Information on EC 3.4.24.3 - microbial collagenase

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The expected taxonomic range for this enzyme is: Bacteria

EC NUMBER
COMMENTARY hide
3.4.24.3
-
RECOMMENDED NAME
GeneOntology No.
microbial collagenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Digestion of native collagen in the triple helical region at -/-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
endopeptidase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9001-12-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
Clostridium capitorale
-
-
-
Manually annotated by BRENDA team
Clostridium histolyticum
-
-
-
Manually annotated by BRENDA team
isoform ColT
UniProt
Manually annotated by BRENDA team
Clostridium welchii
-
-
-
Manually annotated by BRENDA team
L43-1 strain
-
-
Manually annotated by BRENDA team
L43-1 strain
-
-
Manually annotated by BRENDA team
Empedobacter collagenolyticum
-
-
-
Manually annotated by BRENDA team
Geobacillus sp.
strain MO-1
UniProt
Manually annotated by BRENDA team
Bacteroides gingivalis
-
-
Manually annotated by BRENDA team
B-30
-
-
Manually annotated by BRENDA team
B-30
-
-
Manually annotated by BRENDA team
CYK279H
-
-
Manually annotated by BRENDA team
CYK279H
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-(S-methylcysteine)-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-(S-methylcysteine)-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00018
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ala-Gly-Pro-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Ala-Gly-Pro-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00204
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ala-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Ala-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00095
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ala-Tyr-Lys-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Ala-Tyr-Lys-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00309
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Arg-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Arg-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00026
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Asn-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Asn-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00022
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Asp-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Asp-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00022
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gln-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gln-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.0003
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Glu-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Glu-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00022
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-(S-methylcysteine)-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-(S-methylcysteine)-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00072
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00082
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Arg-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Arg-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00595
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00037
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Gly-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Gly-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00124
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Ile-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Ile-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00086
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Leu-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Leu-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00134
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Lys-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Lys-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.006
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Met-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Met-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00131
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Phe-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Phe-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00051
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Pro-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Pro-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00565
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Trp-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Trp-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00073
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Tyr-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Tyr-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00113
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Val-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Val-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00056
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Asn-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gly-Ala-Asn-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00376
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Asp-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gly-Ala-Asp-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00043
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Gln-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gly-Ala-Gln-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00435
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Glu-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gly-Ala-Glu-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00042
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ser-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ser-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00405
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Thr-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Thr-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00466
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Arg-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Arg-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00011
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Asn-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Asn-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00096
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Asp-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Asp-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.0004
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Gln-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Gln-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00049
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Glu-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Glu-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00035
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Gly-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Gly-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00042
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-His-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-His-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00084
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ile-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ile-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00065
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Leu-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Leu-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00029
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Lys-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Lys-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00017
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Met-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Met-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00027
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Phe-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Phe-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00056
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.008
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ser-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ser-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00098
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Thr-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Thr-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00082
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Trp-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Trp-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00037
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Tyr-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Tyr-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00038
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Val-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Val-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00039
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-His-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-His-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00029
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ile-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Ile-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00017
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Leu-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Leu-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00021
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Lys-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Lys-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00021
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Met-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Met-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00028
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Phe-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Phe-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00022
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Pro-Lys-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Pro-Lys-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00276
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Pro-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Pro-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00088
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ser-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Ser-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.0007
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Thr-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Thr-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.0004
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Trp-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Trp-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00014
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Tyr-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Tyr-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00029
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Val-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Val-Pro-Ala-beta-Ala
show the reaction diagram
Clostridium histolyticum
-
ratio of turnover number to Km-value is 0.00036
-
-
?
2-furanacryloyl-Leu-Gly-Pro-Ala + H2O
2-furanacryloyl-Leu + Gly-Pro-Ala
show the reaction diagram
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
show the reaction diagram
Azocoll + H2O
Hydrolyzed azocoll
show the reaction diagram
azokoll + H2O
?
show the reaction diagram
Clostridium histolyticum
-
-
-
?
Bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala + H2O
carbobenzoxy-Gly-Pro-Gly + Gly-Pro-Ala
show the reaction diagram
carbobenzoxy-Gly-Pro-Leu-Gly-Pro + H2O
carbobenzoxy-Gly-Pro-Leu + Gly-Pro
show the reaction diagram
casein + H2O
?
show the reaction diagram
Collagen + H2O
?
show the reaction diagram
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
Collagen type I + H2O
?
show the reaction diagram
Collagen type III + H2O
?
show the reaction diagram
Clostridium histolyticum
-
-
Clostridium collagenase itself and the degradation products of type I and III collagens lead toan increase in keratinocyte and fibroblast migration
-
?
collagen type IV + H2O
?
show the reaction diagram
Clostridium histolyticum
-
-
degradation products of collagen type IV induce fibroblast migration
-
?
collagen type V + H2O
?
show the reaction diagram
Clostridium histolyticum
-
-
-
-
?
furanacryloyl-Leu-Gly-Pro-Ala + H2O
furanacryloyl-Leu + Gly-Pro-Ala
show the reaction diagram
Clostridium histolyticum
-
-
-
-
?
furylacryloyl-L-Phe-Gly-Gly
?
show the reaction diagram
-
-
-
-
?
furylacryloyl-Leu-Gly-Pro-Ala + H2O
furylacryloyl-Leu + Gly-Pro-Ala
show the reaction diagram
GDPCMPIISN + H2O
?
show the reaction diagram
Gelatin + H2O
Hydrolyzed gelatin
show the reaction diagram
N-[3-(2-furyl) acryloyl]-L-Leu-Gly-L-Pro-L-Ala + H2O
?
show the reaction diagram
Clostridium histolyticum
-
-
-
-
?
Type I collagen + H2O
?
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Collagen + H2O
?
show the reaction diagram
Type I collagen + H2O
?
show the reaction diagram
additional information
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Calcium
Clostridium histolyticum
-
binding of calcium ions triggers the formation of a cis peptide bond in the collagen-binding domain. The calcium ions not only stabilize the cis peptide bond thermodynamically but also catalyze its formation. The free energy barrier to the formation of the cis peptide bond decreases from 21.4 kcal/mol in the absence of calciumions to 10.3 kcal/mol in their presence. The calcium ions electrostatically stabilize the lone pair on the nitrogen atom that forms during the isomerization. Their attraction to acidic amino acid side chains and formation of a hydrogen bond network constrain the peptide backbone in a way that makes it easier for the nitrogen to pyramidalize
Co2+
-
activates at low concentration, inhibits at high concentration
Li+
-
activates
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
2-(1-benzyl-3-naphthalen-1-yl-ureido)-3-methyl-butyric acid
Clostridium histolyticum
-
-
2-(1-benzyl-3-naphthalen-1-yl-ureido)-N-hydroxy-3-methyl-butyramide
Clostridium histolyticum
-
-
2-(3-benzoyl-1-benzyl-thioureido)-N-hydroxy-3-methyl-butyramide
Clostridium histolyticum
-
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)propanoic acid
Clostridium histolyticum
-
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)propanoic acid
Clostridium histolyticum
-
-
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-(benzyl[[(3-chlorphenyl)amino]carbonyl]amino)propanoic acid
Clostridium histolyticum
-
-
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-(benzyl[[(4-chlorphenyl)amino]carbonyl]amino)propanoic acid
Clostridium histolyticum
-
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)propanoic acid
Clostridium histolyticum
-
-
2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)propanoic acid
Clostridium histolyticum
-
-
2-mercaptoethanol
2-[benzyl(1-naphthylsulfonyl)amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl(2-naphthylsulfonyl)amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl(5-methylnaphthalene-1-sulfonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl(benzylsulfonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl(benzylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl(benzylsulfonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl(benzylsulfonyl)amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl(methylsulfonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl(methylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl(methylsulfonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl(methylsulfonyl)amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl(naphthalene-1-sulfonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl(naphthalene-2-sulfonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl(phenylcarbonothioyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl(phenylsulfonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl(phenylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl(phenylsulfonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl(phenylsulfonyl)amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl(thien-2-ylsulfonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl(thien-2-ylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl(thien-2-ylsulfonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl(thien-2-ylsulfonyl)amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
Clostridium histolyticum
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
Clostridium histolyticum
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
Clostridium histolyticum
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
Clostridium histolyticum
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl-(2,4,6-tripropyl-benzenesulfonyl)-amino]-N-hydroxy-propionamide
Clostridium histolyticum
-
-
2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-N-hydroxy-propionamide
Clostridium histolyticum
-
-
2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-propionic acid
Clostridium histolyticum
-
-
2-[benzyl-(3-tert-butoxycarbonylamino-4-methoxy-benzenesulfonyl)-amino]-propionic acid
Clostridium histolyticum
-
-
2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide
Clostridium histolyticum
-
-
2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-propionic acid
Clostridium histolyticum
-
-
2-[Benzyl-(5-methylnaphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
Clostridium histolyticum
-
-
2-[benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-3-methyl-butyric acid
Clostridium histolyticum
-
-
2-[Benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
Clostridium histolyticum
-
-
2-[Benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
Clostridium histolyticum
-
-
2-[benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide
Clostridium histolyticum
-
-
2-[Benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
Clostridium histolyticum
-
-
2-[benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-propionamide
Clostridium histolyticum
-
-
2-[benzyl-(toluene-4-sulfonyl)-amino]-N-hydroxy-propionamide
Clostridium histolyticum
-
-
2-[benzyl[(1-naphthylamino)carbonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(1-naphthylamino)carbonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(2,4-dinitrophenyl)thio]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(2-nitrophenyl)thio]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(2-nitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(3-carboxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(3-nitrophenyl)thio]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(3-nitrophenyl)thio]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-bromophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-carboxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-iodophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-methylphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-methylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-methylphenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-nitrophenyl)thio]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(4-nitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-nitrophenyl)thio]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(4-nitrophenyl)thio]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(dimethylamino)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(dimethylamino)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(heptadecafluorooctyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(heptadecfluorooctyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(trichloromethyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(trichloromethyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
-
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
-
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[benzyl[(trifluoromethyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
-
2-[[[2,4,6-(tripropyl)phenyl]sulfonyl](benzyl)amino]propanoic acid
Clostridium histolyticum
-
-
2-[[[3-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
Clostridium histolyticum
-
-
2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
-
2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
Clostridium histolyticum
-
-
2-[[[4-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
Clostridium histolyticum
-
-
2-[[[4-(methoxy)phenyl]sulfonyl](benzyl)amino]propanoic acid
Clostridium histolyticum
-
-
3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid
Clostridium histolyticum
-
-
3-[benzyl-(1-carboxy-ethyl)-sulfamoyl]-benzoic acid
Clostridium histolyticum
-
-
3-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide
Clostridium histolyticum
-
-
3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide
Clostridium histolyticum
-
-
3-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid
Clostridium histolyticum
-
-
4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid
Clostridium histolyticum
-
-
4-[benzyl-(1-carboxy-ethyl)-sulfamoyl]-benzoic acid
Clostridium histolyticum
-
-
4-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide
Clostridium histolyticum
-
-
4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide
Clostridium histolyticum
-
-
4-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid
Clostridium histolyticum
-
-
8-hydroxyquinoline
-
-
alpha,alpha-dipyridyl
-
-
batimastat
Clostridium histolyticum
-
i.e. BB-94
BAY 12-9566
Clostridium histolyticum
-
-
diphosphate
-
-
erucic acid
Clostridium histolyticum
-
IC50: 0.415 mM
glutathione
Guanidine-HCl
-
-
heptadecanoic acid
Clostridium histolyticum
-
IC50: 0.03 mM
HS-CH2-CH2-CO-Pro-(N-methyl)Ala
Empedobacter collagenolyticum
-
-
HS-CH2-CH2-CO-Pro-(N-methyl)Leu
Empedobacter collagenolyticum
-
-
HS-CH2-CH2-CO-Pro-(N-methyl)Nle
Empedobacter collagenolyticum
-
-
i-C5H11-PO(OH)-Gly-Pro-Ala
Clostridium histolyticum
-
-
-
isoamyl-phosphonyl-Gly-Pro-Ala
Clostridium histolyticum
peptidomimetic inhibitor, binds to the edge strand in an antiparallel orientation
L-cysteine
-
-
L-histidine
-
-
linoleic acid
Clostridium histolyticum
-
IC50: 0.375 mM
linolenic acid
Clostridium histolyticum
-
IC50: 0.46 mM
marimastat
Clostridium histolyticum
-
i.e. BB-2516
myristic acid
Clostridium histolyticum
-
IC50: 0.27 mM
N-(2-chlorobenzyl)-N-(dimethylsulfamoyl)-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-(methylsulfonyl)-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-(naphthalen-1-ylcarbamoyl)-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-(naphthalen-1-ylsulfonyl)-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-(naphthalen-2-ylsulfonyl)-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-(phenylsulfonyl)-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-(thiophen-2-ylsulfonyl)-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(2,4,6-trimethylphenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(2,4-difluorophenyl)carbamoyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(2,4-dinitrophenyl)sulfanyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(2,5-dichlorophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(2-nitrophenyl)sulfanyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(2-nitrophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(3,4-dichlorophenyl)carbamoyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(3-chloro-4-nitrophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(3-chlorophenyl)carbamoyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(3-nitrophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(4-bromophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(4-chlorophenyl)carbamoyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(4-chlorophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(4-fluorophenyl)carbamoyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(4-fluorophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(4-iodophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(4-methoxyphenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(4-methylphenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(4-nitrophenyl)sulfanyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(4-nitrophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(heptadecafluorooctyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(nonafluorobutyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(trichloromethyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[(trifluoromethyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[[(2-methylphenyl)sulfonyl]carbamoyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[[(4-chlorophenyl)sulfonyl]carbamoyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[[(4-fluorophenyl)sulfonyl]carbamoyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[[(4-methylphenyl)sulfonyl]carbamoyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(2-chlorobenzyl)-N-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-L-alanine
Clostridium histolyticum
-
-
N-(benzylsulfonyl)-N-(2-chlorobenzyl)-L-alanine
Clostridium histolyticum
-
-
N-([(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]amino]methyl)benzamide
Clostridium histolyticum
-
-
N-([3-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
Clostridium histolyticum
-
-
N-([3-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
Clostridium histolyticum
-
-
N-([4-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
Clostridium histolyticum
-
-
N-2-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
-
N-2-methylphenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
-
N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
-
N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
-
N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
-
N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
-
N-2-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
Clostridium histolyticum
-
-
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
-
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
-
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-chlorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
-
N-4-chlorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
-
N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-chlorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
-
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
-
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-fluorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
-
N-4-fluorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
-
N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
-
N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
-
N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
-
N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
-
N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
-
N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
-
N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
Clostridium histolyticum
-
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
-
N-etyhlmaleimide
-
-
N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
-
N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
-
N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
Clostridium histolyticum
-
-
N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
Clostridium histolyticum
-
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
-
N-[[4-(acetylamino)phenyl]sulfonyl]-N-(2-chlorobenzyl)-L-alanine
Clostridium histolyticum
-
-
N2(2-chlorobenzyl)-N-hydroxy-N2-[(trifluoromethyl)sulfonyl]-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylcarbamoyl)-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylsulfonyl)-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-2-ylsulfonyl)-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(phenylsulfonyl)-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(quinolin-8-ylsulfonyl)-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(thiophen-2-ylsulfonyl)-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4,6-trimethylphenyl)sulfonyl]-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4-dinitrophenyl)sulfanyl]-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-nitrophenyl)sulfanyl]-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(nonafluorobutyl)sulfonyl]-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(trichloromethyl)sulfonyl]-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-(dimethylsulfamoyl)-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(2,4-difluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(2,5-dichlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(2-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(3,4-dichlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(3-chloro-4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(3-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(3-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(4-bromophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(4-iodophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(4-methylphenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[(heptadecafluorooctyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[[(2-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[[(4-chlorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[[(4-fluorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[[(4-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(2-chlorobenzyl)-N2-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-(benzylsulfonyl)-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
N2-chlorobenzyl)-N-hydroxy-N2-(methylsulfonyl)-L-alaninamide
Clostridium histolyticum
-
-
N2-[[4-(acetylamino)phenyl]sulfonyl]-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
-
nonadecanoic acid
Clostridium histolyticum
-
0.045 mM
oleic acid
Clostridium histolyticum
-
IC50: 0.46 mM
p-O2NC6H4CH2CH2PO(OH)Gly-Pro-2-aminohexanoic acid
Clostridium histolyticum
-
-
-
palmitic acid
Clostridium histolyticum
-
IC50: 0.035 mM
palmitoleic acid
Clostridium histolyticum
-
IC50: 0.405 mM
pentadecanoic acid
Clostridium histolyticum
-
IC50: 0.125 mM
Phosphate buffer
-
-
-
Pro6-Gly-Pro-Gly
Clostridium histolyticum
-
-
-
Pro6-Gly-Pro-Gly-H
Clostridium histolyticum
-
-
-
SDS
-
surface active substance
Sodiumthioglycolate
-
-
stearic acid
Clostridium histolyticum
-
IC50: 0.03 mM
Tannic acid
Clostridium histolyticum
-
competitive, almost complete inhibition. Pretreatment of collagen fibers with tannic acid results in polymerization and complex formation
tert-butyl (3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate
Clostridium histolyticum
-
-
tert-butyl (4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate
Clostridium histolyticum
-
-
tert-butyl (5-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]-2-methoxyphenyl)carbamate
Clostridium histolyticum
-
-
trocade
Clostridium histolyticum
-
i.e. RO-22-3555
[3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester
Clostridium histolyticum
-
-
[4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester
Clostridium histolyticum
-
-
[5-[benzyl-(3-hydroxy-1-methyl-2-oxo-propyl)-sulfamoyl]-2-methoxy-phenyl]-carbamic acid tert-butyl ester
Clostridium histolyticum
-
-
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
activates
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.06
2-furanacryloyl-Leu-Gly-Pro-Ala
-
-
0.71
Carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala
Clostridium histolyticum
-
-
0.269 - 1.26
furylacryloyl-Leu-Gly-Pro-Ala
0.555
N-[3-(2-furyl) acryloyl]-L-Leu-Gly-L-Pro-L-Ala
Clostridium histolyticum
-
pH 7.5, 25C
additional information
additional information
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.092 - 15.9
furylacryloyl-Leu-Gly-Pro-Ala
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0056
2-(1-benzyl-3-naphthalen-1-yl-ureido)-3-methyl-butyric acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000012
2-(1-benzyl-3-naphthalen-1-yl-ureido)-N-hydroxy-3-methyl-butyramide
Clostridium histolyticum
-
pH 7.5, 25C
0.000006
2-(3-benzoyl-1-benzyl-thioureido)-N-hydroxy-3-methyl-butyramide
Clostridium histolyticum
-
pH 7.5, 25C
0.0074
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000021
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000024
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0073
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0042
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000009
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.00001
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0048
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.01
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000033
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000034
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.011
2-(benzyl[[(3-chlorphenyl)amino]carbonyl]amino)propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0083
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.00003
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
0.0088
2-(benzyl[[(4-chlorphenyl)amino]carbonyl]amino)propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0091
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000031
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000033
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.01
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000006
2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0006
2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0036
2-[benzyl(1-naphthylsulfonyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0014
2-[benzyl(2-naphthylsulfonyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.002
2-[benzyl(5-methylnaphthalene-1-sulfonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.015
2-[benzyl(benzylsulfonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.00004
2-[benzyl(benzylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000043
2-[benzyl(benzylsulfonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.017
2-[benzyl(benzylsulfonyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.018
2-[benzyl(methylsulfonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000103
2-[benzyl(methylsulfonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.02
2-[benzyl(methylsulfonyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0033
2-[benzyl(naphthalene-1-sulfonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0014
2-[benzyl(naphthalene-2-sulfonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000005
2-[benzyl(phenylcarbonothioyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.02
2-[benzyl(phenylsulfonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000054
2-[benzyl(phenylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000051
2-[benzyl(phenylsulfonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.022
2-[benzyl(phenylsulfonyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0021
2-[benzyl(thien-2-ylsulfonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.00001
2-[benzyl(thien-2-ylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000011
2-[benzyl(thien-2-ylsulfonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0024
2-[benzyl(thien-2-ylsulfonyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.008
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000012
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000017
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000014
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.009
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0069
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000015
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
0.0064
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0075
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000019
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000021
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000018
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0082
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.007
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000013
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000016
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000015
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0071
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000019
2-[benzyl-(2,4,6-tripropyl-benzenesulfonyl)-amino]-N-hydroxy-propionamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000008
2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-N-hydroxy-propionamide
Clostridium histolyticum
-
pH 7.5, 25C
0.003
2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-propionic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0031
2-[benzyl-(3-tert-butoxycarbonylamino-4-methoxy-benzenesulfonyl)-amino]-propionic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.00001
2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0025
2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-propionic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000008
2-[Benzyl-(5-methylnaphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
Clostridium histolyticum
-
pH 7.5, 25C
0.0019
2-[benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-3-methyl-butyric acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000008
2-[Benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
Clostridium histolyticum
-
pH 7.5, 25C
0.000009
2-[Benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
Clostridium histolyticum
-
pH 7.5, 25C
0.00001
2-[benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000006
2-[Benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
Clostridium histolyticum
-
pH 7.5, 25C
0.000009
2-[benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-propionamide
Clostridium histolyticum
-
pH 7.5, 25C
0.00004
2-[benzyl-(toluene-4-sulfonyl)-amino]-N-hydroxy-propionamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000011
2-[benzyl[(1-naphthylamino)carbonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0051
2-[benzyl[(1-naphthylamino)carbonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0061
2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000018
2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.007
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000008
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.00001
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0071
2-[benzyl[(2,4-dinitrophenyl)thio]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.004
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000011
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000014
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0047
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0053
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000018
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000021
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0059
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0062
2-[benzyl[(2-nitrophenyl)thio]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000012
2-[benzyl[(2-nitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0032
2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000007
2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0033
2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000007
2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0023
2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000007
2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0045
2-[benzyl[(3-carboxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.003
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000011
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
0.003
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0051
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000011
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000012
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0052
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000012
2-[benzyl[(3-nitrophenyl)thio]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0063
2-[benzyl[(3-nitrophenyl)thio]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0006
2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000006
2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0035
2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.00001
2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.01
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000036
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000037
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.011
2-[benzyl[(4-bromophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0024
2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000008
2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0024
2-[benzyl[(4-carboxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.011
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000044
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
0.013
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.012
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000042
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000045
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.013
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.01
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.00003
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000032
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.01
2-[benzyl[(4-iodophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0063
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000017
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.00002
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.015
2-[benzyl[(4-methylphenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000033
2-[benzyl[(4-methylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.016
2-[benzyl[(4-methylphenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.005
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000015
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
0.0055
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.006
2-[benzyl[(4-nitrophenyl)thio]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000013
2-[benzyl[(4-nitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000015
2-[benzyl[(4-nitrophenyl)thio]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.006
2-[benzyl[(4-nitrophenyl)thio]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.041
2-[benzyl[(dimethylamino)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000065
2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000068
2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.04
2-[benzyl[(dimethylamino)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0018
2-[benzyl[(heptadecafluorooctyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000007
2-[benzyl[(heptadecfluorooctyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0032
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.00001
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000012
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0031
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0004
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000005
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000006
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0005
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0056
2-[benzyl[(trichloromethyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000052
2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.00005
2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0055
2-[benzyl[(trichloromethyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0033
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-3-methylbutanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000047
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000048
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0036
2-[benzyl[(trifluoromethyl)sulfonyl]amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0068
2-[[[2,4,6-(tripropyl)phenyl]sulfonyl](benzyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0022
2-[[[3-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000012
2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]-N-hydroxypropanamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0036
2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0027
2-[[[4-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0062
2-[[[4-(methoxy)phenyl]sulfonyl](benzyl)amino]propanoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000008
3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0045
3-[benzyl-(1-carboxy-ethyl)-sulfamoyl]-benzoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000009
3-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide
0.0041
3-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000007
4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.0029
4-[benzyl-(1-carboxy-ethyl)-sulfamoyl]-benzoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000008
4-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000007
4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0038
4-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.016
i-C5H11-PO(OH)-Gly-Pro-Ala
Clostridium histolyticum
-
pH 7.5, 25C
-
0.04
N-(2-chlorobenzyl)-N-(dimethylsulfamoyl)-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.021
N-(2-chlorobenzyl)-N-(methylsulfonyl)-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.005
N-(2-chlorobenzyl)-N-(naphthalen-1-ylcarbamoyl)-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0016
N-(2-chlorobenzyl)-N-(naphthalen-1-ylsulfonyl)-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0015
N-(2-chlorobenzyl)-N-(naphthalen-2-ylsulfonyl)-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0004 - 0.024
N-(2-chlorobenzyl)-N-(phenylsulfonyl)-L-alanine
0.002 - 0.0024
N-(2-chlorobenzyl)-N-(thiophen-2-ylsulfonyl)-L-alanine
0.0068
N-(2-chlorobenzyl)-N-[(2,4,6-trimethylphenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0055
N-(2-chlorobenzyl)-N-[(2,4-difluorophenyl)carbamoyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0041
N-(2-chlorobenzyl)-N-[(2,5-dichlorophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0049
N-(2-chlorobenzyl)-N-[(2-nitrophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0058
N-(2-chlorobenzyl)-N-[(3,4-dichlorophenyl)carbamoyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0024
N-(2-chlorobenzyl)-N-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0031
N-(2-chlorobenzyl)-N-[(3-chloro-4-nitrophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0076
N-(2-chlorobenzyl)-N-[(3-chlorophenyl)carbamoyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.005
N-(2-chlorobenzyl)-N-[(3-nitrophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.01
N-(2-chlorobenzyl)-N-[(4-bromophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0068
N-(2-chlorobenzyl)-N-[(4-chlorophenyl)carbamoyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.013
N-(2-chlorobenzyl)-N-[(4-chlorophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0074
N-(2-chlorobenzyl)-N-[(4-fluorophenyl)carbamoyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.012
N-(2-chlorobenzyl)-N-[(4-fluorophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.01
N-(2-chlorobenzyl)-N-[(4-iodophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.006
N-(2-chlorobenzyl)-N-[(4-methoxyphenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.018
N-(2-chlorobenzyl)-N-[(4-methylphenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0051
N-(2-chlorobenzyl)-N-[(4-nitrophenyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0015
N-(2-chlorobenzyl)-N-[(heptadecafluorooctyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.003
N-(2-chlorobenzyl)-N-[(nonafluorobutyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0052
N-(2-chlorobenzyl)-N-[(trichloromethyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0033
N-(2-chlorobenzyl)-N-[(trifluoromethyl)sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.004
N-(2-chlorobenzyl)-N-[[(2-methylphenyl)sulfonyl]carbamoyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0034
N-(2-chlorobenzyl)-N-[[(4-chlorophenyl)sulfonyl]carbamoyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0036
N-(2-chlorobenzyl)-N-[[(4-fluorophenyl)sulfonyl]carbamoyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0041
N-(2-chlorobenzyl)-N-[[(4-methylphenyl)sulfonyl]carbamoyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0005
N-(2-chlorobenzyl)-N-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0021
N-(2-chlorobenzyl)-N-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.016
N-(benzylsulfonyl)-N-(2-chlorobenzyl)-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.000006
N-([(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]amino]methyl)benzamide
Clostridium histolyticum
-
pH 7.5, 25C
0.003
N-([3-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0024
N-([3-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.0027
N-([4-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.000189
N-2-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000028
N-2-methylphenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.00015
N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000021
N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000061
N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000043
N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.00002
N-2-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000045
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.00004
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000015
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.00017
N-4-chlorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000021
N-4-chlorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000125
N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000014
N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000009
N-4-chlorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000026
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000025
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000007
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000163
N-4-fluorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000018
N-4-fluorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.00014
N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000013
N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.00005
N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.00006
N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000013
N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000007
N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000033
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.00001
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000021
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000006
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000165
N-4-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000133
N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000018
N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000055
N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000042
N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000018
N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000019
N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.00004
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000015
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000038
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000012
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000125
N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000016
N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000015
N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.00001
N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000086
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000013
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000035
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
Clostridium histolyticum
-
pH 7.5, 25C
0.000008
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
Clostridium histolyticum
-
pH 7.5, 25C
0.003
N-[[4-(acetylamino)phenyl]sulfonyl]-N-(2-chlorobenzyl)-L-alanine
Clostridium histolyticum
-
pH 7.5, 25C
0.000076
N2(2-chlorobenzyl)-N-hydroxy-N2-[(trifluoromethyl)sulfonyl]-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000011
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylcarbamoyl)-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000008
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylsulfonyl)-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000009
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-2-ylsulfonyl)-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.0000005 - 0.000058
N2-(2-chlorobenzyl)-N-hydroxy-N2-(phenylsulfonyl)-L-alaninamide
0.000007
N2-(2-chlorobenzyl)-N-hydroxy-N2-(quinolin-8-ylsulfonyl)-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000011
N2-(2-chlorobenzyl)-N-hydroxy-N2-(thiophen-2-ylsulfonyl)-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000017
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4,6-trimethylphenyl)sulfonyl]-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000011
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4-dinitrophenyl)sulfanyl]-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000022
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000013
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-nitrophenyl)sulfanyl]-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000011
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(nonafluorobutyl)sulfonyl]-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000071
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(trichloromethyl)sulfonyl]-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000006
N2-(2-chlorobenzyl)-N-hydroxy-N2-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000077
N2-(2-chlorobenzyl)-N2-(dimethylsulfamoyl)-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000014
N2-(2-chlorobenzyl)-N2-[(2,4-difluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000015
N2-(2-chlorobenzyl)-N2-[(2,5-dichlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000016
N2-(2-chlorobenzyl)-N2-[(2-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000015
N2-(2-chlorobenzyl)-N2-[(3,4-dichlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000009
N2-(2-chlorobenzyl)-N2-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.00001
N2-(2-chlorobenzyl)-N2-[(3-chloro-4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000017
N2-(2-chlorobenzyl)-N2-[(3-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000011
N2-(2-chlorobenzyl)-N2-[(3-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000033
N2-(2-chlorobenzyl)-N2-[(4-bromophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000015
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000035
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000018
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000036
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.00003
N2-(2-chlorobenzyl)-N2-[(4-iodophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000045
N2-(2-chlorobenzyl)-N2-[(4-methylphenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000015
N2-(2-chlorobenzyl)-N2-[(4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000008
N2-(2-chlorobenzyl)-N2-[(heptadecafluorooctyl)sulfonyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000011
N2-(2-chlorobenzyl)-N2-[[(4-chlorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000008 - 0.000009
N2-(2-chlorobenzyl)-N2-[[(4-fluorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
0.00001
N2-(2-chlorobenzyl)-N2-[[(4-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
0.000054
N2-(benzylsulfonyl)-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000092
N2-chlorobenzyl)-N-hydroxy-N2-(methylsulfonyl)-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000011
N2-[[4-(acetylamino)phenyl]sulfonyl]-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide
Clostridium histolyticum
-
pH 7.5, 25C
0.000005 - 0.34
p-O2NC6H4CH2CH2PO(OH)Gly-Pro-2-aminohexanoic acid
0.34
Pro6-Gly-Pro-Gly
Clostridium histolyticum
-
pH 7.5, 25C
-
0.000005
Pro6-Gly-Pro-Gly-H
Clostridium histolyticum
-
pH 7.5, 25C
-
0.02
Tannic acid
Clostridium histolyticum
-
pH 7.5, 25C
0.000008
tert-butyl (3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000009
tert-butyl (4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000008
tert-butyl (5-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]-2-methoxyphenyl)carbamate
Clostridium histolyticum
-
pH 7.5, 25C
0.000007
[3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester
Clostridium histolyticum
-
pH 7.5, 25C
0.000009
[4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester
Clostridium histolyticum
-
pH 7.5, 25C
0.000007
[5-[benzyl-(3-hydroxy-1-methyl-2-oxo-propyl)-sulfamoyl]-2-methoxy-phenyl]-carbamic acid tert-butyl ester
Clostridium histolyticum
-
pH 7.5, 25C
additional information
additional information
Clostridium histolyticum
-
inhibition kinetics using diverse variants of 5-amino-2-mercapto-1,3,4-thiadiazoles, overview
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.025 - 0.15
1,10-phenanthroline
0.415
erucic acid
Clostridium histolyticum
-
IC50: 0.415 mM
0.03
heptadecanoic acid
Clostridium histolyticum
-
IC50: 0.03 mM
0.375
linoleic acid
Clostridium histolyticum
-
IC50: 0.375 mM
0.46
linolenic acid
Clostridium histolyticum
-
IC50: 0.46 mM
0.27
myristic acid
Clostridium histolyticum
-
IC50: 0.27 mM
0.46
oleic acid
Clostridium histolyticum
-
IC50: 0.46 mM
0.405
palmitoleic acid
Clostridium histolyticum
-
IC50: 0.405 mM
0.125
pentadecanoic acid
Clostridium histolyticum
-
IC50: 0.125 mM
0.03
stearic acid
Clostridium histolyticum
-
IC50: 0.03 mM
0.5
additional information
Clostridium histolyticum
-
no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.02
-
-
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.3 - 8.8
Clostridium histolyticum
-
-
6.5 - 8.8
7.6
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.2 - 10.2
-
pH 10.2: about 85% of activity maximum; pH 4.2: about 20% of activity maximum
5 - 11
Clostridium histolyticum
-
pH 11: about 35% of activity maximum; pH 5: about 35% of activity maximum
5.5 - 8.5
-
pH 5.5: about 40% of activity maximum; pH 8.5: about 20% of activity maximum
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
35 - 40
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
-
intimately associated with the cell but released during autolysis
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
UNIPROT
Clostridium histolyticum
Clostridium histolyticum
Clostridium histolyticum
Clostridium histolyticum
Clostridium histolyticum
Clostridium histolyticum
Clostridium histolyticum
Clostridium histolyticum
Clostridium histolyticum
Clostridium histolyticum
Clostridium histolyticum
Clostridium histolyticum
Clostridium tetani (strain Massachusetts / E88)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
11470
Clostridium histolyticum
-
mutant enzyme S906F in presence of 1 mM Ca2+, gel filtration
11750
Clostridium histolyticum
-
mutant enzyme S906A in presence of 1 mM Ca2+, gel filtration
11810
Clostridium histolyticum
-
mutant enzyme Q972A in presence of 1 mM Ca2+, gel filtration
11910
Clostridium histolyticum
-
mutant enzyme V973A in presence of 1 mM Ca2+, gel filtration
11920
Clostridium histolyticum
-
wild-type enzyme in presence of 1 mM Ca2+, gel filtration
13720
Clostridium histolyticum
-
mutant enzyme E901A in presence of 1 mM Ca2+, gel filtration
13750
Clostridium histolyticum
-
mutant enzyme D904A in presence of 1 mM Ca2+, gel filtration
14390
Clostridium histolyticum
-
mutant enzyme E899A in presence of 1 mM Ca2+, gel filtration
15370
Clostridium histolyticum
-
mutant enzyme D930A in presence of 1 mM Ca2+, gel filtration
15420
Clostridium histolyticum
-
mutant enzyme D930A in presence of 1 mM EDTA, gel filtration
15730
Clostridium histolyticum
-
mutant enzyme N903A in presence of 1 mM Ca2+, gel filtration
15790
Clostridium histolyticum
-
mutant enzyme D927A in presence of 1 mM Ca2+, gel filtration
15890
Clostridium histolyticum
-
mutant enzyme E899A in presence of 1 mM EDTA, gel filtration
16160
Clostridium histolyticum
-
mutant enzyme D904A in presence of 1 mM EDTA, gel filtration
16190
Clostridium histolyticum
-
mutant enzyme D927A in presence of 1 mM EDTA, gel filtration
16410
Clostridium histolyticum
-
mutant enzyme S906A in presence of 1 mM EDTA, gel filtration
16430
Clostridium histolyticum
-
wild-type enzyme in presence of 1 mM EGTA, gel filtration
16470
Clostridium histolyticum
-
mutant enzyme Q972A in presence of 1 mM EDTA, gel filtration
16510
Clostridium histolyticum
-
mutant enzyme V973A in presence of 1 mM EDTA, gel filtration
16530
Clostridium histolyticum
-
mutant enzyme N903A in presence of 1 mM EDTA, gel filtration
16650
Clostridium histolyticum
-
mutant enzyme S906F in presence of 1 mM EDTA, gel filtration
62000
-
gel filtration
70000
Clostridium histolyticum
-
gel filtration
74000
-
gel filtration
82000
Clostridium histolyticum
-
gel filtration
90000
-
A2, gel filtration
100000
105000
-
gel filtration
110000
-
A1, gel filtration
112000
Clostridium histolyticum
-
ultracentrifugation
113000
Clostridium histolyticum
-
mass spectrometry
114200
Clostridium histolyticum
-
mutant enzyme E414Q, MALDI-TOF mass spectrometry; wild-type enzyme, MALDI-TOF mass spectrometry
119000
Clostridium histolyticum
-
gel filtration, presence of EGTA
120000
Clostridium histolyticum
-
gel filtration
147200
Clostridium histolyticum
-
gel filtration
additional information
Clostridium histolyticum
-
MW of various C-terminal segments
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
tetramer
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
no modification
side-chain modification
-
glycoprotein
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
apo-enzyme, free enzyme and in complex with inhibitor isoamyl-phosphonyl-Gly-Pro-Ala, to 2.55 A, 2.8 A and 3.25 A resolution. Structure shows a distinct segmentation of the N-terminal collagenase module, residues Tyr119-Gly790, forming a saddle-shaped two-domain architecture. The smaller N-terminal saddle flap serves as an activator domain, residues Tyr119-Asp388, and comprises an array of 12 parallel alpha-helices. The catalytic subdomain, residues Asp398-Gln669, adopts a thermolysin-like peptidase fold of mixed alpha and beta type. Leu517-Leu534 form the central helix of the fold and contain the Zn2+-binding 523-HEXXH-527 motif
Clostridium histolyticum
crystal structure of ColG collagen-binding domain s3b, to 2.0 A resolution. All but one residue, whose side chain chelates with Ca2+, are conserved; crystal structures of ColH collagen-binding domain, to 2.0 A resolution. All but one residue, whose side chain chelates with Ca2+, are conserved. The dual Ca2+ binding site in s3 is completed by an unconserved aspartate. Domain s3 gains thermal stability, comparable to domain s3b of isoform ColG, by binding to Ca2+. holo s3 is also stabilized against chemical denaturants urea and guanidine HCl. The general shape of the binding pocket is retained by altered loop structures and side chain positions. Domain s3 also binds asymmetrically to minicollagen
Clostridium histolyticum
-
crystal structures of the collagenase unit of ColG in the presence and absence of the peptidic inhibitor isoamylphosphonyl-Gly-Pro-Ala bound to the active site. Comparison of isoforms ColH, ColT and ColG reveals differences in domain breathing motions and regulatory elements. Calcium and zinc are required for full peptidolytic activity; crystal structures of the peptidase domains of ColH in the presence and absence of the peptidic inhibitor isoamylphosphonyl-Gly-Pro-Ala bound to the active site. In the unliganded ColH structure, the quaternary subdomain dynamics is modulated by an aspartate switch motion that binds to the catalytic zinc. One calcium binding site is in proximity to the catalytic zinc. Both ions are required for full activity. Loops close to the active site serve as characteristic substrate selectivity filter. Comparison of isoforms ColH, ColT and ColG reveals differences in domain breathing motions and regulatory elements. Calcium and zinc are required for full peptidolytic activity
Clostridium histolyticum
-
hanging drop vapor diffusion method, structure of the collagen-binding domain with an N-terminal domain linker from class I collagenase, determined at 1.0 A resolution in the absence of Ca2+ and at 1.65 A resolution in the presence of calcium
Clostridium histolyticum
-
purified recombinant His-tagged catalytic domain of collagenase G, sitting drop vapour diffusion method, 10 mg/ml protein in 25 mM Tris, pH 7.5, and 50 mM NaCl, mixed with reservoir solution containing 0.12 M sodium citrate and 23% v/v PEG 3350 at 20C, 10 days, X-ray diffraction structure determination and anaylsis at 2.75 A resolution
Clostridium histolyticum
X-ray crystal structures of Ca2+-bound domain apo s2 to 1.4 A and 1.6 A resolution. ColG-derived domains lack surface aromatic residues, suggesting that the domain is less directly involved in interactions with collagen than that in isoform ColH. The domains are extremely stable in the presence of physiological concentrations of Ca2+; X-ray crystal structures of Ca2+-bound domains holo s2b to 1.4 A resolution, and holo s2a to 1.9 A resolution, as well as of Ca2+-free apo s2a to 1.8 A resolution. ColH-derived domains exhibit exposed aromatic residues and are found in M9B collagenases with a single collagen-binding domain. The domains are extremely stable in the presence of physiological concentrations of Ca2+
Clostridium histolyticum
-
crystal structures of the peptidase domains of ColT in the presence and absence of the peptidic inhibitor isoamylphosphonyl-Gly-Pro-Ala bound to the active site. Comparison of isoforms ColH, ColT and ColG reveals differences in domain breathing motions and regulatory elements. Calcium and zinc are required for full peptidolytic activity
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.4 - 7.4
-
4C, 24 h
37104
6.8 - 8
-
-
668044
7.2 - 8.7
-
unstable outside the range
37101
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
20 h, pH 7-8
40
Clostridium histolyticum
-
3 h, Ca2+ added
49
Clostridium histolyticum
-
melting point, presence of EGTA. Addition of excess Ca2+ restores melting point to 54C
50
Clostridium histolyticum
-
2 h, Ca2+ added
54
Clostridium histolyticum
-
melting point