Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | mitochondrial matrix space | Homo sapiens | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | the N-terminus of MPP-processed frataxin shows a unique high-affinity iron site, and this iron center appears to mediate a self-cleavage reaction, the N-terminus blocks previously defined iron-binding sites located on the carboxylate-rich surface defined by the helix alpha1 and the beta-sheet beta1, most likely through electrostatic contact with the carboxylate-rich surface on the core protein, as well as inhibiting iron-promoted binding of the iron-sulfur cluster assembly scaffold partner protein, ISU, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
frataxin + H2O | removal of the N-terminal peptide, MPP cleavage site between residues 55 and 56 | Homo sapiens | mature frataxin 56-210 + prepeptide | the N-terminus of MPP-processed frataxin shows a unique high-affinity iron site, and this iron center appears to mediate a self-cleavage reaction, overview | ? | |
additional information | binding of the iron-promoted binding of the iron-sulfur cluster assembly scaffold partner protein, ISU, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MPP | - |
Homo sapiens |