 57000) Neurospora crassa ?
-
 ?
additional information The mitochondrial processing peptidase from Neurospora crassa consists of two components: MPP and processing enhancing protein Neurospora crassa ?
-
 ?
Processing enhancing protein precursor + H2O processed by the combined mature forms of MPP and processing enhancing protein Neurospora crassa Processing enhancing protein i.e. PEP ?
Processing enhancing protein precursor + H2O i.e. PEP precursor, takes part in its own precursor activation Neurospora crassa Processing enhancing protein i.e. PEP ?

Subunits

Subunits Comment Organism
More The mitochondrial processing peptidase from Neurospora crassa consists of two components: MPP and processing enhancing protein Neurospora crassa
More MPP alone has a low processing activity, processing enhancing protein alone has none, upon recombining both, full processing activity is restored, both proteins cooperate in binding precursor substrates and proteolytic activity, the latter is associated with the MPP protein (MW 57000) Neurospora crassa