Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.64 extracted from

  • Yoon, T.; Dizin, E.; Cowan, J.A.
    N-terminal iron-mediated self-cleavage of human frataxin: regulation of iron binding and complex formation with target proteins (2007), J. Biol. Inorg. Chem., 12, 535-542.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion mitochondrial matrix space Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ the N-terminus of MPP-processed frataxin shows a unique high-affinity iron site, and this iron center appears to mediate a self-cleavage reaction, the N-terminus blocks previously defined iron-binding sites located on the carboxylate-rich surface defined by the helix alpha1 and the beta-sheet beta1, most likely through electrostatic contact with the carboxylate-rich surface on the core protein, as well as inhibiting iron-promoted binding of the iron-sulfur cluster assembly scaffold partner protein, ISU, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
frataxin + H2O removal of the N-terminal peptide, MPP cleavage site between residues 55 and 56 Homo sapiens mature frataxin 56-210 + prepeptide the N-terminus of MPP-processed frataxin shows a unique high-affinity iron site, and this iron center appears to mediate a self-cleavage reaction, overview ?
additional information binding of the iron-promoted binding of the iron-sulfur cluster assembly scaffold partner protein, ISU, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
MPP
-
Homo sapiens