Information on EC 3.4.24.3 - microbial collagenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Bacteria

EC NUMBER
COMMENTARY
3.4.24.3
-
RECOMMENDED NAME
GeneOntology No.
microbial collagenase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
Digestion of native collagen in the triple helical region at -/-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of peptide bond
-
-
endopeptidase
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
120 kDa collagenase
-
-
-
-
Achromobacter iophagus collagenase
-
-
-
-
aspergillopeptidase C
-
-
-
-
azocollase
-
-
-
-
bacterial collagenase
-
-
clostridial collagenase A
-
-
clostridiopeptidase A
-
-
-
-
clostridiopeptidase A
-
-
clostridiopeptidase I
-
-
-
-
clostridiopeptidase II
-
-
-
-
Clostridium histolyticum collagenase
-
-
-
-
Clostridium histolyticum collagenase
-
-
ColG
-
class I collagenase
collagen peptidase
-
-
-
-
collagen protease
-
-
-
-
collagenase A
-
-
-
-
collagenase G
Q9X721
-
collagenase H
-
-
collagenase I
-
-
-
-
collagenase MMP-1
-
-
-
-
collagenase T
-
-
EC 3.4.4.19
-
-
formerly
-
EC 3.4.99.5
-
-
formerly
-
kollaza
-
-
-
-
matirx metalloproteinase-18
-
-
-
-
matrix metalloproteinase-1
-
-
-
-
metallocollagenase
-
-
-
-
metalloproteinase-1
-
-
-
-
nucleolysin
-
-
-
-
peptidase, clostridio-, A
-
-
-
-
proteinase, Clostridium histolyticum, A
-
-
-
-
soycollagestin
-
-
-
-
thermophilic collagenolytic protease
Geobacillus sp.
Q0KK26
-
MMP-1
-
-
-
-
additional information
Geobacillus sp.
Q0KK26
the enzyme is a member of the subtilisin family of serine proteases
CAS REGISTRY NUMBER
COMMENTARY
9001-12-1
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Bacteroides melaninogenicus
-
-
-
Manually annotated by BRENDA team
Clostridium capitorale
-
-
-
Manually annotated by BRENDA team
2 fractions differ in specificity
-
-
Manually annotated by BRENDA team
2 multiple forms: I and II differ in substrate specificity
-
-
Manually annotated by BRENDA team
2-6 different collagenase fractions can be differentiated on the basis of substrate preference
-
-
Manually annotated by BRENDA team
2-6 different collagenase fractions can be differentiated on the basis of substrate preference; 2 multiple forms: I and II differ in substrate specificity
-
-
Manually annotated by BRENDA team
3 forms: A-alpha, B-alpha and B-beta differ in substrate specificity
-
-
Manually annotated by BRENDA team
3 forms: C1, C2, C3 differ in molecular weight
-
-
Manually annotated by BRENDA team
4 forms: I, II, IIIa, IIIb
-
-
Manually annotated by BRENDA team
6 forms: alpha, beta, gamma, delta, epsilon, zeta differ in substrate specificity
-
-
Manually annotated by BRENDA team
class I collagenase
-
-
Manually annotated by BRENDA team
collagenase type VII
-
-
Manually annotated by BRENDA team
gene colG
SwissProt
Manually annotated by BRENDA team
type I collagenase ColG
-
-
Manually annotated by BRENDA team
Clostridium welchii
-
-
-
Manually annotated by BRENDA team
L43-1 strain
-
-
Manually annotated by BRENDA team
Cytophaga sp. L43-1
L43-1 strain
-
-
Manually annotated by BRENDA team
Empedobacter collagenolyticum
-
-
-
Manually annotated by BRENDA team
Geobacillus sp.
strain MO-1
UniProt
Manually annotated by BRENDA team
Bacteroides gingivalis
-
-
Manually annotated by BRENDA team
chemovar iophagus, two forms: A1 and A2 without difference in substrate specificity
-
-
Manually annotated by BRENDA team
Vibrio sp. B-30
B-30
-
-
Manually annotated by BRENDA team
Vibrio vulnificus CYK279H
CYK279H
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-(S-methylcysteine)-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-(S-methylcysteine)-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00018
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ala-Gly-Pro-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Ala-Gly-Pro-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00204
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ala-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Ala-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00095
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ala-Tyr-Lys-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Ala-Tyr-Lys-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00309
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Arg-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Arg-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00026
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Asn-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Asn-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00022
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Asp-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Asp-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00022
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gln-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gln-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.0003
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Glu-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Glu-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00022
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-(S-methylcysteine)-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-(S-methylcysteine)-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00072
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00082
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Arg-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Arg-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00595
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00037
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Gly-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Gly-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00124
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Ile-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Ile-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00086
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Leu-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Leu-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00134
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Lys-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Lys-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.006
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Met-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Met-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00131
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Phe-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Phe-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00051
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Pro-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Pro-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00565
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Trp-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Trp-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00073
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Tyr-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Tyr-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00113
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ala-Val-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ala-Val-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00056
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Asn-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gly-Ala-Asn-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00376
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Asp-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gly-Ala-Asp-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00043
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Gln-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gly-Ala-Gln-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00435
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Glu-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Gly-Ala-Glu-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00042
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Ser-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Ser-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00405
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ala-Thr-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ala-Thr-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00466
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Arg-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Arg-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00011
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Asn-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Asn-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00096
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Asp-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Asp-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.0004
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Gln-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Gln-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00049
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Glu-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Glu-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00035
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Gly-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Gly-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00042
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-His-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-His-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00084
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ile-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ile-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00065
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Leu-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Leu-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00029
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Lys-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Lys-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00017
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Met-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Met-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00027
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Phe-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Phe-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00056
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.008
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Ser-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Ser-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00098
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Thr-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Thr-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00082
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Trp-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Trp-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00037
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Tyr-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Tyr-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00038
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Gly-Val-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala + Gly-Val-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00039
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-His-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-His-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00029
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ile-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Ile-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00017
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Leu-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Leu-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00021
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Lys-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Lys-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00021
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Met-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Met-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00028
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Phe-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Phe-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00022
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Pro-Lys-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Pro-Lys-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00276
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Pro-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Pro-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00088
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Ser-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Ser-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.0007
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Thr-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Thr-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.0004
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Trp-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Trp-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00014
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Tyr-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Tyr-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00029
-
-
?
(7-hydroxycoumarin-4-propanoyl)-Ala-Ala-Val-Pro-Ala-beta-Ala + H2O
(7-hydroxycoumarin-4-propanoyl)-Ala + Ala-Val-Pro-Ala-beta-Ala
show the reaction diagram
-
ratio of turnover number to Km-value is 0.00036
-
-
?
2-furanacryloyl-Leu-Gly-Pro-Ala + H2O
2-furanacryloyl-Leu + Gly-Pro-Ala
show the reaction diagram
-
-
-
?
2-furanacryloyl-Leu-Gly-Pro-Ala + H2O
2-furanacryloyl-Leu + Gly-Pro-Ala
show the reaction diagram
-
-
-
?
2-furanacryloyl-Leu-Gly-Pro-Ala + H2O
2-furanacryloyl-Leu + Gly-Pro-Ala
show the reaction diagram
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
show the reaction diagram
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
show the reaction diagram
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
show the reaction diagram
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
show the reaction diagram
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
show the reaction diagram
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
show the reaction diagram
-
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
show the reaction diagram
-
-
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg + H2O
4-phenylazobenzyloxycarbonyl-Pro-Leu + Gly-Pro-Arg
show the reaction diagram
-
-
-
-
?
Azocoll + H2O
Hydrolyzed azocoll
show the reaction diagram
-
-
-
-
?
Azocoll + H2O
Hydrolyzed azocoll
show the reaction diagram
Bacteroides melaninogenicus
-
-
-
-
?
Azocoll + H2O
Hydrolyzed azocoll
show the reaction diagram
-
-
-
-
?
Azocoll + H2O
Hydrolyzed azocoll
show the reaction diagram
-
denatured collagen with bound dye, no hydrolysis
-
-
-
Bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala + H2O
carbobenzoxy-Gly-Pro-Gly + Gly-Pro-Ala
show the reaction diagram
-
-
-
?
carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala + H2O
carbobenzoxy-Gly-Pro-Gly + Gly-Pro-Ala
show the reaction diagram
-
-
-
?
carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala + H2O
carbobenzoxy-Gly-Pro-Gly + Gly-Pro-Ala
show the reaction diagram
-
-
-
?
carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala + H2O
carbobenzoxy-Gly-Pro-Gly + Gly-Pro-Ala
show the reaction diagram
-
-
-
?
carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala + H2O
carbobenzoxy-Gly-Pro-Gly + Gly-Pro-Ala
show the reaction diagram
Cytophaga sp., Cytophaga sp. L43-1
-
-
-
-
?
carbobenzoxy-Gly-Pro-Leu-Gly-Pro + H2O
carbobenzoxy-Gly-Pro-Leu + Gly-Pro
show the reaction diagram
-
-
-
?
carbobenzoxy-Gly-Pro-Leu-Gly-Pro + H2O
carbobenzoxy-Gly-Pro-Leu + Gly-Pro
show the reaction diagram
-
-
-
-
?
casein + H2O
?
show the reaction diagram
Cytophaga sp., Cytophaga sp. L43-1
-
-
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
-
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
-
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
-
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
-
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
-
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
-
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
Empedobacter collagenolyticum
-
-
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
denatured
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
collagen types I, II and III
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
Bacteroides melaninogenicus
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
Clostridium capitorale, Clostridium welchii
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
Vibrio sp. B-30
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence-Pro-Xaa-Gly-Pro, nondenatured triple helical form
-
-
?
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
Cytophaga sp. L43-1
-
-
-
-
?
Collagen + H2O
?
show the reaction diagram
-
-
-
-
-
Collagen + H2O
?
show the reaction diagram
-
-
-
-
-
Collagen + H2O
?
show the reaction diagram
-
-
-
-
-
Collagen + H2O
?
show the reaction diagram
-
-
-
-
-
Collagen + H2O
?
show the reaction diagram
-
-
-
-
-
Collagen + H2O
?
show the reaction diagram
-
-
-
-
-
Collagen + H2O
?
show the reaction diagram
Empedobacter collagenolyticum
-
-
-
-
-
Collagen + H2O
?
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
Bacteroides melaninogenicus
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
Clostridium capitorale, Clostridium welchii
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
-
a collagen-binding domain specifically recognizes the triple-helical conformation made by three chains in the collagenous region
-
-
?
Collagen + H2O
?
show the reaction diagram
-
triple helical collagen
-
-
?
Collagen + H2O
?
show the reaction diagram
-
proteolytic degradation
-
-
?
Collagen + H2O
?
show the reaction diagram
-
proteolytic degradation
-
-
?
Collagen + H2O
?
show the reaction diagram
-
clostridial collagenase A is effective in degrading collagen in eschar tissue and promoting healing in partial-thickness burns, CCA aggravates the systemic inflammatory response in rats with partial-thickness burns, inflammatory reactions such as fever, leukocytosis or leukocytopenia and increased CRP levels in sera are often observed in a significant proportion of burn victims treated with CCA ointment, although synchronous wound swab cultures show no signs of infection, overview
-
-
?
Collagen + H2O
?
show the reaction diagram
-
proteolytic degradation, the enzyme helps the skin to heal after burns and dermal ulcers, but can cause allergic reactions, overview
-
-
?
Collagen + H2O
?
show the reaction diagram
Vibrio sp. B-30
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
Cytophaga sp. L43-1
-
-
-
-
-
Collagen type I + H2O
?
show the reaction diagram
-
-
Clostridium collagenase itself and the degradation products of type I and III collagens lead toan increase in keratinocyte and fibroblast migration
-
?
Collagen type I + H2O
?
show the reaction diagram
-
tensile loads higher than 3 pN tenfold reduce the enzymatic degradation rate of recombinant human type I collagen monomers compared to unloaded controls. Collagen molecular architecture may be generally more stable when mechanically strained in tension. The tensile mechanical state of collagen monomers is likely to be correlated to their longevity in tissues
-
-
?
Collagen type III + H2O
?
show the reaction diagram
-
-
Clostridium collagenase itself and the degradation products of type I and III collagens lead toan increase in keratinocyte and fibroblast migration
-
?
collagen type IV + H2O
?
show the reaction diagram
-
-
degradation products of collagen type IV induce fibroblast migration
-
?
collagen type V + H2O
?
show the reaction diagram
-
-
-
-
?
furanacryloyl-Leu-Gly-Pro-Ala + H2O
furanacryloyl-Leu + Gly-Pro-Ala
show the reaction diagram
-
-
-
-
?
furylacryloyl-L-Phe-Gly-Gly
?
show the reaction diagram
-
-
-
-
?
furylacryloyl-Leu-Gly-Pro-Ala + H2O
furylacryloyl-Leu + Gly-Pro-Ala
show the reaction diagram
-
-
-
-
?
GDPCMPIISN + H2O
?
show the reaction diagram
Vibrio vulnificus, Vibrio vulnificus CYK279H
-
-
-
-
?
Gelatin + H2O
Hydrolyzed gelatin
show the reaction diagram
-
-
-
-
?
Gelatin + H2O
Hydrolyzed gelatin
show the reaction diagram
-
-
-
-
?
N-[3-(2-furyl) acryloyl]-L-Leu-Gly-L-Pro-L-Ala + H2O
?
show the reaction diagram
-
-
-
-
?
Type I collagen + H2O
?
show the reaction diagram
-
degradation
-
-
?
Type I collagen + H2O
?
show the reaction diagram
Geobacillus sp.
Q0KK26
degradation
-
-
?
Type I collagen + H2O
?
show the reaction diagram
-
bovine substrate from corium, degradation, cleavage at multiple sites by the bacterial enzyme
-
-
?
Gelatin + H2O
Hydrolyzed gelatin
show the reaction diagram
Cytophaga sp., Cytophaga sp. L43-1
-
-
-
-
?
additional information
?
-
-
-
-
-
-
additional information
?
-
-
other forms with broader specificity isolated from the same source: collagenase B, collagenase II, pseudocollagenase
-
-
-
additional information
?
-
Bacteroides melaninogenicus
-
bacterial collagenases of similar specificity isolated from Bacteroides melaninogenius
-
-
-
additional information
?
-
-
minimum sequence requirement: R-Pro-X-Gly-Pro, Pro can be substituted by Hyp and the first imino group must be blocked, cleavage between X and Gly
-
-
-
additional information
?
-
-
the N-terminal region of the collagen-binding region is not an essential structural component for collagen binding or recognition but rather a cation-controlled multiconformational domain-linker
-
-
-
additional information
?
-
-
collagenase is capable of eliciting a variety of tissue responses in mice depending upon its route of administration. Intranasal instillation results in confluent pulmonary hemorrhage, intraperitoneal injections result in severe abdominal hemorrhage with foci in the intestinal serosa. Intravenous injections elicit abdominal hemorrhage and petichial hemorrhage with focal necrosis of the lungs, subcutaneous injections result in necrotic, ulcerating lesions
-
-
-
additional information
?
-
-
human dentin surfaces bonded to adhesive material in teeth repair are sensitive to aging, microtensile bond strength values are affected by different adhesives, specimen sizes and storing periods, but not by the presence or absence of bacterial collagenase, overview
-
-
-
additional information
?
-
-
no substrate: collagen type VI
-
-
-
additional information
?
-
Q9X721
two-step mechanism in which the N-terminal activator domain cooperates with the peptidase domain in recognition and processing of both collagen triple helices and microfibrils. The activator and peptidase domains remain mostly closed during collagen cleavage but relax to the open ground state once the collagen is degraded, as collagen is the source of the attractive interaction for collagenase closing
-
-
-
additional information
?
-
Vibrio sp. B-30
-
other forms with broader specificity isolated from the same source: collagenase B, collagenase II, pseudocollagenase, minimum sequence requirement: R-Pro-X-Gly-Pro, Pro can be substituted by Hyp and the first imino group must be blocked, cleavage between X and Gly
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Collagen + H2O
?
show the reaction diagram
-
-
-
-
-
Collagen + H2O
?
show the reaction diagram
-
-
-
-
-
Collagen + H2O
?
show the reaction diagram
-
-
-
-
-
Collagen + H2O
?
show the reaction diagram
-
-
-
-
-
Collagen + H2O
?
show the reaction diagram
-
-
-
-
-
Collagen + H2O
?
show the reaction diagram
-
-
-
-
-
Collagen + H2O
?
show the reaction diagram
Empedobacter collagenolyticum
-
-
-
-
-
Collagen + H2O
?
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
Bacteroides melaninogenicus
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
Clostridium capitorale, Clostridium welchii
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Collagen + H2O
?
show the reaction diagram
-
clostridial collagenase A is effective in degrading collagen in eschar tissue and promoting healing in partial-thickness burns, CCA aggravates the systemic inflammatory response in rats with partial-thickness burns, inflammatory reactions such as fever, leukocytosis or leukocytopenia and increased CRP levels in sera are often observed in a significant proportion of burn victims treated with CCA ointment, although synchronous wound swab cultures show no signs of infection, overview
-
-
?
Collagen + H2O
?
show the reaction diagram
-
proteolytic degradation, the enzyme helps the skin to heal after burns and dermal ulcers, but can cause allergic reactions, overview
-
-
?
Collagen + H2O
?
show the reaction diagram
Vibrio sp. B-30
-
degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro
-
-
-
Type I collagen + H2O
?
show the reaction diagram
-
degradation
-
-
?
Type I collagen + H2O
?
show the reaction diagram
Geobacillus sp.
Q0KK26
degradation
-
-
?
Collagen + H2O
?
show the reaction diagram
Cytophaga sp. L43-1
-
-
-
-
-
additional information
?
-
-
collagenase is capable of eliciting a variety of tissue responses in mice depending upon its route of administration. Intranasal instillation results in confluent pulmonary hemorrhage, intraperitoneal injections result in severe abdominal hemorrhage with foci in the intestinal serosa. Intravenous injections elicit abdominal hemorrhage and petichial hemorrhage with focal necrosis of the lungs, subcutaneous injections result in necrotic, ulcerating lesions
-
-
-
additional information
?
-
-
human dentin surfaces bonded to adhesive material in teeth repair are sensitive to aging, microtensile bond strength values are affected by different adhesives, specimen sizes and storing periods, but not by the presence or absence of bacterial collagenase, overview
-
-
-
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Ca2+
-
required for stability and activity
Ca2+
-
Ca-enzyme, alpha: 2.2, beta: 7.9, gamma: 3.1, delta: 3.0, epsilon: 4. 5, zeta: 6.5 mol Ca2+ per mol enzyme
Ca2+
-
4 g-atom Calcium per mol enzyme; activates
Ca2+
Bacteroides melaninogenicus
-
activates
Ca2+
-
activates
Ca2+
-
activates
Ca2+
-
conformational change of the linker upon calcium binding in the structure of the collagen-binding domain with an N-terminal domain linker from class I collagenase
Ca2+
-
activates
Calcium
-
binding of calcium ions triggers the formation of a cis peptide bond in the collagen-binding domain. The calcium ions not only stabilize the cis peptide bond thermodynamically but also catalyze its formation. The free energy barrier to the formation of the cis peptide bond decreases from 21.4 kcal/mol in the absence of calciumions to 10.3 kcal/mol in their presence. The calcium ions electrostatically stabilize the lone pair on the nitrogen atom that forms during the isomerization. Their attraction to acidic amino acid side chains and formation of a hydrogen bond network constrain the peptide backbone in a way that makes it easier for the nitrogen to pyramidalize
Co2+
-
activates at low concentration, inhibits at high concentration
Li+
-
activates
Mg2+
-
activates
Zinc
-
metallopeptidase
Zinc
-
expression of a truncated construct Y53-A506 which stops shortly after the third zinc binding residue and consitstent with the prediction of a minimal catalytic domain. The construct shows no catalytic activity at all, despite containing all zinc binding residues including the catalytic glutamate that is supposed to act as general base
Zn2+
-
zinc enzyme, 1.14 mol zinc per mol, enzyme form C1, 0.82 mol zinc per mol enzyme, form C3
Zn2+
-
1 mol zinc per mol enzyme
Zn2+
-
1 mol zinc per mol enzyme
Zn2+
-
1 mol zinc per mol enzyme
Zn2+
-
activates
Zn2+
Q9X721
the catalytic domain contains the consensus motif HEXXH that harbours the catalytic Zn2+ ion, in contrast to the zinc ligation in metzincins such as MMPs, bacterial collagenases are believed to employ glutamate as a third zinc ligand
Zn2+
Q9X721
the catalytic Zn2+ is tetrahedrally coordinated by the side chains of His523, His527 and Glu555, as well as a water molecule that is further hydrogen-bonded to the general base Glu524
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
1,10-phenanthroline
-
-
1,10-phenanthroline
-
The half maximal inhibitory concentrations of the catalytic domains for 1,10-phenanthroline are significantly decreased for both isoforms ColG and ColH in the presence of the N-terminal His6-tag
1,10-phenanthroline
-
The half maximal inhibitory concentrations of the catalytic domains for 1,10-phenanthroline are significantly decreased in the presence of the N-terminal His6-tag
1,10-phenantroline
-
activity restored by Co2+, Mn2+, Ca2+, Cu2+, Ni2+ and Zn2+
2-(1-benzyl-3-naphthalen-1-yl-ureido)-3-methyl-butyric acid
-
-
2-(1-benzyl-3-naphthalen-1-yl-ureido)-N-hydroxy-3-methyl-butyramide
-
-
2-(3-benzoyl-1-benzyl-thioureido)-N-hydroxy-3-methyl-butyramide
-
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)propanoic acid
-
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)propanoic acid
-
-
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
-
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
-
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
-
2-(benzyl[[(3-chlorphenyl)amino]carbonyl]amino)propanoic acid
-
-
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
-
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
-
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
-
2-(benzyl[[(4-chlorphenyl)amino]carbonyl]amino)propanoic acid
-
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)propanoic acid
-
-
2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)-N-hydroxypropanamide
-
-
2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)propanoic acid
-
-
2-mercaptoethanol
-
-
2-mercaptoethanol
-
-
2-mercaptoethanol
-
-
2-[benzyl(1-naphthylsulfonyl)amino]propanoic acid
-
-
2-[benzyl(2-naphthylsulfonyl)amino]propanoic acid
-
-
2-[benzyl(5-methylnaphthalene-1-sulfonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl(benzylsulfonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl(benzylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl(benzylsulfonyl)amino]-N-hydroxypropanamide
-
-
2-[benzyl(benzylsulfonyl)amino]propanoic acid
-
-
2-[benzyl(methylsulfonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl(methylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl(methylsulfonyl)amino]-N-hydroxypropanamide
-
-
2-[benzyl(methylsulfonyl)amino]propanoic acid
-
-
2-[benzyl(naphthalene-1-sulfonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl(naphthalene-2-sulfonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl(phenylcarbonothioyl)amino]-N-hydroxypropanamide
-
-
2-[benzyl(phenylsulfonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl(phenylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl(phenylsulfonyl)amino]-N-hydroxypropanamide
-
-
2-[benzyl(phenylsulfonyl)amino]propanoic acid
-
-
2-[benzyl(thien-2-ylsulfonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl(thien-2-ylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl(thien-2-ylsulfonyl)amino]-N-hydroxypropanamide
-
-
2-[benzyl(thien-2-ylsulfonyl)amino]propanoic acid
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
-
2-[benzyl-(2,4,6-tripropyl-benzenesulfonyl)-amino]-N-hydroxy-propionamide
-
-
2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-N-hydroxy-propionamide
-
-
2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-propionic acid
-
-
2-[benzyl-(3-tert-butoxycarbonylamino-4-methoxy-benzenesulfonyl)-amino]-propionic acid
-
-
2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide
-
-
2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-propionic acid
-
-
2-[Benzyl-(5-methylnaphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
-
2-[Benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-3-methyl-butyric acid
-
-
2-[Benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
-
2-[Benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
-
2-[benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide
-
-
2-[Benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
-
2-[benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-propionamide
-
-
2-[benzyl-(toluene-4-sulfonyl)-amino]-N-hydroxy-propionamide
-
-
2-[benzyl[(1-naphthylamino)carbonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(1-naphthylamino)carbonyl]amino]propanoic acid
-
-
2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(2,4-dinitrophenyl)thio]amino]propanoic acid
-
-
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(2-nitrophenyl)thio]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(2-nitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(3-carboxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(3-nitrophenyl)thio]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(3-nitrophenyl)thio]amino]propanoic acid
-
-
2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(4-bromophenyl)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-carboxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(4-iodophenyl)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(4-methylphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(4-methylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-methylphenyl)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(4-nitrophenyl)thio]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(4-nitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(4-nitrophenyl)thio]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(4-nitrophenyl)thio]amino]propanoic acid
-
-
2-[benzyl[(dimethylamino)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(dimethylamino)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(heptadecafluorooctyl)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(heptadecfluorooctyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(trichloromethyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(trichloromethyl)sulfonyl]amino]propanoic acid
-
-
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-3-methylbutanoic acid
-
-
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
-
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxypropanamide
-
-
2-[benzyl[(trifluoromethyl)sulfonyl]amino]propanoic acid
-
-
2-[[[2,4,6-(tripropyl)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
-
2-[[[3-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
-
2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]-N-hydroxypropanamide
-
-
2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
-
2-[[[4-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
-
2-[[[4-(methoxy)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
-
3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid
-
-
3-[benzyl-(1-carboxy-ethyl)-sulfamoyl]-benzoic acid
-
-
3-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide
-
-
3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide
-
-
3-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid
-
-
4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid
-
-
4-[benzyl-(1-carboxy-ethyl)-sulfamoyl]-benzoic acid
-
-
4-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide
-
-
4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide
-
-
4-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid
-
-
8-hydroxyquinoline
-
-
alpha,alpha-Dipyridyl
-
-
batimastat
-
i.e. BB-94
diphosphate
-
-
EDTA
-
activity restored by Co2+, Mn2+, Ca2+, Cu2+, Ni2+ and Zn2+
EGTA
-
activity restored by Co2+, Mn2+, Ca2+, Cu2+, Ni2+ and Zn2+
erucic acid
-
IC50: 0.415 mM
glutathione
-
reduced
glutathione
-
reduced
heptadecanoic acid
-
IC50: 0.03 mM
HS-CH2-CH2-CO-Pro-(N-methyl)Ala
Empedobacter collagenolyticum
-
-
HS-CH2-CH2-CO-Pro-(N-methyl)Leu
Empedobacter collagenolyticum
-
-
HS-CH2-CH2-CO-Pro-(N-methyl)Nle
Empedobacter collagenolyticum
-
-
i-C5H11-PO(OH)-Gly-Pro-Ala
-
-
-
isoamyl-phosphonyl-Gly-Pro-Ala
Q9X721
peptidomimetic inhibitor, binds to the edge strand in an antiparallel orientation
-
L-cysteine
-
-
L-histidine
-
-
linoleic acid
-
IC50: 0.375 mM
linolenic acid
-
IC50: 0.46 mM
marimastat
-
i.e. BB-2516
myristic acid
-
IC50: 0.27 mM
N-(2-chlorobenzyl)-N-(dimethylsulfamoyl)-L-alanine
-
-
N-(2-chlorobenzyl)-N-(methylsulfonyl)-L-alanine
-
-
N-(2-chlorobenzyl)-N-(naphthalen-1-ylcarbamoyl)-L-alanine
-
-
N-(2-chlorobenzyl)-N-(naphthalen-1-ylsulfonyl)-L-alanine
-
-
N-(2-chlorobenzyl)-N-(naphthalen-2-ylsulfonyl)-L-alanine
-
-
N-(2-chlorobenzyl)-N-(phenylsulfonyl)-L-alanine
-
-
N-(2-chlorobenzyl)-N-(thiophen-2-ylsulfonyl)-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(2,4,6-trimethylphenyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(2,4-difluorophenyl)carbamoyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(2,4-dinitrophenyl)sulfanyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(2,5-dichlorophenyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(2-nitrophenyl)sulfanyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(2-nitrophenyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(3,4-dichlorophenyl)carbamoyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(3-chloro-4-nitrophenyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(3-chlorophenyl)carbamoyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(3-nitrophenyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(4-bromophenyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(4-chlorophenyl)carbamoyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(4-chlorophenyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(4-fluorophenyl)carbamoyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(4-fluorophenyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(4-iodophenyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(4-methoxyphenyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(4-methylphenyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(4-nitrophenyl)sulfanyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(4-nitrophenyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(heptadecafluorooctyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(nonafluorobutyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(trichloromethyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[(trifluoromethyl)sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[[(2-methylphenyl)sulfonyl]carbamoyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[[(4-chlorophenyl)sulfonyl]carbamoyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[[(4-fluorophenyl)sulfonyl]carbamoyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[[(4-methylphenyl)sulfonyl]carbamoyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alanine
-
-
N-(2-chlorobenzyl)-N-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-L-alanine
-
-
N-(benzylsulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
-
N-([(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]amino]methyl)benzamide
-
-
N-([3-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
-
N-([3-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
-
N-([4-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
-
N-2-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-2-methylphenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-2-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
-
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-4-chlorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-4-chlorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-4-chlorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-4-fluorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-4-fluorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
-
N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-4-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
-
N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-etyhlmaleimide
-
-
N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
-
N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
-
N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
-
N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
-
N-[[4-(acetylamino)phenyl]sulfonyl]-N-(2-chlorobenzyl)-L-alanine
-
-
N2(2-chlorobenzyl)-N-hydroxy-N2-[(trifluoromethyl)sulfonyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylcarbamoyl)-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylsulfonyl)-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-2-ylsulfonyl)-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(phenylsulfonyl)-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(quinolin-8-ylsulfonyl)-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(thiophen-2-ylsulfonyl)-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4,6-trimethylphenyl)sulfonyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4-dinitrophenyl)sulfanyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-nitrophenyl)sulfanyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(nonafluorobutyl)sulfonyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(trichloromethyl)sulfonyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-(dimethylsulfamoyl)-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(2,4-difluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(2,5-dichlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(2-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(3,4-dichlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(3-chloro-4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(3-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(3-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-bromophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-iodophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-methylphenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[(heptadecafluorooctyl)sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[[(2-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[[(4-chlorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[[(4-fluorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[[(4-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
-
N2-(2-chlorobenzyl)-N2-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-N-hydroxy-L-alaninamide
-
-
N2-(benzylsulfonyl)-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide
-
-
N2-chlorobenzyl)-N-hydroxy-N2-(methylsulfonyl)-L-alaninamide
-
-
N2-[[4-(acetylamino)phenyl]sulfonyl]-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide
-
-
nonadecanoic acid
-
0.045 mM
oleic acid
-
IC50: 0.46 mM
p-O2NC6H4CH2CH2PO(OH)Gly-Pro-2-aminohexanoic acid
-
-
-
palmitic acid
-
IC50: 0.035 mM
palmitoleic acid
-
IC50: 0.405 mM
pentadecanoic acid
-
IC50: 0.125 mM
Phosphate buffer
-
-
-
Pro6-Gly-Pro-Gly
-
-
-
Pro6-Gly-Pro-Gly-H
-
-
-
SDS
-
surface active substance
stearic acid
-
IC50: 0.03 mM
Tannic acid
-
competitive, almost complete inhibition. Pretreatment of collagen fibers with tannic acid results in polymerization and complex formation
tert-butyl (3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate
-
-
tert-butyl (4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate
-
-
tert-butyl (5-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]-2-methoxyphenyl)carbamate
-
-
trocade
-
i.e. RO-22-3555
[3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester
-
-
[4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester
-
-
[5-[benzyl-(3-hydroxy-1-methyl-2-oxo-propyl)-sulfamoyl]-2-methoxy-phenyl]-carbamic acid tert-butyl ester
-
-
additional information
-
no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid
-
additional information
-
quantitative structure-activity relationship analysis of some 5-amino-2-mercapto-1,3,4-thiadiazole based inhibitors, overview
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
2-mercaptoethanol
-
activates
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
1.06
-
2-furanacryloyl-Leu-Gly-Pro-Ala
-
-
0.71
-
Carbobenzoxy-Gly-Pro-Gly-Gly-Pro-Ala
-
-
0.269
-
furylacryloyl-Leu-Gly-Pro-Ala
-
wild-type ColH, pH 7.5, 25C
0.425
-
furylacryloyl-Leu-Gly-Pro-Ala
-
isoform ColH with N-terminal His6-tag, pH 7.5, 25C
0.84
-
furylacryloyl-Leu-Gly-Pro-Ala
-
wild-type ColG, pH 7.5, 25C
0.97
-
furylacryloyl-Leu-Gly-Pro-Ala
-
wild-type ColT, pH 7.5, 25C
1.24
-
furylacryloyl-Leu-Gly-Pro-Ala
-
isoform ColT with N-terminal His6-tag, pH 7.5, 25C
0.555
-
N-[3-(2-furyl) acryloyl]-L-Leu-Gly-L-Pro-L-Ala
-
pH 7.5, 25C
-
1.26
-
furylacryloyl-Leu-Gly-Pro-Ala
-
isoform ColG with N-terminal His6-tag, pH 7.5, 25C
additional information
-
additional information
-
-
-
additional information
-
additional information
-
-
-
additional information
-
additional information
-
-
-
TURNOVER NUMBER [1/s]
TURNOVER NUMBER MAXIMUM[1/s]
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.092
-
furylacryloyl-Leu-Gly-Pro-Ala
-
isoform ColG with N-terminal His6-tag, pH 7.5, 25C
0.11
-
furylacryloyl-Leu-Gly-Pro-Ala
-
wild-type ColG, pH 7.5, 25C
3.65
-
furylacryloyl-Leu-Gly-Pro-Ala
-
isoform ColT with N-terminal His6-tag, pH 7.5, 25C
7.24
-
furylacryloyl-Leu-Gly-Pro-Ala
-
wild-type ColT, pH 7.5, 25C
13.6
-
furylacryloyl-Leu-Gly-Pro-Ala
-
isoform ColH with N-terminal His6-tag, pH 7.5, 25C
15.9
-
furylacryloyl-Leu-Gly-Pro-Ala
-
wild-type ColH, pH 7.5, 25C
Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.0056
-
2-(1-benzyl-3-naphthalen-1-yl-ureido)-3-methyl-butyric acid
-
pH 7.5, 25C
0.000012
-
2-(1-benzyl-3-naphthalen-1-yl-ureido)-N-hydroxy-3-methyl-butyramide
-
pH 7.5, 25C
0.000006
-
2-(3-benzoyl-1-benzyl-thioureido)-N-hydroxy-3-methyl-butyramide
-
pH 7.5, 25C
0.0074
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
pH 7.5, 25C
0.000021
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000024
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
pH 7.5, 25C
0.0073
-
2-(benzyl[[(2,4-difluorophenyl)amino]carbonyl]amino)propanoic acid
-
pH 7.5, 25C
0.0042
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
pH 7.5, 25C
0.000009
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.00001
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
pH 7.5, 25C
0.0048
-
2-(benzyl[[(3,4-dichlorophenyl)amino]carbonyl]amino)propanoic acid
-
pH 7.5, 25C
0.01
-
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
pH 7.5, 25C
0.000033
-
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000034
-
2-(benzyl[[(3-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
pH 7.5, 25C
0.011
-
2-(benzyl[[(3-chlorphenyl)amino]carbonyl]amino)propanoic acid
-
pH 7.5, 25C
0.0083
-
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
pH 7.5, 25C
0.00003
-
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.00003
-
2-(benzyl[[(4-chlorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
pH 7.5, 25C
0.0088
-
2-(benzyl[[(4-chlorphenyl)amino]carbonyl]amino)propanoic acid
-
pH 7.5, 25C
0.0091
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-3-methylbutanoic acid
-
pH 7.5, 25C
0.000031
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000033
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)-N-hydroxypropanamide
-
pH 7.5, 25C
0.01
-
2-(benzyl[[(4-fluorophenyl)amino]carbonyl]amino)propanoic acid
-
pH 7.5, 25C
0.000006
-
2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)-N-hydroxypropanamide
-
pH 7.5, 25C
0.0006
-
2-(benzyl[[3-(trifluoromethyl)phenyl]sulfonyl]amino)propanoic acid
-
pH 7.5, 25C
0.0036
-
2-[benzyl(1-naphthylsulfonyl)amino]propanoic acid
-
pH 7.5, 25C
0.0014
-
2-[benzyl(2-naphthylsulfonyl)amino]propanoic acid
-
pH 7.5, 25C
0.002
-
2-[benzyl(5-methylnaphthalene-1-sulfonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.015
-
2-[benzyl(benzylsulfonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.00004
-
2-[benzyl(benzylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000043
-
2-[benzyl(benzylsulfonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.017
-
2-[benzyl(benzylsulfonyl)amino]propanoic acid
-
pH 7.5, 25C
0.018
-
2-[benzyl(methylsulfonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000103
-
2-[benzyl(methylsulfonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.02
-
2-[benzyl(methylsulfonyl)amino]propanoic acid
-
pH 7.5, 25C
0.0033
-
2-[benzyl(naphthalene-1-sulfonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.0014
-
2-[benzyl(naphthalene-2-sulfonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000005
-
2-[benzyl(phenylcarbonothioyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.02
-
2-[benzyl(phenylsulfonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000054
-
2-[benzyl(phenylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000051
-
2-[benzyl(phenylsulfonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.022
-
2-[benzyl(phenylsulfonyl)amino]propanoic acid
-
pH 7.5, 25C
0.0021
-
2-[benzyl(thien-2-ylsulfonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.00001
-
2-[benzyl(thien-2-ylsulfonyl)amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000011
-
2-[benzyl(thien-2-ylsulfonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0024
-
2-[benzyl(thien-2-ylsulfonyl)amino]propanoic acid
-
pH 7.5, 25C
0.008
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000012
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000017
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
pH 7.5, 25C
0.000014
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.009
-
2-[benzyl([[(2-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
pH 7.5, 25C
0.0069
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000015
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000015
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
pH 7.5, 25C
0.000015
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0064
-
2-[benzyl([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
pH 7.5, 25C
0.0075
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000019
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000021
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
pH 7.5, 25C
0.000018
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0082
-
2-[benzyl([[(4-fluorophenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
pH 7.5, 25C
0.007
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000013
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000016
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxyacetamide
-
pH 7.5, 25C
0.000015
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0071
-
2-[benzyl([[(4-methylphenyl)sulfonyl]amino]carbonyl)amino]propanoic acid
-
pH 7.5, 25C
0.000019
-
2-[benzyl-(2,4,6-tripropyl-benzenesulfonyl)-amino]-N-hydroxy-propionamide
-
pH 7.5, 25C
0.000008
-
2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-N-hydroxy-propionamide
-
pH 7.5, 25C
0.003
-
2-[benzyl-(3,5-dichloro-2-hydroxy-benzenesulfonyl)-amino]-propionic acid
-
pH 7.5, 25C
0.0031
-
2-[benzyl-(3-tert-butoxycarbonylamino-4-methoxy-benzenesulfonyl)-amino]-propionic acid
-
pH 7.5, 25C
0.00001
-
2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide
-
pH 7.5, 25C
0.0025
-
2-[benzyl-(5-dimethylamino-naphthalene-1-sulfonyl)-amino]-propionic acid
-
pH 7.5, 25C
0.000008
-
2-[Benzyl-(5-methylnaphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
pH 7.5, 25C
0.0019
-
2-[Benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-3-methyl-butyric acid
-
pH 7.5, 25C
0.000008
-
2-[Benzyl-(heptadecafluorooctane-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
pH 7.5, 25C
0.000009
-
2-[Benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
pH 7.5, 25C
0.00001
-
2-[benzyl-(naphthalene-1-sulfonyl)-amino]-N-hydroxy-propionamide
-
pH 7.5, 25C
0.000006
-
2-[Benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-3-methyl-butyramide
-
pH 7.5, 25C
0.000009
-
2-[benzyl-(naphthalene-2-sulfonyl)-amino]-N-hydroxy-propionamide
-
pH 7.5, 25C
0.00004
-
2-[benzyl-(toluene-4-sulfonyl)-amino]-N-hydroxy-propionamide
-
pH 7.5, 25C
0.000011
-
2-[benzyl[(1-naphthylamino)carbonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0051
-
2-[benzyl[(1-naphthylamino)carbonyl]amino]propanoic acid
-
pH 7.5, 25C
0.0061
-
2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000018
-
2-[benzyl[(2,4,6-trimethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.007
-
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000008
-
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.00001
-
2-[benzyl[(2,4-dinitrophenyl)thio]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0071
-
2-[benzyl[(2,4-dinitrophenyl)thio]amino]propanoic acid
-
pH 7.5, 25C
0.004
-
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000011
-
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000014
-
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0047
-
2-[benzyl[(2,5-dichlorophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.0053
-
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000018
-
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000021
-
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0059
-
2-[benzyl[(2-nitrophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.0062
-
2-[benzyl[(2-nitrophenyl)thio]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000012
-
2-[benzyl[(2-nitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.0032
-
2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000007
-
2-[benzyl[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.0033
-
2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000007
-
2-[benzyl[(3-butyloxycarbonylamino-4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.0023
-
2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000007
-
2-[benzyl[(3-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.0045
-
2-[benzyl[(3-carboxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.003
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000011
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000011
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.003
-
2-[benzyl[(3-chloro-4-nitrophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.0051
-
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000011
-
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000012
-
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0052
-
2-[benzyl[(3-nitrophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.000012
-
2-[benzyl[(3-nitrophenyl)thio]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0063
-
2-[benzyl[(3-nitrophenyl)thio]amino]propanoic acid
-
pH 7.5, 25C
0.0006
-
2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000006
-
2-[benzyl[(3-trifluoromethylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.0035
-
2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.00001
-
2-[benzyl[(4-acetamidophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.01
-
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000036
-
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000037
-
2-[benzyl[(4-bromophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.011
-
2-[benzyl[(4-bromophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.0024
-
2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000008
-
2-[benzyl[(4-butyloxycarbonylaminophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.0024
-
2-[benzyl[(4-carboxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.011
-
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000044
-
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000044
-
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.013
-
2-[benzyl[(4-chlorophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.012
-
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000042
-
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000045
-
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.013
-
2-[benzyl[(4-fluorophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.01
-
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.00003
-
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000032
-
2-[benzyl[(4-iodophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.01
-
2-[benzyl[(4-iodophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.0063
-
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000017
-
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.00002
-
2-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.015
-
2-[benzyl[(4-methylphenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000033
-
2-[benzyl[(4-methylphenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.016
-
2-[benzyl[(4-methylphenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.005
-
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000015
-
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000015
-
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0055
-
2-[benzyl[(4-nitrophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.006
-
2-[benzyl[(4-nitrophenyl)thio]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000013
-
2-[benzyl[(4-nitrophenyl)thio]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000015
-
2-[benzyl[(4-nitrophenyl)thio]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.006
-
2-[benzyl[(4-nitrophenyl)thio]amino]propanoic acid
-
pH 7.5, 25C
0.041
-
2-[benzyl[(dimethylamino)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000065
-
2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000068
-
2-[benzyl[(dimethylamino)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.04
-
2-[benzyl[(dimethylamino)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.0018
-
2-[benzyl[(heptadecafluorooctyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.000007
-
2-[benzyl[(heptadecfluorooctyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0032
-
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.00001
-
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000012
-
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0031
-
2-[benzyl[(nonafluorobutyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.0004
-
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000005
-
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000006
-
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0005
-
2-[benzyl[(pentafluorophenyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.0056
-
2-[benzyl[(trichloromethyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000052
-
2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.00005
-
2-[benzyl[(trichloromethyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0055
-
2-[benzyl[(trichloromethyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.0033
-
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-3-methylbutanoic acid
-
pH 7.5, 25C
0.000047
-
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxy-3-methylbutanamide
-
pH 7.5, 25C
0.000048
-
2-[benzyl[(trifluoromethyl)sulfonyl]amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0036
-
2-[benzyl[(trifluoromethyl)sulfonyl]amino]propanoic acid
-
pH 7.5, 25C
0.0068
-
2-[[[2,4,6-(tripropyl)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
pH 7.5, 25C
0.0022
-
2-[[[3-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
pH 7.5, 25C
0.000012
-
2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]-N-hydroxypropanamide
-
pH 7.5, 25C
0.0036
-
2-[[[4-(acetylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
pH 7.5, 25C
0.0027
-
2-[[[4-(benzyloxycarbonylamino)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
pH 7.5, 25C
0.0062
-
2-[[[4-(methoxy)phenyl]sulfonyl](benzyl)amino]propanoic acid
-
pH 7.5, 25C
0.000008
-
3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid
-
pH 7.5, 25C
0.0045
-
3-[benzyl-(1-carboxy-ethyl)-sulfamoyl]-benzoic acid
-
pH 7.5, 25C
0.000009
-
3-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide
-
pH 7.5, 25C
0.000009
-
3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide
-
pH 7.5, 25C
0.0041
-
3-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid
-
pH 7.5, 25C
0.000007
-
4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]benzoic acid
-
pH 7.5, 25C
0.0029
-
4-[benzyl-(1-carboxy-ethyl)-sulfamoyl]-benzoic acid
-
pH 7.5, 25C
0.000008
-
4-[Benzyl-(1-hydrazinocarbonyl-2-methyl-propyl)-sulfamoyl]-N-hydroxy-benzamide
-
pH 7.5, 25C
0.000007
-
4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-N-hydroxy-benzamide
-
pH 7.5, 25C
0.0038
-
4-[[(1S)-1-carboxyethyl](2-chlorobenzyl)sulfamoyl]benzoic acid
-
pH 7.5, 25C
0.04
-
N-(2-chlorobenzyl)-N-(dimethylsulfamoyl)-L-alanine
-
pH 7.5, 25C
0.021
-
N-(2-chlorobenzyl)-N-(methylsulfonyl)-L-alanine
-
pH 7.5, 25C
0.005
-
N-(2-chlorobenzyl)-N-(naphthalen-1-ylcarbamoyl)-L-alanine
-
pH 7.5, 25C
0.0016
-
N-(2-chlorobenzyl)-N-(naphthalen-1-ylsulfonyl)-L-alanine
-
pH 7.5, 25C
0.0015
-
N-(2-chlorobenzyl)-N-(naphthalen-2-ylsulfonyl)-L-alanine
-
pH 7.5, 25C
0.0004
-
N-(2-chlorobenzyl)-N-(phenylsulfonyl)-L-alanine
-
pH 7.5, 25C
0.024
-
N-(2-chlorobenzyl)-N-(phenylsulfonyl)-L-alanine
-
pH 7.5, 25C
0.002
-
N-(2-chlorobenzyl)-N-(thiophen-2-ylsulfonyl)-L-alanine
-
pH 7.5, 25C
0.0024
-
N-(2-chlorobenzyl)-N-(thiophen-2-ylsulfonyl)-L-alanine
-
pH 7.5, 25C
0.0068
-
N-(2-chlorobenzyl)-N-[(2,4,6-trimethylphenyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.0055
-
N-(2-chlorobenzyl)-N-[(2,4-difluorophenyl)carbamoyl]-L-alanine
-
pH 7.5, 25C
0.0041
-
N-(2-chlorobenzyl)-N-[(2,5-dichlorophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.0049
-
N-(2-chlorobenzyl)-N-[(2-nitrophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.0058
-
N-(2-chlorobenzyl)-N-[(3,4-dichlorophenyl)carbamoyl]-L-alanine
-
pH 7.5, 25C
0.0024
-
N-(2-chlorobenzyl)-N-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.0031
-
N-(2-chlorobenzyl)-N-[(3-chloro-4-nitrophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.0076
-
N-(2-chlorobenzyl)-N-[(3-chlorophenyl)carbamoyl]-L-alanine
-
pH 7.5, 25C
0.005
-
N-(2-chlorobenzyl)-N-[(3-nitrophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.01
-
N-(2-chlorobenzyl)-N-[(4-bromophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.0068
-
N-(2-chlorobenzyl)-N-[(4-chlorophenyl)carbamoyl]-L-alanine
-
pH 7.5, 25C
0.013
-
N-(2-chlorobenzyl)-N-[(4-chlorophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.0074
-
N-(2-chlorobenzyl)-N-[(4-fluorophenyl)carbamoyl]-L-alanine
-
pH 7.5, 25C
0.012
-
N-(2-chlorobenzyl)-N-[(4-fluorophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.01
-
N-(2-chlorobenzyl)-N-[(4-iodophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.006
-
N-(2-chlorobenzyl)-N-[(4-methoxyphenyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.018
-
N-(2-chlorobenzyl)-N-[(4-methylphenyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.0051
-
N-(2-chlorobenzyl)-N-[(4-nitrophenyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.0015
-
N-(2-chlorobenzyl)-N-[(heptadecafluorooctyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.003
-
N-(2-chlorobenzyl)-N-[(nonafluorobutyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.0052
-
N-(2-chlorobenzyl)-N-[(trichloromethyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.0033
-
N-(2-chlorobenzyl)-N-[(trifluoromethyl)sulfonyl]-L-alanine
-
pH 7.5, 25C
0.004
-
N-(2-chlorobenzyl)-N-[[(2-methylphenyl)sulfonyl]carbamoyl]-L-alanine
-
pH 7.5, 25C
0.0034
-
N-(2-chlorobenzyl)-N-[[(4-chlorophenyl)sulfonyl]carbamoyl]-L-alanine
-
pH 7.5, 25C
0.0036
-
N-(2-chlorobenzyl)-N-[[(4-fluorophenyl)sulfonyl]carbamoyl]-L-alanine
-
pH 7.5, 25C
0.0041
-
N-(2-chlorobenzyl)-N-[[(4-methylphenyl)sulfonyl]carbamoyl]-L-alanine
-
pH 7.5, 25C
0.0005
-
N-(2-chlorobenzyl)-N-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alanine
-
pH 7.5, 25C
0.0021
-
N-(2-chlorobenzyl)-N-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-L-alanine
-
pH 7.5, 25C
0.016
-
N-(benzylsulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
pH 7.5, 25C
0.000006
-
N-([(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]amino]methyl)benzamide
-
pH 7.5, 25C
0.003
-
N-([3-[(tert-butoxycarbonyl)amino]-4-methoxyphenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
pH 7.5, 25C
0.0024
-
N-([3-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
pH 7.5, 25C
0.0027
-
N-([4-[(tert-butoxycarbonyl)amino]phenyl]sulfonyl)-N-(2-chlorobenzyl)-L-alanine
-
pH 7.5, 25C
0.000189
-
N-2-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25C
0.000028
-
N-2-methylphenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25C
0.00015
-
N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25C
0.000021
-
N-2-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25C
0.000061
-
N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25C
0.000043
-
N-2-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25C
0.00002
-
N-2-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
pH 7.5, 25C
0.000045
-
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25C
0.00004
-
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25C
0.000015
-
N-2-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25C
0.00017
-
N-4-chlorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25C
0.000021
-
N-4-chlorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25C
0.000125
-
N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25C
0.000014
-
N-4-chlorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25C
0.000009
-
N-4-chlorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25C
0.000026
-
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25C
0.000025
-
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25C
0.000007
-
N-4-chlorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25C
0.000163
-
N-4-fluorophenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25C
0.000018
-
N-4-fluorophenylsulfonylureido-N-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25C
0.00014
-
N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25C
0.000013
-
N-4-fluorophenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25C
0.00005
-
N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25C
0.00006
-
N-4-fluorophenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25C
0.000013
-
N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
pH 7.5, 25C
0.000007
-
N-4-fluorophenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25C
0.000033
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25C
0.00001
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
pH 7.5, 25C
0.000021
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25C
0.000006
-
N-4-fluorophenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25C
0.000165
-
N-4-methylphenylsulfonylureido-N-(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25C
0.000133
-
N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25C
0.000018
-
N-4-methylphenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25C
0.000055
-
N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25C
0.000042
-
N-4-methylphenylsulfonylureido-N-[(10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25C
0.000018
-
N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
pH 7.5, 25C
0.000019
-
N-4-methylphenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25C
0.00004
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25C
0.000015
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
pH 7.5, 25C
0.000038
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25C
0.000012
-
N-4-methylphenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25C
0.000125
-
N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine
-
pH 7.5, 25C
0.000016
-
N-phenylsulfonylureido-N-(5H-dibenzo[a,d]cyclohepten-5-yl)-glycine hydroxamate
-
pH 7.5, 25C
0.000015
-
N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
pH 7.5, 25C
0.00001
-
N-phenylsulfonylureido-N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25C
0.000086
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine
-
pH 7.5, 25C
0.000013
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)ethylene]-glycine hydroxamate
-
pH 7.5, 25C
0.000035
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine
-
pH 7.5, 25C
0.000008
-
N-phenylsulfonylureido-N-[(5H-dibenzo[a,d]cyclohepten-5-yl)methylen]-glycine hydroxamate
-
pH 7.5, 25C
0.003
-
N-[[4-(acetylamino)phenyl]sulfonyl]-N-(2-chlorobenzyl)-L-alanine
-
pH 7.5, 25C
0.000076
-
N2(2-chlorobenzyl)-N-hydroxy-N2-[(trifluoromethyl)sulfonyl]-L-alaninamide
-
pH 7.5, 25C
0.000011
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylcarbamoyl)-L-alaninamide
-
pH 7.5, 25C
0.000008
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-1-ylsulfonyl)-L-alaninamide
-
pH 7.5, 25C
0.000009
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(naphthalen-2-ylsulfonyl)-L-alaninamide
-
pH 7.5, 25C
0.0000005
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(phenylsulfonyl)-L-alaninamide
-
pH 7.5, 25C
0.000058
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(phenylsulfonyl)-L-alaninamide
-
pH 7.5, 25C
0.000007
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(quinolin-8-ylsulfonyl)-L-alaninamide
-
pH 7.5, 25C
0.000011
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-(thiophen-2-ylsulfonyl)-L-alaninamide
-
pH 7.5, 25C
0.000017
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4,6-trimethylphenyl)sulfonyl]-L-alaninamide
-
pH 7.5, 25C
0.000011
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(2,4-dinitrophenyl)sulfanyl]-L-alaninamide
-
pH 7.5, 25C
0.000022
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alaninamide
-
pH 7.5, 25C
0.000013
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(4-nitrophenyl)sulfanyl]-L-alaninamide
-
pH 7.5, 25C
0.000011
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(nonafluorobutyl)sulfonyl]-L-alaninamide
-
pH 7.5, 25C
0.000071
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[(trichloromethyl)sulfonyl]-L-alaninamide
-
pH 7.5, 25C
0.000006
-
N2-(2-chlorobenzyl)-N-hydroxy-N2-[[3-(trifluoromethyl)phenyl]sulfonyl]-L-alaninamide
-
pH 7.5, 25C
0.000077
-
N2-(2-chlorobenzyl)-N2-(dimethylsulfamoyl)-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000014
-
N2-(2-chlorobenzyl)-N2-[(2,4-difluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000015
-
N2-(2-chlorobenzyl)-N2-[(2,5-dichlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000016
-
N2-(2-chlorobenzyl)-N2-[(2-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000015
-
N2-(2-chlorobenzyl)-N2-[(3,4-dichlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000009
-
N2-(2-chlorobenzyl)-N2-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.00001
-
N2-(2-chlorobenzyl)-N2-[(3-chloro-4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000017
-
N2-(2-chlorobenzyl)-N2-[(3-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000011
-
N2-(2-chlorobenzyl)-N2-[(3-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000033
-
N2-(2-chlorobenzyl)-N2-[(4-bromophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000015
-
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000035
-
N2-(2-chlorobenzyl)-N2-[(4-chlorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000018
-
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000036
-
N2-(2-chlorobenzyl)-N2-[(4-fluorophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.00003
-
N2-(2-chlorobenzyl)-N2-[(4-iodophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000045
-
N2-(2-chlorobenzyl)-N2-[(4-methylphenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000015
-
N2-(2-chlorobenzyl)-N2-[(4-nitrophenyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000008
-
N2-(2-chlorobenzyl)-N2-[(heptadecafluorooctyl)sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000011
-
N2-(2-chlorobenzyl)-N2-[[(4-chlorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000008
-
N2-(2-chlorobenzyl)-N2-[[(4-fluorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000009
-
N2-(2-chlorobenzyl)-N2-[[(4-fluorophenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.00001
-
N2-(2-chlorobenzyl)-N2-[[(4-methylphenyl)sulfonyl]carbamoyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.00001
-
N2-(2-chlorobenzyl)-N2-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000054
-
N2-(benzylsulfonyl)-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000092
-
N2-chlorobenzyl)-N-hydroxy-N2-(methylsulfonyl)-L-alaninamide
-
pH 7.5, 25C
0.000011
-
N2-[[4-(acetylamino)phenyl]sulfonyl]-N2-(2-chlorobenzyl)-N-hydroxy-L-alaninamide
-
pH 7.5, 25C
0.000005
-
p-O2NC6H4CH2CH2PO(OH)Gly-Pro-2-aminohexanoic acid
-
pH 7.5, 25C
-
0.34
-
p-O2NC6H4CH2CH2PO(OH)Gly-Pro-2-aminohexanoic acid
-
pH 7.5, 25C
-
0.34
-
Pro6-Gly-Pro-Gly
-
pH 7.5, 25C
-
0.000005
-
Pro6-Gly-Pro-Gly-H
-
pH 7.5, 25C
-
0.02
-
Tannic acid
-
pH 7.5, 25C
0.000008
-
tert-butyl (3-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate
-
pH 7.5, 25C
0.000009
-
tert-butyl (4-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]phenyl)carbamate
-
pH 7.5, 25C
0.000008
-
tert-butyl (5-[(2-chlorobenzyl)[(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]sulfamoyl]-2-methoxyphenyl)carbamate
-
pH 7.5, 25C
0.000007
-
[3-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester
-
pH 7.5, 25C
0.000009
-
[4-[benzyl-(1-hydroxycarbamoyl-ethyl)-sulfamoyl]-phenyl]-carbamic acid tert-butyl ester
-
pH 7.5, 25C
0.000007
-
[5-[benzyl-(3-hydroxy-1-methyl-2-oxo-propyl)-sulfamoyl]-2-methoxy-phenyl]-carbamic acid tert-butyl ester
-
pH 7.5, 25C
0.016
-
i-C5H11-PO(OH)-Gly-Pro-Ala
-
pH 7.5, 25C
-
additional information
-
additional information
-
inhibition kinetics using diverse variants of 5-amino-2-mercapto-1,3,4-thiadiazoles, overview
-
IC50 VALUE [mM]
IC50 VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.025
-
1,10-phenanthroline
-
isoform ColH with N-terminal His6-tag, pH 7.5, 25C
0.04
-
1,10-phenanthroline
-
isoform ColT with N-terminal His6-tag, pH 7.5, 25C
0.055
-
1,10-phenanthroline
-
wild-type ColH, pH 7.5, 25C
0.1
-
1,10-phenanthroline
-
isoform ColG with N-terminal His6-tag, pH 7.5, 25C
0.15
-
1,10-phenanthroline
-
wild-type ColG, pH 7.5, 25C
0.15
-
1,10-phenanthroline
-
wild-type ColT, pH 7.5, 25C
0.415
-
erucic acid
-
IC50: 0.415 mM
0.03
-
heptadecanoic acid
-
IC50: 0.03 mM
0.375
-
linoleic acid
-
IC50: 0.375 mM
0.27
-
myristic acid
-
IC50: 0.27 mM
0.46
-
oleic acid
-
IC50: 0.46 mM
0.405
-
palmitoleic acid
-
IC50: 0.405 mM
0.125
-
pentadecanoic acid
-
IC50: 0.125 mM
0.03
-
stearic acid
-
IC50: 0.03 mM
0.46
-
linolenic acid
-
IC50: 0.46 mM
0.5
-
additional information
-
no inhibition by lauric acid, behenic acid, docosahexaenoic acid and eicosapentaenoic acid. IC50 above 0.5 mM: arachidic acid and gamma-linolenic acid
-
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7.02
-
-
-
additional information
-
-
-
additional information
-
-
-
additional information
-
-
-
additional information
-
-
-
additional information
-
-
-
additional information
-
-
-
additional information
-
Geobacillus sp.
Q0KK26
collagen-binding analysis, assay method, the three nonionic detergents, Triton X-100, Tween 20, and Tween 60, are ineffective for the release of the collagenolytic protease from collagen, overview
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.8
7.3
Bacteroides melaninogenicus
-
-
7.5
-
Geobacillus sp.
Q0KK26
assay at
7.5
-
-
assay at
7.6
-
-
-
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
4.2
10.2
-
pH 10.2: about 85% of activity maximum; pH 4.2: about 20% of activity maximum
5
11
-
pH 11: about 35% of activity maximum; pH 5: about 35% of activity maximum
5.5
8.5
Bacteroides melaninogenicus
-
pH 5.5: about 40% of activity maximum; pH 8.5: about 20% of activity maximum
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
37
-
-
-
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Geobacillus sp.
Q0KK26
the enzyme is secreted
-
Manually annotated by BRENDA team
additional information
Bacteroides melaninogenicus
-
intimately associated with the cell but released during autolysis
-
Manually annotated by BRENDA team
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
11470
-
-
mutant enzyme S906F in presence of 1 mM Ca2+, gel filtration
11750
-
-
mutant enzyme S906A in presence of 1 mM Ca2+, gel filtration
11810
-
-
mutant enzyme Q972A in presence of 1 mM Ca2+, gel filtration
11910
-
-
mutant enzyme V973A in presence of 1 mM Ca2+, gel filtration
11920
-
-
wild-type enzyme in presence of 1 mM Ca2+, gel filtration
13720
-
-
mutant enzyme E901A in presence of 1 mM Ca2+, gel filtration
13750
-
-
mutant enzyme D904A in presence of 1 mM Ca2+, gel filtration
14390
-
-
mutant enzyme E899A in presence of 1 mM Ca2+, gel filtration
15370
-
-
mutant enzyme D930A in presence of 1 mM Ca2+, gel filtration
15420
-
-
mutant enzyme D930A in presence of 1 mM EDTA, gel filtration
15730
-
-
mutant enzyme N903A in presence of 1 mM Ca2+, gel filtration
15790
-
-
mutant enzyme D927A in presence of 1 mM Ca2+, gel filtration
15890
-
-
mutant enzyme E899A in presence of 1 mM EDTA, gel filtration
16160
-
-
mutant enzyme D904A in presence of 1 mM EDTA, gel filtration
16190
-
-
mutant enzyme D927A in presence of 1 mM EDTA, gel filtration
16410
-
-
mutant enzyme S906A in presence of 1 mM EDTA, gel filtration
16430
-
-
wild-type enzyme in presence of 1 mM EGTA, gel filtration
16470
-
-
mutant enzyme Q972A in presence of 1 mM EDTA, gel filtration
16510
-
-
mutant enzyme V973A in presence of 1 mM EDTA, gel filtration
16530
-
-
mutant enzyme N903A in presence of 1 mM EDTA, gel filtration
16650
-
-
mutant enzyme S906F in presence of 1 mM EDTA, gel filtration
62000
-
-
gel filtration
70000
-
-
gel filtration
74000
-
-
gel filtration
90000
-
-
A2, gel filtration
100000
-
-
gel filtration
100000
-
-
gamma, SDS-PAGE
100000
-
-
SDS-PAGE
105000
-
-
gel filtration
110000
-
-
A1, gel filtration
112000
-
-
ultracentrifugation
113000
-
-
mass spectrometry
114200
-
-
mutant enzyme E414Q, MALDI-TOF mass spectrometry; wild-type enzyme, MALDI-TOF mass spectrometry
120000
-
-
gel filtration
147200
-
-
gel filtration
additional information
-
-
MW of various C-terminal segments
SUBUNITS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
?
-
? * 76000, C3, SDS-PAGE; ? * 92000, C2, SDS-PAGE; ? * 96000, C1, SDS-PAGE
?
-
? * 110000, delta, SDS-PAGE; ? * 115000, beta, SDS-PAGE; ? * 125000, zeta, SDS-PAGE; ? * 68000, alpha, SDS-PAGE; ? * 79000, gamma, SDS-PAGE
?
-
? * 75000, SDS-PAGE
?
-
x * 35000, SDS-PAGE
?
-
x * 113866, mass spectrometry, full length enzyme containing two collagen-binding domains
?
Vibrio vulnificus CYK279H
-
x * 35000, SDS-PAGE
-
monomer
-
1 * 72000, IIIb, SDS-PAGE; 1 * 81000, I, II, IIIa, SDS-PAGE
monomer
-
1 * 75000, no dissociation into subunits after lithium chloride treatment, SDS-PAGE
tetramer
-
x * 24000 + x * 28000, SDS-PAGE after denaturation with SDS and beta-mercaptoethanol
tetramer
Vibrio sp. B-30
-
x * 24000 + x * 28000, SDS-PAGE after denaturation with SDS and beta-mercaptoethanol
-
monomer
-
1 * 64000, SDS-PAGE
additional information
Q9X721
ColG possesses a single PKD-like domain and a duplicated CBD domain in addition to the catalytic domain, comprising residues Tyr119-Ala790
additional information
Geobacillus sp.
Q0KK26
the enzyme consists of a signal sequence for secretion, a prosequence for maturation, a catalytic region, 14 direct repeats of 20 amino acids at the C terminus, and a region with unknown function intervening between the catalytic region and the numerous repeats
additional information
-
enzyme exists in two isoforms differing in the presence of one or two collagen-binding domains of 12 amino acids, respectively
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
no modification
-
C1: no carbohydrate
side-chain modification
-
glycoprotein
no modification
-
carbohydrate not detected
Crystallization/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
apo-enzyme, free enzyme and in complex with inhibitor isoamyl-phosphonyl-Gly-Pro-Ala, to 2.55 A, 2.8 A and 3.25 A resolution. Structure shows a distinct segmentation of the N-terminal collagenase module, residues Tyr119-Gly790, forming a saddle-shaped two-domain architecture. The smaller N-terminal saddle flap serves as an activator domain, residues Tyr119-Asp388, and comprises an array of 12 parallel alpha-helices. The catalytic subdomain, residues Asp398-Gln669, adopts a thermolysin-like peptidase fold of mixed alpha and beta type. Leu517-Leu534 form the central helix of the fold and contain the Zn2+-binding 523-HEXXH-527 motif
Q9X721
hanging drop vapor diffusion method, structure of the collagen-binding domain with an N-terminal domain linker from class I collagenase, determined at 1.0 A resolution in the absence of Ca2+ and at 1.65 A resolution in the presence of calcium
-
purified recombinant His-tagged catalytic domain of collagenase G, sitting drop vapour diffusion method, 10 mg/ml protein in 25 mM Tris, pH 7.5, and 50 mM NaCl, mixed with reservoir solution containing 0.12 M sodium citrate and 23% v/v PEG 3350 at 20C, 10 days, X-ray diffraction structure determination and anaylsis at 2.75 A resolution
Q9X721
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
4.4
7.4
-
4C, 24 h
7.2
8.7
-
unstable outside the range
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
30
-
-
20 h, pH 7-8
40
-
-
3 h, Ca2+ added
50
-
-
2 h, Ca2+ added
55
-
-
30 min, 40% loss of activity
60
-
-
5 min, complete inactivation
60
-
-
30 min, complete inactivation
60
-
Bacteroides melaninogenicus
-
10 min, 65% loss of activity
additional information
-
-
-
GENERAL STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
4C, 24 h, plus 10 mM cysteine
Bacteroides melaninogenicus
-
-20C, lyophilized enzyme: 5 years, solutions: several months
-
37C, loss of 10% activity after 24 h and of 30% after 48 h, crude commercial preparation, overview
-
4C, 24 h, pH 4.4-7.4
-
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
consists of four segments: S1, S2a, S2b and S3; expressed in Bacillus subtilis
-
expressed in Bacillus subtilis
-
full-length type I collagenase and C-terminal fragments
-
ligands for chromatographic purification
-
recombinant catalytic domain of His-tagged collagenase G from Escherichia coli strain BL21 (DE3) by nickel affinity chromatography and gel filtration to about 95% purity
Q9X721
recombinant GST-tagged enzyme fragments, e.g. GST-Cat, a fusion protein with the catalytic region of the enzyme, by glutathione affinity chromatography to homogeneity
Geobacillus sp.
Q0KK26
expressed in Escherichia coli
-
partial
-
Cloned/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
expressed in Bacillus subtilis
-
expression in Escherichia coli
-
gene colG, expression of the catalytic domain of N-terminally His-tagged, separated from ColG by a TEV cleavage site, collagenase G in Escherichia coli strain BL21 (DE3)
Q9X721
expression in Escherichia coli
-
DNA and amino acid sequence determination and anaylsis, sequence comparison, overexpression in Escherichia coli strains DH5alpha and BL21(DE3), overexpression of various regions of the collagenolytic protease as GST-tagged proteins
Geobacillus sp.
Q0KK26
expressed in Escherichia coli
-
ENGINEERING
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
D904A
-
mutant enzyme with increased MW in presence of Ca2+ and decreased MW in presence of 1 mM EGTA, determined by gel filtration
D927A
-
mutant enzyme with increased MW in presence of Ca2+ and slightly decreased MW in presence of 1 mM EGTA, determined by gel filtration
D930A
-
mutant enzyme with increased MW in presence of Ca2+ and slightly decreased MW in presence of 1 mM EGTA, determined by gel filtration
E414Q
-
mutant enzyme with a with a lower level of hydrolytic activity against insoluble collagen compared to wild-type enzyme
E899A
-
mutant enzyme with increased MW in presence of Ca2+ and decreased MW in presence of 1 mM EGTA, determined by gel filtration
E901A
-
mutant enzyme with increased MW in presence of Ca2+ and decreased MW in presence of 1 mM EGTA, determined by gel filtration
N903A
-
mutant enzyme with increased MW in presence of Ca2+ and slightly increased MW in presence of 1 mM EGTA, determined by gel filtration
Q972A
-
mutant enzyme with slightly decreased MW in presence of Ca2+
S906A
-
mutant enzyme with slightly decreased MW in presence of Ca2+
G426V
-
isoform ColH, complete loss of enzymatic activity
additional information
-
addition of an N-terminal His-tag. The Michaelis-Menten constant of ColG and ColH increases by approximately 50% and 60%, respectively
additional information
Q9X721
an activator-deletion construct, containing only the segment Lys396-Lys1118, shows 100% activity against small peptidic substrates as compared to the full-length ColG protease. The peptidase domain alone is completely inactive toward collagen substrates. Full collagenolytic activity is, however, contained in the segment Tyr119-Gly790, comprising the activator and peptidase domains
S906F
-
mutant enzyme with slightly decreased MW in presence of Ca2+ ad slightly increased MW in presence of 1 mM EGTA, determined by gel filtration
additional information
-
addition of an N-terminal His-tag. The Michaelis-Menten constant of ColT increases by approximately 60%. Expression of a truncated construct Y53-A506 which stops shortly after the third zinc binding residue and consitstent with the prediction of a minimal catalytic domain. The construct shows no catalytic activity at all, despite containing all zinc binding residues including the catalytic glutamate that is supposed to act as general base
APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
medicine
-
preparations containing clostridiopeptidase A are used topically for the debridement of dermal ulcers, burns and other necrotic lesions to facilitate the formation of granulationtissue and subsequent epithelization, allergic contact dermatitis with clostridiopeptidase A contained in an ointment used for treatment of dermal ulcers may occur
medicine
-
Clostridium histolyticum collagenase can effectively digest collagen isoforms that are present in necrotic wound tissues. Collagenase treatment enhances cell migration mediated by collagenase itself and by collagen degradation products