Literature summary for 3.4.24.3 extracted from

Uchida, K.; Matsushita, O.; Nishi, N.; Inoue, G.; Horikawa, K.; Takaso, M.
Enhancement of periosteal bone formation by basic fibroblast-derived growth factor containing polycystic kidney disease and collagen-binding domains from Clostridium histolyticum collagenase (2017), J. Tissue Eng. Regen. Med., 11, 1165-1172.

Search for more literature for 3.4.24.3

Application

Application	Comment	Organism
medicine	construction of fusion proteins between the collagen-binding domain (CBD) and polycystic kidney disease (PKD) domain of Clostridium histolyticum class II collagenase and basic fibroblast growth factor. Both fusion proteins bFGF-CBD and bFGF-PKD-CBD promote the in vitro proliferation of periosteal mesenchymal cells. Both bFGF-CBD and bFGF-PKD-CBD induce periosteal bone formation at higher rates than collagen sheet alone and bFGF. bFGF-PKD-CBD markedly enhances bone formation and has higher collagen-binding ability than bFGF-CBD in in vitro protein release assays	Hathewaya histolytica

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of fusion proteins between the collagen-binding domain (CBD) and polycystic kidney disease (PKD) domain of Clostridium histolyticum class II collagenase and basic fibroblast growth factor. Both fusion proteins bFGF-CBD and bFGF-PKD-CBD promote the in vitro proliferation of periosteal mesenchymal cells. Both bFGF-CBD and bFGF-PKD-CBD induce periosteal bone formation at higher rates than collagen sheet alone and bFGF. bFGF-PKD-CBD markedly enhances bone formation and has higher collagen-binding ability than bFGF-CBD in in vitro protein release assays	Hathewaya histolytica

Organism

Organism	UniProt	Comment	Textmining
Hathewaya histolytica	Q46085	-	-

Synonyms

Synonyms	Comment	Organism
ColH	-	Hathewaya histolytica

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Release 2023.1 (January 2023)