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Literature summary for 3.4.24.64 extracted from
- Activation of a matrix processing peptidase from the crystalline cytochrome bc1 complex of bovine heart mitochondria (1998), J. Biol. Chem., 273, 20752-20757.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | - |
Bos taurus |  |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystalline cytochrome bc1 complex | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | partial, 81% inhibition | Bos taurus | |
| EDTA | - |
Bos taurus | |
| ferricyanide | partial, 28% inhibition | Bos taurus | |
| additional information | antimycin, phenylmethylsulfonyl fluoride, hemin, pepstatin, and N-ethylmaleimide are no inhibitors | Bos taurus | |
| Myxothiazol | partial, 58% inhibition | Bos taurus | |
| o-phenanthroline | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Bos taurus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | divalent cation required for enzyme activity | Bos taurus | |
| Fe2+ | divalent cation required for enzyme activity | Bos taurus | |
| Mg2+ | divalent cation required for enzyme activity | Bos taurus | |
| Mn2+ | divalent cation required for enzyme activity | Bos taurus | |
| Zn2+ | divalent cation required for enzyme activity | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
bovine, beef | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| cytochrome bc1 complex | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ALQPARDYAAQASPSPKA + H2O | - |
Bos taurus | ? | - |
? | |
| ALQPARDYAAQASPSPKAGATTGRIVAV + H2O | - |
Bos taurus | ? | - |
? | |
| ASVRYSHTDIKVPDFSDYRRPEVLD + H2O | - |
Bos taurus | ? | - |
? | |
| AVALHSAVSASDLELHPPSY + H2O | - |
Bos taurus | ? | - |
? | |
| AVALHSAVSASDLELHPPSYPWSHRGLLSS + H2O | - |
Bos taurus | ? | - |
? | |
| RPLVASVSLNVPASVRYSHTDIKVPDF + H2O | - |
Bos taurus | ? | - |
? | |
| VPASVRYSHTDIK + H2O | - |
Bos taurus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MPP | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Bos taurus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 42 | - |
drastic decrease in activity, activated enzyme is unstable and becomes partially denatured | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8.5 | - |
Bos taurus |
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Release 2023.1 (January 2023)
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