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Abortion, Spontaneous
[Expression of cathepsins B and L in early gestational decidua and chorionic villi]
Acidosis
Acid-mediated tumor proteolysis: contribution of cysteine cathepsins.
Acidosis
Effect of metabolic acidosis on the insulin-like growth factor-I system and cathepsins B and L gene expression in the kidney.
Acidosis
Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.
Acquired Immunodeficiency Syndrome
Functional analysis of cathepsin B-like cysteine proteases from Leishmania donovani complex. Evidence for the activation of latent transforming growth factor beta.
Acquired Immunodeficiency Syndrome
Upregulation of cystatin M during the progression of oropharyngeal squamous cell carcinoma from primary tumor to metastasis.
Acromegaly
Human nasal septal cartilage: analysis of intracellular enzyme activities, glycogen content, cell density and clonal proliferation of septal chondrocytes of healthy adults and acromegalic patients.
Acromegaly
Human nasal septal cartilage: local distribution of different enzyme activities in healthy adults and acromegalic patients.
Acromegaly
Matrix metalloproteinase 2 (MMP-2) levels are increased in active acromegaly patients.
Acromegaly
The imbalance of cathepsin B-like activity in acromegalic patients - preliminary report.
Acute Coronary Syndrome
NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins.
Acute Kidney Injury
Distribution and amount of cathepsin B in gentamicin-induced acute kidney injury in rats.
Acute Lung Injury
Cathepsin B and D activity in alveolar macrophages from rats with pulmonary granulomatous inflammation or acute lung injury.
Adenocarcinoma
A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma.
Adenocarcinoma
Activity and concentration of cathepsin B as prognostic criteria for the development of mouse LS lymphosarcoma and Lewis lung adenocarcinoma.
Adenocarcinoma
Angiogenesis and cathepsin expression are prognostic factors in pancreatic adenocarcinoma after curative resection.
Adenocarcinoma
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue.
Adenocarcinoma
Biochemical methods for predicting metastatic ability of prostatic cancer utilizing the dunning R-3327 rat prostatic adenocarcinoma system as a model.
Adenocarcinoma
Cathepsin B and L activities in gastric cancer tissue: correlation with histological findings.
Adenocarcinoma
Cathepsin B expression in tumour cells and laminin distribution in pulmonary adenocarcinoma.
Adenocarcinoma
Cathepsin B in angiogenesis of human prostate: an immunohistochemical and immunoelectron microscopic analysis.
Adenocarcinoma
Cathepsin B in the growth of colorectal cancer: increased activity of cathepsin B in human colorectal cancer.
Adenocarcinoma
Cathepsin B Is Upregulated and Mediates ECM Degradation in Colon Adenocarcinoma HT29 Cells Overexpressing Snail.
Adenocarcinoma
Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice.
Adenocarcinoma
Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors.
Adenocarcinoma
Elevated serum cathepsin B1 and vaginal pathology after prenatal DES exposure.
Adenocarcinoma
Fluorescent microplate assay for cancer cell-associated cathepsin B.
Adenocarcinoma
Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene.
Adenocarcinoma
Immunochemical analysis of cathepsin B in lung tumours: an independent prognostic factor for squamous cell carcinoma patients.
Adenocarcinoma
Immunohistochemical analysis of cathepsin B expression in human lung adenocarcinoma: the role in cancer progression.
Adenocarcinoma
Immunohistochemical and biochemical study of a cathepsin B-like proteinase in human colonic cancers.
Adenocarcinoma
Immunohistochemical study of cathepsin B. Prognostic significance in human lung cancer.
Adenocarcinoma
Increased cathepsin B activity in human lung tumors.
Adenocarcinoma
Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles.
Adenocarcinoma
MMP-9 and cathepsin B expression in tumor budding as an indicator of a more aggressive phenotype of colorectal cancer (CRC).
Adenocarcinoma
Neutral and ionic platinum compounds containing a cyclometallated chiral primary amine: synthesis, antitumor activity, DNA interaction and topoisomerase I-cathepsin B inhibition.
Adenocarcinoma
Observing proteases in living cells.
Adenocarcinoma
Optical Imaging with a Cathepsin B Activated Probe for the Enhanced Detection of Esophageal Adenocarcinoma by Dual Channel Fluorescent Upper GI Endoscopy.
Adenocarcinoma
Pancreatic trypsinogen and cathepsin B in human pancreatic carcinomas and associated metastatic lesions.
Adenocarcinoma
Polymorphism L26V in the cathepsin B gene may be associated with a risk of prostate cancer and differentiation.
Adenocarcinoma
Prognostic impact of cathepsin B and matrix metalloproteinase-9 in pulmonary adenocarcinomas by immunohistochemical study.
Adenocarcinoma
Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma.
Adenocarcinoma
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.
Adenocarcinoma
Synthesis, characterization and biological activity of new cyclometallated platinum(iv) complexes containing a para-tolyl ligand.
Adenocarcinoma
[Digestion in vitro of basal membrane, bovine lens capsule, by human liver lysosome cathepsins B, H and L and ascitic fluid tumor cathepsin B from ovarian adenocarcinoma]
Adenocarcinoma
[Pro-cathepsin D can activate in vitro pro-cathepsin B secreted by ovarian cancers]
Adenocarcinoma
[The activity of cathepsin B in colorectal adenocarcinomas]
Adenocarcinoma of Lung
Activity and concentration of cathepsin B as prognostic criteria for the development of mouse LS lymphosarcoma and Lewis lung adenocarcinoma.
Adenocarcinoma of Lung
Cathepsin B expression and laminin degradation as factors influencing prognosis of surgically treated patients with lung adenocarcinoma.
Adenocarcinoma of Lung
Cysteine proteases and cysteine protease inhibitors in non-small cell lung cancer.
Adenocarcinoma of Lung
Identifying Thoracic Malignancies Through Pleural Fluid Biomarkers: A Predictive Multivariate Model.
Adenocarcinoma of Lung
Immunohistochemical analysis of cathepsin B expression in human lung adenocarcinoma: the role in cancer progression.
Adenocarcinoma of Lung
Immunohistochemical distributions of cathepsin B and basement membrane antigens in human lung adenocarcinoma: association with invasion and metastasis.
Adenocarcinoma of Lung
Multiple forms of cathepsin B in human lung cancer.
Adenocarcinoma, Papillary
Pancreatic trypsinogen and cathepsin B in human pancreatic carcinomas and associated metastatic lesions.
Adenoma
Cathepsin B and Cathepsin D Expression in Follicular Adenomas and Carcinomas of the Thyroid Gland.
Adenoma
Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma.
Adenoma
Cathepsin B and tumor-associated laminin expression in the progression of colorectal adenoma to carcinoma.
Adenoma
Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival.
Adenoma
Cathepsin B in the growth of colorectal cancer: increased activity of cathepsin B in human colorectal cancer.
Adenoma
Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis.
Adenoma
Comparative localization of cathepsin B protein and activity in colorectal cancer.
Adenoma
Cysteine endopeptidase activity levels in normal human tissues, colorectal adenomas and carcinomas.
Adenoma
Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice.
Adenoma
Elevations in cathepsin B protein content and enzyme activity occur independently of glycosylation during colorectal tumor progression.
Adenoma
Expression of cathepsin B and cystatin C in the human adenohypophysis and in pituitary adenomas.
Adenoma
Study on cathepsin B activity in human thyroid tumors.
Adenomatous Polyps
Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice.
AIDS Dementia Complex
Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIV-infected macrophages.
Albuminuria
Urinary activities of cathepsin B, N-acetyl-beta-D-glucosaminidase, and albuminuria in patients with type 2 diabetes mellitus.
Albuminuria
[Urinary excretion of extracellular matrix proteins in insulin dependent diabetes mellitus]
Alzheimer Disease
6-Shogaol has anti-amyloidogenic activity and ameliorates Alzheimer's disease via CysLT1R-mediated inhibition of cathepsin B.
Alzheimer Disease
Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease.
Alzheimer Disease
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.
Alzheimer Disease
Brain Pyroglutamate Amyloid-Beta is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimer's Disease Therapeutic.
Alzheimer Disease
Cat and Mouse.
Alzheimer Disease
Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer's Disease.
Alzheimer Disease
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders.
Alzheimer Disease
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.
Alzheimer Disease
Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat.
Alzheimer Disease
Chia Seed Does Not Improve Cognitive Impairment in SAMP8 Mice Fed with High Fat Diet.
Alzheimer Disease
Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease.
Alzheimer Disease
Deletion of the Cathepsin B Gene Improves Memory Deficits in a Transgenic Alzheimer's Disease Mouse Model Expressing A?PP Containing the Wild-Type ?-Secretase Site Sequence.
Alzheimer Disease
Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma.
Alzheimer Disease
Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls.
Alzheimer Disease
Homology modeling, molecular docking and MD simulation studies to investigate role of cysteine protease from Xanthomonas campestris in degradation of A? peptide.
Alzheimer Disease
Identification of Novel Cathepsin B Inhibitors with Implications in Alzheimer's Disease: Computational Refining and Biochemical Evaluation.
Alzheimer Disease
Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease.
Alzheimer Disease
Inhibitors of Cathepsin B Improve Memory and Reduce {beta}-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, {beta}-Secretase Site of the Amyloid Precursor Protein.
Alzheimer Disease
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Alzheimer Disease
Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin.
Alzheimer Disease
Microglial cathepsin B and Porphyromonas gingivalis gingipains as potential therapeutic targets for sporadic Alzheimer's disease.
Alzheimer Disease
Molecular determinants of improved cathepsin B inhibition by new cystatins obtained by DNA shuffling.
Alzheimer Disease
Neuroproteases in peptide neurotransmission and neurodegenerative diseases: applications to drug discovery research.
Alzheimer Disease
New insights into the roles of endolysosomal cathepsins in the pathogenesis of Alzheimer's disease: cathepsin inhibitors as potential therapeutics.
Alzheimer Disease
Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease.
Alzheimer Disease
Potential Alzheimer's Disease Therapeutics Among Weak Cysteine Protease Inhibitors Exhibit Mechanistic Differences Regarding Extent of Cathepsin B Up-Regulation and Ability to Block Calpain.
Alzheimer Disease
Putative roles of cathepsin B in Alzheimer's disease pathology: The good, the bad, and the ugly in one?
Alzheimer Disease
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Alzheimer Disease
The Cysteine Protease Inhibitor, E64d, Reduces Brain Amyloid-? and Improves Memory Deficits in Alzheimer's Disease Animal Models by Inhibiting Cathepsin B, but not BACE1, ?-Secretase Activity.
Alzheimer Disease
Theoretical insight into the mechanism for the inhibition of the cysteine protease cathepsin B by 1,2,4-thiadiazole derivatives.
Alzheimer Disease
Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease.
Amebiasis
Entamoeba histolytica: purification of cathepsin B.
Amyloidosis
Humoral proinflammatory cytokine and SAA generation profiles and spatio-temporal relationship between SAA and lysosomal cathepsin B and D in murine splenic monocytoid cells during AA amyloidosis.
Amyloidosis
Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation.
Amyloidosis
Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway.
Amyotrophic Lateral Sclerosis
Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat.
Amyotrophic Lateral Sclerosis
Involvement of cathepsin B in the motor neuron degeneration of amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Amyotrophic Lateral Sclerosis
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Aneurysm
A potential role for glycated cross-links in abdominal aortic aneurysm disease.
Aneurysm
Activity and localization of cathepsin B, D and G in aortic aneurysm.
Aneurysm
Activity of enzymes with different subcellular localization in the blood plasma of patients with aortic aneurysm.
Aneurysm
Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms.
Aneurysm
Distribution, activity and concentration of cathepsin B and cystatin C in the wall of aortic aneurysm.
Anthrax
Cross-inhibition of pathogenic agents and the host proteins they exploit.
Aortic Aneurysm
Activity and localization of cathepsin B, D and G in aortic aneurysm.
Aortic Aneurysm
Distribution, activity and concentration of cathepsin B and cystatin C in the wall of aortic aneurysm.
Appendicitis
Determination of the concentration of cathepsin B by SPRI biosensor in children with appendicitis, and its correlation with proteasomes.
Appendicitis
[Prognostic significance and clinic utility of serum and immunohistochemical cathepsin B levels in colorectal cancer]
Arteritis
Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis.
Arthritis
Activation-dependent cell death of human monocytes is a novel mechanism of fine-tuning inflammation and autoimmunity.
Arthritis
Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B.
Arthritis
Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity arthritis (DTHA) model.
Arthritis
Cathepsin B and cystatin C play an inflammatory role in gouty arthritis of the knee.
Arthritis
Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis.
Arthritis
Cysteine proteinase activity in arthritic rat knee joints and the effects of a selective systemic inhibitor, Z-Phe-AlaCH2F.
Arthritis
Determination of cathepsins B and H in sera and synovial fluids of patients with different joint diseases.
Arthritis
Effect of adjuvant arthritis on collagenase and certain lysosomal enzymes in relation to the catabolism of collagen.
Arthritis
Exploring fragment-based target-specific ranking protocol with machine learning on cathepsin S.
Arthritis
Expression of cathepsin B, D and L protein in juvenile idiopathic arthritis.
Arthritis
Glioblastoma Invasion, Cathepsin B, and the Potential for Both to be Inhibited by Auranofin, an Old Anti-Rheumatoid Arthritis Drug.
Arthritis
Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint diseases.
Arthritis
Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design.
Arthritis
Localization and cytophotometric analysis of cathepsin B activity in unfixed and undecalcified cryostat sections of whole rat knee joints.
Arthritis
Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1? and Cathepsin B in macrophages.
Arthritis
Molecular determinants of improved cathepsin B inhibition by new cystatins obtained by DNA shuffling.
Arthritis
Molecular regulation of human cathepsin B: implication in pathologies.
Arthritis
Peptidyl fluoromethyl ketones as inhibitors of cathepsin B. Implication for treatment of rheumatoid arthritis.
Arthritis
Prodrug-inspired probes selective to cathepsin B over other cysteine cathepsins.
Arthritis
Reduced expression and proteolytic susceptibility of lubricin/superficial zone protein may explain early elevation in the coefficient of friction in the joints of rats with antigen-induced arthritis.
Arthritis
The effects of fluoromethyl ketone inhibitors of cathepsin B on adjuvant induced arthritis.
Arthritis, Gouty
Cathepsin B and cystatin C play an inflammatory role in gouty arthritis of the knee.
Arthritis, Gouty
Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation.
Arthritis, Juvenile
Expression of cathepsin B, D and L protein in juvenile idiopathic arthritis.
Arthritis, Rheumatoid
A serum antibody in patients with rheumatoid arthritis stimulates cathepsin B activity in peritoneal mouse macrophages.
Arthritis, Rheumatoid
Cathepsin B and its endogenous inhibitor cystatin C in rheumatoid arthritis synovium.
Arthritis, Rheumatoid
Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes.
Arthritis, Rheumatoid
Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis.
Arthritis, Rheumatoid
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.
Arthritis, Rheumatoid
Cathepsins B and L in synovial fluids from patients with rheumatoid arthritis and the effect of cathepsin B on the activation of pro-urokinase.
Arthritis, Rheumatoid
Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis.
Arthritis, Rheumatoid
Cytochemical investigation of cathepsin B in rheumatoid synovial membrane and fluid.
Arthritis, Rheumatoid
Detecting cathepsin activity in human osteoarthritis via activity-based probes.
Arthritis, Rheumatoid
Determination of cathepsins B and H in sera and synovial fluids of patients with different joint diseases.
Arthritis, Rheumatoid
Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoid arthritis and osteoarthritis: a parallel investigation by semiquantitative reverse transcriptase-polymerase chain reaction and immunohistochemistry.
Arthritis, Rheumatoid
Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint diseases.
Arthritis, Rheumatoid
Interleukin-6 and cyclic AMP stimulate release of cathepsin B in human osteoblasts.
Arthritis, Rheumatoid
Lysosomal peptidases and glycosidases in rheumatoid arthritis.
Arthritis, Rheumatoid
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Arthritis, Rheumatoid
Peptidyl fluoromethyl ketones as inhibitors of cathepsin B. Implication for treatment of rheumatoid arthritis.
Arthritis, Rheumatoid
Relationship between cathepsin B and thrombin in rheumatoid arthritis.
Arthritis, Rheumatoid
Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Significance of cathepsin B accumulation in synovial fluid of rheumatoid arthritis.
Arthritis, Rheumatoid
Stimulation of murine macrophage cathepsin B by serum from patients with rheumatoid arthritis: an indicator of disease activity.
Arthritis, Rheumatoid
Synovial giant cells in rheumatoid arthritis: expression of cystatin C, but not of cathepsin B.
Arthritis, Rheumatoid
Targeted drug delivery by in vivo coupling to endogenous albumin: an albumin-binding prodrug of methotrexate (MTX) is better than MTX in the treatment of murine collagen-induced arthritis.
Arthritis, Rheumatoid
The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide.
Arthritis, Rheumatoid
The distribution of cathepsin B in human tissues.
Arthritis, Rheumatoid
The effect of recombinant interferons on cathepsin B activity in human monocytes.
Arthritis, Rheumatoid
Trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B.
Asthma
Binding of chondroitin 4-sulfate to cathepsin s regulates its enzymatic activity.
Astrocytoma
Degradation of extracellular matrix protein tenascin-C by cathepsin B: an interaction involved in the progression of gliomas.
Astrocytoma
Elevated levels of cathepsin B in human glioblastoma cell lines.
Astrocytoma
Expression of cathepsin B and microvascular density increases with higher grade of astrocytomas.
Astrocytoma
High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas.
Astrocytoma
Lysosomal enzymes, cathepsins in brain tumour invasion.
Astrocytoma
Overexpression and localization of cathepsin B during the progression of human gliomas.
Ataxia
Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1).
Atherosclerosis
A Theranostic Cathepsin Activity-Based Probe for Noninvasive Intervention in Cardiovascular Diseases.
Atherosclerosis
Activity of Cathepsin B in Serum of Patients after Kidney Transplantation Depends on Glucocorticosteroids Treatment.
Atherosclerosis
Atorvastatin and clopidogrel interfere with photosensitization in vitro.
Atherosclerosis
Binding of chondroitin 4-sulfate to cathepsin s regulates its enzymatic activity.
Atherosclerosis
Cathepsin B-mediated CD18 shedding regulates leukocyte recruitment from angiogenic vessels.
Atherosclerosis
Cathepsin cysteine proteases in cardiovascular disease.
Atherosclerosis
Characterizing Cathepsin Activity and Macrophage Subtypes in Excised Human Carotid Plaques.
Atherosclerosis
In vivo imaging of proteolytic activity in atherosclerosis.
Atherosclerosis
NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins.
Atherosclerosis
Significances of viable synergistic autophagy-associated cathepsin B and cathepsin D (CTSB/CTSD) as potential biomarkers for sudden cardiac death.
Autoimmune Diseases
Binding of chondroitin 4-sulfate to cathepsin s regulates its enzymatic activity.
Bacterial Infections
Identification of cathepsin B in the razor clam Sinonovacula constricta and its role in innate immune responses.
Bacterial Infections
Molecular characterization of the cathepsin B of turbot (Scophthalmus maximus).
Blister
Acid hydrolases in blister fluid. 3. Characterization and quantification of peptide hydrolases.
Bone Resorption
Cystatins and cathepsin B during orthodontic tooth movement.
Bone Resorption
Distinct roles of cathepsin K and cathepsin L in osteoclastic bone resorption.
Bone Resorption
Immunohistochemical localization of cathepsins B, D and L in the rat osteoclast.
Bone Resorption
Immunolocalization of the cation-independent mannose 6-phosphate receptor and cathepsin B in the enamel organ and alveolar bone of the rat incisor.
Bone Resorption
In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption.
Bone Resorption
Profiling signalling pathways of the receptor activator of NF-kappaB ligand-induced osteoclast formation in mouse monocyte cells, RAW264.7.
Bone Resorption
Regulated proteolysis of nonmuscle myosin IIA stimulates osteoclast fusion.
Bone Resorption
Zeolite A inhibits osteoclast-mediated bone resorption in vitro.
Bowen's Disease
Cathepsin B and D expression in squamous cell carcinoma.
Brain Diseases
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders.
Brain Diseases
Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging.
Brain Edema
Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke.
Brain Injuries
The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage.
Brain Injuries
The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release.
Brain Injuries, Traumatic
Cathepsin B contributes to traumatic brain injury-induced cell death through a mitochondria-mediated apoptotic pathway.
Brain Injuries, Traumatic
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders.
Brain Injuries, Traumatic
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.
Brain Injuries, Traumatic
Cystatin C has a dual role in post-traumatic brain injury recovery.
Brain Injuries, Traumatic
Immunoblot analyses of the relative contributions of cysteine and aspartic proteases to neurofilament breakdown products following experimental brain injury in rats.
Brain Injuries, Traumatic
Penetrating Traumatic Brain Injury Triggers Subacute Dysregulation of Cathepsin B Protein Levels Independently of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid.
Brain Injuries, Traumatic
The Cysteine Protease Cathepsin B is a Key Drug Target and Cysteine Protease Inhibitors are Potential Therapeutics for Traumatic Brain Injury.
Brain Injuries, Traumatic
[Expression of cathepsin-B and -D in rat's brain after traumatic brain injury]
Brain Ischemia
2-(3',5'-Dimethoxybenzylidene) cyclopentanone, a novel synthetic small-molecule compound, provides neuroprotective effects against ischemic stroke.
Brain Ischemia
Activation of calpain, cathepsin-b and caspase-3 during transient focal cerebral ischemia in rat model.
Brain Ischemia
Activation of proinflammatory caspases by cathepsin B in focal cerebral ischemia.
Brain Ischemia
Alterations in mRNA expression of BACE1, cathepsin B, and glutaminyl cyclase in mice ischemic brain.
Brain Ischemia
Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia.
Brain Ischemia
Cathepsin B and middle cerebral artery occlusion in the rat.
Brain Ischemia
Cathepsin B and Phospo-JNK in Relation to Ongoing Apoptosis after Transient Focal Cerebral Ischemia in the Rat.
Brain Ischemia
Dysfunction of Membrane Trafficking Leads to Ischemia-Reperfusion Injury After Transient Cerebral Ischemia.
Brain Ischemia
Improvement in recovery after experimental intracerebral hemorrhage using a selective cathepsin B and L inhibitor.
Brain Ischemia
Inactivation of NSF ATPase Leads to Cathepsin B Release After Transient Cerebral Ischemia.
Brain Ischemia
Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid-mitochondrial apoptotic signaling pathway.
Brain Ischemia
Multiple apoptogenic proteins are involved in the nuclear translocation of Apoptosis Inducing Factor during transient focal cerebral ischemia in rat.
Brain Ischemia
Neurovascular and neuronal protection by E64d after focal cerebral ischemia in rats.
Brain Ischemia
The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage.
Brain Ischemia
The role of autophagic and lysosomal pathways in ischemic brain injury.
Brain Neoplasms
Cathepsin B and its inhibitor stefin A in brain tumors.
Brain Neoplasms
Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors.
Brain Neoplasms
Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat.
Brain Neoplasms
Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells.
Brain Neoplasms
Downregulation of uPAR and cathepsin B induces apoptosis via regulation of Bcl-2 and Bax and inhibition of the PI3K/Akt pathway in gliomas.
Breast Diseases
Inhibition of cathepsin B activity in human breast cancer tissue by cysteine peptidase inhibitor isolated from human placenta: immunohistochemical and biochemical studies.
Breast Neoplasms
4-tert-Octylphenol stimulates the expression of cathepsins in human breast cancer cells and xenografted breast tumors of a mouse model via an estrogen receptor-mediated signaling pathway.
Breast Neoplasms
A cysteine proteinase secreted from human breast tumours is immunologically related to cathepsin B.
Breast Neoplasms
A latent form of cathepsin B in pleural effusions. I. Characterization of the enzyme in breast cancer patients.
Breast Neoplasms
Autophagy-related genes are induced by histone deacetylase inhibitor suberoylanilide hydroxamic acid via the activation of cathepsin B in human breast cancer cells.
Breast Neoplasms
BID-Deficient Breast Cancer MCF-7 Cells as a Model for the Study of Autophagy in Cancer Therapy.
Breast Neoplasms
Cathepsin B and D are Localized at the Surface of Human Breast Cancer Cells.
Breast Neoplasms
Cathepsin B in human breast tumor tissue and cancer cells.
Breast Neoplasms
Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer.
Breast Neoplasms
Cathepsin B is involved in the apoptosis intrinsic pathway induced by Bacillus Calmette-Guérin in transitional cancer cell lines.
Breast Neoplasms
Cathepsin B, a prognostic indicator in lymph node-negative breast carcinoma patients: comparison with cathepsin D, cathepsin L, and other clinical indicators.
Breast Neoplasms
Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies.
Breast Neoplasms
Cathepsins and BID are involved in the molecular switch between apoptosis and autophagy in breast cancer MCF-7 cells exposed to camptothecin.
Breast Neoplasms
Cathepsins B, H and L in human breast carcinoma.
Breast Neoplasms
CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion.
Breast Neoplasms
Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression.
Breast Neoplasms
Characterization of a cysteine proteinase secreted by mouse mammary gland.
Breast Neoplasms
Comparison of Functional Proteomic Analyses of Human Breast Cancer Cell Lines T47D and MCF7.
Breast Neoplasms
Comparison of potential biological markers cathepsin B, cathepsin L, stefin A and stefin B with urokinase and plasminogen activator inhibitor-1 and clinicopathological data of breast carcinoma patients.
Breast Neoplasms
Cystatins and cathepsins in breast carcinoma.
Breast Neoplasms
Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer.
Breast Neoplasms
Detection of cathepsin B in tumor cytosol and urine of breast cancer patients.
Breast Neoplasms
Development of cell-active non-peptidyl inhibitors of cysteine cathepsins.
Breast Neoplasms
Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas.
Breast Neoplasms
Effects of combined in vivo treatment of transplantable solid mammary carcinoma in wistar rats using vitamin E and cysteine peptidase inhibitors from human placenta.
Breast Neoplasms
Effects of Vacuolar H(+)-ATPase Inhibition on Activation of Cathepsin B and Cathepsin L Secreted from MDA-MB231 Breast Cancer Cells.
Breast Neoplasms
ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression.
Breast Neoplasms
Estrogen-induced lysosomal proteases secreted by breast cancer cells: a role in carcinogenesis?
Breast Neoplasms
Expression analysis of cystatin C and M in laser-capture microdissectioned human breast cancer cells--a preliminary study.
Breast Neoplasms
Expression of cathepsin B and cystatin C in human breast cancer.
Breast Neoplasms
Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients.
Breast Neoplasms
High levels of cathepsin B predict poor outcome in patients with breast cancer.
Breast Neoplasms
Hormonal-receptor positive breast cancer: IL-6 augments invasion and lymph node metastasis via stimulating cathepsin B expression.
Breast Neoplasms
Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells.
Breast Neoplasms
Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes.
Breast Neoplasms
Imaging proteolysis by living human breast cancer cells.
Breast Neoplasms
Imaging Sites of Inhibition of Proteolysis in Pathomimetic Human Breast Cancer Cultures by Light-Activated Ruthenium Compound.
Breast Neoplasms
Immunonanoparticles--an effective tool to impair harmful proteolysis in invasive breast tumor cells.
Breast Neoplasms
Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers.
Breast Neoplasms
In Situ Proapoptotic Peptide-Generating Rapeseed Protein-Based Nanocomplexes Synergize Chemotherapy for Cathepsin-B Overexpressing Breast Cancer.
Breast Neoplasms
Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells.
Breast Neoplasms
Inhibition of cathepsin B activity in human breast cancer tissue by cysteine peptidase inhibitor isolated from human placenta: immunohistochemical and biochemical studies.
Breast Neoplasms
Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors.
Breast Neoplasms
Is There Any Role for Serum Cathepsin S and CRP Levels on Prognostic Information in Breast Cancer? The Swedish Mammography Cohort.
Breast Neoplasms
Lysosomal cathepsin initiates apoptosis, which is regulated by photodamage to Bcl-2 at mitochondria in photodynamic therapy using a novel photosensitizer, ATX-s10 (Na).
Breast Neoplasms
Mechanism of the malabaricone C-induced toxicity to the MCF-7 cell line.
Breast Neoplasms
Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion.
Breast Neoplasms
Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin.
Breast Neoplasms
Primary tumour expression of the cysteine cathepsin inhibitor Stefin A inhibits distant metastasis in breast cancer.
Breast Neoplasms
Prognostic significance of cathepsins B and L in primary human breast cancer.
Breast Neoplasms
Prognostic value of the cysteine proteases cathepsins B and cathepsin L in human breast cancer.
Breast Neoplasms
Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment.
Breast Neoplasms
Quantitative electrochemical detection of cathepsin B activity in breast cancer cell lysates using carbon nanofiber nanoelectrode arrays toward identification of cancer formation.
Breast Neoplasms
Screening and identification of small molecule inhibitors of ErbB2-induced invasion.
Breast Neoplasms
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.
Breast Neoplasms
Targeting Cathepsin B for Cancer Therapies.
Breast Neoplasms
The combined action of two enzymes in human serum can mimic the activity of cathepsin B.
Breast Neoplasms
The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer.
Breast Neoplasms
The Role of Cathepsins in Involution and Breast Cancer.
Breast Neoplasms
Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins.
Breast Neoplasms
Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice.
Breast Neoplasms
Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model.
Breast Neoplasms
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.
Breast Neoplasms
[Knockdown of TRAIL-DR5 gene inhibits autophagy of ER-positive MCF-7 breast cancer cells induced by SAHA].
Breast Neoplasms
[Significance of cathepsin B and D in physiologic and pathologic processes]
Bronchiectasis
Levels of neutrophil elastase and cathepsin B activities, and cystatins in human sputum: relationship to inflammation.
Bronchiectasis
Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme.
Bronchiolitis
Cathepsin B promotes collagen biosynthesis, which drives bronchiolitis obliterans syndrome.
Bronchiolitis Obliterans
Cathepsin B promotes collagen biosynthesis, which drives bronchiolitis obliterans syndrome.
Bulbo-Spinal Atrophy, X-Linked
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Carcinogenesis
Abnormal cell-cycle expression of the proteins p27, mdm2 and cathepsin B in oral squamous-cell carcinoma infected with human papillomavirus.
Carcinogenesis
Cathepsin B and cystatins: evidence for a role in cancer progression.
Carcinogenesis
Cathepsin B as a cancer target.
Carcinogenesis
Cathepsin B in the growth of colorectal cancer: suppressive effect of leupeptin on the growth of DMH-induced rat colon neoplasm.
Carcinogenesis
Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis.
Carcinogenesis
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis.
Carcinogenesis
Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice.
Carcinogenesis
Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors.
Carcinogenesis
Changes of cathepsin B in human photoaging skin both in vivo and in vitro.
Carcinogenesis
Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells.
Carcinogenesis
Cysteine cathepsins (proteases)--on the main stage of cancer?
Carcinogenesis
Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target.
Carcinogenesis
Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.
Carcinogenesis
Increased levels of cathepsin B and L, urokinase-type plasminogen activator and its inhibitor type-1 as an early event in gastric carcinogenesis.
Carcinogenesis
Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer.
Carcinogenesis
Overexpression of EMMPRIN Isoform 2 Is Associated with Head and Neck Cancer Metastasis.
Carcinogenesis
Role of cathepsin B in cancer progression: a potential target for coordination compounds.
Carcinogenesis
TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.
Carcinoma
A possible application of cathepsin B activity determination for estimating the spread of the cervix uteri carcinoma.
Carcinoma
Abnormal cell-cycle expression of the proteins p27, mdm2 and cathepsin B in oral squamous-cell carcinoma infected with human papillomavirus.
Carcinoma
Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s).
Carcinoma
Activities of serum cathepsin (B, H and L) and metalloproteinase (MMP7-ase) in patients with gastrointestinal and bronchial malignant tumours.
Carcinoma
Alterations in cathepsin H activity and protein patterns in human colorectal carcinomas.
Carcinoma
An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells.
Carcinoma
An intracellular form of cathepsin B contributes to invasiveness in cancer.
Carcinoma
Analysis of heparanase isoforms and cathepsin B in the plasma of patients with gastrointestinal carcinomas: analytical cross-sectional study.
Carcinoma
Antimetastatic activity of adriamycin in combinations with proteinase inhibitors in mice.
Carcinoma
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue.
Carcinoma
Cathepsin B and antiproteases in patients with carcinoma of the cervix.
Carcinoma
Cathepsin B and Cathepsin D Expression in Follicular Adenomas and Carcinomas of the Thyroid Gland.
Carcinoma
Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma.
Carcinoma
Cathepsin B and D expression in squamous cell carcinoma.
Carcinoma
Cathepsin B and L and stefin A and B levels as serum tumor markers in squamous cell carcinoma of the head and neck.
Carcinoma
Cathepsin B and tumor-associated laminin expression in the progression of colorectal adenoma to carcinoma.
Carcinoma
Cathepsin B as a potential prognostic and therapeutic marker for human lung squamous cell carcinoma.
Carcinoma
Cathepsin B containing cells in the rabbit mesentery during invasion of V2 carcinoma cells.
Carcinoma
Cathepsin B defines leader cells during the collective invasion of salivary adenoid cystic carcinoma.
Carcinoma
Cathepsin B expression and its correlation with tumor-associated laminin and tumor progression in gastric cancer.
Carcinoma
Cathepsin B Expression and the Correlation with Clinical Aspects of Oral Squamous Cell Carcinoma.
Carcinoma
Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival.
Carcinoma
Cathepsin B fraction active at physiological pH of 7.5 is of prognostic significance in squamous cell carcinoma of human lung.
Carcinoma
Cathepsin B in infiltrated lymph nodes is of prognostic significance for patients with nonsmall cell lung carcinoma.
Carcinoma
Cathepsin B in predicting the extent of the cervix carcinoma.
Carcinoma
Cathepsin B may be a potential biomarker in cervical cancer.
Carcinoma
Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells.
Carcinoma
Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells.
Carcinoma
Cathepsin B on invasion and metastasis of gastric carcinoma.
Carcinoma
Cathepsin B promotes both motility and invasiveness of oral carcinoma cells.
Carcinoma
Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice.
Carcinoma
Cathepsin B, p53 expression and AgNORs in transitional cell carcinoma.
Carcinoma
Cathepsin B, thiols and cysteine protease inhibitors in squamous-cell lung cancer.
Carcinoma
Cathepsin B: multiple enzyme forms from a single gene and their relation to cancer.
Carcinoma
Cathepsin B: Multiple Roles in Cancer.
Carcinoma
Cathepsins B, H and L in human breast carcinoma.
Carcinoma
Characterization of the cathepsin B gene and multiple mRNAs in human tissues: evidence for alternative splicing of cathepsin B pre-mRNA.
Carcinoma
Clinical significance of serum cathepsin B and cystatin C levels and their ratio in the prognosis of patients with esophageal cancer.
Carcinoma
Clinicopathologic significance of cathepsin B immunostaining in transitional neoplasia.
Carcinoma
Comparative localization of cathepsin B protein and activity in colorectal cancer.
Carcinoma
Comparison of proteinase activities in squamous cell carcinoma, basal cell epithelioma, and seborrheic keratosis.
Carcinoma
Cystatin C and cathepsin B in human colon carcinoma: expression by cell lines and matrix degradation.
Carcinoma
Cystatins and cathepsins in breast carcinoma.
Carcinoma
Cysteine proteases and cysteine protease inhibitors in non-small cell lung cancer.
Carcinoma
Cysteine proteinases produced by cultured rabbit V2 carcinoma cells and rabbit skin fibroblasts.
Carcinoma
Detection of esophageal squamous cell carcinoma by cathepsin B activity in nude mice.
Carcinoma
Diagnostic Efficiency of Serum and Urine Procathepsin B and Cathepsin B in Patients with Carcinoma of the Urinary Bladder.
Carcinoma
Differential expression of pancreatic trypsinogen and cathepsin-B in human scirrhous-type and intestinal-type gastric carcinomas.
Carcinoma
Drug-resistant human laryngeal carcinoma cells have increased levels of cathepsin B.
Carcinoma
Effect of endothelin-1 in esophageal squamous cell carcinoma invasion and its correlation with cathepsin B.
Carcinoma
Elevations in cathepsin B protein content and enzyme activity occur independently of glycosylation during colorectal tumor progression.
Carcinoma
Expression of cathepsin B in small cell lung carcinoma cells in relation to in vitro invasiveness.
Carcinoma
Expression of cathepsins B, D and K in thymic epithelial tumours.
Carcinoma
Expression of cystatin C and its effect on EC9706 cells in esophageal carcinoma.
Carcinoma
Expression profiling of supraglottic carcinoma: PTEN and thrombospondin 2 are associated with inhibition of lymphatic metastasis.
Carcinoma
Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer.
Carcinoma
Extracellular matrix components and proteolytic enzymes in uterine cervical carcinoma.
Carcinoma
Fluorescent microplate assay for cancer cell-associated cathepsin B.
Carcinoma
Heterogeneous suppression of experimentally induced colon cancer metastasis in rat liver lobes by inhibition of extracellular cathepsin B.
Carcinoma
High expression of cathepsin B in transitional bladder carcinoma correlates with tumor invasion.
Carcinoma
Histochemical localization of cathepsin B at the invasion front of the rabbit V2 carcinoma.
Carcinoma
Hypoxia alters cathepsin B / inhibitor profiles in oral carcinoma cell lines.
Carcinoma
Immunochemical analysis of cathepsin B in lung tumours: an independent prognostic factor for squamous cell carcinoma patients.
Carcinoma
Immunohistochemical Expression of Cathepsin D in Primary and Recurrent Squamous Cell Carcinoma.
Carcinoma
Immunohistochemical markers of prolonged survival in small cell carcinoma of the lung. An immunohistochemical study.
Carcinoma
Immunohistochemical study of cathepsin B. Prognostic significance in human lung cancer.
Carcinoma
Increase of endo-peptidases and exo-peptidases in thyroid-tumors.
Carcinoma
Increased cathepsin B activity in human lung tumors.
Carcinoma
Increased expression of Cathepsin B in oral squamous cell carcinoma.
Carcinoma
Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64.
Carcinoma
Interactions between human colon carcinoma cells, fibroblasts and monocytic cells in coculture--regulation of cathepsin B expression and invasiveness.
Carcinoma
Latency of cathepsin B secreted by human colon carcinoma cells is not linked to secretion of cystatin C and is relieved by neutrophil elastase.
Carcinoma
Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C.
Carcinoma
Multiple forms of cathepsin B in human lung cancer.
Carcinoma
Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells.
Carcinoma
Nuclear factor-kappaB mediates up-regulation of cathepsin B by doxorubicin in tumor cells.
Carcinoma
Pancreatic trypsinogen and cathepsin B in human pancreatic carcinomas and associated metastatic lesions.
Carcinoma
Prediction of pelvic lymph node metastasis by the ratio of cathepsin B to stefin A in patients with prostate carcinoma.
Carcinoma
Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice.
Carcinoma
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Carcinoma
Protease and antiprotease concentrations in serum and vaginal fluid of patients with carcinoma of the cervix.
Carcinoma
Protease-mediated fragmentation of p-amidobenzyl ethers: a new strategy for the activation of anticancer prodrugs.
Carcinoma
Proteinase activity in invasive cancer of the breast. Correlation with tumor progression.
Carcinoma
Role of urinary cathepsin B and L in the detection of bladder urothelial cell carcinoma.
Carcinoma
Stage-specific increases in cathepsin B messenger RNA content in human colorectal carcinoma.
Carcinoma
Studies of the activities of lysosomal enzymes in serum and buccal pouch tissue of hamsters during 7,12-dimethylbenz[a]anthracene-induced carcinogenesis.
Carcinoma
Study of Cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts.
Carcinoma
Study on cathepsin B activity in human thyroid tumors.
Carcinoma
Synthesis, cleavage profile, and antitumor efficacy of an albumin-binding prodrug of methotrexate that is cleaved by plasmin and cathepsin B.
Carcinoma
The activities and subcellular localization of cathepsin B and cysteine proteinase inhibitors in human ovarian carcinoma.
Carcinoma
The expression of matrix metalloproteinase 9 and cathepsin B in gastric carcinoma is associated with lymph node metastasis, but not with postoperative survival.
Carcinoma
The state of differentiation of HT-29 colon carcinoma cells alters the secretion of cathepsin D and of plasminogen activator.
Carcinoma
Tumor progression and angiogenesis: cathepsin B & Co.
Carcinoma
Tumor-host interactions in the rabbit V2 carcinoma: stimulation of cathepsin B in host fibroblasts by a tumor-derived cytokine.
Carcinoma
Urine and serum cathepsin B concentrations in the transitional cell carcinoma of the bladder.
Carcinoma
Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer.
Carcinoma
[A study on cathepsin B-like substance in patients with urological cancer]
Carcinoma
[Changes in active cysteine cathepsins in lysosomes from tissues thyroid papillary carcinomas with various biological characteristics].
Carcinoma
[Clinical significance of cathepsin B expressions in cervical cancer in tissues]
Carcinoma
[Comparison of cathepsin-B-like activity and CA 125 assays use in ovarian cancer diagnosis]
Carcinoma
[Dependence of serous activity of cathepsin B on histological types of ovarian carcinomas]
Carcinoma
[Immunohistochemical localization of cathepsin B in the rabbit's mesenterium following intraperitoneal implantation of V2 carcinoma cells]
Carcinoma in Situ
Protease and antiprotease concentrations in serum and vaginal fluid of patients with carcinoma of the cervix.
Carcinoma, Adenoid Cystic
Cathepsin B defines leader cells during the collective invasion of salivary adenoid cystic carcinoma.
Carcinoma, Basal Cell
Comparison of proteinase activities in squamous cell carcinoma, basal cell epithelioma, and seborrheic keratosis.
Carcinoma, Bronchogenic
Activities of serum cathepsin (B, H and L) and metalloproteinase (MMP7-ase) in patients with gastrointestinal and bronchial malignant tumours.
Carcinoma, Ductal
Cathepsins B, H and L in human breast carcinoma.
Carcinoma, Ductal
Determination of cathepsins B, H, L and kininogen in breast cancer patients.
Carcinoma, Ductal
Prognostic value of total cathepsin B in invasive ductal carcinoma of the breast.
Carcinoma, Hepatocellular
Activation of procathepsin B in human hepatoma cells: the conversion into the mature enzyme relies on the action of cathepsin B itself.
Carcinoma, Hepatocellular
Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis.
Carcinoma, Hepatocellular
Cathepsin B mediated scramblase activation triggers cytotoxicity and cell cycle arrest by andrographolide to overcome cellular resistance in cisplatin resistant human hepatocellular carcinoma HepG2 cells.
Carcinoma, Hepatocellular
CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma.
Carcinoma, Hepatocellular
cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis.
Carcinoma, Hepatocellular
Characterization of the cathepsin B gene and multiple mRNAs in human tissues: evidence for alternative splicing of cathepsin B pre-mRNA.
Carcinoma, Hepatocellular
Construction of cathepsin B-responsive fluorescent probe and photosensitizer using a ferrocenyl boron dipyrromethene dark quencher.
Carcinoma, Hepatocellular
Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line.
Carcinoma, Hepatocellular
Differential localization of cysteine protease inhibitors and a target cysteine protease, cathepsin B, by immuno-confocal microscopy.
Carcinoma, Hepatocellular
Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B.
Carcinoma, Hepatocellular
Expression of cathepsin B and aryl hydrocarbon hydroxylase activities, and of apolipoprotein B in human hepatoma cells maintained long-term in a serum-free medium.
Carcinoma, Hepatocellular
Expression of pancreatic trypsinogen/trypsin and cathepsin B in human cholangiocarcinomas and hepatocellular carcinomas.
Carcinoma, Hepatocellular
IGF-1 promotes the growth and metastasis of hepatocellular carcinoma via the inhibition of proteasome-mediated cathepsin B degradation.
Carcinoma, Hepatocellular
Interaction of the hepatitis B spliced protein with cathepsin B promotes hepatoma cell migration and invasion.
Carcinoma, Hepatocellular
Lysosomal cathepsins B and L and Stefin A blood levels in patients with hepatocellular carcinoma and/or liver cirrhosis: potential clinical implications.
Carcinoma, Hepatocellular
Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients.
Carcinoma, Hepatocellular
Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzyme.
Carcinoma, Hepatocellular
Targeted Nanoparticles for Co-Delivery of 5-FU and Nitroxoline, a Cathepsin B Inhibitor, in HepG2 Cells of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
The secretion of high molecular weight cathepsin B from cultured human liver cancers.
Carcinoma, Hepatocellular
[Cysteine proteinases and their inhibitors in the development of mouse HA-1 hepatoma and antineoplastic therapy]
Carcinoma, Hepatocellular
[Enzymatic activity of cathepsin B, cathepsin B and L, plasmin, trypsin and collagenase in hepatocellular carcinoma]
Carcinoma, Lewis Lung
Antimetastatic activity of adriamycin in combinations with proteinase inhibitors in mice.
Carcinoma, Lewis Lung
Fluorescent microplate assay for cancer cell-associated cathepsin B.
Carcinoma, Lewis Lung
Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64.
Carcinoma, Non-Small-Cell Lung
Cathepsin B and cysteine proteinase inhibitors in human lung cancer cell lines.
Carcinoma, Non-Small-Cell Lung
Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Cathepsin B, plasminogenactivator-inhibitor (PAI-1) and plasminogenactivator-receptor (uPAR) are prognostic factors for patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer.
Carcinoma, Non-Small-Cell Lung
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Immunochemical analysis of cathepsin B in lung tumours: an independent prognostic factor for squamous cell carcinoma patients.
Carcinoma, Non-Small-Cell Lung
Immunohistochemical study of cathepsin B. Prognostic significance in human lung cancer.
Carcinoma, Non-Small-Cell Lung
Laminin and cathepsin B as prognostic factors in stage I non-small cell lung cancer: are they useful?
Carcinoma, Non-Small-Cell Lung
Prognostic impact of cathepsin B and matrix metalloproteinase-9 in pulmonary adenocarcinomas by immunohistochemical study.
Carcinoma, Non-Small-Cell Lung
[Cathepsin B expression and its significance in non-small cell lung cancer tissues]
Carcinoma, Non-Small-Cell Lung
[Molecular biological prognostic markers in lung cancer]
Carcinoma, Papillary
Marked increases in cathepsin B and L activities distinguish papillary carcinoma of the thyroid from normal thyroid or thyroid with non-neoplastic disease.
Carcinoma, Papillary
Study on cathepsin B activity in human thyroid tumors.
Carcinoma, Papillary
[Changes in active cysteine cathepsins in lysosomes from tissues thyroid papillary carcinomas with various biological characteristics].
Carcinoma, Renal Cell
Study of Cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts.
Carcinoma, Renal Cell
[A study on cathepsin B-like substance in patients with urological cancer]
Carcinoma, Small Cell
Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer.
Carcinoma, Small Cell
Immunohistochemical markers of prolonged survival in small cell carcinoma of the lung. An immunohistochemical study.
Carcinoma, Squamous Cell
An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells.
Carcinoma, Squamous Cell
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue.
Carcinoma, Squamous Cell
Cathepsin B and D expression in squamous cell carcinoma.
Carcinoma, Squamous Cell
Cathepsin B and L and stefin A and B levels as serum tumor markers in squamous cell carcinoma of the head and neck.
Carcinoma, Squamous Cell
Cathepsin B as a potential prognostic and therapeutic marker for human lung squamous cell carcinoma.
Carcinoma, Squamous Cell
Cathepsin B fraction active at physiological pH of 7.5 is of prognostic significance in squamous cell carcinoma of human lung.
Carcinoma, Squamous Cell
Cathepsin B may be a potential biomarker in cervical cancer.
Carcinoma, Squamous Cell
Comparison of proteinase activities in squamous cell carcinoma, basal cell epithelioma, and seborrheic keratosis.
Carcinoma, Squamous Cell
Expression of cathepsins B, D and K in thymic epithelial tumours.
Carcinoma, Squamous Cell
Immunochemical analysis of cathepsin B in lung tumours: an independent prognostic factor for squamous cell carcinoma patients.
Carcinoma, Squamous Cell
Immunohistochemical study of cathepsin B. Prognostic significance in human lung cancer.
Carcinoma, Squamous Cell
Invasive properties of murine squamous carcinoma cells: secretion of matrix-degrading cathepsins is attributable to a deficiency in the mannose 6-phosphate/insulin-like growth factor II receptor.
Carcinoma, Squamous Cell
Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C.
Carcinoma, Transitional Cell
Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s).
Carcinoma, Transitional Cell
Cathepsin B, p53 expression and AgNORs in transitional cell carcinoma.
Carcinoma, Transitional Cell
Urine and serum cathepsin B concentrations in the transitional cell carcinoma of the bladder.
Carcinosarcoma
The expression of cathepsin B and other lysosomal proteinases in normal tissues and in tumors.
Cardiomegaly
Hypertension-mediated albuminuria is associated with reduced lysosomal activity in the kidney and the heart.
Cardiomegaly
The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival.
Cardiomyopathy, Dilated
Clinical significance of cathepsin L and cathepsin B in dilated cardiomyopathy.
Cardiomyopathy, Dilated
Enhanced myocardial cathepsin B expression in patients with dilated cardiomyopathy.
Cardiotoxicity
Carrier-free nanoparticles of cathepsin B-cleavable peptide-conjugated doxorubicin prodrug for cancer targeting therapy.
Cardiotoxicity
Cathepsin B Dependent Cleavage Product of Serum Amyloid A1 Identifies Patients with Chemotherapy-Related Cardiotoxicity.
Cardiovascular Diseases
Cathepsin S promotes the development of pulmonary arterial hypertension.
Cardiovascular Diseases
Endothelial cells and cathepsins: Biochemical and biomechanical regulation.
Cardiovascular Diseases
Exploring fragment-based target-specific ranking protocol with machine learning on cathepsin S.
cathepsin b deficiency
Apparent cathepsin B deficiency in neuronal ceroid lipofuscinosis can be explained by peroxide inhibition.
cathepsin b deficiency
Cathepsin B controls the persistence of memory CD8+ T lymphocytes.
cathepsin b deficiency
Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis.
cathepsin b deficiency
Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF?/ASK1/JNK pathway.
cathepsin b deficiency
Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents.
cathepsin b deficiency
Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein.
cathepsin s deficiency
Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors.
cathepsin s deficiency
Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.
cathepsin x deficiency
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.
Central Nervous System Diseases
Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat.
Cerebral Hemorrhage
Improvement in recovery after experimental intracerebral hemorrhage using a selective cathepsin B and L inhibitor.
Cerebral Infarction
Cathepsin B and middle cerebral artery occlusion in the rat.
Cerebral Infarction
Inhibition of Cathepsin B Alleviates Secondary Degeneration in Ipsilateral Thalamus After Focal Cerebral Infarction in Adult Rats.
Chagas Disease
Specific human antibodies do not inhibit Trypanosoma cruzi oligopeptidase B and cathepsin B, and immunoglobulin G enhances the activity of trypomastigote-secreted oligopeptidase B.
Chagas Disease
Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases: rhodesain, cruzain and Schistosoma mansoni cathepsin B1.
Cholangiocarcinoma
Differential LC-MS-based proteomics of surgical human cholangiocarcinoma tissues.
Cholangiocarcinoma
Expression of pancreatic trypsinogen/trypsin and cathepsin B in human cholangiocarcinomas and hepatocellular carcinomas.
Cholangiocarcinoma
mir-637 inhibits the proliferation of cholangiocarcinoma cell QBC939 through interfering CTSB expression.
Cholangiocarcinoma
Serum cathepsin B to cystatin C ratio as a potential marker for the diagnosis of cholangiocarcinoma.
Cholangiocarcinoma
Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins.
Cholangiocarcinoma
[Cathepsin B-like substance in the monitoring of chemically induced primary cholangiocarcinoma in swine]
Cholestasis
Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis.
Cholesteatoma
Clinical and biochemical studies of bone destruction in cholesteatoma.
Chondrosarcoma
Overexpression of cathepsin B and urokinase plasminogen activator is associated with increased risk of recurrence and metastasis in patients with chondrosarcoma.
Chondrosarcoma
[New findings in orthopedic pathology]
Chordoma
Expression of matrix metalloproteinase (MMP)-1, MMP-2, MMP-9, cathepsin B, and urokinase plasminogen activator in non-skull base chordoma.
Chordoma
Expression of matrix metalloproteinases-1, -2, and -9; tissue inhibitors of matrix metalloproteinases-1 and -2; cathepsin B; urokinase plasminogen activator; and plasminogen activator inhibitor, type I in skull base chordoma.
Chronic Periodontitis
Cathepsin B in gingival crevicular fluid of adult periodontitis patients: identification by immunological and enzymological methods.
Chronic Periodontitis
Cathepsin B, alpha2-macroglobulin and cystatin levels in gingival crevicular fluid from chronic periodontitis patients.
Chronic Periodontitis
Secretory leukocyte protease inhibitor and its potential interactions with elastase and cathepsin B in gingival crevicular fluid and saliva from patients with chronic periodontitis.
Chronic Periodontitis
The relationship between gingival crevicular fluid cathepsin B activity and periodontal attachment loss in chronic periodontitis patients: a 2-year longitudinal study.
Chronic Periodontitis
Ultrastructural localization of cathepsin B in gingival tissue from chronic periodontitis patients.
Clonorchiasis
Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis.
Clonorchiasis
Molecular characterization of cathepsin B from Clonorchis sinensis excretory/secretory products and assessment of its potential for serodiagnosis of clonorchiasis.
Colitis
Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release.
Colonic Neoplasms
Blastocystis sp. subtype 3 triggers higher proliferation of human colorectal cancer cells, HCT116.
Colonic Neoplasms
Cathepsin B Expression and Survival in Colon Cancer: Implications for Molecular Detection of Neoplasia.
Colonic Neoplasms
Cathepsin B in the growth of colorectal cancer: suppressive effect of leupeptin on the growth of DMH-induced rat colon neoplasm.
Colonic Neoplasms
Cathepsin B Is Upregulated and Mediates ECM Degradation in Colon Adenocarcinoma HT29 Cells Overexpressing Snail.
Colonic Neoplasms
Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells.
Colonic Neoplasms
Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.
Colonic Neoplasms
Heterogeneous suppression of experimentally induced colon cancer metastasis in rat liver lobes by inhibition of extracellular cathepsin B.
Colonic Neoplasms
Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples.
Colonic Neoplasms
Intracellularly biorecognizable derivatives of 5-fluorouracil. Implications for site-specific delivery in the human condition.
Colonic Neoplasms
Near-Infrared Fluorescent Activated Polymeric Probe for Imaging Intraluminal Colorectal Cancer Tumors.
Colonic Neoplasms
Overexpression of cathepsin B correlates with angiogenesis in colon adenocarcinoma.
Colonic Neoplasms
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Colonic Neoplasms
Signal amplification in immunohistochemistry at the light microscopic level using biotinylated tyramide and nanogold-silver staining.
Colonic Neoplasms
The Anticancer Action of a Novel 1,2,4-Triazine Sulfonamide Derivative in Colon Cancer Cells.
Colonic Neoplasms
The effect of 3-bromopyruvate on the properties of cathepsin B in the aspect of metastatic potential of colon cancer cells.
Colonic Neoplasms
[Protease activities in gastric and colon cancer tissues]
Colorectal Neoplasms
Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D.
Colorectal Neoplasms
Activity of cathepsin B and D in colorectal cancer: relationships with tumour budding.
Colorectal Neoplasms
Alterations in cathepsin H activity and protein patterns in human colorectal carcinomas.
Colorectal Neoplasms
Cathepsin B and other proteases in human colorectal carcinoma.
Colorectal Neoplasms
Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival.
Colorectal Neoplasms
Cathepsin B in the growth of colorectal cancer: increased activity of cathepsin B in human colorectal cancer.
Colorectal Neoplasms
Cathepsin B in the growth of colorectal cancer: suppressive effect of leupeptin on the growth of DMH-induced rat colon neoplasm.
Colorectal Neoplasms
Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis.
Colorectal Neoplasms
Cathepsin B, L, and D activities in colorectal carcinomas: relationship with clinico-pathological parameters.
Colorectal Neoplasms
Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells.
Colorectal Neoplasms
Comparative localization of cathepsin B protein and activity in colorectal cancer.
Colorectal Neoplasms
Construction of a plasmid coding for green fluorescent protein tagged cathepsin L and data on expression in colorectal carcinoma cells.
Colorectal Neoplasms
Cysteine endopeptidase activity levels in normal human tissues, colorectal adenomas and carcinomas.
Colorectal Neoplasms
Elevations in cathepsin B protein content and enzyme activity occur independently of glycosylation during colorectal tumor progression.
Colorectal Neoplasms
Evaluation of serum cathepsin B and D in relation to clinicopathological staging of colorectal cancer.
Colorectal Neoplasms
Evaluation of the 5' spliced form of human cathepsin B mRNA in colorectal mucosa and tumors.
Colorectal Neoplasms
Expression of cathepsin B and cystatin C in human colorectal cancer.
Colorectal Neoplasms
Expression of Cathepsin B and L antigen and activity is associated with early colorectal cancer progression.
Colorectal Neoplasms
Increasing Cystatin C and Cathepsin B in Serum of Colorectal Cancer Patients.
Colorectal Neoplasms
MMP-9 and cathepsin B expression in tumor budding as an indicator of a more aggressive phenotype of colorectal cancer (CRC).
Colorectal Neoplasms
Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells.
Colorectal Neoplasms
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Colorectal Neoplasms
Prognostic values of cathepsin B and carcinoembryonic antigen in sera of patients with colorectal cancer.
Colorectal Neoplasms
Proteases in human tumors.
Colorectal Neoplasms
Relationship between cathepsin B, cathepsin D expression and biological behaviour in mucinous colorectal carcinoma.
Colorectal Neoplasms
Relationship between morphological diversity and AgNORs or cathepsin B expression in colorectal cancers.
Colorectal Neoplasms
Serum cathepsin-B levels and urinary-excretion of cathepsin-B in the patients with colorectal-cancer - possible indicators for tumor malignancy.
Colorectal Neoplasms
Serum proteolytic activities and antiproteases in human colorectal carcinoma.
Colorectal Neoplasms
Stage-specific increases in cathepsin B messenger RNA content in human colorectal carcinoma.
Colorectal Neoplasms
Targeting Cathepsin B for Cancer Therapies.
Colorectal Neoplasms
The role of cysteine and serine proteases in colorectal carcinoma.
Colorectal Neoplasms
Tissue cathepsins as tumor markers.
Colorectal Neoplasms
Total and lipid-bound plasma sialic acid as diagnostic markers in colorectal cancer patients: correlation with cathepsin B expression in progression to Dukes stage.
Colorectal Neoplasms
Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer.
Colorectal Neoplasms
[Effect of jianpi-jiedu formula on tumor angiogenesis-relevant genes expression in colorectal cancer].
Colorectal Neoplasms
[Expression of cathepsin B and its clinical importance in colorectal cancer]
Colorectal Neoplasms
[Prognostic significance and clinic utility of serum and immunohistochemical cathepsin B levels in colorectal cancer]
Coronary Artery Disease
Increased plasma levels of CATS mRNA but not CATB mRNA in patients with coronary atherosclerosis.
Coronary Artery Disease
Optimisation of methods for quantifying plasma mRNA levels from genes responsible for coronary artery plaque development and destabilization.
Coronary Disease
Cathepsin B and S as markers for cardiovascular risk and all-cause mortality in patients with stable coronary heart disease during 10 years: a CLARICOR trial sub-study.
Craniopharyngioma
Cathepsin B, D and K expression in adamantinomatous craniopharyngiomas relates to their levels of differentiation as determined by the patterns of retinoic acid receptor expression.
Cystic Fibrosis
Arginine esterase and lysosomal hydrolases in liver from cystic fibrosis subjects.
Cystic Fibrosis
Association of airway cathepsin B and S with inflammation in cystic fibrosis.
Cystic Fibrosis
Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures.
Cystic Fibrosis
Do the cysteine proteinases cathepsin B and S contribute to cystic fibrosis lung disease?
Cystic Fibrosis
Frequency of CFTR, SPINK1, and Cathepsin B Gene Mutation in North Indian Population: Connections between Genetics and Clinical Data.
Cystic Fibrosis
Genetic and phenotypic heterogeneity in tropical calcific pancreatitis.
Cystic Fibrosis
Genetic Evaluation of Children with Idiopathic Recurrent Acute Pancreatitis.
Cystic Fibrosis
Genetics of acute and chronic pancreatitis: An update.
Cystic Fibrosis
Germline mutations and gene polymorphism associated with human pancreatitis.
Cystic Fibrosis
Specific cleavage of the lung surfactant protein A by human cathepsin S may impair its antibacterial properties.
Cystic Fibrosis
Targeted Gene Next-Generation Sequencing in Chinese Children with Chronic Pancreatitis and Acute Recurrent Pancreatitis.
Cysts
Cysteine proteases and cell differentiation: excystment of the ciliated protist Sterkiella histriomuscorum.
Cysts
Proteomic characterisation of Echinococcus granulosus hydatid cyst fluid from sheep, cattle and humans.
Death, Sudden, Cardiac
Significances of viable synergistic autophagy-associated cathepsin B and cathepsin D (CTSB/CTSD) as potential biomarkers for sudden cardiac death.
Decompression Sickness
An enormously active and selective azapeptide inhibitor of cathepsin B.
Dementia
miR128 up-regulation correlates with impaired amyloid ?(1-42) degradation in monocytes from patients with sporadic Alzheimer's disease.
Dementia
New insights into the roles of endolysosomal cathepsins in the pathogenesis of Alzheimer's disease: cathepsin inhibitors as potential therapeutics.
Dementia, Vascular
Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma.
Demyelinating Diseases
Degradation of myelin proteins by cathepsin B and inhibition by E-64 analogue.
Demyelinating Diseases
Isolation and characterization of cathepsin B from bovine brain.
Demyelinating Diseases
Lipid-induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders.
Demyelinating Diseases
Sevoflurane Post-Conditioning Ameliorates Neuronal Deficits and Axon Demyelination After Neonatal Hypoxic Ischemic Brain Injury: Role of Microglia/Macrophage.
Demyelinating Diseases
The distribution of cathepsin B in human tissues.
Dengue
Role of cathepsin B in dengue virus-mediated apoptosis.
Dental Caries
Cysteine cathepsins in human carious dentin.
Dermatitis, Contact
Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions.
Dermatitis, Phototoxic
In vivo near-infrared imaging and phototherapy of tumors using a cathepsin B-activated fluorescent probe.
Diabetes Mellitus
An update on pancreatic pathophysiology (Do we have to rewrite pancreatic pathophysiology?).
Diabetes Mellitus
Streptozotocin-induced diabetes mellitus affects lysosomal enzymes in rat liver.
Diabetes Mellitus
Urinary activities of cathepsin B, N-acetyl-beta-D-glucosaminidase, and albuminuria in patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 1
[Urinary excretion of extracellular matrix proteins in insulin dependent diabetes mellitus]
Diabetes Mellitus, Type 2
Regulation of muscle cathepsin B proteolytic activity in protein-depleted patients with chronic diseases.
Diabetes Mellitus, Type 2
Urinary activities of cathepsin B, N-acetyl-beta-D-glucosaminidase, and albuminuria in patients with type 2 diabetes mellitus.
Diabetic Nephropathies
Lysosomal enzymes are decreased in the kidney of diabetic rats.
Diabetic Nephropathies
SMAD3 promotes autophagy dysregulation by triggering lysosome depletion in tubular epithelial cells in diabetic nephropathy.
Drug-Related Side Effects and Adverse Reactions
CHEMOTHERAPY DRUG RESPONSE IN OVARIAN CANCER CELLS STRICTLY DEPENDS ON A CATHEPSIN D - BAX ACTIVATION LOOP.
Ectromelia
Apoptosis during ectromelia orthopoxvirus infection is DEVDase dependent: in vitro and in vivo studies.
Encephalitis
Cathepsin B and cystatin B in HIV-seropositive women are associated with infection and HIV-1-associated neurocognitive disorders.
Encephalitis
HIV-infected microglia mediate cathepsin B-induced neurotoxicity.
Encephalitis
The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release.
Endometrial Neoplasms
Cathepsin B protein levels in endometrial cancer: Potential value as a tumour biomarker.
Endometrial Neoplasms
Silencing of Cathepsin B suppresses the proliferation and invasion of endometrial cancer.
Endometriosis
Cathepsin B in eutopic and ectopic endometrial tissues of patients with endometriosis.
Endometriosis
Cathepsin Protease Inhibition Reduces Endometriosis Lesion Establishment.
Epilepsy
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.
Epilepsy, Rolandic
Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.
Esophageal Neoplasms
Clinical significance of serum cathepsin B and cystatin C levels and their ratio in the prognosis of patients with esophageal cancer.
Esophageal Neoplasms
Effect of endothelin-1 in esophageal squamous cell carcinoma invasion and its correlation with cathepsin B.
Esophageal Neoplasms
Granulocyte collagenase and cathepsin B in patients with cancer of digestive organs.
Esophageal Squamous Cell Carcinoma
Detection of esophageal squamous cell carcinoma by cathepsin B activity in nude mice.
Esophageal Squamous Cell Carcinoma
Effect of endothelin-1 in esophageal squamous cell carcinoma invasion and its correlation with cathepsin B.
Fatty Liver
Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation.
Fatty Liver
Mir214-3p and Hnf4a/Hnf4? reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis.
Fatty Liver
[Effects of Qushi Huayu Decoction on cathepsin B and tumor necrosis factor-alpha expression in rats with non-alcoholic steatohepatitis]
Fibroadenoma
Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas.
Fibrosarcoma
An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells.
Fibrosarcoma
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor.
Fibrosarcoma
Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells.
Fibrosarcoma
Cystatin C and cathepsin B in human colon carcinoma: expression by cell lines and matrix degradation.
Fibrosarcoma
Fluorescent microplate assay for cancer cell-associated cathepsin B.
Fibrosarcoma
Studies on the intracellular degradation of newly synthesized collagen in 3-methylcholanthrene induced fibrosarcoma cells.
Frontotemporal Dementia
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Gallstones
A new experimental model for gallstone pancreatitis: short-termed pancreatico-biliary duct obstruction and exocrine stimulation with systemic hypotension in rats.
Gallstones
A possible mechanism for gallstone pancreatitis: repeated short-term pancreaticobiliary duct obstruction with exocrine stimulation in rats.
Gallstones
Lysosomal enzyme activities in gallbladder mucosa of gallstone-free subjects and patients with gallstones.
Gastrointestinal Neoplasms
Serum cathepsin B and plasma urokinase-type plasminogen activator levels in gastrointestinal tract cancers.
Gastrointestinal Neoplasms
Tumor progression and angiogenesis: cathepsin B & Co.
Gaucher Disease
Pathologic gene expression in Gaucher disease: up-regulation of cysteine proteinases including osteoclastic cathepsin K.
Giant Cell Tumors
Estrogen modulation of osteoclast lysosomal enzyme secretion.
Gingival Hyperplasia
Cathepsin B, D, and L regulation in cyclosporin A-mediated gingival hyperplasia of a patient with sarcoidosis.
Gingival Overgrowth
Long-term cyclosporin A exposure suppresses cathepsin-B and -L activity in gingival fibroblasts.
Gingivitis
Identification of a cathepsin b-like protease in the crevicular fluid of gingivitis patients.
Glaucoma
Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma.
Glioblastoma
Arsenic Trioxide Induces Apoptosis and Incapacitates Proliferation and Invasive Properties of U87MG Glioblastoma Cells through a Possible NF-?B-Mediated Mechanism.
Glioblastoma
Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death.
Glioblastoma
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.
Glioblastoma
Caffeine suppresses the progression of human glioblastoma via cathepsin B and MAPK signaling pathway.
Glioblastoma
Cathepsin B contributes to radioresistance by enhancing homologous recombination in glioblastoma.
Glioblastoma
Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors.
Glioblastoma
Degradation of extracellular matrix protein tenascin-C by cathepsin B: an interaction involved in the progression of gliomas.
Glioblastoma
Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells.
Glioblastoma
Elevated levels of cathepsin B in human glioblastoma cell lines.
Glioblastoma
Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9.
Glioblastoma
Glioblastoma Invasion, Cathepsin B, and the Potential for Both to be Inhibited by Auranofin, an Old Anti-Rheumatoid Arthritis Drug.
Glioblastoma
High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas.
Glioblastoma
Immunotherapeutic Potential of Oncolytic H-1 Parvovirus: Hints of Glioblastoma Microenvironment Conversion towards Immunogenicity.
Glioblastoma
Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis.
Glioblastoma
Lysosomal enzymes, cathepsins in brain tumour invasion.
Glioblastoma
Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.
Glioblastoma
Overexpression and localization of cathepsin B during the progression of human gliomas.
Glioblastoma
Post-Translational Regulation of Cathepsin B, but not of Other Cysteine Cathepsins, Contributes to Increased Glioblastoma Cell Invasiveness In Vitro.
Glioblastoma
Proteases in brain tumour progression.
Glioblastoma
Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9.
Glioblastoma
Single-Cell Sequencing of Glioblastoma Reveals Central Nervous System Susceptibility to SARS-CoV-2.
Glioblastoma
Tracking the Footprints of Paclitaxel Delivery and Mechanistic Action via SERS Trajectory in Glioblastoma Cells.
Glioblastoma
Transcription of cathepsin B in glioma cells: regulation by an E-box adjacent to the transcription initiation site.
Glioblastoma
Tumor progression and angiogenesis: cathepsin B & Co.
Glioma
Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas.
Glioma
Cathepsin B and glioma invasion.
Glioma
Cathepsin B and uPAR knockdown inhibits tumor-induced angiogenesis by modulating VEGF expression in glioma.
Glioma
Cathepsin B expression and localization in glioma progression and invasion.
Glioma
Cathepsin B expression in human tumors.
Glioma
Cathepsin B: Multiple Roles in Cancer.
Glioma
Cathepsin L in glioma progression: comparison with cathepsin B.
Glioma
CCNB2/SASP/Cathepsin B & PGE2 Axis Induce Cell Senescence Mediated Malignant Transformation.
Glioma
Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation.
Glioma
Comparative Proteomic Analysis of Tumor Mesenchymal-Like Stem Cells Derived from High Grade versus Low Grade Gliomas.
Glioma
Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells.
Glioma
Degradation of extracellular matrix protein tenascin-C by cathepsin B: an interaction involved in the progression of gliomas.
Glioma
Delivery of substances and their target-specific topical activation.
Glioma
Down-regulation of uPAR and cathepsin B retards cofilin dephosphorylation.
Glioma
Downregulation of uPAR and cathepsin B induces apoptosis via regulation of Bcl-2 and Bax and inhibition of the PI3K/Akt pathway in gliomas.
Glioma
Elevated levels of cathepsin B in human glioblastoma cell lines.
Glioma
Gold Nanoparticles-Based Colorimetric Assay for Cathepsin B Activity and the Efficiency of Its Inhibitors.
Glioma
Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells.
Glioma
Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid.
Glioma
Immunolocalization of cathepsin B in human glioma: implications for tumor invasion and angiogenesis.
Glioma
Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B.
Glioma
Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis.
Glioma
Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas.
Glioma
Knockdown of cathepsin B and uPAR inhibits CD151 and ?3?1 integrin-mediated cell adhesion and invasion in glioma.
Glioma
Lysosomal enzymes, cathepsins in brain tumour invasion.
Glioma
Mechanism of p27 upregulation induced by downregulation of cathepsin B and uPAR in glioma.
Glioma
Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells.
Glioma
MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice.
Glioma
Modeling endophilin-mediated A? disposal in glioma cells.
Glioma
Modulation of cystatin C expression impairs the invasive and tumorigenic potential of human glioblastoma cells.
Glioma
Overexpression and localization of cathepsin B during the progression of human gliomas.
Glioma
Prognostic impact of CD68 and kallikrein 6 in human glioma.
Glioma
Proteolytic disassembly is a critical determinant for reovirus oncolysis.
Glioma
Purification and characterisation of an inhibitor of a cathepsin B-like proteinase from sunflower seed.
Glioma
Regulation and function of aquaporin-1 in glioma cells.
Glioma
Regulation of DNA repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice.
Glioma
Retraction Note to: uPAR and cathepsin B downregulation induces apoptosis by targeting calcineurin A to BAD via Bcl-2 in glioma.
Glioma
Retraction: Co-Depletion of Cathepsin B and uPAR Induces G0/G1 Arrest in Glioma via FOXO3a Mediated p27Kip1 Upregulation.
Glioma
Retraction: Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas.
Glioma
RNA interference-mediated simultaneous down-regulation of urokinase-type plasminogen activator receptor and cathepsin B induces caspase-8-mediated apoptosis in SNB19 human glioma cells.
Glioma
RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas.
Glioma
Secretion of cathepsin B by human gliomas in vitro.
Glioma
Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner.
Glioma
TI-VAMP/VAMP7 is the SNARE of secretory lysosomes contributing to ATP secretion from astrocytes.
Glioma
Transcription of cathepsin B in glioma cells: regulation by an E-box adjacent to the transcription initiation site.
Glioma
Transcription of human cathepsin B is mediated by Sp1 and Ets family factors in glioma.
Glioma
uPAR and cathepsin B downregulation induces apoptosis by targeting calcineurin A to BAD via Bcl-2 in glioma.
Glioma
uPAR and cathepsin B inhibition enhanced radiation-induced apoptosis in gliomainitiating cells.
Glioma
uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells.
Glioma
[Cathepsin B expression and malignances and angiogenesis in gliomas]
Glomerulonephritis, Membranous
Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis.
Glomerulonephritis, Membranous
Urine activity of cathepsin B, collagenase and urine excretion of TGF-beta 1 and fibronectin in membranous glomerulonephritis.
Glomerulonephritis, Membranous
[Activity of cathepsin B and collagenase in urine and excretion of fibronectin and TGF-beta 1 in urine of patients with membranous glomerulonephritis]
Goiter
Cathepsin B activity and protein levels in thyroid carcinoma, Graves' disease, and multinodular goiters.
Gout
Cathepsin B and cystatin C play an inflammatory role in gouty arthritis of the knee.
Gout
Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint diseases.
Gout
Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1? and Cathepsin B in macrophages.
Granuloma
Cellular distribution of proteolytic enzymes in the skeletal muscle of sarcoid myopathy.
Granuloma
Cellular origin of cathepsin B in carrageenin-induced granuloma tissues in rats.
Granuloma
The role of cathepsin B1 in the collagen breakdown of carrageenin granuloma in rats.
Granulomatous Disease, Chronic
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Graves Disease
Cathepsin B activity and protein levels in thyroid carcinoma, Graves' disease, and multinodular goiters.
Head and Neck Neoplasms
Overexpression of EMMPRIN Isoform 2 Is Associated with Head and Neck Cancer Metastasis.
Hearing Loss
Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss.
Heart Diseases
Progressive heart disease in mucopolysaccharidosis type I mice may be mediated by increased cathepsin B activity.
Heart Failure
Enhanced myocardial cathepsin B expression in patients with dilated cardiomyopathy.
Heart Failure
Progressive heart disease in mucopolysaccharidosis type I mice may be mediated by increased cathepsin B activity.
Hepatitis A
SMAD3 promotes autophagy dysregulation by triggering lysosome depletion in tubular epithelial cells in diabetic nephropathy.
Hepatitis B
Insights into the roles of cathepsins in antigen processing and presentation revealed by specific inhibitors.
Hepatitis B
Interaction of the hepatitis B spliced protein with cathepsin B promotes hepatoma cell migration and invasion.
Hepatitis B
Mechanism and regulation of antigen processing by cathepsin B.
Hepatitis B
Participation of cathepsin B in processing of antigen presentation to MHC class II.
Herpes Simplex
Cathepsin B mediates cleavage of herpes simplex virus type 1 origin binding protein (OBP) to yield OBPC-1, and cleavage is dependent upon viral DNA replication.
Herpes Simplex
Characterization of Novel Piperidine-Based Inhibitor of Cathepsin B-Dependent Bacterial Toxins and Viruses.
Herpes Zoster
Effect of vitrification on the zona pellucida hardening and follistatin and cathepsin B genes expression and developmental competence of in vitro matured bovine oocytes.
Herpes Zoster
Identification of differentially expressed ovarian genes during primary and early secondary oocyte growth in coho salmon, Oncorhynchus kisutch.
Histiocytoma, Malignant Fibrous
Histopathological and immunohistochemical studies on nickel sulfide-induced tumors in F344 rats.
HIV Infections
Dimethyl Fumarate Prevents HIV-Induced Lysosomal Dysfunction and Cathepsin B Release from Macrophages.
HIV Infections
Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis.
HIV Infections
HIV Infection Induces Extracellular Cathepsin B Uptake and Damage to Neurons.
HIV Infections
HIV-infected microglia mediate cathepsin B-induced neurotoxicity.
Hodgkin Disease
Immunohistochemical demonstration of cathepsin B in the macrophages of benign and malignant lymphoid tissues.
Huntington Disease
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.
Huntington Disease
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Huntington Disease
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Hydatidiform Mole
[Expression of cathepsins B and L in early gestational decidua and chorionic villi]
Hypercalcemia
Mechanism and role of trypsinogen activation in acute pancreatitis.
Hyperglycemia
Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy.
Hypersensitivity
Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: the roles of Bcl-2 downregulation and cathepsin B.
Hypersensitivity
Significant accumulations of cathepsin B and prolylendopeptidase in inflammatory focus of delayed-type hypersensitivity induced by Mycobacterium tuberculosis in mice.
Hypertension
An update on pancreatic pathophysiology (Do we have to rewrite pancreatic pathophysiology?).
Hypertension
Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome.
Hypertension
Renal Consequences of Gestational Diabetes Mellitus in Term Neonates: A Multidisciplinary Approach to the DOHaD Perspective in the Prevention and Early Recognition of Neonates of GDM Mothers at Risk of Hypertension and Chronic Renal Diseases in Later Life.
Hypertension
Role of glomerular proteinases in the evolution of glomerulosclerosis.
Hypertension
Simulated glomerular hypertension promotes mesangial cell apoptosis and expression of cathepsin-B and SGP-2.
Hypotension
A new experimental model for gallstone pancreatitis: short-termed pancreatico-biliary duct obstruction and exocrine stimulation with systemic hypotension in rats.
Hypotension
Inactivation of NSF ATPase Leads to Cathepsin B Release After Transient Cerebral Ischemia.
Hypothyroidism
Effect of altered thyroid status on lysosomal enzymes and thymidylate synthetase activity in tumors and livers of host animals.
Idiopathic Pulmonary Fibrosis
Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis.
Ileus
Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases.
Infarction, Middle Cerebral Artery
Cathepsin B and middle cerebral artery occlusion in the rat.
Infarction, Middle Cerebral Artery
Cathepsin B and Phospo-JNK in Relation to Ongoing Apoptosis after Transient Focal Cerebral Ischemia in the Rat.
Infarction, Middle Cerebral Artery
Endostatin expression in neurons during the early stage of cerebral ischemia is associated with neuronal apoptotic cell death in adult hypertensive rat model of stroke.
Infarction, Middle Cerebral Artery
Inhibition of Cathepsin B Alleviates Secondary Degeneration in Ipsilateral Thalamus After Focal Cerebral Infarction in Adult Rats.
Infarction, Middle Cerebral Artery
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Infarction, Middle Cerebral Artery
Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia.
Infarction, Middle Cerebral Artery
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Infections
A food-responsive switch modulates TFEB and autophagy, and determines susceptibility to coxsackievirus infection and pancreatitis.
Infections
A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus.
Infections
A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response.
Infections
Abnormal cell-cycle expression of the proteins p27, mdm2 and cathepsin B in oral squamous-cell carcinoma infected with human papillomavirus.
Infections
Adenovirus type 5 rupture of lysosomes leads to cathepsin B dependent mitochondrial stress and production of reactive oxygen species.
Infections
Analysis of expressed sequence tags (ESTs) and gene expression changes under different growth conditions for the ciliate Anophryoides haemophila, the causative agent of bumper car disease in the American lobster (Homarus americanus).
Infections
Apoptosis during ectromelia orthopoxvirus infection is DEVDase dependent: in vitro and in vivo studies.
Infections
Biochemical Basis for Increased Activity of Ebola Glycoprotein in the 2013-16 Epidemic.
Infections
Bioinformatics characterization of a cathepsin B transcript from the giant river prawn, Macrobrachium rosenbergii: Homology modeling and expression analysis after Aeromonas hydrophila infection.
Infections
Cathepsin B & L are not required for ebola virus replication.
Infections
Cathepsin B and cystatin B in HIV-seropositive women are associated with infection and HIV-1-associated neurocognitive disorders.
Infections
Cathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infection.
Infections
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.
Infections
Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection.
Infections
Cathepsin B Protease Facilitates Chikungunya Virus Envelope Protein-Mediated Infection via Endocytosis or Macropinocytosis.
Infections
Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells.
Infections
Cathepsin L maturation and activity is impaired in macrophages harboring M. avium and M. tuberculosis.
Infections
Cathepsins in the kidney of olive flounder, Paralichthys olivaceus, and their responses to bacterial infection.
Infections
CD4-independent human immunodeficiency virus infection involves participation of endocytosis and cathepsin B.
Infections
Characterization and function of a cathepsin B in red crayfish (Procambarus clarkii) following lipopolysaccharide challenge.
Infections
Characterization of cathepsin B gene from orange-spotted grouper, Epinephelus coioides involved in SGIV infection.
Infections
Chlamydia muridarum infection of macrophages elicits bactericidal nitric oxide production via reactive oxygen species and cathepsin B.
Infections
Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection.
Infections
Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIV-infected macrophages.
Infections
Corrigendum to "Leptospira interrogans infection leads to IL-1? and IL-18 secretion from a human macrophage cell line through reactive oxygen species and cathepsin B mediated-NLRP3 inflammasome activation" [Microbe Infect (2018) 254-260].
Infections
Cysteine peptidases as schistosomiasis vaccines with inbuilt adjuvanticity.
Infections
Cysteine protease activation and apoptosis in Murine norovirus infection.
Infections
Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells.
Infections
DEVDase activity is induced in potato leaves during Phytophthora infestans infection.
Infections
Diagnosis of sheep fasciolosis caused by Fasciola hepatica using cathepsin L enzyme-linked immunosorbent assays (ELISA).
Infections
Differential role for low pH and cathepsin-mediated cleavage of the viral spike protein during entry of serotype II feline coronaviruses.
Infections
Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis.
Infections
Ectromelia virus suppresses expression of cathepsins and cystatins in conventional dendritic cells to efficiently execute the replication process.
Infections
Efficient inhibition of cathepsin B by a secreted type 1 cystatin of Fasciola gigantica.
Infections
HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.
Infections
Host cell cathepsins potentiate Moloney murine leukemia virus infection.
Infections
Identification and expression of cathepsin B from the freshwater mussel Cristaria plicata.
Infections
Identification and mucosal expression analysis of cathepsin B in channel catfish (Ictalurus punctatus) following bacterial challenge.
Infections
Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting.
Infections
Identification of cathepsin B in the razor clam Sinonovacula constricta and its role in innate immune responses.
Infections
Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases.
Infections
Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis.
Infections
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Infections
L'entrée du virus Ébola et Marburg : interaction entre la glycoprotéine virale et les facteurs cellulaires.
Infections
Leptospira interrogans infection leads to IL-1? and IL-18 secretion from a human macrophage cell line through reactive oxygen species and cathepsin B mediated-NLRP3 inflammasome activation.
Infections
Macrophage derived cystatin B/cathepsin B in HIV replication and neuropathogenesis.
Infections
Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells.
Infections
Molecular cloning and functional characterization of cathepsin B from the sea cucumber Apostichopus japonicus.
Infections
Mycobacterial secretion systems ESX-1 and ESX-5 play distinct roles in host cell death and inflammasome activation.
Infections
NLRP3 Controls Trypanosoma cruzi Infection through a Caspase-1-Dependent IL-1R-Independent NO Production.
Infections
P. gingivalis Regulates the Expression of Cathepsin B and Cystatin C.
Infections
P7 - regulation of cathepsin B in endothelial cells after infection by porphyromonas gingivalis and stimulation with its LPS.
Infections
Porcine deltacoronavirus enters cells via two pathways: A protease-mediated one at the cell surface and another facilitated by cathepsins in the endosome.
Infections
Porphyromonas gingivalis and its lipopolysaccharide differentially regulate the expression of cathepsin B in endothelial cells.
Infections
Protection against Schistosoma haematobium infection in hamsters by immunization with Schistosoma mansoni gut-derived cysteine peptidases, SmCB1 and SmCL3.
Infections
Protective immune responses against Schistosoma mansoni infection by immunization with functionally active gut-derived cysteine peptidases alone and in combination with glyceraldehyde 3-phosphate dehydrogenase.
Infections
Receptor for advanced glycation end products up-regulation in cerebral endothelial cells mediates cerebrovascular-related amyloid ? accumulation after Porphyromonas gingivalis infection.
Infections
RNA Interference of Trypanosoma brucei Cathepsin B and L Affects Disease Progression in a Mouse Model.
Infections
Role for gingipains in Porphyromonas gingivalis traffic to phagolysosomes and survival in human aortic endothelial cells.
Infections
Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein.
Infections
Switch of CD4+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis.
Infections
The cysteine protease inhibitors cystatins inhibit herpes simplex virus type 1-induced apoptosis and virus yield in HEp-2 cells.
Infections
The Multitasking Fasciola gigantica Cathepsin B Interferes With Various Functions of Goat Peripheral Blood Mononuclear Cells in vitro.
Infections
The role of NH4Cl and cysteine proteases in Human Papillomavirus type 16 infection.
Infections
Toxopain-1 is critical for infection in a novel chicken embryo model of congenital toxoplasmosis.
Infections
Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition.
Infections
[Cytoplasmic protein vaccine against bacterial hemorrhagic septicemia (aeromonosis) of fish]
Infertility
Proteomic characterisation of Echinococcus granulosus hydatid cyst fluid from sheep, cattle and humans.
Infertility
The association between follicular fluid levels of cathepsin B, relaxin or AMH with clinical pregnancy rates in infertile patients.
Inflammatory Breast Neoplasms
Cathepsin B, cathepsin H, cathepsin X and cystatin C in sera of patients with early-stage and inflammatory breast cancer.
Inflammatory Breast Neoplasms
Cathepsin B: a potential prognostic marker for inflammatory breast cancer.
Inflammatory Breast Neoplasms
Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion.
Influenza, Human
Cathepsin B plays a key role in optimal production of the influenza A virus.
Influenza, Human
Influenza A virus elevates active cathepsin B in primary murine DC.
Influenza, Human
More efficient peptide binding to MHC class II molecules during cathepsin B digestion of Ii than after Ii release.
Insulinoma
A case of secretin-responsive insulinoma with low serum C-peptide levels.
Insulinoma
Cathepsin B Contributes to Atg7-induced NLRP3 Dependent Pro-inflammatory Response and Aggravates Lipotoxicity in Rat Insulinoma Cell Line.
Insulinoma
Immunocytochemical localization of cathepsins B and H in human pancreatic endocrine cells and insulinoma cells.
Insulinoma
Intracellular degradation of the C-peptide of proinsulin, in a human insulinoma: identification of sites of cleavage and evidence for a role for cathepsin B.
Intervertebral Disc Degeneration
Inflammatory biomarkers in sera of patients with intervertebral disc degeneration.
Intracranial Aneurysm
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.
Intracranial Aneurysm
Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms.
Intracranial Aneurysm
Differential expression levels of collagen 1A2, tissue inhibitor of metalloproteinase 4, and cathepsin B in intracranial aneurysms.
Intracranial Aneurysm
Gene Expression during the Development of Experimentally Induced Cerebral Aneurysms.
Intracranial Aneurysm
Study on the role of Cathepsin B and JNK signaling pathway in the development of cerebral aneurysm.
Irritable Bowel Syndrome
Is the genetic variability of Cathepsin B important in the pathogenesis of Blastocystis spp.?
Ischemic Attack, Transient
Correction to: Inactivation of NSF ATPase Leads to Cathepsin B Release After Transient Cerebral Ischemia.
Ischemic Attack, Transient
Inactivation of NSF ATPase Leads to Cathepsin B Release After Transient Cerebral Ischemia.
Ischemic Stroke
Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke.
Ischemic Stroke
CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke.
Ischemic Stroke
Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma.
Ischemic Stroke
Sevoflurane postconditioning attenuates reactive astrogliosis and glial scar formation after ischemia-reperfusion brain injury.
Joint Diseases
Cytochemical investigation of cathepsin B in rheumatoid synovial membrane and fluid.
Joint Diseases
Determination of cathepsins B and H in sera and synovial fluids of patients with different joint diseases.
Joint Diseases
Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint diseases.
Joint Diseases
The effects of fluoromethyl ketone inhibitors of cathepsin B on adjuvant induced arthritis.
Keloid
Expression of Cathepsins B, D and G by the Embryonic Stem Cell-like Population within Human Keloid Tissues and keloid-derived Primary Cell Lines.
Keratoconus
Are proteinases the reason for keratoconus?
Keratoconus
Effects of Sp1 overexpression on cultured human corneal stromal cells.
Keratoconus
Involvement of corneal nerves in the progression of keratoconus.
Keratoconus
Involvement of Sp1 elements in the promoter activity of genes affected in keratoconus.
Keratoconus
Is the corneal degradation in keratoconus caused by matrix-metalloproteinases?
Keratoconus
Kruppel-like factor 6 (KLF6) affects the promoter activity of the alpha1-proteinase inhibitor gene.
Keratoderma, Palmoplantar
Palmoplantar keratoderma caused by a missense variant in CTSB encoding cathepsin B.
Keratosis
Cathepsin B and D expression in squamous cell carcinoma.
Keratosis, Seborrheic
Comparison of proteinase activities in squamous cell carcinoma, basal cell epithelioma, and seborrheic keratosis.
Kidney Diseases
Renal Consequences of Gestational Diabetes Mellitus in Term Neonates: A Multidisciplinary Approach to the DOHaD Perspective in the Prevention and Early Recognition of Neonates of GDM Mothers at Risk of Hypertension and Chronic Renal Diseases in Later Life.
Laryngeal Neoplasms
Expression and clinical significance of cathepsin B and stefin A in laryngeal cancer.
Leiomyoma
Cathepsin B in human myometrium and in uterine leiomyomas at various stages of tumour growth.
Leishmaniasis
Switch of CD4+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis.
Leishmaniasis, Mucocutaneous
Specific human antibodies do not inhibit Trypanosoma cruzi oligopeptidase B and cathepsin B, and immunoglobulin G enhances the activity of trypomastigote-secreted oligopeptidase B.
Leishmaniasis, Visceral
Specific human antibodies do not inhibit Trypanosoma cruzi oligopeptidase B and cathepsin B, and immunoglobulin G enhances the activity of trypomastigote-secreted oligopeptidase B.
Leukemia
Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells.
Leukemia
Effect of protein kinase modulators on the regulation of cathepsin B activity in THP-1 human monocytic leukemia cells.
Leukemia
Glycogen synthase kinase-3beta mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia.
Leukemia
Modulatory Effect of Myokines on Reactive Oxygen Species in Ischemia/Reperfusion.
Leukemia
Nitric oxide induces the apoptosis of human BCR-ABL-positive myeloid leukemia cells: evidence for the chelation of intracellular iron.
Leukemia L1210
Determinants of the apoptotic response to lysosomal photodamage.
Leukemia, Lymphocytic, Chronic, B-Cell
[Comparative characterization of altered activity of lysosomal cysteine proteinases in various leukocytic fractions inpatients with chronic lymphocytic leukemia]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cathepsin B release after imatinib-mediated lysosomal membrane permeabilization triggers BCR-ABL cleavage and elimination of chronic myelogenous leukemia cells.
Leukemia, Myeloid
Murine myeloid leukemia: in vivo suppression by sericystatin A, a proteinase inhibitor from leukocytes.
Leukemia, Myeloid, Acute
Prognostic and therapeutic relevance of cathepsin B in pediatric acute myeloid leukemia.
Lichen Planus, Oral
Role of Cathepsin B as a Marker of Malignant Transformation in Oral Lichen Planus: An Immunohistochemical Study.
Liver Cirrhosis
Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease.
Liver Cirrhosis
Effect of colchicine on the activity of cathepsin B and D in human liver cirrhosis.
Liver Cirrhosis
Lysosomal cathepsins B and L and Stefin A blood levels in patients with hepatocellular carcinoma and/or liver cirrhosis: potential clinical implications.
Liver Cirrhosis
Regulation of TGF-?1-driven differentiation of human lung fibroblasts: emerging roles of cathepsin B and cystatin C.
Liver Diseases
Cysteine cathepsins control hepatic NF-?B-dependent inflammation via sirtuin-1 regulation.
Liver Diseases
Mir214-3p and Hnf4a/Hnf4? reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis.
Liver Failure, Acute
Hepatoprotective effects of cathepsin B inhibitor on acute hepatic failure induced by lipopolysaccharide/D-galactosamine in mice.
Liver Failure, Acute
Role of cathepsin B-mediated apoptosis in fulminant hepatic failure in mice.
Liver Neoplasms
The cycloartane triterpenoid ADCX impairs autophagic degradation through Akt overactivation and promotes apoptotic cell death in multidrug-resistant HepG2/ADM cells.
Liver Neoplasms
The secretion of high molecular weight cathepsin B from cultured human liver cancers.
Liver Neoplasms, Experimental
Serum cathepsin B activity during regression of Morris hepatoma 5123 D.
Lung Diseases
Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.
Lung Diseases
Association of airway cathepsin B and S with inflammation in cystic fibrosis.
Lung Diseases
Inhibition of neutrophil elastase-induced interleukin-8 gene expression by urinary trypsin inhibitor in human bronchial epithelial cells.
Lung Injury
Cathepsin B inhibition improves lung injury associated to D: -galactosamine/tumor necrosis factor-alpha-induced liver injury in mice.
Lung Neoplasms
An outlined review for the role of Nedd4-1 and Nedd4-2 in lung disorders.
Lung Neoplasms
Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues.
Lung Neoplasms
Cathepsin B and cysteine proteinase inhibitors in bronchoalveolar lavage fluid of lung cancer patients.
Lung Neoplasms
Cathepsin B and cysteine proteinase inhibitors in human lung cancer cell lines.
Lung Neoplasms
Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells.
Lung Neoplasms
Cathepsin B, plasminogenactivator-inhibitor (PAI-1) and plasminogenactivator-receptor (uPAR) are prognostic factors for patients with non-small cell lung cancer.
Lung Neoplasms
Cathepsin B, thiols and cysteine protease inhibitors in squamous-cell lung cancer.
Lung Neoplasms
Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients.
Lung Neoplasms
Detection of cathepsin B, plasminogen activators and plasminogen activator inhibitor in human non-small lung cancer cell lines.
Lung Neoplasms
Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer.
Lung Neoplasms
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
Lung Neoplasms
Immunochemical analysis of cathepsin B in lung tumours: an independent prognostic factor for squamous cell carcinoma patients.
Lung Neoplasms
Immunohistochemical study of cathepsin B. Prognostic significance in human lung cancer.
Lung Neoplasms
Laminin and cathepsin B as prognostic factors in stage I non-small cell lung cancer: are they useful?
Lung Neoplasms
Localization of cathepsin B in two human lung cancer cell lines.
Lung Neoplasms
Mechanism of action of Panax notoginoside against lung cancer in mice based on response to CTSB gene.
Lung Neoplasms
Multiple forms of cathepsin B in human lung cancer.
Lung Neoplasms
Prognostic impact of cathepsin B and matrix metalloproteinase-9 in pulmonary adenocarcinomas by immunohistochemical study.
Lung Neoplasms
Quantification of intracellular cathepsin activities in human lung tumor cell lines by flow cytometry.
Lung Neoplasms
Skeletal muscle mRNA levels for cathepsin B, but not components of the ubiquitin-proteasome pathway, are increased in patients with lung cancer referred for thoracotomy.
Lung Neoplasms
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
Lung Neoplasms
[Cathepsin B activity and concentration of elastase and alpha-1 proteinase inhibitor complex in non-small-cell lung cancer: 2 year follow-up study]
Lung Neoplasms
[Cathepsin B expression and its significance in non-small cell lung cancer tissues]
Lung Neoplasms
[Clinical indicators of malignancy of lung cancer]
Lung Neoplasms
[Molecular biological prognostic markers in lung cancer]
Lung Neoplasms
[Screening the Drug Sensitivity Genes Related to GEM and CDDP in the Lung Cancer Cell-lines.]
Lymphatic Metastasis
Cathepsin B may be a potential biomarker in cervical cancer.
Lymphatic Metastasis
Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients.
Lymphatic Metastasis
Expression and clinical significance of cathepsin B and stefin A in laryngeal cancer.
Lymphatic Metastasis
Heterogeneity of cathepsin B and stefin A expression in Gleason pattern 3+3 (score 6) prostate cancer needle biopsies.
Lymphatic Metastasis
Hormonal-receptor positive breast cancer: IL-6 augments invasion and lymph node metastasis via stimulating cathepsin B expression.
Lymphatic Metastasis
LncRNA DLX6-AS1 Promotes Malignant Phenotype and Lymph Node Metastasis in Prostate Cancer by Inducing LARGE Methylation.
Lymphatic Metastasis
MMP-9 and cathepsin B expression in tumor budding as an indicator of a more aggressive phenotype of colorectal cancer (CRC).
Lymphatic Metastasis
Prediction of pelvic lymph node metastasis by the ratio of cathepsin B to stefin A in patients with prostate carcinoma.
Lymphatic Metastasis
Study on cathepsin B activity in human thyroid tumors.
Lymphatic Metastasis
The expression of matrix metalloproteinase 9 and cathepsin B in gastric carcinoma is associated with lymph node metastasis, but not with postoperative survival.
Lymphohistiocytosis, Hemophagocytic
Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency.
Lymphoma
Immunohistochemical demonstration of cathepsin B in the macrophages of benign and malignant lymphoid tissues.
Lymphoma, Non-Hodgkin
Activity and concentration of cathepsin B as prognostic criteria for the development of mouse LS lymphosarcoma and Lewis lung adenocarcinoma.
Lymphoma, Non-Hodgkin
Cystatin C in LS lymphosarcoma and HA-1 hepatoma treated with Ukrain and cyclophosphamide and involvement of apoptosis.
Lysosomal Storage Diseases
Pathologic gene expression in Gaucher disease: up-regulation of cysteine proteinases including osteoclastic cathepsin K.
Lysosomal Storage Diseases
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Macular Degeneration
Cathepsin B pH-Dependent Activity Is Involved in Lysosomal Dysregulation in Atrophic Age-Related Macular Degeneration.
Macular Degeneration
[Prevention and treatment of age-related macular degeneration by extract of Fructus lycii and its constituents lutein/zeaxanthin: an in vive and in vitro experimental research].
Malaria
Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'.
Malaria, Cerebral
Proteolytic breakdown of cytoskeleton induces neurodegeneration during pathology of murine cerebral malaria.
Melanoma
A thiol protease inhibitor released from cultured human malignant melanoma cells.
Melanoma
Abl and Arg mediate cysteine cathepsin secretion to facilitate melanoma invasion and metastasis.
Melanoma
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.
Melanoma
Activity, expression, and transcription rate of the cathepsins B, D, H, and L in cutaneous malignant melanoma.
Melanoma
An intracellular form of cathepsin B contributes to invasiveness in cancer.
Melanoma
Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential.
Melanoma
Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study.
Melanoma
Cathepsin B inhibitory activities of phthalates isolated from a marine Pseudomonas strain.
Melanoma
Cathepsin B: association with plasma membrane in metastatic tumors.
Melanoma
Cathepsins B, H, and L and their inhibitors stefin A and cystatin C in sera of melanoma patients.
Melanoma
Cepharanthine as a Potential Novel Tumor-Regional Therapy in Treating Cutaneous Melanoma: Altering the Expression of Cathepsin B, Tumor Suppressor Genes and Autophagy-Related Proteins.
Melanoma
Characterization of multiple cathepsin B mRNAs in murine B16a melanoma.
Melanoma
Characterization of the cathepsin B gene and multiple mRNAs in human tissues: evidence for alternative splicing of cathepsin B pre-mRNA.
Melanoma
Clinical relevance of cathepsin B-like enzyme activity and cysteine proteinase inhibitor in melanocytic tumours.
Melanoma
Contact of high-invasive, but not low-invasive, melanoma cells to native collagen I induces the release of mature cathepsin B.
Melanoma
Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIP(L) from degradation by the E3 ligase itch in human melanoma cells.
Melanoma
Cystatin E/M suppresses legumain activity and invasion of human melanoma.
Melanoma
Differences in the expression of cathepsin B in B16 melanoma metastatic variants depend on transcription factor Sp1.
Melanoma
Effect of cysteine proteinase inhibitors on murine B16 melanoma cell invasion in vitro.
Melanoma
Enhanced levels of cathepsin B mRNA in murine tumors.
Melanoma
Estrogen-induced lysosomal proteases secreted by breast cancer cells: a role in carcinogenesis?
Melanoma
Expression of five cathepsins in murine melanomas of varying metastatic potential and normal tissues.
Melanoma
Fluorescent microplate assay for cancer cell-associated cathepsin B.
Melanoma
Gold Nanoparticles-Based Colorimetric Assay for Cathepsin B Activity and the Efficiency of Its Inhibitors.
Melanoma
IL8 and Cathepsin B as Melanoma Serum Biomarkers.
Melanoma
Immunocytochemical and immunoelectron microscopic demonstration of cathepsin B in human malignant melanoma.
Melanoma
Increased activity of cathepsin B in fibroblasts isolated from primary melanoma in comparison to fibroblasts from normal skin.
Melanoma
Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells.
Melanoma
Melanoma heterogeneity: differential, invasive, metastatic properties and profiles of cathepsin B, D and L activities in subclones of the B16F10-NEX2 cell line.
Melanoma
Microarrays of 41 human tumor cell lines for the characterization of new molecular targets: expression patterns of cathepsin B and the transferrin receptor.
Melanoma
Phosphorothioate oligodeoxynucleotides and G3139 induce apoptosis in 518A2 melanoma cells.
Melanoma
Pyridinyl imidazole compounds interfere with melanosomes sorting through the inhibition of cyclin G-associated Kinase, a regulator of cathepsins maturation.
Melanoma
Pyrimethamine induces apoptosis of melanoma cells via a caspase and cathepsin double-edged mechanism.
Melanoma
SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H.
Melanoma
SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B.
Melanoma
Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway.
Melanoma
Sp1 regulates cathepsin B transcription and invasiveness in murine B16 melanoma cells.
Melanoma
Targeting Cathepsin B for Cancer Therapies.
Melanoma
TGF-? signaling, activated stromal fibroblasts, and cysteine cathepsins B and L drive the invasive growth of human melanoma cells.
Melanoma
The expression of cathepsin B and other lysosomal proteinases in normal tissues and in tumors.
Melanoma
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Melanoma
Transcriptional regulation of cathepsin B expression in B16 melanomas of varying metastatic potential.
Melanoma
Tumor-associated cysteine proteinase activities in human melanoma cells and fibroblasts of different origin.
Melanoma, Amelanotic
Enhanced levels of cathepsin B mRNA in murine tumors.
Melanoma, Amelanotic
Tumor cell membrane cathepsin B.
Melanoma, Experimental
A lipoxygenase metabolite, 12-(S)-HETE, stimulates protein kinase C-mediated release of cathepsin B from malignant cells.
Melanoma, Experimental
Activation of protein kinase C-alpha isoform in murine melanoma cells with high metastatic potential.
Melanoma, Experimental
Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential.
Melanoma, Experimental
Cathepsin B: association with plasma membrane in metastatic tumors.
Melanoma, Experimental
Characterization of multiple cathepsin B mRNAs in murine B16a melanoma.
Melanoma, Experimental
Differences in induction of lysosomal protease activity by protease inhibitors in B16 melanoma cell lines.
Melanoma, Experimental
Differences in the expression of cathepsin B in B16 melanoma metastatic variants depend on transcription factor Sp1.
Melanoma, Experimental
Induction and inhibition of cathepsin B and hemoglobin-hydrolase activity in murine B16 melanoma by thiol protease inhibitors.
Melanoma, Experimental
Interaction of tumor and surrounding tissue of mice inoculated B16 melanoma variants in terms of enzyme activity.
Melanoma, Experimental
Lysosomal cathepsin B: correlation with metastatic potential.
Melanoma, Experimental
Sp1 regulates cathepsin B transcription and invasiveness in murine B16 melanoma cells.
Melanoma, Experimental
The expression of cathepsin B and other lysosomal proteinases in normal tissues and in tumors.
Melanoma, Experimental
The malignant phenotype and cysteine proteinases.
Melanoma, Experimental
Transcriptional regulation of cathepsin B expression in B16 melanomas of varying metastatic potential.
Memory Disorders
Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease.
Memory Disorders
Deletion of the Cathepsin B Gene Improves Memory Deficits in a Transgenic Alzheimer's Disease Mouse Model Expressing A?PP Containing the Wild-Type ?-Secretase Site Sequence.
Memory Disorders
Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease.
Memory Disorders
The Cysteine Protease Inhibitor, E64d, Reduces Brain Amyloid-? and Improves Memory Deficits in Alzheimer's Disease Animal Models by Inhibiting Cathepsin B, but not BACE1, ?-Secretase Activity.
Meningioma
Cathepsins B and L are markers for clinically invasive types of meningiomas.
Meningioma
Lysosomal enzymes, cathepsins in brain tumour invasion.
Meningioma
Oncogenic role of p53 is suppressed by si-RNA bicistronic construct of uPA, uPAR and cathepsin-B in meningiomas both in vitro and in vivo.
Meningioma
Proteases in brain tumour progression.
Meningioma
RNAi-mediated abrogation of cathepsin B and MMP-9 gene expression in a malignant meningioma cell line leads to decreased tumor growth, invasion and angiogenesis.
Meningioma
S100A5: a marker of recurrence in WHO grade I meningiomas.
Meningioma
Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors.
Meningioma
uPAR and cathepsin B shRNA impedes TGF-?1-driven proliferation and invasion of meningioma cells in a XIAP-dependent pathway.
Meningitis, Pneumococcal
The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release.
Mesothelioma
Identifying Thoracic Malignancies Through Pleural Fluid Biomarkers: A Predictive Multivariate Model.
Mouth Neoplasms
Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells.
Mouth Neoplasms
Cathepsin B SNPs elevate the pathological development of oral cancer and raise the susceptibility to carcinogen-mediated oral cancer.
Mouth Neoplasms
Differential susceptibility of metastatic and primary oral cancer cells to TRAIL-induced apoptosis.
Mouth Neoplasms
Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer.
Movement Disorders
Characterization of the Cerebrospinal Fluid Proteome in Patients with Fragile X-Associated Tremor/Ataxia Syndrome.
Mucolipidoses
Collagen degradation in I-cells is normal.
Mucopolysaccharidoses
Progressive heart disease in mucopolysaccharidosis type I mice may be mediated by increased cathepsin B activity.
Mucopolysaccharidosis I
Cathepsin B inhibition attenuates cardiovascular pathology in mucopolysaccharidosis I mice.
Mucopolysaccharidosis I
Progressive heart disease in mucopolysaccharidosis type I mice may be mediated by increased cathepsin B activity.
Multiple Myeloma
Potentiation of apoptosis by histone deacetylase inhibitors and doxorubicin combination: cytoplasmic cathepsin B as a mediator of apoptosis in multiple myeloma.
Multiple Sclerosis
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate.
Multiple Sclerosis
Increased cathepsin B activity in multiple sclerosis brain.
Multiple Sclerosis
Increased cathepsin B activity in peripheral blood mononuclear cells of multiple sclerosis patients.
Multiple Sclerosis
Redundancy between Cysteine Cathepsins in Murine Experimental Autoimmune Encephalomyelitis.
Muscular Atrophy
Daily variations in dietary lysine content alter the expression of genes related to proteolysis in chicken pectoralis major muscle.
Muscular Atrophy
Inhibitors of prostaglandin synthesis or cathepsin B prevent muscle wasting due to sepsis in the rat.
Muscular Atrophy
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Muscular Diseases
Endogenous cathepsin B inhibitor activity in normal and myopathic red and white skeletal muscle.
Muscular Dystrophies
Chymostatin has no apparent beneficial effect on muscular dystrophy in the mdx mouse.
Muscular Dystrophies
Paradoxical effect of leupeptin in vivo on cathepsin B activity.
Muscular Dystrophies
Serine protease in mice with hereditary muscular dystrophy.
Muscular Dystrophies
Theoretical insight into the mechanism for the inhibition of the cysteine protease cathepsin B by 1,2,4-thiadiazole derivatives.
Muscular Dystrophy, Duchenne
Non-invasive Optical Imaging of Muscle Pathology in mdx Mice Using Cathepsin Caged Near-Infrared Imaging.
Muscular Dystrophy, Oculopharyngeal
Rimmed vacuoles of inclusion body myositis and oculopharyngeal muscular dystrophy contain amyloid precursor protein and lysosomal markers.
Myocardial Infarction
CA-074Me inhibits Cathepsin-B and alleviates fibrosis after myocardial infarction.
Myocardial Infarction
Cathepsin B inhibition attenuates cardiac dysfunction and remodeling following myocardial infarction by inhibiting the NLRP3 pathway.
Myocardial Infarction
Enhanced myocardial cathepsin B expression in patients with dilated cardiomyopathy.
Myocardial Infarction
Influence of isoproterenol-induced myocardial infarction on certain glycohydrolases and cathepsins in rats.
Myocardial Infarction
Levels of cathepsins in acute myocardial infarction.
Myocardial Infarction
Suppression of myocardial protein degradation by the protease inhibitor bis[ethyl(2R,3R)-3-[(S)-methyl-1-[4-(2,3,4-tri-methoxy-phenyl-methyl) piperazine-1-ylcarbonyl]butyl-carbonyl]oxiran-2-carboxylat e]sulfate under hypoxia.
Myocardial Infarction
[Retracted] Cathepsin B inhibition attenuates cardiac dysfunction and remodeling following myocardial infarction by inhibiting the NLRP3 pathway.
Myocardial Ischemia
Degradation of the cardiac sarcoplasmic reticulum in acute myocardial ischemia.
Myocardial Ischemia
Degrading process of acute ischemic myocardial cells.
Myocarditis
Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis.
Myoclonic Epilepsies, Progressive
Altered Expression of Peroxiredoxins in Mouse Model of Progressive Myoclonus Epilepsy upon LPS-Induced Neuroinflammation.
Myoclonic Epilepsies, Progressive
Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1).
Myoclonic Epilepsies, Progressive
Thickened skull, scoliosis and other skeletal findings in Unverricht-Lundborg disease link cystatin B function to bone metabolism.
Myositis
Rimmed vacuoles of inclusion body myositis and oculopharyngeal muscular dystrophy contain amyloid precursor protein and lysosomal markers.
Myositis, Inclusion Body
Rimmed vacuoles of inclusion body myositis and oculopharyngeal muscular dystrophy contain amyloid precursor protein and lysosomal markers.
Myotonic Dystrophy
Leukocyte protease activities in myotonic dystrophy: studies on effects of protease inhibitors.
Nasopharyngeal Carcinoma
Diagnostic values of serum cathepsin B and D in patients with nasopharyngeal carcinoma.
Neoplasm Invasiveness
[Cathepsin B and neoplasm invasiveness]
Neoplasm Metastasis
A Digital Pathology-Based Shotgun-Proteomics Approach to Biomarker Discovery in Colorectal Cancer.
Neoplasm Metastasis
A functional proteomics screen of proteases in colorectal carcinoma.
Neoplasm Metastasis
A polymorphic marker for the human cathepsin B gene.
Neoplasm Metastasis
A possible application of cathepsin B activity determination for estimating the spread of the cervix uteri carcinoma.
Neoplasm Metastasis
A suppressor of multiple extracellular matrix-degrading proteases and cancer metastasis.
Neoplasm Metastasis
Abl and Arg mediate cysteine cathepsin secretion to facilitate melanoma invasion and metastasis.
Neoplasm Metastasis
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.
Neoplasm Metastasis
Alkyne-tag SERS screening and identification of small-molecule-binding sites in protein.
Neoplasm Metastasis
Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.
Neoplasm Metastasis
An outlined review for the role of Nedd4-1 and Nedd4-2 in lung disorders.
Neoplasm Metastasis
Analysis of heparanase isoforms and cathepsin B in the plasma of patients with gastrointestinal carcinomas: analytical cross-sectional study.
Neoplasm Metastasis
Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis.
Neoplasm Metastasis
Beta-cyclodextrin/epoxysuccinyl peptide conjugates: a new drug targeting system for tumor cells.
Neoplasm Metastasis
Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer.
Neoplasm Metastasis
Cancer metastasis: biological and clinical aspects.
Neoplasm Metastasis
Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential.
Neoplasm Metastasis
Cathepsin B activity in human lung tumor cell lines: ultrastructural localization, pH sensitivity, and inhibitor status at the cellular level.
Neoplasm Metastasis
Cathepsin B activity regulation. Heparin-like glycosaminogylcans protect human cathepsin B from alkaline pH-induced inactivation.
Neoplasm Metastasis
Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasis.
Neoplasm Metastasis
Cathepsin B and its role(s) in cancer progression.
Neoplasm Metastasis
Cathepsin B and L activities in gastric cancer tissue: correlation with histological findings.
Neoplasm Metastasis
Cathepsin B defines leader cells during the collective invasion of salivary adenoid cystic carcinoma.
Neoplasm Metastasis
Cathepsin B expression and its correlation with tumor-associated laminin and tumor progression in gastric cancer.
Neoplasm Metastasis
Cathepsin B in cells of two rat sarcomas with different rates of spontaneous metastasis.
Neoplasm Metastasis
Cathepsin B in human breast tumor tissue and cancer cells.
Neoplasm Metastasis
Cathepsin B in infiltrated lymph nodes is of prognostic significance for patients with nonsmall cell lung carcinoma.
Neoplasm Metastasis
Cathepsin B in predicting the extent of the cervix carcinoma.
Neoplasm Metastasis
Cathepsin B in the growth of colorectal cancer: increased activity of cathepsin B in human colorectal cancer.
Neoplasm Metastasis
Cathepsin B in the growth of colorectal cancer: suppressive effect of leupeptin on the growth of DMH-induced rat colon neoplasm.
Neoplasm Metastasis
Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer.
Neoplasm Metastasis
Cathepsin B on invasion and metastasis of gastric carcinoma.
Neoplasm Metastasis
Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis.
Neoplasm Metastasis
Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice.
Neoplasm Metastasis
Cathepsin B trafficking in thyroid carcinoma cells.
Neoplasm Metastasis
Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies.
Neoplasm Metastasis
Cathepsin B: a sellsword of cancer progression.
Neoplasm Metastasis
Cathepsin B: could it prevent bone metastases from breast cancer?
Neoplasm Metastasis
Cathepsin B: Multiple Roles in Cancer.
Neoplasm Metastasis
Cathepsins B, H and L in human breast carcinoma.
Neoplasm Metastasis
CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma.
Neoplasm Metastasis
Characterization of 3 oral squamous cell carcinoma cell lines with different invasion and/or metastatic potentials.
Neoplasm Metastasis
Characterization of protease expression in human prostate-cancer cell-lines.
Neoplasm Metastasis
Cigarette smoke condensate increases cathepsin-mediated invasiveness of oral carcinoma cells.
Neoplasm Metastasis
Clioquinol-ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity.
Neoplasm Metastasis
Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells.
Neoplasm Metastasis
Codistribution of procathepsin B and mature cathepsin B forms in human prostate tumors detected by confocal and immunofluorescence microscopy.
Neoplasm Metastasis
Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients.
Neoplasm Metastasis
Detection of fibronectin conformational changes in the extracellular matrix of live cells using plasmonic nanoplates.
Neoplasm Metastasis
Development of Novel Bisphosphonate Prodrugs of Doxorubicin for Targeting Bone Metastases That Are Cleaved pH Dependently or by Cathepsin B: Synthesis, Cleavage Properties, and Binding Properties to Hydroxyapatite As Well As Bone Matrix.
Neoplasm Metastasis
Diagnostic Efficiency of Serum and Urine Procathepsin B and Cathepsin B in Patients with Carcinoma of the Urinary Bladder.
Neoplasm Metastasis
Differences in cysteine peptidases-like activity in sera of patients with breast cancer.
Neoplasm Metastasis
Differential levels of cathepsin B and L in serum between young and aged healthy people and their association with matrix metalloproteinase 2.
Neoplasm Metastasis
Drug-resistant human laryngeal carcinoma cells have increased levels of cathepsin B.
Neoplasm Metastasis
Effect of liver macrophage depression on the development of liver metastases of HA-1 tumor in mice.
Neoplasm Metastasis
Effect of protein kinase modulators on the regulation of cathepsin B activity in THP-1 human monocytic leukemia cells.
Neoplasm Metastasis
Effects of E-64 (cysteine-proteinase inhibitor) and pepstatin (aspartyl-proteinase inhibitor) on metastasis formation in mice with mammary and ovarian tumors.
Neoplasm Metastasis
Effects of zoledronic acid on proteinase plasma levels in patients with bone metastases.
Neoplasm Metastasis
Expression of cathepsin B and cystatin C in human colorectal cancer.
Neoplasm Metastasis
Expression of Cathepsin B and L antigen and activity is associated with early colorectal cancer progression.
Neoplasm Metastasis
Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma.
Neoplasm Metastasis
Expression of five cathepsins in murine melanomas of varying metastatic potential and normal tissues.
Neoplasm Metastasis
Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients.
Neoplasm Metastasis
Expression, subcellular distribution and plasma membrane binding of cathepsin B and gelatinases in bone metastatic tissue.
Neoplasm Metastasis
Fluorescent microplate assay for cancer cell-associated cathepsin B.
Neoplasm Metastasis
Functional selection of protease inhibitory antibodies.
Neoplasm Metastasis
Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents.
Neoplasm Metastasis
Heterogeneity of cathepsin B and stefin A expression in Gleason pattern 3+3 (score 6) prostate cancer needle biopsies.
Neoplasm Metastasis
Heterogeneous suppression of experimentally induced colon cancer metastasis in rat liver lobes by inhibition of extracellular cathepsin B.
Neoplasm Metastasis
High levels of cathepsin B predict poor outcome in patients with breast cancer.
Neoplasm Metastasis
Hormonal-receptor positive breast cancer: IL-6 augments invasion and lymph node metastasis via stimulating cathepsin B expression.
Neoplasm Metastasis
Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells.
Neoplasm Metastasis
Identification of upregulated genes in the thymus of spontaneously hypertensive rats by cDNA representational difference analysis.
Neoplasm Metastasis
IGF-1 promotes the growth and metastasis of hepatocellular carcinoma via the inhibition of proteasome-mediated cathepsin B degradation.
Neoplasm Metastasis
Imaging Sites of Inhibition of Proteolysis in Pathomimetic Human Breast Cancer Cultures by Light-Activated Ruthenium Compound.
Neoplasm Metastasis
Immunohistochemical analysis of cathepsin B expression in human lung adenocarcinoma: the role in cancer progression.
Neoplasm Metastasis
Immunohistochemical distributions of cathepsin B and basement membrane antigens in human lung adenocarcinoma: association with invasion and metastasis.
Neoplasm Metastasis
Immunohistochemical localization of cathepsin B in neoplastic human prostate.
Neoplasm Metastasis
Immunohistochemical study on cathepsin-B and cathepsin-d in pancreatic-cancer.
Neoplasm Metastasis
Improved synthesis strategy for peptide nucleic acids (PNA) appropriate for cell-specific fluorescence imaging.
Neoplasm Metastasis
Increased cathepsin B activity in human lung tumors.
Neoplasm Metastasis
Increased expression of cathepsins L and B and decreased activity of their inhibitors in metastatic, ras-transformed NIH 3T3 cells.
Neoplasm Metastasis
Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples.
Neoplasm Metastasis
Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells.
Neoplasm Metastasis
Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64.
Neoplasm Metastasis
Inhibition of invasion and metastasis of MHCC97H cells by expression of snake venom cystatin through reduction of proteinases activity and epithelial-mesenchymal transition.
Neoplasm Metastasis
Interaction of tumor and surrounding tissue of mice inoculated B16 melanoma variants in terms of enzyme activity.
Neoplasm Metastasis
Internalization of cystatin C in human cell lines.
Neoplasm Metastasis
Invasion of ras-transformed breast epithelial cells depends on the proteolytic activity of cysteine and aspartic proteinases.
Neoplasm Metastasis
iRGD-targeted delivery of a pro-apoptotic peptide activated by cathepsin B inhibits tumor growth and metastasis in mice.
Neoplasm Metastasis
Knockdown of cathepsin B and uPAR inhibits CD151 and ?3?1 integrin-mediated cell adhesion and invasion in glioma.
Neoplasm Metastasis
Laminin and cathepsin B as prognostic factors in stage I non-small cell lung cancer: are they useful?
Neoplasm Metastasis
LncRNA DLX6-AS1 Promotes Malignant Phenotype and Lymph Node Metastasis in Prostate Cancer by Inducing LARGE Methylation.
Neoplasm Metastasis
Localization of a biotinylated cathepsin B oligonucleotide probe in human prostate including invasive cells and invasive edges by in situ hybridization.
Neoplasm Metastasis
Localization of cathepsin B in two human lung cancer cell lines.
Neoplasm Metastasis
Lysosome-Targeting Fluorogenic Probe for Cathepsin B Imaging in Living Cells.
Neoplasm Metastasis
MMP-9 and cathepsin B expression in tumor budding as an indicator of a more aggressive phenotype of colorectal cancer (CRC).
Neoplasm Metastasis
MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice.
Neoplasm Metastasis
Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C.
Neoplasm Metastasis
Molecular dynamic simulation (MDS) and in vitro cathepsin-B inhibitory activity of decrusin angelate, ibuprofen, and thymol.
Neoplasm Metastasis
Molecular Mechanisms by Which S100A4 Regulates the Migration and Invasion of PGCCs With Their Daughter Cells in Human Colorectal Cancer.
Neoplasm Metastasis
Monocyte-derived macrophage assisted breast cancer cell invasion as a personalized, predictive metric to score metastatic risk.
Neoplasm Metastasis
MTA1 drives malignant progression and bone metastasis in prostate cancer.
Neoplasm Metastasis
Nitroxoline impairs tumor progression in vitro and in vivo by regulating cathepsin B activity.
Neoplasm Metastasis
Non-invasive optical imaging of cathepsin B with activatable fluorogenic nanoprobes in various metastatic models.
Neoplasm Metastasis
Nuclear cysteine cathepsin variants in thyroid carcinoma cells.
Neoplasm Metastasis
Nucleolin-Targeted Ratiometric Fluorescent Carbon Dots with a Remarkably Large Emission Wavelength Shift for Precise Imaging of Cathepsin B in Living Cancer Cells.
Neoplasm Metastasis
Observing proteases in living cells.
Neoplasm Metastasis
Organoruthenated Nitroxoline Derivatives Impair Tumor Cell Invasion through Inhibition of Cathepsin B Activity.
Neoplasm Metastasis
Overexpression of cathepsin B and urokinase plasminogen activator is associated with increased risk of recurrence and metastasis in patients with chondrosarcoma.
Neoplasm Metastasis
Overexpression of cathepsin B in gastric cancer identified by proteome analysis.
Neoplasm Metastasis
Overexpression of cysteine cathepsin L is a marker of invasion and metastasis in ovarian cancer.
Neoplasm Metastasis
Overexpression of stefin A in human esophageal squamous cell carcinoma cells inhibits tumor cell growth, angiogenesis, invasion, and metastasis.
Neoplasm Metastasis
Pancreatic trypsinogen and cathepsin B in human pancreatic carcinomas and associated metastatic lesions.
Neoplasm Metastasis
Polymorphism L26V in the cathepsin B gene may be associated with a risk of prostate cancer and differentiation.
Neoplasm Metastasis
Prediction of pelvic lymph node metastasis by the ratio of cathepsin B to stefin A in patients with prostate carcinoma.
Neoplasm Metastasis
Primary tumour expression of the cysteine cathepsin inhibitor Stefin A inhibits distant metastasis in breast cancer.
Neoplasm Metastasis
Prognostic impact of cathepsin B and matrix metalloproteinase-9 in pulmonary adenocarcinomas by immunohistochemical study.
Neoplasm Metastasis
Prognostic value of the cysteine proteases cathepsins B and cathepsin L in human breast cancer.
Neoplasm Metastasis
Purification and characterisation of an inhibitor of a cathepsin B-like proteinase from sunflower seed.
Neoplasm Metastasis
Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice.
Neoplasm Metastasis
Reduction of experimental human fibrosarcoma lung metastasis in mice by adenovirus-mediated cystatin C overexpression in the host.
Neoplasm Metastasis
Regulation of cathepsin B activity by modulators of arachidonic acid metabolism in human monocytes.
Neoplasm Metastasis
RNA interference mediated suppression of TRPV6 inhibits the progression of prostate cancer in vitro by modulating cathepsin B and MMP9 expression.
Neoplasm Metastasis
Serum cathepsin B and plasma urokinase-type plasminogen activator levels in gastrointestinal tract cancers.
Neoplasm Metastasis
Serum cathepsin B levels and urinary excretion of cathepsin B in the cancer patients with remote metastasis.
Neoplasm Metastasis
Serum level of cathepsin B and its density in men with prostate cancer as novel markers of disease progression.
Neoplasm Metastasis
Signal amplification in immunohistochemistry at the light microscopic level using biotinylated tyramide and nanogold-silver staining.
Neoplasm Metastasis
Simultaneous enzyme overlay membrane (EOM)-based in situ zymography and immunofluorescence technique reveals cathepsin B-like activity in a subset of tumour vessels.
Neoplasm Metastasis
Strategy in inhibition of cathepsin B, a target in tumor invasion and metastasis.
Neoplasm Metastasis
Study on cathepsin B activity in human thyroid tumors.
Neoplasm Metastasis
Sunitinib treatment promotes metastasis of drug-resistant renal cell carcinoma via TFE3 signaling pathway.
Neoplasm Metastasis
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.
Neoplasm Metastasis
Synthesis of Novel Nitroxoline Analogs with Potent Cathepsin B Exopeptidase Inhibitory Activity.
Neoplasm Metastasis
Targeting Cathepsin B for Cancer Therapies.
Neoplasm Metastasis
The effect of 3-bromopyruvate on the properties of cathepsin B in the aspect of metastatic potential of colon cancer cells.
Neoplasm Metastasis
The expression of matrix metalloproteinase 9 and cathepsin B in gastric carcinoma is associated with lymph node metastasis, but not with postoperative survival.
Neoplasm Metastasis
The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer.
Neoplasm Metastasis
The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer.
Neoplasm Metastasis
The metastatic potential of human pancreatic cell lines in the liver of nude mice correlates well with cathepsin B activity.
Neoplasm Metastasis
The Role of Cathepsins in Involution and Breast Cancer.
Neoplasm Metastasis
The role of cysteine and serine proteases in colorectal carcinoma.
Neoplasm Metastasis
The role of proteolytic enzymes in cancer invasion and metastasis.
Neoplasm Metastasis
Theoretical insight into the mechanism for the inhibition of the cysteine protease cathepsin B by 1,2,4-thiadiazole derivatives.
Neoplasm Metastasis
Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice.
Neoplasm Metastasis
Tumor cathepsin B and its endogenous inhibitors in metastasis.
Neoplasm Metastasis
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.
Neoplasm Metastasis
Unraveling the role of proteases in cancer.
Neoplasm Metastasis
uPAR enhances malignant potential of triple-negative breast cancer by directly interacting with uPA and IGF1R.
Neoplasm Metastasis
Upregulation of cystatin M during the progression of oropharyngeal squamous cell carcinoma from primary tumor to metastasis.
Neoplasm Metastasis
Variant cathepsin B activity secreted from human pancreatic cancer cell lines into protein-free chemically defined medium.
Neoplasm Metastasis
[A study on cathepsin B-like substance in cancer of the urinary tract]
Neoplasm Metastasis
[A study on cathepsin B-like substance in patients with urological cancer]
Neoplasm Metastasis
[Cathepsin B activity and concentration of elastase and alpha-1 proteinase inhibitor complex in non-small-cell lung cancer: 2 year follow-up study]
Neoplasm Metastasis
[Expression of cathepsin B and its clinical importance in colorectal cancer]
Neoplasm Metastasis
[Prognostic significance and clinic utility of serum and immunohistochemical cathepsin B levels in colorectal cancer]
Neoplasm Metastasis
[Prognostic significance of determining cathepsin B activity in malignant ovarian tumors]
Neoplasm Metastasis
[Role and behavior of cathepsin B and cathepsin L in gastric cancer]
Neoplasms
A case of secretin-responsive insulinoma with low serum C-peptide levels.
Neoplasms
A Digital Pathology-Based Shotgun-Proteomics Approach to Biomarker Discovery in Colorectal Cancer.
Neoplasms
A Dual-Targeting Octaguanidine-Doxorubicin Conjugate Transporter for Inducing Caspase-Mediated Apoptosis on Folate-Expressing Cancer Cells.
Neoplasms
A folate receptor-specific activatable probe for near-infrared fluorescence imaging of ovarian cancer.
Neoplasms
A functional proteomics screen of proteases in colorectal carcinoma.
Neoplasms
A highly potential cleavable linker for tumor targeting antibody-chemokines.
Neoplasms
A latent form of cathepsin B in pleural effusions. I. Characterization of the enzyme in breast cancer patients.
Neoplasms
A latent thiol proteinase from ascitic fluid of patients with neoplasia.
Neoplasms
A minimal critical region of the 8p22-23 amplicon in esophageal adenocarcinomas defined using sequence tagged site-amplification mapping and quantitative polymerase chain reaction includes the GATA-4 gene.
Neoplasms
A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma.
Neoplasms
A novel cysteine cathepsin inhibitor yields macrophage cell death and mammary tumor regression.
Neoplasms
A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion.
Neoplasms
A partial catalog of proteins secreted by epidermal keratinocytes in culture.
Neoplasms
A Peptide-Duocarmycin Conjugate Targeting the Thomsen-Friedenreich Antigen Has Potent and Selective Antitumor Activity.
Neoplasms
A polymorphic marker for the human cathepsin B gene.
Neoplasms
A possible application of cathepsin B activity determination for estimating the spread of the cervix uteri carcinoma.
Neoplasms
A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase.
Neoplasms
A suppressor of multiple extracellular matrix-degrading proteases and cancer metastasis.
Neoplasms
A triple-targeting delivery system carrying two anticancer agents.
Neoplasms
A4383C and C76G SNP in Cathepsin B is respectively associated with the high risk and tumor size of hepatocarcinoma.
Neoplasms
Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through up-regulation of cathepsin B.
Neoplasms
Acid-mediated tumor proteolysis: contribution of cysteine cathepsins.
Neoplasms
Action of endogenous proteases on the distribution of tyrosinase isozymes in Harding-Passey mouse melanoma.
Neoplasms
Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases.
Neoplasms
Activity and concentration of cathepsin B as prognostic criteria for the development of mouse LS lymphosarcoma and Lewis lung adenocarcinoma.
Neoplasms
Activity of cathepsin B and D in colorectal cancer: relationships with tumour budding.
Neoplasms
Activity of Cathepsin B in Serum of Patients after Kidney Transplantation Depends on Glucocorticosteroids Treatment.
Neoplasms
Activity, expression, and transcription rate of the cathepsins B, D, H, and L in cutaneous malignant melanoma.
Neoplasms
Addition of 2-(ethylamino)acetonitrile group to nitroxoline results in significantly improved anti-tumor activity in vitro and in vivo.
Neoplasms
Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas.
Neoplasms
Advances in bladder cancer.
Neoplasms
Albumin-binding prodrugs of camptothecin and doxorubicin with an Ala-Leu-Ala-Leu-linker that are cleaved by cathepsin B: synthesis and antitumor efficacy.
Neoplasms
Alkyne-tag SERS screening and identification of small-molecule-binding sites in protein.
Neoplasms
Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.
Neoplasms
Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B.
Neoplasms
An intracellular form of cathepsin B contributes to invasiveness in cancer.
Neoplasms
An intracellularly activatable, fluorogenic probe for cancer imaging.
Neoplasms
Analysis of heparanase isoforms and cathepsin B in the plasma of patients with gastrointestinal carcinomas: analytical cross-sectional study.
Neoplasms
Angiogenesis and cathepsin expression are prognostic factors in pancreatic adenocarcinoma after curative resection.
Neoplasms
Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer.
Neoplasms
Anticancer C,N-cycloplatinated(II) complexes containing fluorinated phosphine ligands: synthesis, structural characterization, and biological activity.
Neoplasms
Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis.
Neoplasms
Aptitude of auricular and nasoseptal chondrocytes cultured under a monolayer or three-dimensional condition for cartilage tissue engineering.
Neoplasms
Artemisinin-Based Smart Nanomedicines with Self-Supply of Ferrous Ion to Enhance Oxidative Stress for Specific and Efficient Cancer Treatment.
Neoplasms
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue.
Neoplasms
Association of airway cathepsin B and S with inflammation in cystic fibrosis.
Neoplasms
Bacillus Calmette-Guerin abrogates in vitro invasion and motility of human bladder tumor cells via fibronectin interaction.
Neoplasms
Bcl-2 expression and apoptosis induction in human HL60 leukaemic cells treated with a novel organotellurium(IV) compound RT-04.
Neoplasms
Benign clear (sugar) cell tumor of the lung with CD1a expression.
Neoplasms
Benign cutaneous histiocytic tumors in childhood and adolescence, excluding Langerhans' cell proliferations. A clinicopathologic and immunohistochemical analysis.
Neoplasms
Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor.
Neoplasms
Beta-cyclodextrin/epoxysuccinyl peptide conjugates: a new drug targeting system for tumor cells.
Neoplasms
Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis.
Neoplasms
Binding of chondroitin 4-sulfate to cathepsin s regulates its enzymatic activity.
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Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting.
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Biological and clinical characterization of paclitaxel poliglumex (PPX, CT-2103), a macromolecular polymer-drug conjugate.
Neoplasms
Biological evaluation of a novel Herceptin-platinum (II) conjugate for efficient and cancer cell specific delivery.
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Biological inhibitory effects of the Chinese herb danggui on brain astrocytoma.
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Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.
Neoplasms
BODIPY-Caged Photoactivated Inhibitors of Cathepsin B Flip the Light Switch on Cancer Cell Apoptosis.
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Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer.
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Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation.
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c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer.
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Caffeine suppresses the progression of human glioblastoma via cathepsin B and MAPK signaling pathway.
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Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues.
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Caspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis.
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Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential.
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Cathepsin B activity in human lung tumor cell lines: ultrastructural localization, pH sensitivity, and inhibitor status at the cellular level.
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Cathepsin B activity regulation. Heparin-like glycosaminogylcans protect human cathepsin B from alkaline pH-induced inactivation.
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Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor.
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Cathepsin B and Cathepsin D Expression in Follicular Adenomas and Carcinomas of the Thyroid Gland.
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Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma.
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Cathepsin B and cystatins: evidence for a role in cancer progression.
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Cathepsin B and cysteine proteinase inhibitors in bronchoalveolar lavage fluid of lung cancer patients.
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Cathepsin B and D expression in squamous cell carcinoma.
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Cathepsin B and glioma invasion.
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Cathepsin B and human tumor progression.
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Cathepsin B and its endogenous inhibitors: the role in tumor malignancy.
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Cathepsin B and its inhibitor stefin A in brain tumors.
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Cathepsin B and its role(s) in cancer progression.
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Cathepsin B and L and stefin A and B levels as serum tumor markers in squamous cell carcinoma of the head and neck.
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Cathepsin B and L inhibitors: a patent review (2010 - present).
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Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment.
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Cathepsin B and tumor-associated laminin expression in the progression of colorectal adenoma to carcinoma.
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Cathepsin B and uPAR knockdown inhibits tumor-induced angiogenesis by modulating VEGF expression in glioma.
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Cathepsin B as a cancer target.
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Cathepsin B containing cells in the rabbit mesentery during invasion of V2 carcinoma cells.
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Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF?/ASK1/JNK pathway.
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Cathepsin B defines leader cells during the collective invasion of salivary adenoid cystic carcinoma.
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Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).
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Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes.
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Cathepsin B expression and its correlation with tumor-associated laminin and tumor progression in gastric cancer.
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Cathepsin B expression and laminin degradation as factors influencing prognosis of surgically treated patients with lung adenocarcinoma.
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Cathepsin B expression and localization in glioma progression and invasion.
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Cathepsin B Expression and Survival in Colon Cancer: Implications for Molecular Detection of Neoplasia.
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Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival.
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Cathepsin B expression in human tumors.
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Cathepsin B expression in tumour cells and laminin distribution in pulmonary adenocarcinoma.
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Cathepsin B expression is similar in African-American and Caucasian prostate cancer patients.
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Cathepsin B fraction active at physiological pH of 7.5 is of prognostic significance in squamous cell carcinoma of human lung.
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Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors.
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Cathepsin B in angiogenesis of human prostate: an immunohistochemical and immunoelectron microscopic analysis.
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Cathepsin B in cells of two rat sarcomas with different rates of spontaneous metastasis.
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Cathepsin B in human breast tumor tissue and cancer cells.
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Cathepsin B in human myometrium and in uterine leiomyomas at various stages of tumour growth.
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Cathepsin B in infiltrated lymph nodes is of prognostic significance for patients with nonsmall cell lung carcinoma.
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Cathepsin B in predicting the extent of the cervix carcinoma.
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Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis.
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Cathepsin B in the growth of colorectal cancer: increased activity of cathepsin B in human colorectal cancer.
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Cathepsin B in the growth of colorectal cancer: suppressive effect of leupeptin on the growth of DMH-induced rat colon neoplasm.
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Cathepsin B in tumors, normal tissue and isolated cells from the human lung.
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Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer.
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Cathepsin B inhibitors: Further exploration of the nitroxoline core.
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Cathepsin B is involved in the apoptosis intrinsic pathway induced by Bacillus Calmette-Guérin in transitional cancer cell lines.
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Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications.
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Cathepsin B may be a potential biomarker in cervical cancer.
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Cathepsin B mediates the pH-dependent proinvasive activity of tumor-shed microvesicles.
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Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells.
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Cathepsin B promotes both motility and invasiveness of oral carcinoma cells.
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Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis.
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Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice.
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Cathepsin B protein levels in endometrial cancer: Potential value as a tumour biomarker.
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Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells.
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Cathepsin B to cysteine proteinase inhibitor balance in metastatic cell subpopulations isolated from murine tumors.
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Cathepsin B Turning Bioluminescence "On" for Tumor Imaging.
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Cathepsin B, cathepsin H, cathepsin X and cystatin C in sera of patients with early-stage and inflammatory breast cancer.
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Cathepsin B, L, and D activities in colorectal carcinomas: relationship with clinico-pathological parameters.
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Cathepsin B, p53 expression and AgNORs in transitional cell carcinoma.
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Cathepsin B-Activated Fluorescent and Photoacoustic Imaging of Tumor.
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Cathepsin B-Cleavable Cyclopeptidic Chemotherapeutic Prodrugs.
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Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies.
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Cathepsin B-degradable, NIR-responsive nanoparticulate platform for target-specific cancer therapy.
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Cathepsin B-mediated CD18 shedding regulates leukocyte recruitment from angiogenic vessels.
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Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment.
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Cathepsin B: a potential prognostic marker for inflammatory breast cancer.
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Cathepsin B: a sellsword of cancer progression.
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Cathepsin B: association with plasma membrane in metastatic tumors.
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Cathepsin B: multiple enzyme forms from a single gene and their relation to cancer.
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Cathepsin B: Multiple Roles in Cancer.
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Cathepsin C is a tissue-specific regulator of squamous carcinogenesis.
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Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis.
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Cathepsin L in glioma progression: comparison with cathepsin B.
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Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice.
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Cathepsin S Controls Angiogenesis and Tumor Growth via Matrix-derived Angiogenic Factors.
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Cathepsin-B and cathepsin-L expression levels do not correlate with sensitivity of tumour cells to TNF-alpha-mediated apoptosis.
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Cathepsin-d activity levels in colorectal-cancer - correlation with cathepsin-B and cathepsin-L and other biological and clinical-parameters.
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Cathepsins B and L are markers for clinically invasive types of meningiomas.
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Cathepsins B and L in peripheral blood mononuclear cells of pediatric acute myeloid leukemia: potential poor prognostic markers.
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Cathepsins B, H and L in human breast carcinoma.
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Cathepsins D, B and L in breast carcinoma and in transformed human breast epithelial cells (HBEC).
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Cathepsins in basal cell carcinomas: activity, immunoreactivity and mRNA staining of cathepsins B, D, H and L.
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CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma.
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CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion.
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Cell surface complex of cathepsin B/annexin II tetramer in malignant progression.
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Cells producing cathepsins D, B, and L in human breast carcinoma and their association with prognosis.
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Cepharanthine as a Potential Novel Tumor-Regional Therapy in Treating Cutaneous Melanoma: Altering the Expression of Cathepsin B, Tumor Suppressor Genes and Autophagy-Related Proteins.
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Characterization of a cysteine proteinase secreted by mouse mammary gland.
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Characterization of a latent cysteine proteinase from ascitic fluid as a high molecular weight form of cathepsin B.
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Characterization of a thiol proteinase secreted by malignant human breast tumours.
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Characterization of multiple cathepsin B mRNAs in murine B16a melanoma.
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Characterization of protease expression in human prostate-cancer cell-lines.
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Characterization of the cathepsin B gene and multiple mRNAs in human tissues: evidence for alternative splicing of cathepsin B pre-mRNA.
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Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
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Chiral cyclopalladated complexes derived from N,N-dimethyl-1-phenethylamine with bridging bis(diphenylphosphine)ferrocene ligand as inhibitors of the cathepsin B activity and as antitumoral agents.
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Chlorin e6-Conjugated and PEGylated Immune Checkpoint Inhibitor Nanocomposites for Pulmonary Metastatic Colorectal Cancer.
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Chymotrypsin B Cached in Rat Liver Lysosomes and Involved in Apoptotic Regulation through a Mitochondrial Pathway.
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Cigarette smoke condensate increases cathepsin-mediated invasiveness of oral carcinoma cells.
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Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma.
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Clinicopathologic Analysis of Cathepsin B as a Prognostic Marker of Thyroid Cancer.
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Clinicopathologic significance of cathepsin B immunostaining in transitional neoplasia.
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Clinicopathologic significance of cystatin C expression in gliomas.
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Clioquinol-ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity.
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Codistribution of procathepsin B and mature cathepsin B forms in human prostate tumors detected by confocal and immunofluorescence microscopy.
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Colonic adenocarcinomas: near-infrared microcatheter imaging of smart probes for early detection--study in mice.
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Comparative localization of cathepsin B protein and activity in colorectal cancer.
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Comparative studies of mouse liver cathepsin B and an analogous tumor thiol proteinase.
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Comparison of proteinase activities in squamous cell carcinoma, basal cell epithelioma, and seborrheic keratosis.
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Construction of cathepsin B-responsive fluorescent probe and photosensitizer using a ferrocenyl boron dipyrromethene dark quencher.
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CTSB Knockdown Inhibits Proliferation and Tumorigenesis in HL-60 Cells.
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CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide.
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Cyr61 and YB-1 are novel interacting partners of uPAR and elevate the malignancy of triple-negative breast cancer.
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Cystatin C and cathepsin B in human colon carcinoma: expression by cell lines and matrix degradation.
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Cystatins and cathepsins in breast carcinoma.
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Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer.
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Cysteine Cathepsin Protease Inhibition: An update on its Diagnostic, Prognostic and Therapeutic Potential in Cancer.
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Cysteine cathepsin proteases as pharmacological targets in cancer.
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Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response.
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Cysteine cathepsins (proteases)--on the main stage of cancer?
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Cysteine cathepsins B and X promote epithelial-mesenchymal transition of tumor cells.
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Cysteine cathepsins B, X and K expression in peri-arteriolar glioblastoma stem cell niches.
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Cysteine Cathepsins in Tumor-Associated Immune Cells.
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Cysteine cathepsins L and X differentially modulate interactions between myeloid-derived suppressor cells and tumor cells.
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Cysteine proteinase cathepsin H in tumours and sera of lung cancer patients: relation to prognosis and cigarette smoking.
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Cysteine proteinases and metastasis.
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Cysteine proteinases in cancer progression and their clinical relevance for prognosis.
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Cysteine proteinases produced by cultured rabbit V2 carcinoma cells and rabbit skin fibroblasts.
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Cytochemical and biochemical evidence of cathepsin B in malignant, transformed and normal breast epithelial cells.
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Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.
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Degradation of extracellular matrix protein tenascin-C by cathepsin B: an interaction involved in the progression of gliomas.
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Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues.
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Degradation of laminin by human tumor cathepsin B.
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Delivering wasp venom for cancer therapy.
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Delivery of substances and their target-specific topical activation.
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Demonstration of proteases in basal cell carcinomas. A histochemical study using amino acid-4-methoxy-2-naphthylamides as chromogenic substrates.
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Dendritic hexadecapeptide as a cathepsin B degradable carrier for delivery of HSP90 inhibitor.
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Design and synthesis of fluorogenic substrate-based probes for detecting Cathepsin B activity.
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Design, synthesis and docking studies of bischalcones based quinazoline-2(1H)-ones and quinazoline-2(1H)-thiones derivatives as novel inhibitors of cathepsin B and cathepsin H.
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Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L.
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Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B.
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Design, synthesis, and evaluation of fluorine and Naphthyridine-Based half-sandwich organoiridium/ruthenium complexes with bioimaging and anticancer activity.
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Detection of cathepsin B in tumor cytosol and urine of breast cancer patients.
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Detection of fibronectin conformational changes in the extracellular matrix of live cells using plasmonic nanoplates.
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Determination of cathepsin B expression may offer additional prognostic information for ovarian cancer patients.
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Determination of cathepsins B, H, L and kininogen in breast cancer patients.
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Development of bimetallic titanocene-ruthenium-arene complexes as anticancer agents: relationships between structural and biological properties.
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Development of dual-acting prodrugs for circumventing multidrug resistance.
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Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives.
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Diagnostic values of serum cathepsin B and D in patients with nasopharyngeal carcinoma.
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Differences in cysteine peptidases-like activity in sera of patients with breast cancer.
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Differences in the repertoires of basement membrane degrading enzymes in two carcinoma sublines with distinct patterns of site-selective metastasis.
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Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target.
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Differential levels of cathepsin B and L in serum between young and aged healthy people and their association with matrix metalloproteinase 2.
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Differentiation of tumours of ductal and lobular origin: II. Proteomics of invasive ductal and lobular breast carcinomas.
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Dipeptidyl peptidase IV, prolyl endopeptidase and cathepsin B activities in primary human lung tumors and lung parenchyma.
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Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.
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Distribution and colocalization of markers for proliferation, invasion, motility and neoangiogenesis in benign melanocytic naevi and malignant melanomas.
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Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells.
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Down-regulation of uPAR and cathepsin B retards cofilin dephosphorylation.
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Downregulation of uPAR and cathepsin B induces apoptosis via regulation of Bcl-2 and Bax and inhibition of the PI3K/Akt pathway in gliomas.
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Doxorubicin-induced cell death requires cathepsin B in HeLa cells.
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Drug-resistant human laryngeal carcinoma cells have increased levels of cathepsin B.
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Dual-locking nanoprobe based on hemicyanine for orthogonal stimuli-triggered precise cancer imaging and therapy.
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Effect of protein kinase modulators on the regulation of cathepsin B activity in THP-1 human monocytic leukemia cells.
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Effect of trenbolone acetate plus estradiol on transcriptional regulation of metabolism pathways in bovine liver.
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Effects of 8-bromoadenosine 3':5'-cyclic monophosphate on proteolytic enzymes, adhesiveness and lung-colonizing ability of cloned low-metastatic Lewis lung carcinoma cells.
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Effects of combined in vivo treatment of transplantable solid mammary carcinoma in wistar rats using vitamin E and cysteine peptidase inhibitors from human placenta.
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Effects of E-64 (cysteine-proteinase inhibitor) and pepstatin (aspartyl-proteinase inhibitor) on metastasis formation in mice with mammary and ovarian tumors.
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Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes.
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Elevated levels of cathepsin B in human glioblastoma cell lines.
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Elevation of tissue cathepsin B and L activities in gastric cancer.
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Elevations in cathepsin B protein content and enzyme activity occur independently of glycosylation during colorectal tumor progression.
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Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B.
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Enhanced levels of cathepsin B mRNA in murine tumors.
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Enhanced tumor retention of NTSR1-targeted agents by employing a hydrophilic cysteine cathepsin inhibitor.
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Enhancing effect of new biological response modifier sulfoethylated (1-->3)-beta-D-glucan on antitumor activity of cyclophosphamide in the treatment of experimental murine leukoses.
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Enzymatic degradation study of 111In-labeled minigastrin peptides using cathepsin B enzyme and AR42J cancer cell line for the development of neuroendocrine tumor imaging radiopharmaceuticals.
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Enzymatically active cathepsin B dissociating from its inhibitor complexes is elevated in blood plasma of patients with septic shock and some malignant tumors.
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Enzyme-Driven Switchable Fluorescence-SERS Diagnostic Nanococktail for the Multiplex Detection of Lung Cancer Biomarkers.
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Enzyme-induced and tumor-targeted drug delivery system based on multifunctional mesoporous silica nanoparticles.
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Enzyme-Responsive Cell-Penetrating Peptides Conjugated Mesoporous Silica Quantum Dots Nanocarriers for Controlled Release of Nucleus-Targeted Drug Molecules and Real-Time Intracellular Fluorescence Imaging of Tumor Cells.
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Enzyme-responsive doxorubicin release from dendrimer nanoparticles for anticancer drug delivery.
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Enzyme-responsive multifunctional magnetic nanoparticles for tumor intracellular drug delivery and imaging.
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Enzyme-responsive peptide dendrimer-gemcitabine conjugate as a controlled-release drug delivery vehicle with enhanced antitumor efficacy.
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Estrogen modulation of osteoclast lysosomal enzyme secretion.
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Evaluation of flavonols and derivatives as human cathepsin B inhibitor.
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Evaluation of serum cathepsin B and D in relation to clinicopathological staging of colorectal cancer.
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Evaluation of the 5' spliced form of human cathepsin B mRNA in colorectal mucosa and tumors.
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Ex Vivo and In Vivo Noninvasive Imaging of Epidermal Growth Factor Receptor Inhibition on Colon Tumorigenesis Using Activatable Near-Infrared Fluorescent Probes.
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Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles.
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Exploring fragment-based target-specific ranking protocol with machine learning on cathepsin S.
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Exploring the role of 5' alternative splicing and of the 3'-untranslated region of cathepsin B mRNA.
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Expression and Localization of Cathepsins B, D and G in Cancer Stem Cells in Liver Metastasis From Colon Adenocarcinoma.
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Expression and Localization of Cathepsins B, D, and G in Two Cancer Stem Cell Subpopulations in Moderately Differentiated Oral Tongue Squamous Cell Carcinoma.
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Expression of cathepsin B and cystatin C in human colorectal cancer.
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Expression of Cathepsin B and L antigen and activity is associated with early colorectal cancer progression.
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Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma.
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Expression of cathepsins B, H, and L and their inhibitors as markers of transitional cell carcinoma of the bladder.
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Expression of five cathepsins in murine melanomas of varying metastatic potential and normal tissues.
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Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation.
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Extracellular cysteine proteinase and collagenase activities as a consequence of tumor-host interaction in the rabbit V2 carcinoma.
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Fabrication of doxorubicin-loaded ellipsoid micelle based on diblock copolymer with a linkage of enzyme-cleavable peptide.
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Feasibility of in vivo multichannel optical imaging of gene expression: experimental study in mice.
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First-in-Human Phase 1 Study of MORAb-202, an Antibody-Drug Conjugate Comprising Farletuzumab Linked to Eribulin Mesylate, in Patients with Folate Receptor-?-Positive Advanced Solid Tumors.
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Flow cytometric DNA analysis and lysosomal cathepsins B and L in locally advanced laryngeal cancer. Relationship with clinicopathologic parameters and prognostic significance.
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Fluorescent microplate assay for cancer cell-associated cathepsin B.
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Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples.
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Fluorescent, internally quenched, peptides for exploring the pH-dependent substrate specificity of cathepsin B.
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Folate Receptor-Targeted and Cathepsin B-Activatable Nanoprobe for In Situ Therapeutic Monitoring of Photosensitive Cell Death.
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Forced retraction of spinal root injury enhances activation of p38 MAPK cascade in infiltrating macrophages.
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FRET Imaging of Enzyme-Responsive HPMA Copolymer Conjugate.
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Gelatin-methotrexate conjugate microspheres as a potential drug delivery system.
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Generation of ammodytoxin-anti-cathepsin B immuno-conjugate as a model for delivery of secretory phospholipase A(2) into cancer cells.
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Genetic polymorphisms of Cathepsin B are associated with gastric cancer risk and prognosis in a Chinese population.
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Glatiramer acetate blocks the activation of THP-1 cells by interferon-gamma.
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Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9.
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Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, ?-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase.
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Gold Nanoparticles-Based Colorimetric Assay for Cathepsin B Activity and the Efficiency of Its Inhibitors.
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Granulocyte collagenase and cathepsin B in patients with cancer of digestive organs.
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Granulysin induces cathepsin B release from lysosomes of target tumor cells to attack mitochondria through processing of bid leading to Necroptosis.
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Ha-ras oncogene induction of invasion and metastasis is associated with the activation and redistribution of protease(s) in rat-kidney cells.
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Heterogeneity of cathepsin B and stefin A expression in Gleason pattern 3+3 (score 6) prostate cancer needle biopsies.
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Heterogeneous suppression of experimentally induced colon cancer metastasis in rat liver lobes by inhibition of extracellular cathepsin B.
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HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+-H+ exchangers.
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High expression of cathepsin B in transitional bladder carcinoma correlates with tumor invasion.
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High levels of cathepsin B predict poor outcome in patients with breast cancer.
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Histochemical localization of cathepsin B at the invasion front of the rabbit V2 carcinoma.
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Histopathological and immunohistochemical studies on nickel sulfide-induced tumors in F344 rats.
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Human and murine macrophages mediate activation of MEN 4901/T-0128: a new promising camptothecin analogue-polysaccharide conjugate.
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Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene.
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Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells.
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Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells.
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Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells.
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Human tumour cathepsin B. Comparison with normal liver cathepsin B.
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Hypoxia alters cathepsin B / inhibitor profiles in oral carcinoma cell lines.
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Identification of cell surface cathepsin B-like activity on murine melanomas and fibrosarcomas: modulation by butanol extraction.
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Identification of diagnostic upper gastrointestinal cancer tissue type-specific urinary biomarkers.
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Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design.
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IL-8 and MCP-1/CCL2 regulate proteolytic activity in triple negative inflammatory breast cancer a mechanism that might be modulated by Src and Erk1/2.
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Imaging cathepsin B up-regulation in HT-1080 tumor models using fluorescence-mediated molecular tomography (FMT).
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Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes.
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Imaging Sites of Inhibition of Proteolysis in Pathomimetic Human Breast Cancer Cultures by Light-Activated Ruthenium Compound.
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Imbalance between cathepsin-B and cysteine proteinase-inhibitors is of prognostic-significance in human lung-cancer.
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Immunochemical analysis of cathepsin B in lung tumours: an independent prognostic factor for squamous cell carcinoma patients.
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Immunocytochemical and immunoelectron microscopic demonstration of cathepsin B in human malignant melanoma.
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Immunofluorescent studies on the occurrence of cathepsin B1 at tumor cell surfaces.
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Immunohistochemical analysis of cathepsin B expression in human lung adenocarcinoma: the role in cancer progression.
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Immunohistochemical analysis of cathepsins D, B, and L in human breast cancer.
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Immunohistochemical and biochemical study of a cathepsin B-like proteinase in human colonic cancers.
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Immunohistochemical localization of cathepsin B in neoplastic human prostate.
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Immunohistochemical markers of prolonged survival in small cell carcinoma of the lung. An immunohistochemical study.
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Immunohistochemical staining of cathepsins B, L and stefin A in human hypophysis and pituitary adenomas.
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Immunohistochemical study of cathepsin B. Prognostic significance in human lung cancer.
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Immunohistochemical study on cathepsin-B and cathepsin-d in pancreatic-cancer.
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Immunolocalization of cathepsin B in human glioma: implications for tumor invasion and angiogenesis.
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Immunomodulating tellurium compounds as anti-cancer agents.
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Immunonanoparticles--an effective tool to impair harmful proteolysis in invasive breast tumor cells.
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Immunophenotyping of hematopoietic malignancies in paraffin sections.
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Immunostained cathepsins B and L correlate with depth of invasion and different metastatic pathways in early stage gastric carcinoma.
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Immunotherapeutic Potential of Oncolytic H-1 Parvovirus: Hints of Glioblastoma Microenvironment Conversion towards Immunogenicity.
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Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers.
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Improved synthesis strategy for peptide nucleic acids (PNA) appropriate for cell-specific fluorescence imaging.
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In Situ Proapoptotic Peptide-Generating Rapeseed Protein-Based Nanocomplexes Synergize Chemotherapy for Cathepsin-B Overexpressing Breast Cancer.
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In vitro activation of pro-cathepsin B by three serine proteinases: leucocyte elastase, cathepsin G, and the urokinase-type plasminogen activator.
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In vitro and in vivo metabolism of paclitaxel poliglumex: identification of metabolites and active proteases.
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In vitro and in vivo study of an albumin-binding prodrug of doxorubicin that is cleaved by cathepsin B.
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In vivo chemoresistance of prostate cancer in metronomic cyclophosphamide therapy.
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In vivo expression of an alternatively spliced human tumor message that encodes a truncated form of cathepsin B. Subcellular distribution of the truncated enzyme in COS cells.
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In vivo imaging of intraperitoneally disseminated tumors in model mice by using activatable fluorescent small-molecular probes for activity of cathepsins.
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In-Silico Identification of Irreversible Cathepsin B Inhibitors as Anti-Cancer Agents: Virtual Screening, Covalent Docking Analysis and Molecular Dynamics Simulations.
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Inactivation of harmful tumour-associated proteolysis by nanoparticulate system.
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Increased carcinogenic potential of myeloid tumor cells induced by aberrant TGF-beta1-signaling and upregulation of cathepsin B.
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Increased cathepsin B activity in human lung tumors.
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Increased cell-surface urokinase in advanced ovarian cancer.
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Increased expression of Cathepsin B in oral squamous cell carcinoma.
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Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples.
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Increased invasiveness of MMP-9-deficient tumors in two mouse models of neuroendocrine tumorigenesis.
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Increasing Cystatin C and Cathepsin B in Serum of Colorectal Cancer Patients.
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Increasing time on target: utilization of inhibitors of cysteine cathepsins to enhance the tumor retention of receptor-targeted agents.
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Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells.
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Influence of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) on the localization of cathepsin B and cathepsin L in human lung tumor cells.
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Inhibition of cathepsin B activity in human breast cancer tissue by cysteine peptidase inhibitor isolated from human placenta: immunohistochemical and biochemical studies.
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Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis.
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Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer.
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Inhibition of endopeptidase and exopeptidase activity of cathepsin B impairs extracellular matrix degradation and tumour invasion.
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Inhibition of the cathepsin B like proteinase by a low molecular weight cysteine-proteinase inhibitor from ascitic fluid and plasma alpha 2 macroglobulin.
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Inhibitors of cathepsin B.
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Inhibitory effect of the sugarcane cystatin CaneCPI-4 on cathepsins B and L and human breast cancer cell invasion.
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Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line.
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Inhibitory properties of low molecular mass cysteine proteinase inhibitors from human sarcoma.
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Integrin ?v?3 is required for cathepsin B-induced hepatocellular carcinoma progression.
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Interaction of tumor and surrounding tissue of mice inoculated B16 melanoma variants in terms of enzyme activity.
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Interactions between human colon carcinoma cells, fibroblasts and monocytic cells in coculture--regulation of cathepsin B expression and invasiveness.
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Internalization of cystatin C in human cell lines.
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Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M.
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Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro.
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Intracellular delivery of peptide drugs using viral nanoparticles of bacteriophage P22: covalent loading and cleavable release.
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Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro.
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Invasion of ras-transformed breast epithelial cells depends on the proteolytic activity of cysteine and aspartic proteinases.
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Investigating the performance of a novel pH and cathepsin B sensitive, stimulus-responsive nanoparticle for optimised sonodynamic therapy in prostate cancer.
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In vivo near-infrared imaging and phototherapy of tumors using a cathepsin B-activated fluorescent probe.
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iRGD-targeted delivery of a pro-apoptotic peptide activated by cathepsin B inhibits tumor growth and metastasis in mice.
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Isolation and characterization of cancer procoagulant: a cysteine proteinase from malignant tissue.
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Label-free multimodal protease detection based on protein/perylene dye coassembly and enzyme-triggered disassembly.
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Laminin and cathepsin B as prognostic factors in stage I non-small cell lung cancer: are they useful?
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Leiomyosarcoma of somatic soft tissues in childhood: an immunohistochemical analysis of six cases with ultrastructural correlation.
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Levels of urinary cathepsin B-like substance in patients with gynecologic malignancy.
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LncRNA DLX6-AS1 Promotes Malignant Phenotype and Lymph Node Metastasis in Prostate Cancer by Inducing LARGE Methylation.
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Localization of a biotinylated cathepsin B oligonucleotide probe in human prostate including invasive cells and invasive edges by in situ hybridization.
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Localization of cathepsin B in two human lung cancer cell lines.
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Long-term follow-up confirms prognostic impact of PAI-1 and cathepsin D and L in primary breast cancer.
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Lung fibroblasts promote metastatic colonization through upregulation of stearoyl-CoA desaturase 1 in tumor cells.
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Lysosomal cathepsin B: correlation with metastatic potential.
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Lysosomal enzymes, cathepsins in brain tumour invasion.
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Lysosome-Targeting Fluorogenic Probe for Cathepsin B Imaging in Living Cells.
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Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles.
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Mechanism of muscle protein degradation induced by a cancer cachectic factor.
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Mechanism of p27 upregulation induced by downregulation of cathepsin B and uPAR in glioma.
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Mechanisms of human bladder tumor invasion: role of protease cathepsin B.
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Membrane association of cathepsin B can be induced by transfection of human breast epithelial cells with c-Ha-ras oncogene.
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Microarrays of 41 human tumor cell lines for the characterization of new molecular targets: expression patterns of cathepsin B and the transferrin receptor.
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miR-140 targeting CTSB signaling suppresses the mesenchymal transition and enhances temozolomide cytotoxicity in glioblastoma multiforme.
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MMP-9 and cathepsin B expression in tumor budding as an indicator of a more aggressive phenotype of colorectal cancer (CRC).
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MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice.
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Modelling TGF?R and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer.
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Modulation of cystatin C expression impairs the invasive and tumorigenic potential of human glioblastoma cells.
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Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C.
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Molecular cloning and chimerisation of an inhibitory anti-cathepsin B antibody and its expression in Chinese hamster ovary cells.
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Molecular determinants of improved cathepsin B inhibition by new cystatins obtained by DNA shuffling.
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Molecular dynamic simulation (MDS) and in vitro cathepsin-B inhibitory activity of decrusin angelate, ibuprofen, and thymol.
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Molecular imaging: Bridging the gap between neuroradiology and neurohistology.
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Molecular regulation of human cathepsin B: implication in pathologies.
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Molecular regulation, membrane association and secretion of tumor cathepsin B.
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Monocyte-derived macrophage assisted breast cancer cell invasion as a personalized, predictive metric to score metastatic risk.
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mRNA Expression of Bax, Bcl-2, p53, Cathepsin B, Caspase-3 and Caspase-9 in the HepG2 Cell Line Following Induction by a Novel Monoclonal Ab Hep88 mAb: Cross-Talk for Paraptosis and Apoptosis.
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MTA1 drives malignant progression and bone metastasis in prostate cancer.
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Multiple forms of cathepsin B in human lung cancer.
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Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells.
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Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells.
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Natural biflavones as novel inhibitors of cathepsin B and K.
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Near infrared thoracoscopy of tumoral protease activity for improved detection of peripheral lung cancer.
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Near-Infrared Fluorescent Activated Polymeric Probe for Imaging Intraluminal Colorectal Cancer Tumors.
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Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells.
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Nitric oxide regulates tumor cell cross-talk with stromal cells in the tumor microenvironment of the liver.
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Nitroxoline impairs tumor progression in vitro and in vivo by regulating cathepsin B activity.
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Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe.
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Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin.
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Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme.
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Novel bis-C,N-cyclometalated iridium(III) thiosemicarbazide antitumor complexes: interactions with human serum albumin and DNA, and inhibition of cathepsin B.
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Novel C,N-chelate rhodium(iii) and iridium(iii) antitumor complexes incorporating a lipophilic steroidal conjugate and their interaction with DNA.
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Novel cathepsin B-sensitive paclitaxel conjugate: Higher water solubility, better efficacy and lower toxicity.
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Novel lysosome targeted molecular transporter built on a guanidinium-poly-(propylene imine) hybrid dendron for efficient delivery of doxorubicin into cancer cells.
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Novel polymeric micelles as enzyme-sensitive nuclear-targeted dual-functional drug delivery vehicles for enhanced 9-nitro-20(S)-camptothecin delivery and antitumor efficacy.
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Nuclear factor-kappaB mediates up-regulation of cathepsin B by doxorubicin in tumor cells.
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Nuclear translocation of ?-catenin during mesenchymal stem cells differentiation into hepatocytes is associated with a tumoral phenotype.
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Nucleolin-Targeted Ratiometric Fluorescent Carbon Dots with a Remarkably Large Emission Wavelength Shift for Precise Imaging of Cathepsin B in Living Cancer Cells.
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Observing proteases in living cells.
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Oncogenic role of p53 is suppressed by si-RNA bicistronic construct of uPA, uPAR and cathepsin-B in meningiomas both in vitro and in vivo.
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Optical imaging of cancer-related proteases using near-infrared fluorescence matrix metalloproteinase-sensitive and cathepsin B-sensitive probes.
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Optical imaging of spontaneous breast tumors using protease sensing 'smart' optical probes.
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Oral granular cell myoblastoma: an immunohistochemical study.
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Organoruthenated Nitroxoline Derivatives Impair Tumor Cell Invasion through Inhibition of Cathepsin B Activity.
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Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients.
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Overexpression and localization of cathepsin B during the progression of human gliomas.
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Overexpression level of stromelysin 3 is related to the lymph node involvement in non-small cell lung cancer.
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Overexpression of cathepsin B and urokinase plasminogen activator is associated with increased risk of recurrence and metastasis in patients with chondrosarcoma.
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Overexpression of cathepsin B correlates with angiogenesis in colon adenocarcinoma.
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Overexpression of cathepsin B in gastric cancer identified by proteome analysis.
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Overexpression of EMMPRIN Isoform 2 Is Associated with Head and Neck Cancer Metastasis.
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Overexpression of stefin A in human esophageal squamous cell carcinoma cells inhibits tumor cell growth, angiogenesis, invasion, and metastasis.
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PDEPT: polymer-directed enzyme prodrug therapy. I. HPMA copolymer-cathepsin B and PK1 as a model combination.
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PDMS-PMOXA-Nanoparticles Featuring a Cathepsin B-Triggered Release Mechanism.
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Peptide-based tumor inhibitor encoding mitochondrial p14(ARF) is highly efficacious to diverse tumors.
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Pericellular cathepsin B and malignant progression.
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Pericellular pH affects distribution and secretion of cathepsin B in malignant cells.
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pH Dependence of inhibitors targeting the occluding loop of cathepsin B.
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pH-dependent and cathepsin B activable CaCO3 nanoprobe for targeted in vivo tumor imaging.
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pH-Driven Targeting Nanoprobe with Dual-Responsive Drug Release for Persistent Luminescence Imaging and Chemotherapy of Tumor.
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Pharmacokinetics and Catabolism of [3H]TAK-164, a Guanylyl Cyclase C Targeted Antibody-Drug Conjugate.
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Photodynamic therapy combined with a cysteine proteinase inhibitor synergistically decrease VEGF production and promote tumour necrosis in a rat mammary carcinoma.
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Plasma membrane association of cathepsin B in human prostate cancer: biochemical and immunogold electron microscopic analysis.
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Plasma membrane-associated cysteine proteinases in human and animal tumors.
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Polymorphism L26V in the cathepsin B gene may be associated with a risk of prostate cancer and differentiation.
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Post-Translational Regulation of Cathepsin B, but not of Other Cysteine Cathepsins, Contributes to Increased Glioblastoma Cell Invasiveness In Vitro.
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Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice.
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Primary cutaneous leiomyosarcoma. A histological and immunohistochemical study of 9 cases, with ultrastructural correlation.
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Primary tumor growth and formation of spontaneous lung metastases in mice bearing Lewis carcinoma treated with proteinase inhibitors.
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Primary tumour expression of the cysteine cathepsin inhibitor Stefin A inhibits distant metastasis in breast cancer.
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Prodrug-inspired probes selective to cathepsin B over other cysteine cathepsins.
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Prognostic impact of cathepsin B and matrix metalloproteinase-9 in pulmonary adenocarcinomas by immunohistochemical study.
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Prognostic impact of CD68 and kallikrein 6 in human glioma.
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Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma.
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Prognostic markers in pheochromocytoma.
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Prognostic significance of cathepsins B and L in primary human breast cancer.
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Prognostic significance of cysteine proteinases cathepsins B and L and their endogenous inhibitors stefins A and B in patients with squamous cell carcinoma of the head and neck.
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Prognostic value of cathepsins B, H, L, D and their endogenous inhibitors stefins A and B in head and neck carcinoma.
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Prognostic value of increased lung tumor tissue cathepsin B.
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Prognostic value of the cysteine proteases cathepsins B and cathepsin L in human breast cancer.
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Protease expression in dedifferentiated parosteal osteosarcoma.
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Proteases and their inhibitors in human brain tumours: a review.
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Proteases as prognostic markers in cancer.
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Proteases in brain tumour progression.
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Proteases in gastrointestinal neoplastic diseases.
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Proteinase activity in invasive cancer of the breast. Correlation with tumor progression.
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Proteinases and proteinase inhibition by cytotoxic and antimetastatic drugs in transplantable solid metastasizing tumors in mice.
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Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment.
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Proteolytic disassembly is a critical determinant for reovirus oncolysis.
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Proteolytic networks in cancer.
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Proteolytic-antiproteolytic balance and its regulation in carcinogenesis.
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Proteomic Identification of Cysteine Cathepsin Substrates Shed from the Surface of Cancer Cells.
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Purification and characterisation of an inhibitor of a cathepsin B-like proteinase from sunflower seed.
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Quantitative electrochemical detection of cathepsin B activity in breast cancer cell lysates using carbon nanofiber nanoelectrode arrays toward identification of cancer formation.
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Rapid, High-Yielding Solid-Phase Synthesis of Cathepsin-B Cleavable Linkers for Targeted Cancer Therapeutics.
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Ratio of cathepsin B to stefin A identifies heterogeneity within Gleason histologic scores for human prostate cancer.
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Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice.
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Reducing Dendrimer Generation and PEG Chain Length Increases Drug Release and Promotes Anticancer Activity of PEGylated Polylysine Dendrimers Conjugated with Doxorubicin via a Cathepsin-Cleavable Peptide Linker.
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Reduction of experimental human fibrosarcoma lung metastasis in mice by adenovirus-mediated cystatin C overexpression in the host.
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Regulation and function of aquaporin-1 in glioma cells.
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Regulation of cathepsin B activity by modulators of arachidonic acid metabolism in human monocytes.
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Regulation of DNA repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice.
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Relationship between drug release of DE-310, macromolecular prodrug of DX-8951f, and cathepsins activity in several tumors.
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Release of cathepsin B precursors from human and murine tumours.
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Rhenium inhibitors of cathepsin B (ReO(SYS)X (where Y = S, py; X = Cl, Br, SPhOMe-p)): Synthesis and mechanism of inhibition.
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RNAi-mediated abrogation of cathepsin B and MMP-9 gene expression in a malignant meningioma cell line leads to decreased tumor growth, invasion and angiogenesis.
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RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas.
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Role for cathepsin B and cystatins in tumor growth and progression.
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Role of cathepsin B in cancer progression: a potential target for coordination compounds.
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Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance.
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Role of cystatin C and cysteine proteinases in the development of mouse LS-lymphosarcoma.
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S100A5: a marker of recurrence in WHO grade I meningiomas.
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SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H.
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SAR studies of o-hydroxychalcones and their cyclized analogs and study them as novel inhibitors of cathepsin B and cathepsin H.
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SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B.
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Secretion of cathepsin B and tumour invasion.
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Selective inhibition of proteolytic enzymes in an in vivo mouse model for experimental metastasis.
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Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2.
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Sensitization to the lysosomal cell death pathway upon immortalization and transformation.
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Separation, purification and N-terminal sequence analysis of a novel leupeptin-sensitive serine endopeptidase present in chemically induced rat mammary tumour.
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Serum cathepsin B activity during regression of Morris hepatoma 5123 D.
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Serum cathepsin B and plasma urokinase-type plasminogen activator levels in gastrointestinal tract cancers.
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Serum cathepsin B levels and urinary excretion of cathepsin B in the cancer patients with remote metastasis.
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Serum cathepsin B levels, urinary excretion of cathepsin B and tissue cathepsin B content in the patients with gastric cancer.
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Serum cathepsin B to cystatin C ratio as a potential marker for the diagnosis of cholangiocarcinoma.
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Serum cathepsin-B levels and urinary-excretion of cathepsin-B in the patients with colorectal-cancer - possible indicators for tumor malignancy.
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Silencing of Cathepsin B suppresses the proliferation and invasion of endometrial cancer.
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Simultaneous enzyme overlay membrane (EOM)-based in situ zymography and immunofluorescence technique reveals cathepsin B-like activity in a subset of tumour vessels.
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Simultaneous, multiplex quantification of protease activities using a gold microelectrode array.
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Skeletal muscle mRNA levels for cathepsin B, but not components of the ubiquitin-proteasome pathway, are increased in patients with lung cancer referred for thoracotomy.
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Smart dual-functional warhead for folate receptor-specific activatable imaging and photodynamic therapy.
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Solubilized antigen of Blastocystis hominis facilitates the growth of human colorectal cancer cells, HCT116.
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Sp1 regulates cathepsin B transcription and invasiveness in murine B16 melanoma cells.
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Spindle cell squamous cell carcinoma exhibiting prominent neutrophil phagocytosis: a case report.
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Stage-specific increases in cathepsin B messenger RNA content in human colorectal carcinoma.
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STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1? Activation.
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Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases.
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Strategy in inhibition of cathepsin B, a target in tumor invasion and metastasis.
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Study on cathepsin B activity in human thyroid tumors.
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Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.
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Synthesis and biological characterization of protease-activated prodrugs of doxazolidine.
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Synthesis and Biological Evaluation of 99mTc(I) Tricarbonyl Complexes Dual-Targeted at Tumoral Mitochondria.
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Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action.
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Synthesis and preliminary radiopharmacological characterisation of an 11 C-labelled azadipeptide nitrile as potential PET tracer for imaging of cysteine cathepsins.
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Synthesis of a diverse library of mechanism-based cysteine protease inhibitors.
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Synthesis of a novel, sequentially active-targeted drug delivery nanoplatform for breast cancer therapy.
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Synthesis of Novel Nitroxoline Analogs with Potent Cathepsin B Exopeptidase Inhibitory Activity.
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Synthesis, cleavage profile, and antitumor efficacy of an albumin-binding prodrug of methotrexate that is cleaved by plasmin and cathepsin B.
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Targeted Nanoparticles for Co-Delivery of 5-FU and Nitroxoline, a Cathepsin B Inhibitor, in HepG2 Cells of Hepatocellular Carcinoma.
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Targeting Cathepsin B for Cancer Therapies.
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Targeting the Expression of Cathepsin B Using CRISPR/Cas9 System in Mammalian Cancer Cells.
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The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide.
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The current stage of cathepsin B inhibitors as potential anticancer agents.
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The effect of 3-bromopyruvate on the properties of cathepsin B in the aspect of metastatic potential of colon cancer cells.
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The effect of Z-FA.FMK on D-galactosamine/TNF-alpha-induced liver injury in mice.
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The effects of chicken egg white cystatin and proteinase inhibitor on cysteine peptidase-like activity in the sera of patients with breast cancer.
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The expression of cathepsin B and other lysosomal proteinases in normal tissues and in tumors.
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The expression of low density lipoprotein receptor-related protein in colorectal carcinoma.
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The Expression of Lysosomal Proteinases and Their Inhibitors in Breast Cancer: Possible Relationship to Prognosis of the Disease.
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The expression of matrix metalloproteinase 9 and cathepsin B in gastric carcinoma is associated with lymph node metastasis, but not with postoperative survival.
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The importance of determining the aggressiveness of prostate cancer using serum and tissue molecular markers.
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The influence of Ukrain on the growth of HA-1 tumor in mice: the role of cysteine proteinases as markers of tumor malignancy.
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The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
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The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer.
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The metastatic potential of human pancreatic cell lines in the liver of nude mice correlates well with cathepsin B activity.
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The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers.
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The relationship of cathepsin B and stefin A mRNA localization identifies a potentially aggressive variant of human prostate cancer within a Gleason histologic score.
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The role of cathepsin B and cystatin C in the mechanisms of invasion by ovarian cancer.
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The Role of Cathepsins in Involution and Breast Cancer.
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The role of peptidases in cancer of the rectum and sigmoid colon.
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The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases.
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The up-regulation of proteasome subunits and lysosomal proteases in hepatocellular carcinomas of the HBx gene knockin transgenic mice.
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The urokinase/urokinase-receptor system and cancer invasion.
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The V2 carcinoma of the rabbit as an integrated model of tumor invasion.
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The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen.
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Theoretical insight into the mechanism for the inhibition of the cysteine protease cathepsin B by 1,2,4-thiadiazole derivatives.
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Thiazolidinediones induce Rab7-RILP-MAPK-dependent juxtanuclear lysosome aggregation and reduce tumor cell invasion.
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Tissue cathepsins as tumor markers.
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Tissue microarrays of human tumor xenografts: characterization of proteins involved in migration and angiogenesis for applications in the development of targeted anticancer agents.
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Tomography of cells by confocal laser scanning microscopy and computer-assisted three-dimensional image reconstruction: localization of cathepsin B in tumor cells penetrating collagen gels in vitro.
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Topical application of activity-based probes for visualization of brain tumor tissue.
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Total and lipid-bound plasma sialic acid as diagnostic markers in colorectal cancer patients: correlation with cathepsin B expression in progression to Dukes stage.
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Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors.
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Trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B.
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Transcription of human cathepsin B is mediated by Sp1 and Ets family factors in glioma.
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Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice.
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Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model.
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Tumor cathepsin B and its endogenous inhibitors in metastasis.
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Tumor cell membrane cathepsin B.
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Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.
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Tumor characteristics involved in the metastatic behaviour as an improvement in primary cutaneous melanoma prognostics.
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Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer.
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Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent.
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Tumor progression and angiogenesis: cathepsin B & Co.
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Tumor protease-activated, pore-forming toxins from a combinatorial library.
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Tumor-host interactions in the rabbit V2 carcinoma: stimulation of cathepsin B in host fibroblasts by a tumor-derived cytokine.
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Ultrastructural localization of cathepsin B in gingival tissue from chronic periodontitis patients.
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Understanding the interaction of an antitumoral platinum(II) 7-azaindolate complex with proteins and DNA.
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Unraveling the role of proteases in cancer.
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uPAR and cathepsin B inhibition enhanced radiation-induced apoptosis in gliomainitiating cells.
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uPAR/cathepsin B overexpression reverse angiogenesis by rescuing FAK phosphorylation in uPAR/cathepsin B down regulated meningioma.
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Upregulation of cystatin M during the progression of oropharyngeal squamous cell carcinoma from primary tumor to metastasis.
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Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.
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V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.
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Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer.
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Visualization of time-dependent inactivation of human tumor cathepsin B isozymes by a peptidyl fluoromethyl ketone using a fluorescent print technique.
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[A study on cathepsin B-like substance in cancer of the urinary tract]
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[A study on cathepsin B-like substance in patients with urological cancer]
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[Activity of cathepsin H in blood and biopsies of patients with precancerous conditions and mouth cancer]
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[Cathepsin B activity and concentration of elastase and alpha-1 proteinase inhibitor complex in non-small-cell lung cancer: 2 year follow-up study]
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[Cathepsin B and pro-drug activation]
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[Changes in active cysteine cathepsins in lysosomes from tissues thyroid papillary carcinomas with various biological characteristics].
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[Clinical indicators of malignancy of lung cancer]
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[Comparison of cathepsin-B-like activity and CA 125 assays use in ovarian cancer diagnosis]
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[Dependence of serous activity of cathepsin B on histological types of ovarian carcinomas]
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[Digestion in vitro of basal membrane, bovine lens capsule, by human liver lysosome cathepsins B, H and L and ascitic fluid tumor cathepsin B from ovarian adenocarcinoma]
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[Effects of Qushi Huayu Decoction on cathepsin B and tumor necrosis factor-alpha expression in rats with non-alcoholic steatohepatitis]
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[Enzymatic activity of cathepsin B, cathepsin B and L, plasmin, trypsin and collagenase in hepatocellular carcinoma]
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[Legionella pneumophila activates Nrf2-Keap1 pathway to inhibit autophagy of mouse RAW264.7 macrophages].
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[Natural history of ovarian adenocarcinomas: from epidemiology to experimentation]
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[Prognostic implications of biologic markers in intracranial meningiomas: 120 cases]
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[Prognostic significance of determining cathepsin B activity in malignant ovarian tumors]
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[Prognostic significance of lysosomal cysteine proteases in the estimation of the effectiveness of the antitumorigenic therapy]
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[Protease activities in gastric and colon cancer tissues]
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[Proteolytic enzyme activity in stomach cancer patients with various prognoses]
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[Proteolytic lysosomal enzymes in ovarian cancer]
Neoplasms
[Research of Herba Artemisiae Scoporiae inhibits the hepatic lipotoxicity]
Neoplasms
[Role and behavior of cathepsin B and cathepsin L in gastric cancer]
Neoplasms
[Significance of cathepsin B and D in physiologic and pathologic processes]
Neoplasms
[The activity of cathepsin B in colorectal adenocarcinomas]
Neoplasms
[The lysosomal cathepsins B, L and D in development of murine experimental leukemias]
Nephritis
Role of cathepsin B and L in anti-glomerular basement membrane nephritis in rats.
Nephrosis
Cathepsin B and L in nephron segments of rats with puromycin aminonucleoside nephrosis.
Nephrosis, Lipoid
Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis.
Nephrotic Syndrome
Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome.
Nervous System Diseases
New insights into the roles of endolysosomal cathepsins in the pathogenesis of Alzheimer's disease: cathepsin inhibitors as potential therapeutics.
Nervous System Diseases
Serum Amyloid A-Mediated Inflammasome Activation of Microglial Cells in Cerebral Ischemia.
Neuroblastoma
Alpha 2-macroglobulin and other proteinase inhibitors do not interfere with the secretion of amyloid precursor protein in mouse neuroblastoma cells.
Neuroblastoma
Characterization of gene expression induced by RET with MEN2A or MEN2B mutation.
Neuroblastoma
Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1).
Neuroblastoma
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Neurocysticercosis
Alteration of immunoproteome profile of Echinococcus granulosus hydatid fluid with progression of cystic echinococcosis.
Neurodegenerative Diseases
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders.
Neurodegenerative Diseases
Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors.
Neurodegenerative Diseases
Novel multi-target directed ligand-based strategies for reducing neuroinflammation in Alzheimer's disease.
Neurodegenerative Diseases
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Neurodegenerative Diseases
Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease.
Neuroectodermal Tumors, Primitive
Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells.
Neuroendocrine Tumors
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.
Neuroendocrine Tumors
Enzymatic degradation study of 111In-labeled minigastrin peptides using cathepsin B enzyme and AR42J cancer cell line for the development of neuroendocrine tumor imaging radiopharmaceuticals.
Neuroinflammatory Diseases
Garcinol pacifies acrylamide induced cognitive impairments, neuroinflammation and neuronal apoptosis by modulating GSK signaling and activation of pCREB by regulating cathepsin B in the brain of zebrafish larvae.
Neuroinflammatory Diseases
Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice.
Neuroinflammatory Diseases
Neuroprotective Effects of Baicalein on Acrolein-induced Neurotoxicity in the Nigrostriatal Dopaminergic System of Rat Brain.
Neuroinflammatory Diseases
Quercetin is protective against short-term dietary advanced glycation end products intake induced cognitive dysfunction in aged ICR mice.
Neurologic Manifestations
CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke.
Neuronal Ceroid-Lipofuscinoses
Abnormal cathepsin B activity in Batten disease.
Neuronal Ceroid-Lipofuscinoses
Analysis of cathepsin B and cathepsin L treatment to clear toxic lysosomal protein aggregates in neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Apparent cathepsin B deficiency in neuronal ceroid lipofuscinosis can be explained by peroxide inhibition.
Neuronal Ceroid-Lipofuscinoses
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.
Nevus
TGF-? signaling, activated stromal fibroblasts, and cysteine cathepsins B and L drive the invasive growth of human melanoma cells.
Newcastle Disease
Autophagy in farm animals: current knowledge and future challenges.
Niemann-Pick Diseases
Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease.
Non-alcoholic Fatty Liver Disease
Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis.
Non-alcoholic Fatty Liver Disease
Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation.
Non-alcoholic Fatty Liver Disease
Cathepsin-B dependent autophagy ameliorates steatoheaptitis in chronic exercise rats.
Non-alcoholic Fatty Liver Disease
Mir214-3p and Hnf4a/Hnf4? reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis.
Obesity
The role of cathepsin B in autophagy during obesity: A systematic review.
Opisthorchiasis
Evaluation of liver fluke recombinant cathepsin B-1 protease as a serodiagnostic antigen for human opisthorchiasis.
Osteoarthritis
Alternative messenger RNA splicing and enzyme forms of cathepsin B in human osteoarthritic cartilage and cultured chondrocytes.
Osteoarthritis
Cathepsin B and cysteine protease inhibitors in human osteoarthritis.
Osteoarthritis
Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes.
Osteoarthritis
Cathepsin B in osteoarthritis: cytochemical and histochemical analysis of human femoral head cartilage.
Osteoarthritis
Cathepsin B in osteoarthritis: uncontrolled proteolysis in the wrong place.
Osteoarthritis
Cathepsin B in osteoarthritis: zonal variation of enzyme activity in human femoral head cartilage.
Osteoarthritis
Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis.
Osteoarthritis
Cytoskeletal architecture and cathepsin B trafficking in human articular chondrocytes.
Osteoarthritis
Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoid arthritis and osteoarthritis: a parallel investigation by semiquantitative reverse transcriptase-polymerase chain reaction and immunohistochemistry.
Osteoarthritis
Early diagnosis of osteoarthritis using cathepsin B sensitive near-infrared fluorescent probes.
Osteoarthritis
Exploring the role of 5' alternative splicing and of the 3'-untranslated region of cathepsin B mRNA.
Osteoarthritis
Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint diseases.
Osteoarthritis
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Osteoarthritis
Relationship between cathepsin B and thrombin in rheumatoid arthritis.
Osteoarthritis
Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases.
Osteoarthritis
Temporal pattern of cysteine endopeptidase (cathepsin B) expression in cartilage and synovium from rabbit knees with experimental osteoarthritis: gene expression in chondrocytes in response to interleukin-1 and matrix depletion.
Osteochondritis Dissecans
Autophagy in farm animals: current knowledge and future challenges.
Osteoma
Cathepsin-B activity in otosclerosis.
Osteophyte
Alternative messenger RNA splicing and enzyme forms of cathepsin B in human osteoarthritic cartilage and cultured chondrocytes.
Osteophyte
The relative importance of cysteine peptidases in osteoarthritis.
Osteoporosis
Cathepsin B and L inhibitors: a patent review (2010 - present).
Osteoporosis
Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis.
Osteoporosis
Natural biflavones as novel inhibitors of cathepsin B and K.
Osteoporosis
Theoretical insight into the mechanism for the inhibition of the cysteine protease cathepsin B by 1,2,4-thiadiazole derivatives.
Osteosarcoma
Antisense inhibition of cathepsin B in a human osteosarcoma cell line.
Osteosarcoma
Cathepsin B activity in normal human osteoblast-like cells and human osteoblastic osteosarcoma cells (MG-63): regulation by interleukin-1 beta and parathyroid hormone.
Osteosarcoma
Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line.
Osteosarcoma
Palladacycle (BPC) antitumour activity against resistant and metastatic cell lines: The relationship with cytosolic calcium mobilisation and cathepsin B activity.
Osteosarcoma
Protease expression in dedifferentiated parosteal osteosarcoma.
Osteosarcoma
SHOX triggers the lysosomal pathway of apoptosis via oxidative stress.
Osteosarcoma
Up-regulation of cathepsin B expression and enhanced secretion in mitochondrial DNA-depleted osteosarcoma cells.
Otitis Media
Endotoxin and lysosomal protease activity in acute and chronic otitis media with effusion.
Otitis Media with Effusion
Endotoxin and lysosomal protease activity in acute and chronic otitis media with effusion.
Otitis Media with Effusion
Kinetics of lysosomal protease activity in human otitis media with effusion.
Otosclerosis
Cathepsin-B activity in otosclerosis.
Ovarian Cysts
[Comparison of cathepsin-B-like activity and CA 125 assays use in ovarian cancer diagnosis]
Ovarian Neoplasms
Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation.
Ovarian Neoplasms
Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90.
Ovarian Neoplasms
Cathepsin B mediates the pH-dependent proinvasive activity of tumor-shed microvesicles.
Ovarian Neoplasms
Determination of cathepsin B expression may offer additional prognostic information for ovarian cancer patients.
Ovarian Neoplasms
Determination of cysteine peptidases-like activity and their inhibitors in the serum of patients with ovarian cancer treated by conventional chemotherapy and vitamin E.
Ovarian Neoplasms
Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes.
Ovarian Neoplasms
Expression of high molecular weight cysteine proteinase inhibitor in ovarian cancer tissues: regulation of cathepsin B expression by placental CPI.
Ovarian Neoplasms
Genome scanning detects amplification of the cathepsin B gene (CtsB) in transformed rat ovarian surface epithelial cells.
Ovarian Neoplasms
Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells.
Ovarian Neoplasms
In vitro invasion assays.
Ovarian Neoplasms
Increased cell-surface urokinase in advanced ovarian cancer.
Ovarian Neoplasms
Inhibition of in vitro ovarian cancer cell invasion by modulation of urokinase-type plasminogen activator and cathepsin B.
Ovarian Neoplasms
Overexpression of cysteine cathepsin L is a marker of invasion and metastasis in ovarian cancer.
Ovarian Neoplasms
PDMS-PMOXA-Nanoparticles Featuring a Cathepsin B-Triggered Release Mechanism.
Ovarian Neoplasms
The role of cathepsin B and cystatin C in the mechanisms of invasion by ovarian cancer.
Ovarian Neoplasms
[Comparison of cathepsin-B-like activity and CA 125 assays use in ovarian cancer diagnosis]
Pancreatic Diseases
Pancreatic lysosomal enzyme secretion via gut-hormone-regulated pathway in rats.
Pancreatic Fistula
Pancreatic Inflammation and Proenzyme Activation Are Associated With Clinically Relevant Postoperative Pancreatic Fistulas After Pancreas Resection.
Pancreatic Neoplasms
177Lu-labeled HPMA copolymers utilizing cathepsin B and S cleavable linkers: synthesis, characterization and preliminary in vivo investigation in a pancreatic cancer model.
Pancreatic Neoplasms
Cathepsin B is a mediator of organelle-specific initiation of ferroptosis.
Pancreatic Neoplasms
Cathepsin B is a target of Hedgehog signaling in pancreatic cancer.
Pancreatic Neoplasms
Cathepsin B is highly expressed in pancreatic cancer stem-like cells and is associated with patients' surgical outcomes.
Pancreatic Neoplasms
CD95-related apoptotic machinery is functional in pancreatic cancer cells.
Pancreatic Neoplasms
Dual Enzymatic Reaction-Assisted Gemcitabine Delivery Systems for Programmed Pancreatic Cancer Therapy.
Pancreatic Neoplasms
Identification of diagnostic upper gastrointestinal cancer tissue type-specific urinary biomarkers.
Pancreatic Neoplasms
Increased cathepsin B activity in pancreatic juice from a patient with pancreatic cancer.
Pancreatic Neoplasms
PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells.
Pancreatic Neoplasms
The metastatic potential of human pancreatic cell lines in the liver of nude mice correlates well with cathepsin B activity.
Pancreatic Neoplasms
Variant cathepsin B activity secreted from human pancreatic cancer cell lines into protein-free chemically defined medium.
Pancreatitis
A new experimental model for gallstone pancreatitis: short-termed pancreatico-biliary duct obstruction and exocrine stimulation with systemic hypotension in rats.
Pancreatitis
A plasma protease which is expressed during supramaximal stimulation causes in vitro subcellular redistribution of lysosomal enzymes in rat exocrine pancreas.
Pancreatitis
A possible mechanism for gallstone pancreatitis: repeated short-term pancreaticobiliary duct obstruction with exocrine stimulation in rats.
Pancreatitis
Activation of proteases in cerulein-induced pancreatitis.
Pancreatitis
Activity of cathepsins in rat's spleen due to experimentally induced pancreatitis.
Pancreatitis
Acute pancreatitis.
Pancreatitis
An update on pancreatic pathophysiology (Do we have to rewrite pancreatic pathophysiology?).
Pancreatitis
Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis.
Pancreatitis
Beneficial effect of iloprost on the course of acute taurocholate pancreatitis in rats and its limitation by antecedent acute ethanol intake.
Pancreatitis
Bile and pancreatic juice replacement ameliorates early ligation-induced acute pancreatitis in rats.
Pancreatitis
Both ethanol consumption and protein deficiency increase the fragility of pancreatic lysosomes.
Pancreatitis
Cathepsin B Activates Human Trypsinogen 1 but Not Proelastase 2 or Procarboxypeptidase B.
Pancreatitis
Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis.
Pancreatitis
Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis.
Pancreatitis
Cathepsin B cleavage of the trypsinogen activation peptide.
Pancreatitis
Cathepsin B inhibition in two models of acute pancreatitis.
Pancreatitis
Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity.
Pancreatitis
Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells.
Pancreatitis
Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice.
Pancreatitis
Cathepsin B.
Pancreatitis
Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis.
Pancreatitis
Cause-effect relationships between zymogen activation and other early events in secretagogue-induced acute pancreatitis.
Pancreatitis
Cellular alterations of parotid gland of rats with acute pancreatitis induced by cerulein.
Pancreatitis
Cerulein-induced in vitro activation of trypsinogen in rat pancreatic acini is mediated by cathepsin B.
Pancreatitis
Changes in the morphology and lability of lysosomal subpopulations in caerulein-induced acute pancreatitis.
Pancreatitis
Combined therapy of a cephalosporin, Shiomarin and a new potent protease inhibitor, E3123 in rat taurocholate-induced pancreatitis.
Pancreatitis
Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis.
Pancreatitis
Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants.
Pancreatitis
Cyclosporin A, But Not FK506, Induces Osmotic Lysis of Pancreas Zymogen Granules, Intra-Acinar Enzyme Release, and Lysosome Instability by Activating K+ Channel.
Pancreatitis
Cytoprotective effects of prostaglandins and a new potent protease inhibitor in acute pancreatitis.
Pancreatitis
Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.
Pancreatitis
Effect of high fiber intake on pancreatic lysosomal stability in ethanol-fed rats.
Pancreatitis
Effect of oral administration of AZD8309, a CXCR2 antagonist, on the severity of experimental pancreatitis.
Pancreatitis
Effect of prostaglandin E on the redistribution of lysosomal enzymes in caerulein-induced pancreatitis.
Pancreatitis
Effect of the oral administration of sepimostat mesilate on cerulein induced acute pancreatitis in rats.
Pancreatitis
Effects of hemorrhagic shock, aspirin, and ethanol on secretagogue-induced experimental pancreatitis.
Pancreatitis
Esterase inhibitors prevent lysosomal enzyme redistribution in two noninvasive models of experimental pancreatitis.
Pancreatitis
Ethanol feeding alters death signaling in the pancreas.
Pancreatitis
Gastric subcellular organelle fragility and impaired gastric energy charge levels in rats with caerulein-induced acute pancreatitis: protective effect of anti-ulcer agent, teprenone.
Pancreatitis
Genetic Evaluation of Children with Idiopathic Recurrent Acute Pancreatitis.
Pancreatitis
Heat shock proteins and autophagy in rats with cerulein-induced acute pancreatitis.
Pancreatitis
Human pancreatitis and the role of cathepsin B.
Pancreatitis
Immune-compromised state in the rat pancreas after chronic alcohol exposure: the role of peroxisome proliferator-activated receptor gamma.
Pancreatitis
Impaired hepatic energy metabolism in rat acute pancreatitis: protective effects of prostaglandin E2 and synthetic protease inhibitor ONO 3307.
Pancreatitis
In vivo and in vitro effects of the azidothymidine analog dideoxyinosine on the exocrine pancreas of the rat.
Pancreatitis
Inhibition of cathepsin B does not affect the intracellular activation of trypsinogen by cerulein hyperstimulation in isolated rat pancreatic acinar cells.
Pancreatitis
Intracellular vacuoles in experimental acute pancreatitis in rats and mice are an acidified compartment.
Pancreatitis
Ligation-induced acute pancreatitis in opossums: acinar cell necrosis in the absence of colocalization.
Pancreatitis
Localization of lysosomal and digestive enzymes in cytoplasmic vacuoles in caerulein-pancreatitis.
Pancreatitis
Lysosomal activity of pulmonary alveolar macrophages in acute experimental pancreatitis in rats with reference to positive PAF-antagonist (BN 52021) effect.
Pancreatitis
Lysosomal enzyme secretion into pancreatic juice in rats injected with pancreatic secretagogues and augmented secretion after short-term pancreatic duct obstruction.
Pancreatitis
Missorting of cathepsin B into the secretory compartment of CI-MPR/IGFII-deficient mice does not induce spontaneous trypsinogen activation but leads to enhanced trypsin activity during experimental pancreatitis--without affecting disease severity.
Pancreatitis
Pancreas Divisum Increases the Risk of Recurrent Acute Pancreatitis in Patients with rs12338 Polymorphism in the Cathepsin B Gene.
Pancreatitis
Pancreatic lysosomal enzyme secretion via gut-hormone-regulated pathway in rats.
Pancreatitis
Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis.
Pancreatitis
Protective effect of a cephalosporin, Shiomarin, plus a new potent protease inhibitor, E3123, on rat taurocholate-induced pancreatitis.
Pancreatitis
Release of Cathepsin B in Cytosol Causes Cell Death in Acute Pancreatitis.
Pancreatitis
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis.
Pancreatitis
Role of cathepsin B in the pathogenesis of acute pancreatitis.
Pancreatitis
Structural, functional and molecular dynamics analysis of cathepsin B gene SNPs associated with tropical calcific pancreatitis, a rare disease of tropics.
Pancreatitis
The effect of chloroquine administration on two experimental models of acute pancreatitis.
Pancreatitis
Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L.
Pancreatitis
Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice.
Pancreatitis
Trypsinogen isoforms in the ferret pancreas.
Pancreatitis
Water immersion stress induces heat shock protein 60 expression and protects against pancreatitis in rats.
Pancreatitis, Acute Necrotizing
Ligation-induced acute pancreatitis in opossums: acinar cell necrosis in the absence of colocalization.
Pancreatitis, Alcoholic
Effect of chronic ethanol feeding on factors leading to inappropriate intrapancreatic activation of zymogens in the rat pancreas.
Pancreatitis, Alcoholic
Effect of ethanol on pancreatic lysosomes in rats: a possible mechanism for alcoholic pancreatitis.
Pancreatitis, Chronic
An update on pancreatic pathophysiology (Do we have to rewrite pancreatic pathophysiology?).
Pancreatitis, Chronic
Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis.
Pancreatitis, Chronic
Cathepsin B gene polymorphism Val26 is not associated with idiopathic chronic pancreatitis in European patients.
Papilloma
Simultaneous human papilloma virus type 16 E7 and cdk inhibitor p21 expression induces apoptosis and cathepsin B activation.
Parasitic Diseases
Cathepsin B activity regulation. Heparin-like glycosaminogylcans protect human cathepsin B from alkaline pH-induced inactivation.
Parasitic Diseases
Inhibitors of cathepsin B.
Parasitic Diseases
Prodrug-inspired probes selective to cathepsin B over other cysteine cathepsins.
Parkinson Disease
C-terminal ?-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease.
Parkinson Disease
Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.
Parkinson Disease
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Parkinson Disease
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Pelvic Inflammatory Disease
Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease.
Periodontal Attachment Loss
The relationship between gingival crevicular fluid cathepsin B activity and periodontal attachment loss in chronic periodontitis patients: a 2-year longitudinal study.
Periodontal Diseases
Expression of proteolytic cathepsins B, D, and L in periodontal gingival fibroblasts and tissues.
Periodontal Diseases
Microglial cathepsin B and Porphyromonas gingivalis gingipains as potential therapeutic targets for sporadic Alzheimer's disease.
Periodontitis
Cathepsin B in gingival crevicular fluid of adult periodontitis patients: identification by immunological and enzymological methods.
Periodontitis
Cathepsin B- and L-like activities at local gingival sites of chronic periodontitis patients.
Periodontitis
Modification of cystatin C activity by bacterial proteinases and neutrophil elastase in periodontitis.
Peritoneal Fibrosis
The Role of Cathepsin B in Peritoneal Fibrosis due to Peritoneal Dialysis.
Peritoneal Neoplasms
Cathepsin B cleavable novel prodrug Ac-Phe-Lys-PABC-ADM enhances efficacy at reduced toxicity in treating gastric cancer peritoneal carcinomatosis: An experimental study.
Peritoneal Neoplasms
Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity.
Peste-des-Petits-Ruminants
Autophagy in farm animals: current knowledge and future challenges.
Pheochromocytoma
Prognostic markers in pheochromocytoma.
Pinealoma
Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy.
Pituitary Neoplasms
Decreased expression of APAF-1 and increased expression of cathepsin B in invasive pituitary adenoma.
Pituitary Neoplasms
Expression of cathepsin B and cystatin C in the human adenohypophysis and in pituitary adenomas.
Plant Diseases
Involvement of cathepsin B in the plant disease resistance hypersensitive response.
Pleural Effusion
A latent form of cathepsin B in pleural effusions. I. Characterization of the enzyme in breast cancer patients.
Pneumococcal Infections
The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo.
Pneumonia
Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.
Pneumonia
Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model.
Pneumonia
Effects of inflammatory stimuli on responses of macrophages to Mycoplasma bovis infection.
Pneumonia
Significant elevation of plasma cathepsin B and cystatin C in patients with community-acquired pneumonia.
Polycystic Kidney, Autosomal Dominant
Functional defects in lysosomal enzymes in autosomal dominant polycystic kidney disease (ADPKD): abnormalities in synthesis, molecular processing, polarity, and secretion.
Polymicrogyria
Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.
Polymyositis
Administration of cathepsin B inhibitor CA-074Me reduces inflammation and apoptosis in polymyositis.
Polymyositis
Treatment with CA-074Me, a Cathepsin B inhibitor, reduces lung interstitial inflammation and fibrosis in a rat model of polymyositis.
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Cystatin C and cathepsin B in CSF from patients with inflammatory neurologic diseases.
Pre-Eclampsia
Elevated serum cathepsin B concentration in pregnant women is associated with preeclampsia.
Pre-Eclampsia
Evaluation of serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia.
Pre-Eclampsia
Serum sFlt-1, cystatin C and cathepsin B are potential severity markers in preeclampsia: a pilot study.
Prion Diseases
Accumulation of prion protein in muscle fibers of experimental chloroquine myopathy: in vivo model for deposition of prion protein in non-neuronal tissues.
Prostatic Hyperplasia
Cathepsin B in angiogenesis of human prostate: an immunohistochemical and immunoelectron microscopic analysis.
Prostatic Hyperplasia
Heterogeneity of cathepsin B and stefin A expression in Gleason pattern 3+3 (score 6) prostate cancer needle biopsies.
Prostatic Hyperplasia
Localization of cathepsin B in normal and hyperplastic human prostate by immunoperoxidase and protein A-gold techniques.
Prostatic Hyperplasia
Serum level of cathepsin B and its density in men with prostate cancer as novel markers of disease progression.
Prostatic Intraepithelial Neoplasia
Cathepsin B in angiogenesis of human prostate: an immunohistochemical and immunoelectron microscopic analysis.
Prostatic Intraepithelial Neoplasia
Heterogeneity of cathepsin B and stefin A expression in Gleason pattern 3+3 (score 6) prostate cancer needle biopsies.
Prostatic Neoplasms
Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through up-regulation of cathepsin B.
Prostatic Neoplasms
Adipocytes promote prostate cancer stem cell self-renewal through amplification of the cholecystokinin autocrine loop.
Prostatic Neoplasms
Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2.
Prostatic Neoplasms
Biochemical methods for predicting metastatic ability of prostatic cancer utilizing the dunning R-3327 rat prostatic adenocarcinoma system as a model.
Prostatic Neoplasms
Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer.
Prostatic Neoplasms
Cathepsin B expression in prostate cancer of native Japanese and Japanese-American patients: an immunohistochemical study.
Prostatic Neoplasms
Cathepsin B expression is similar in African-American and Caucasian prostate cancer patients.
Prostatic Neoplasms
Characterization of prostate cancer in needle biopsy by cathepsin B, cell proliferation and DNA ploidy.
Prostatic Neoplasms
Characterization of protease expression in human prostate-cancer cell-lines.
Prostatic Neoplasms
Codistribution of procathepsin B and mature cathepsin B forms in human prostate tumors detected by confocal and immunofluorescence microscopy.
Prostatic Neoplasms
Delivery of HSP90 Inhibitor Using Water Soluble Polymeric Conjugates with High Drug Payload.
Prostatic Neoplasms
Enhanced therapeutic index of radioimmunotherapy (RIT) in prostate cancer patients: comparison of radiation dosimetry for 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-peptide versus 2IT-DOTA monoclonal antibody linkage for RIT.
Prostatic Neoplasms
Geranylated 4-phenylcoumarins extracted from Mesua elegans induced caspase-independent cell death in prostate cancer cell lines through calpain-2 and cathepsin B.
Prostatic Neoplasms
Heterogeneity of cathepsin B and stefin A expression in Gleason pattern 3+3 (score 6) prostate cancer needle biopsies.
Prostatic Neoplasms
Immunohistochemical localization of cathepsin B in neoplastic human prostate.
Prostatic Neoplasms
Investigating the performance of a novel pH and cathepsin B sensitive, stimulus-responsive nanoparticle for optimised sonodynamic therapy in prostate cancer.
Prostatic Neoplasms
Matrigel influences morphology and cathepsin B distribution of prostate cancer PC3 cells.
Prostatic Neoplasms
Plasma membrane association of cathepsin B in human prostate cancer: biochemical and immunogold electron microscopic analysis.
Prostatic Neoplasms
Polymorphism L26V in the cathepsin B gene may be associated with a risk of prostate cancer and differentiation.
Prostatic Neoplasms
Ratio of cathepsin B to stefin A identifies heterogeneity within Gleason histologic scores for human prostate cancer.
Prostatic Neoplasms
RNA interference mediated suppression of TRPV6 inhibits the progression of prostate cancer in vitro by modulating cathepsin B and MMP9 expression.
Prostatic Neoplasms
Serum level of cathepsin B and its density in men with prostate cancer as novel markers of disease progression.
Prostatic Neoplasms
Targeting MMP-9, uPAR, and cathepsin B inhibits invasion, migration and activates apoptosis in prostate cancer cells.
Prostatic Neoplasms
Targeting the lysosome by an aminomethylated Riccardin D triggers DNA damage through cathepsin B-mediated degradation of BRCA1.
Prostatic Neoplasms
The importance of determining the aggressiveness of prostate cancer using serum and tissue molecular markers.
Prostatic Neoplasms
The relationship of cathepsin B and stefin A mRNA localization identifies a potentially aggressive variant of human prostate cancer within a Gleason histologic score.
Protein Deficiency
Both ethanol consumption and protein deficiency increase the fragility of pancreatic lysosomes.
Protein Deficiency
Effects of ethanol and protein deficiency on pancreatic digestive and lysosomal enzymes.
Proteinuria
Cathepsin B and L in isolated proximal tubular segments during acute and chronic proteinuria.
Proteinuria
Evidence suggesting a role for cathepsin L in an experimental model of glomerulonephritis.
Psoriasis
Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions.
Pulmonary Fibrosis
High cathepsin B activity in alveolar macrophages occurs with elastase-induced emphysema but not with bleomycin-induced pulmonary fibrosis in hamsters.
Pulmonary Fibrosis
[Salidroside improves pulmonary fibrosis by down-regulation of cathepsin B and NF-?Bp65 in rats].
Pyelonephritis
Efficacy and safety of once daily versus intermittent dosing of tobramycin in rabbits with acute pyelonephritis.
Rabies
Mechanism and regulation of antigen processing by cathepsin B.
Rabies
Participation of cathepsin B in processing of antigen presentation to MHC class II.
Rectal Neoplasms
Identification of Blood-Based Biomarkers for the Prediction of the Response to Neoadjuvant Chemoradiation in Rectal Cancer.
Reoviridae Infections
Cathepsin B Is Inhibited in Mutant Cells Selected during Persistent Reovirus Infection.
Reperfusion Injury
Cathepsin B inactivation attenuates hepatocyte apoptosis and liver damage in steatotic livers after cold ischemia-warm reperfusion injury.
Respiratory Distress Syndrome
The role of the kininogens as cysteine proteinase inhibitors in local and systemic inflammation.
Retinal Degeneration
Oligomeric A?1-42 Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function.
Retinal Neovascularization
[The experimental study of specific inhibitor-CA-074Me of Cathepsin B suppressing retinal neovascularization]
Rhabdomyosarcoma
Histopathological and immunohistochemical studies on nickel sulfide-induced tumors in F344 rats.
Rheumatic Diseases
Effect of antirheumatic drugs on cathepsin B1 from bovine spleen.
Rheumatic Fever
Theoretical insight into the mechanism for the inhibition of the cysteine protease cathepsin B by 1,2,4-thiadiazole derivatives.
Sarcoidosis
Cathepsin B, D, and L regulation in cyclosporin A-mediated gingival hyperplasia of a patient with sarcoidosis.
Sarcoma
Cathepsin B in cells of two rat sarcomas with different rates of spontaneous metastasis.
Sarcoma
Differences in targeting and secretion of cathepsins B and L by BALB/3T3 fibroblasts and Moloney murine sarcoma virus-transformed BALB/3T3 fibroblasts.
Sarcoma
Inhibitory properties of low molecular mass cysteine proteinase inhibitors from human sarcoma.
Sarcoma
The expression of cathepsin B and other lysosomal proteinases in normal tissues and in tumors.
Sarcoma
[Prognostic significance of lysosomal cysteine proteases in the estimation of the effectiveness of the antitumorigenic therapy]
Sarcoma, Kaposi
Immunohistochemical analysis of procathepsin L and cathepsin B in cutaneous Kaposi's sarcoma.
Schistosomiasis
A vaccine consisting of Schistosoma mansoni cathepsin B formulated in Montanide ISA 720 VG induces high level protection against murine schistosomiasis.
Schistosomiasis
Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch.
Schistosomiasis
Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity.
Schistosomiasis
De-glycosylation of Pichia pastoris-produced Schistosoma mansoni cathepsin B eliminates non-specific reactivity with IgG in normal human serum.
Schistosomiasis
Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors.
Schistosomiasis
Immunocapture of circulating Schistosoma mansoni cathepsin B antigen (Sm31) by anti-Sm31 polyclonal antibodies.
Schistosomiasis
Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases.
Schistosomiasis
Schistosoma japonicum cathepsin B as potential diagnostic antigen for Asian zoonotic schistosomiasis.
Schistosomiasis
Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases: rhodesain, cruzain and Schistosoma mansoni cathepsin B1.
Schistosomiasis mansoni
Adjuvanted Schistosoma mansoni-Cathepsin B With Sulfated Lactosyl Archaeol Archaeosomes or AddaVax Provides Protection in a Pre-Clinical Schistosomiasis Model.
Scleroderma, Systemic
A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis.
Scrapie
Cathepsin B and L are involved in degradation of prions in GT1-1 neuronal cells.
Seizures
Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1).
Seizures
Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus.
Seizures
Long-term Effects of Recurrent Neonatal Seizures on Neurobehavioral Function and Related Gene Expression and Its Intervention by Inhibitor of Cathepsin B.
Seizures
Plasma kallikrein-kinin system contributes to peripheral inflammation in temporal lobe epilepsy.
Sepsis
Ca2(+)-dependent and Ca2(+)-independent proteinase contents in the skeletal muscle in septic rats.
Sepsis
Cathepsin B regulates non-canonical NLRP3 inflammasome pathway by modulating activation of caspase-11 in Kupffer cells.
Sepsis
Cystatin C Deficiency Increases LPS-Induced Sepsis and NLRP3 Inflammasome Activation in Mice.
Sepsis
Effects of indomethacin and leupeptin on muscle cathepsin B activity and protein degradation during sepsis.
Sepsis
Evidence that cathepsin B contributes to skeletal muscle protein breakdown during sepsis.
Sepsis
Inhibitors of prostaglandin synthesis or cathepsin B prevent muscle wasting due to sepsis in the rat.
Sepsis
Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways.
Sepsis
Myofibrillar proteinase, cathepsin B, and protein breakdown rates in skeletal muscle from septic rats.
Sepsis
Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis.
Sepsis
[Cathepsin B in hepatic Kupffer cells regulates activation of TLR4-independent inflammatory pathways in mice with lipopolysaccharide-induced sepsis].
Shock, Septic
Enzymatically active cathepsin B dissociating from its inhibitor complexes is elevated in blood plasma of patients with septic shock and some malignant tumors.
Sialic Acid Storage Disease
Accumulation of sialic acid in endocytic compartments interferes with the formation of mature lysosomes. Impaired proteolytic processing of cathepsin B in fibroblasts of patients with lysosomal sialic acid storage disease.
Small Cell Lung Carcinoma
Cathepsin B and cysteine proteinase inhibitors in human lung cancer cell lines.
Small Cell Lung Carcinoma
Expression of cathepsin B in small cell lung carcinoma cells in relation to in vitro invasiveness.
Spinal Cord Injuries
Cathepsin B mRNA and protein expression following contusion spinal cord injury in rats.
Spinal Cord Injuries
Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat.
Spinocerebellar Ataxias
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Spondylarthritis
Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint diseases.
Spondylarthropathies
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Squamous Cell Carcinoma of Head and Neck
Cathepsin B Expression and the Correlation with Clinical Aspects of Oral Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells.
Squamous Cell Carcinoma of Head and Neck
Cathepsin B promotes both motility and invasiveness of oral carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
Immunohistochemical Expression of Cathepsin D in Primary and Recurrent Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Increased expression of Cathepsin B in oral squamous cell carcinoma.
Starvation
Amino acid concentrations and protein metabolism of two types of rat skeletal muscle in postprandial state and after brief starvation.
Starvation
Cathepsin B from the white shrimp Litopenaeus vannamei: cDNA sequence analysis, tissues-specific expression and biological activity.
Starvation
Changes in cardiac cathepsin B activity in response to interventions that alter heart size or protein metabolism: comparison with cathepsin D.
Starvation
Effect of fasting and thyroidectomy on cysteine proteinase activities in liver and muscle.
Starvation
Effect of starvation and refeeding on autophagy and heterophagy in rat liver.
Starvation
Hormonal and dietary regulation of lysosomal cysteine proteinases in liver under gluconeogenesis conditions.
Starvation
Recombinant expression, characterization and expressional analysis of clam Meretrix meretrix cathepsin B, an enzyme involved in nutrient digestion.
Steatorrhea
An update on pancreatic pathophysiology (Do we have to rewrite pancreatic pathophysiology?).
Stomach Neoplasms
Cathepsin B and L activities in gastric cancer tissue: correlation with histological findings.
Stomach Neoplasms
Cathepsin B cleavable novel prodrug Ac-Phe-Lys-PABC-ADM enhances efficacy at reduced toxicity in treating gastric cancer peritoneal carcinomatosis: An experimental study.
Stomach Neoplasms
Cathepsin B expression and its correlation with tumor-associated laminin and tumor progression in gastric cancer.
Stomach Neoplasms
Defining the invasive phenotype of proximal gastric cancer cells.
Stomach Neoplasms
Elevation of tissue cathepsin B and L activities in gastric cancer.
Stomach Neoplasms
Genetic polymorphisms of Cathepsin B are associated with gastric cancer risk and prognosis in a Chinese population.
Stomach Neoplasms
Molecular imaging of gastric neoplasia with near-infrared fluorescent activatable probes.
Stomach Neoplasms
Overexpression of cathepsin B in gastric cancer identified by proteome analysis.
Stomach Neoplasms
Regulation of cathepsin B and L expression in vitro in gastric cancer tissues by egg cystatin.
Stomach Neoplasms
Serum cathepsin B levels, urinary excretion of cathepsin B and tissue cathepsin B content in the patients with gastric cancer.
Stomach Neoplasms
[Protease activities in gastric and colon cancer tissues]
Stomach Neoplasms
[Proteolytic enzyme activity in stomach cancer patients with various prognoses]
Stomach Neoplasms
[Role and behavior of cathepsin B and cathepsin L in gastric cancer]
Stomach Ulcer
Elevation of tissue cathepsin B and L activities in gastric cancer.
Stroke
Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat.
Stroke
Inhibition of Cathepsin B Alleviates Secondary Degeneration in Ipsilateral Thalamus After Focal Cerebral Infarction in Adult Rats.
Stroke
Inhibition of Cathepsins B Induces Neuroprotection Against Secondary Degeneration in Ipsilateral Substantia Nigra After Focal Cortical Infarction in Adult Male Rats.
Synovitis
Detecting cathepsin activity in human osteoarthritis via activity-based probes.
Tetanus
Activity-Dependent Secretion of Synaptic Organizer Cbln1 from Lysosomes in Granule Cell Axons.
Tetanus
TI-VAMP/VAMP7 is the SNARE of secretory lysosomes contributing to ATP secretion from astrocytes.
Thrombosis
Distribution, activity and concentration of cathepsin B and cystatin C in the wall of aortic aneurysm.
Thrombosis
Increased levels of the megakaryocyte and platelet expressed cysteine proteases stefin A and cystatin A prevent thrombosis.
Thymoma
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Thyroid Cancer, Papillary
Nuclear cysteine cathepsin variants in thyroid carcinoma cells.
Thyroid Carcinoma, Anaplastic
Nuclear cysteine cathepsin variants in thyroid carcinoma cells.
Thyroid Diseases
Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis.
Thyroid Neoplasms
Cathepsin B activity and protein levels in thyroid carcinoma, Graves' disease, and multinodular goiters.
Thyroid Neoplasms
Cathepsin B trafficking in thyroid carcinoma cells.
Thyroid Neoplasms
Clinicopathologic Analysis of Cathepsin B as a Prognostic Marker of Thyroid Cancer.
Thyroid Neoplasms
Gold Nanoparticles-Based Colorimetric Assay for Cathepsin B Activity and the Efficiency of Its Inhibitors.
Thyroid Neoplasms
Nuclear cysteine cathepsin variants in thyroid carcinoma cells.
Thyroid Neoplasms
Study on cathepsin B activity in human thyroid tumors.
Thyrotoxicosis
Changes in cardiac cathepsin B activity in response to interventions that alter heart size or protein metabolism: comparison with cathepsin D.
Toxoplasmosis
Toxopain-1 is critical for infection in a novel chicken embryo model of congenital toxoplasmosis.
Toxoplasmosis, Congenital
Toxopain-1 is critical for infection in a novel chicken embryo model of congenital toxoplasmosis.
Trichinellosis
A novel antigenic cathepsin B protease induces protective immunity in Trichinella-infected mice.
Triple Negative Breast Neoplasms
Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells.
Trypanosomiasis, African
Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases: rhodesain, cruzain and Schistosoma mansoni cathepsin B1.
Tuberculosis
Cathepsin L maturation and activity is impaired in macrophages harboring M. avium and M. tuberculosis.
Tuberculosis
Significant accumulations of cathepsin B and prolylendopeptidase in inflammatory focus of delayed-type hypersensitivity induced by Mycobacterium tuberculosis in mice.
Tuberculosis
[Comparative characteristics of the activity of proteolytic enzymes and their inhibitors in the lung tissue of guinea pigs during development of generalized and destructive tuberculosis]
Unverricht-Lundborg Syndrome
A role for stefin B (cystatin B) in inflammation and endotoxemia.
Unverricht-Lundborg Syndrome
Altered Expression of Peroxiredoxins in Mouse Model of Progressive Myoclonus Epilepsy upon LPS-Induced Neuroinflammation.
Unverricht-Lundborg Syndrome
Thickened skull, scoliosis and other skeletal findings in Unverricht-Lundborg disease link cystatin B function to bone metabolism.
Urinary Bladder Neoplasms
Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s).
Urinary Bladder Neoplasms
Advances in bladder cancer.
Urinary Bladder Neoplasms
Cathepsin B levels in urine from bladder cancer patients.
Urinary Bladder Neoplasms
Diagnostic Efficiency of Serum and Urine Procathepsin B and Cathepsin B in Patients with Carcinoma of the Urinary Bladder.
Urinary Bladder Neoplasms
HCPT-peptide prodrug with tumor microenvironment -responsive morphology transformable characteristic for boosted bladder tumor chemotherapy.
Urinary Bladder Neoplasms
Levels of plasma cysteine-proteinase activity in bladder cancer patients.
Urinary Bladder Neoplasms
Mechanisms of human bladder tumor invasion: role of protease cathepsin B.
Urinary Bladder Neoplasms
Novel invasive orthotopic bladder cancer model with high cathepsin B activity resembling human bladder cancer.
Urinary Bladder Neoplasms
Role of urinary cathepsin B and L in the detection of bladder urothelial cell carcinoma.
Urinary Bladder Neoplasms
Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells.
Urologic Neoplasms
[A study on cathepsin B-like substance in cancer of the urinary tract]
Urologic Neoplasms
[A study on cathepsin B-like substance in patients with urological cancer]
Uterine Cervical Neoplasms
Cathepsin B may be a potential biomarker in cervical cancer.
Uterine Cervical Neoplasms
Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells.
Uterine Cervical Neoplasms
[Activity of cathepsin B and D in blood serum of women with uterine cervix neoplasms]
Uterine Cervical Neoplasms
[Clinical significance of cathepsin B expressions in cervical cancer in tissues]
Vascular Diseases
Cathepsin B expression is associated with arterial stiffening and atherosclerotic vascular disease.
Vascular Diseases
FLI1 and ERG protein degradation is regulated via Cathepsin B lysosomal pathway in Human Dermal Microvascular Endothelial Cells.
Virus Diseases
CD4-independent human immunodeficiency virus infection involves participation of endocytosis and cathepsin B.
Virus Diseases
Growth-Adaptive Mutations in the Ebola Virus Makona Glycoprotein Alter Different Steps in the Virus Entry Pathway.
Vitamin E Deficiency
Endogenous cathepsin B inhibitor activity in normal and myopathic red and white skeletal muscle.
Whooping Cough
Lysophosphatidic acid triggers cathepsin B-mediated invasiveness of human endometriotic cells.
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Brzin, J.; Popovic, T.; Drobnic-Kosorok, M.; Kotnik, M.; Turk, V.
Inhibitors of cysteine proteinases from potato
Biol. Chem. Hoppe-Seyler
369
233-238
1988
Homo sapiens
brenda
Buttle, D.J.; Bonner, B.C.; Burnett, D.; Barrett, A.J.
A catalytically active high-Mr form of human cathepsin B from sputum
Biochem. J.
254
693-699
1988
Homo sapiens
brenda
Baricos, W.H.; Zhou, Y.; Mason, R.W.; Barrett, A.J.
Human kidney cathepsins B and L. Characterization and potential role in degradation of glomerular basement membrane
Biochem. J.
252
301-304
1988
Homo sapiens
brenda
Simon, J.; Duffy, M.J.
Characterization of a cathepsin B-like enzyme from breast cancer
Biochem. Soc. Trans.
14
460
1986
Homo sapiens
-
brenda
Rich, D.H.; Brown, M.A.; Barrett, A.J.
Purification of cathepsin B by a new form of affinity chromatography
Biochem. J.
235
731-734
1986
Homo sapiens
brenda
Gounaris, A.D.; Slater, E.E.
Cathepsin B from human renal cortex
Biochem. J.
205
295-302
1982
Homo sapiens
brenda
Barrett, A.J.; Kirschke, H.
Cathepsin B, Cathepsin H, and cathepsin L
Methods Enzymol.
80
535-561
1981
Homo sapiens
brenda
Evans, P.; Etherington, D.J.
Characterisation of cathepsin B and collagenolytic cathepsin from human placenta
Eur. J. Biochem.
83
87-97
1978
Homo sapiens
brenda
Swanson, A.A.; Martin, B.J.; Spicer, S.S.
Human placental cathepsin B1. Isolation and some physical properties
Biochem. J.
137
223-228
1974
Homo sapiens
brenda
Musil, D.; Zucic, D.; Engh, R.A.; Mayr, I.; Huber, R.; Popovic, T.; Turk, V.; Towatari, T.; Katanuma, N.; Bode, W.
The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity
EMBO J.
10
2321-2330
1991
Homo sapiens
brenda
Chan, S.J; San Segundo, B.; McCormick, M.B.; Steiner, D.
Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs
Proc. Natl. Acad. Sci. USA
83
7721-7725
1986
Homo sapiens, Mus musculus
brenda
Steed, P.M.; Lasala, D.; Liebman, J.; Wigg, A.; Clark, K.; Knap, A.K.
Characterization of recombinant human cathepsin B expressed at high levels in baculovirus
Protein Sci.
7
2033-2037
1998
Homo sapiens
brenda
Quraishi, O.; Storer, A.C.
Identification of internal autoproteolytic cleavage sites within the prosegments of recombinant procathepsin B and procathepsin S. Contribution of a plausible unimolecular autoproteolytic event for the processing of zymogens belonging to the papain family
J. Biol. Chem.
276
8118-8124
2001
Homo sapiens
brenda
Krupa, J.C.; Hasnain, S.; Nagler, D.K.; Menard, R.; Mort, J.S.
S2' substrate specificity and the role of His110 and His111 in the exopeptidase activity of human cathepsin B
Biochem. J.
361
613-619
2002
Homo sapiens (P07858), Homo sapiens
brenda
Cezari, M.H.; Puzer, L.; Juliano, M.A.; Carmona, A.K.; Juliano, L.
Cathepsin B carboxydipeptidase specificity analysis using internally quenched fluorescent peptides
Biochem. J.
368
365-369
2002
Homo sapiens
brenda
Therrien, C.; Lachance, P.; Sulea, T.; Purisima, E.O.; Qi, H.; Ziomek, E.; Alvarez-Hernandez, A.; Roush, W.R.; Menard, R.
Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities
Biochemistry
40
2702-2711
2001
Homo sapiens (P07858)
brenda
Melo, R.L.; Barbosa Pozzo, R.C.; Alves, L.C.; Perissutti, E.; Caliendo, G.; Santagada, V.; Juliano, L.; Juliano, M.A.
Synthesis and hydrolysis by cathepsin B of fluorogenic substrates with the general structure benzoyl-X-ARG-MCA containing non-natural basic amino acids at position X
Biochim. Biophys. Acta
1547
82-94
2001
Homo sapiens
brenda
Menard, R.; Therrien, C.; Lachance, P.; Sulea, T.; Qi, H.; Alvarez-Hernandez, A.; Roush, W.R.
Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design
Biol. Chem.
382
839-845
2001
Homo sapiens
brenda
Schaschke, N.; Deluca, D.; Assfalg-Machleidt, I.; Hohneke, C.; Sommerhoff, C.P.; Machleidt, W.
Epoxysuccinyl peptide-derived cathepsin B inhibitors: modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin
Biol. Chem.
383
849-852
2002
Homo sapiens
brenda
Nakagomi, K.; Fujimura, A.; Maeda, H.; Sadakane, Y.; Fujii, N.; Akizawa, T.; Tanimura, T.; Hatanaka, Y.
Isolation of novel peptides, cabin-1, -2, -3, and -4, that inhibit cathepsin B from a thermolysin digest of human plasma
Biol. Pharm. Bull.
25
564-568
2002
Homo sapiens
brenda
Cathers, B.E.; Barrett, C.; Palmer, J.T.; Rydzewski, R.M.
pH Dependence of inhibitors targeting the occluding loop of cathepsin B
Bioorg. Chem.
30
264-275
2002
Homo sapiens
brenda
Song, J.; Xu, P.; Xiang, H.; Su, Z.; Storer, A.C.; Ni, F.
The active-site residue Cys-29 is responsible for the neutral-pH inactivation and the refolding barrier of human cathepsin B
FEBS Lett.
475
157-162
2000
Homo sapiens
brenda
Taggart, C.C.; Lowe, G.J.; Greene, C.M.; Mulgrew, A.T.; O'Neill, S.J.; Levine, R.L.; McElvaney, N.G.
Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor
J. Biol. Chem.
276
33345-33352
2001
Homo sapiens
brenda
Almeida, P.C.; Nantes, I.L.; Chagas, J.R.; Rizzi, C.C.; Faljoni-Alario, A.; Carmona, E.; Juliano, L.; Nader, H.B.; Tersariol, I.L.
Cathepsin B activity regulation. Heparin-like glycosaminogylcans protect human cathepsin B from alkaline pH-induced inactivation
J. Biol. Chem.
276
944-951
2001
Homo sapiens
brenda
Greenspan, P.D.; Clark, K.L.; Tommasi, R.A.; Cowen, S.D.; McQuire, L.W.; Farley, D.L.; van Duzer, J.H.; Goldberg, R.L.; Zhou, H.; Du, Z.; Fitt, J.J.; Coppa, D.E.; Fang, Z.; Macchia, W.; Zhu, L.; Capparelli, M.P.; Goldstein, R.; Wigg, A.M.; Doughty, J.R.; Bohacek, R.S.; Knap, A.K.
Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design
J. Med. Chem.
44
4524-4534
2001
Homo sapiens
brenda
Del Nery, E.; Alves, L.C.; Melo, R.L.; Cesari, M.H.; Juliano, L.; Juliano, M.A.
Specificity of cathepsin B to fluorescent substrates containing benzyl side-chain-substituted amino acids at P1 subsite
J. Protein Chem.
19
33-38
2000
Homo sapiens
brenda
Nakagomi, K.; Takatsu, K.; Takagi, S.; Ebisu, H.; Sadakane, Y.; Fujii, N.; Akizawa, T.; Tanimura, T.; Hatanaka, Y.
Isolation of cathepsin B inhibitory peptides, Cabin-A1 and -A2, from a tryptic and chymotryptic hydrolysate of human serum albumin
Peptides
23
1567-1571
2002
Homo sapiens
brenda
Lindkvist, B.; Fajardo, I.; Pejler, G.; Borgstrom, A.
Cathepsin B activates human trypsinogen 1 but not proelastase 2 or procarboxypeptidase B
Pancreatology
6
224-231
2006
Homo sapiens (P07858), Homo sapiens
brenda
Cotrin, S.S.; Puzer, L.; de Souza Judice, W.A.; Juliano, L.; Carmona, A.K.; Juliano, M.A.
Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B
Anal. Biochem.
335
244-252
2004
Homo sapiens (P07858), Homo sapiens
brenda
Pan, X.; Tan, N.; Zeng, G.; Zhang, Y.; Jia, R.
Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B
Bioorg. Med. Chem.
13
5819-5825
2005
Homo sapiens (P07858), Homo sapiens
brenda
Cunha, R.L.; Urano, M.E.; Chagas, J.R.; Almeida, P.C.; Bincoletto, C.; Tersariol, I.L.; Comasseto, J.V.
Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium(IV) compounds as inhibitors of human cathepsin B
Bioorg. Med. Chem. Lett.
15
755-760
2005
Homo sapiens (P07858), Homo sapiens
brenda
Frlan, R.; Gobec, S.
Inhibitors of cathepsin B
Curr. Med. Chem.
13
2309-2327
2006
Homo sapiens (P07858), Homo sapiens
brenda
Troy, A.M.; Sheahan, K.; Mulcahy, H.E.; Duffy, M.J.; Hyland, J.M.; ODonoghue, D.P.
Expression of cathepsin B and L antigen and activity is associated with early colorectal cancer progression
Eur. J. Cancer
40
1610-1616
2004
Homo sapiens (P07858), Homo sapiens
brenda
Zeng, G.Z.; Pan, X.L.; Tan, N.H.; Xiong, J.; Zhang, Y.M.
Natural biflavones as novel inhibitors of cathepsin B and K
Eur. J. Med. Chem.
41
1247-1552
2006
Homo sapiens (P07858), Homo sapiens
brenda
Laurent-Matha, V.; Derocq, D.; Prebois, C.; Katunuma, N.; Liaudet-Coopman, E.
Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B
J. Biochem.
139
363-371
2006
Homo sapiens (P07858), Homo sapiens
brenda
Premzl, A.; Turk, V.; Kos, J.
Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro
J. Cell. Biochem.
97
1230-1240
2006
Homo sapiens (P07858), Homo sapiens
brenda
Wieczerzak, E.; Jankowska, E.; Rodziewicz-Motowidlo, S.; Gieldon, A.; Lagiewka, J.; Grzonka, Z.; Abrahamson, M.; Grubb, A.; Broemme, D.
Novel azapeptide inhibitors of cathepsins B and K. Structural background to increased specificity for cathepsin B
J. Pept. Res.
66 Suppl 1
1-11
2005
Homo sapiens (P07858)
brenda
Taha, T.A.; El-Alwani, M.; Hannun, Y.A.; Obeid, L.M.
Sphingosine kinase-1 is cleaved by cathepsin B in vitro: Identification of the initial cleavage sites for the protease
FEBS Lett.
580
6047-6054
2006
Homo sapiens
brenda
Schmid, B.; Chung, D.E.; Warnecke, A.; Fichtner, I.; Kratz, F.
Albumin-binding prodrugs of camptothecin and doxorubicin with an Ala-Leu-Ala-Leu-linker that are cleaved by cathepsin B: synthesis and antitumor efficacy
Bioconjug. Chem.
18
702-716
2007
Homo sapiens
brenda
Serveau-Avesque, C.; Ferrer-Di Martino, M.; Herve-Grepinet, V.; Hazouard, E.; Gauthier, F.; Diot, E.; Lalmanach, G.
Active cathepsins B, H, K, L and S in human inflammatory bronchoalveolar lavage fluids
Biol. Cell.
98
15-22
2006
Homo sapiens
brenda
Myers, M.C.; Napper, A.D.; Motlekar, N.; Shah, P.P.; Chiu, C.H.; Beavers, M.P.; Diamond, S.L.; Huryn, D.M.; Smith, A.B.
Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays
Bioorg. Med. Chem. Lett.
17
4761-4766
2007
Homo sapiens
brenda
Hoang, V.L.; Li, Y.; Kim, S.K.
Cathepsin B inhibitory activities of phthalates isolated from a marine Pseudomonas strain
Bioorg. Med. Chem. Lett.
18
2083-2088
2008
Homo sapiens
brenda
Fujisawa, A.; Kambe, N.; Saito, M.; Nishikomori, R.; Tanizaki, H.; Kanazawa, N.; Adachi, S.; Heike, T.; Sagara, J.; Suda, T.; Nakahata, T.; Miyachi, Y.
Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells
Blood
109
2903-2911
2007
Homo sapiens
brenda
Bueth, H.; Luigi Buttigieg, P.; Ostafe, R.; Rehders, M.; Dannenmann, S.R.; Schaschke, N.; Stark, H.J.; Boukamp, P.; Brix, K.
Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes
Eur. J. Cell Biol.
86
747-761
2007
Homo sapiens
brenda
Sandes, E.; Lodillinsky, C.; Cwirenbaum, R.; Argueelles, C.; Casabe, A.; Eijan, A.M.
Cathepsin B is involved in the apoptosis intrinsic pathway induced by Bacillus Calmette-Guerin in transitional cancer cell lines
Int. J. Mol. Med.
20
823-828
2007
Homo sapiens
brenda
Gunatilleke, S.S.; de Oliveira, C.A.; McCammon, J.A.; Barrios, A.M.
Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study
J. Biol. Inorg. Chem.
13
555-561
2008
Homo sapiens
brenda
Nagaraj, N.S.; Vigneswaran, N.; Zacharias, W.
Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells
J. Cancer Res. Clin. Oncol.
132
171-183
2006
Homo sapiens
brenda
Hasan, L.; Mazzucchelli, L.; Liebi, M.; Lis, M.; Hunger, R.E.; Tester, A.; Overall, C.M.; Wolf, M.
Function of liver activation-regulated chemokine/CC chemokine ligand 20 is differently affected by cathepsin B and cathepsin D processing
J. Immunol.
176
6512-6522
2006
Homo sapiens
brenda
Gunatilleke, S.S.; Barrios, A.M.
Tuning the Au(I)-mediated inhibition of cathepsin B through ligand substitutions
J. Inorg. Biochem.
102
555-563
2008
Homo sapiens
brenda
Link, M.A.; Silva, L.A.; Schaffer, P.A.
Cathepsin B mediates cleavage of herpes simplex virus type 1 origin binding protein (OBP) to yield OBPC-1, and cleavage is dependent upon viral DNA replication
J. Virol.
81
9175-9182
2007
Homo sapiens (P07858)
brenda
Rhee, S.H.; Kang, J.; Nahm, D.S.
Cystatins and cathepsin B during orthodontic tooth movement
Am. J. Orthod. Dentofacial. Orthop.
135
99-105
2009
Homo sapiens
brenda
Hamer, I.; Delaive, E.; Dieu, M.; Abdel-Sater, F.; Mercy, L.; Jadot, M.; Arnould, T.
Up-regulation of cathepsin B expression and enhanced secretion in mitochondrial DNA-depleted osteosarcoma cells
Biol. Cell
101
31-41
2009
Homo sapiens
brenda
Caglic, D.; Kosec, G.; Bojic, L.; Reinheckel, T.; Turk, V.; Turk, B.
Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery
Biol. Chem.
390
175-179
2009
Homo sapiens (P07858), Homo sapiens, Mus musculus (P10605), Mus musculus
brenda
Kim, S.H.; Jhon, D.J.; Song, J.H.; No, J.S.; Kang, N.S.
Effect of novel N-cyano-tetrahydro-pyridazine compounds, a class of cathepsin K inhibitors, on the bone resorptive activity of mature osteoclasts
Bioorg. Med. Chem. Lett.
18
3988-3991
2008
Homo sapiens
brenda
Herszenyi, L.; Farinati, F.; Cardin, R.; Istvan, G.; Molnar, L.D.; Hritz, I.; De Paoli, M.; Plebani, M.; Tulassay, Z.
Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer
BMC Cancer
8
194
2008
Homo sapiens
brenda
Abu Ajaj, K.; Graeser, R.; Fichtner, I.; Kratz, F.
In vitro and in vivo study of an albumin-binding prodrug of doxorubicin that is cleaved by cathepsin B
Cancer Chemother. Pharmacol.
64
413-418
2009
Homo sapiens
brenda
Hwang, J.H.; Lee, S.H.; Lee, K.H.; Lee, K.Y.; Kim, H.; Ryu, J.K.; Yoon, Y.B.; Kim, Y.T.
Cathepsin B is a target of Hedgehog signaling in pancreatic cancer
Cancer Lett.
273
266-272
2009
Homo sapiens (P07858), Homo sapiens
brenda
Herszenyi, L.; Istvan, G.; Cardin, R.; De Paoli, M.; Plebani, M.; Tulassay, Z.; Farinati, F.
Serum cathepsin B and plasma urokinase-type plasminogen activator levels in gastrointestinal tract cancers
Eur. J. Cancer Prev.
17
438-445
2008
Homo sapiens
brenda
Cavallo-Medved, D.; Rudy, D.; Blum, G.; Bogyo, M.; Caglic, D.; Sloane, B.F.
Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation
Exp. Cell Res.
315
1234-1246
2009
Homo sapiens
brenda
Tsai, H.T.; Wang, P.H.; Tee, Y.T.; Lin, L.Y.; Hsieh, Y.S.; Yang, S.F.
Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease
Fertil. Steril.
91
549-555
2009
Homo sapiens
brenda
Czyzewska, J.; Guzinska-Ustymowicz, K.; Kemona, A.; Bandurski, R.
The expression of matrix metalloproteinase 9 and cathepsin B in gastric carcinoma is associated with lymph node metastasis, but not with postoperative survival
Folia Histochem. Cytobiol.
46
57-64
2008
Homo sapiens
brenda
Devetzi, M.; Scorilas, A.; Tsiambas, E.; Sameni, M.; Fotiou, S.; Sloane, B.F.; Talieri, M.
Cathepsin B protein levels in endometrial cancer: Potential value as a tumour biomarker
Gynecol. Oncol.
112
531-536
2009
Homo sapiens
brenda
Redzynia, I.; Ljunggren, A.; Abrahamson, M.; Mort, J.S.; Krupa, J.C.; Jaskolski, M.; Bujacz, G.
Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B
J. Biol. Chem.
283
22815-22825
2008
Homo sapiens
brenda
Yamaguchi, T.; Naruishi, K.; Arai, H.; Nishimura, F.; Takashiba, S.
IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts
J. Cell. Physiol.
217
423-432
2008
Homo sapiens
brenda
Elkaim, R.; Werner, S.; Kocgozlu, L.; Tenenbaum, H.
P. gingivalis regulates the expression of cathepsin B and cystatin C
J. Dent. Res.
87
932-936
2008
Homo sapiens
brenda
Ha, S.D.; Martins, A.; Khazaie, K.; Han, J.; Chan, B.M.; Kim, S.O.
Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages
J. Immunol.
181
690-697
2008
Homo sapiens, Mus musculus, Mus musculus C57BL/6
brenda
Fricker, S.P.; Mosi, R.M.; Cameron, B.R.; Baird, I.; Zhu, Y.; Anastassov, V.; Cox, J.; Doyle, P.S.; Hansell, E.; Lau, G.; Langille, J.; Olsen, M.; Qin, L.; Skerlj, R.; Wong, R.S.; Santucci, Z.; McKerrow, J.H.
Metal compounds for the treatment of parasitic diseases
J. Inorg. Biochem.
102
1839-1845
2008
Homo sapiens
brenda
Giusti, I.; D'Ascenzo, S.; Millimaggi, D.; Taraboletti, G.; Carta, G.; Franceschini, N.; Pavan, A.; Dolo, V.
Cathepsin B mediates the pH-dependent proinvasive activity of tumor-shed microvesicles
Neoplasia
10
481-488
2008
Homo sapiens
brenda
Schenker, P.; Alfarano, P.; Kolb, P.; Caflisch, A.; Baici, A.
A double-headed cathepsin B inhibitor devoid of warhead
Protein Sci.
17
2145-2155
2008
Homo sapiens
brenda
Aoki, T.; Kataoka, H.; Ishibashi, R.; Nozaki, K.; Hashimoto, N.
Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms
Stroke
39
2603-2610
2008
Homo sapiens, Rattus norvegicus
brenda
Geraghty, P.; Rogan, M.P.; Greene, C.M.; Brantly, M.L.; ONeill, S.J.; Taggart, C.C.; McElvaney, N.G.
Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro
Thorax
63
621-626
2008
Homo sapiens
brenda
Wang, C.; Jiang, Z.; Yao, J.; Wu, X.; Sun, L.; Liu, C.; Duan, W.; Yan, M.; Sun, L.; Liu, J.; Zhang, L.
Participation of cathepsin B in emodin-induced apoptosis in HK-2 cells
Toxicol. Lett.
181
196-204
2008
Homo sapiens
brenda
Colin, C.; Voutsinos-Porche, B.; Nanni, I.; Fina, F.; Metellus, P.; Intagliata, D.; Baeza, N.; Bouvier, C.; Delfino, C.; Loundou, A.; Chinot, O.; Lah, T.; Kos, J.; Martin, P.M.; Ouafik, L.; Figarella-Branger, D.
High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas
Acta Neuropathol.
118
745-754
2009
Homo sapiens
brenda
Li, J.H.; DAlessio, A.; Pober, J.S.
Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells
Am. J. Pathol.
175
1124-1135
2009
Homo sapiens
brenda
Momeny, M.; Malehmir, M.; Zakidizaji, M.; Ghasemi, R.; Ghadimi, H.; Shokrgozar, M.A.; Emami, A.H.; Nafissi, S.; Ghavamzadeh, A.; Ghaffari, S.H.
Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9
Anticancer Drugs
21
252-260
2010
Homo sapiens
brenda
Morishige, T.; Yoshioka, Y.; Tanabe, A.; Yao, X.; Tsunoda, S.; Tsutsumi, Y.; Mukai, Y.; Okada, N.; Nakagawa, S.
Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B
Biochem. Biophys. Res. Commun.
392
160-165
2010
Homo sapiens
brenda
Hwang, S.Y.; Yoo, B.C.; Jung, J.W.; Oh, E.S.; Hwang, J.S.; Shin, J.A.; Kim, S.Y.; Cha, S.H.; Han, I.O.
Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B
Biochim. Biophys. Acta
1793
1656-1668
2009
Homo sapiens, Rattus norvegicus
brenda
Cunha, R.L.; Gouvea, I.E.; Feitosa, G.P.; Alves, M.F.; Broemme, D.; Comasseto, J.V.; Tersariol, I.L.; Juliano, L.
Irreversible inhibition of human cathepsins B, L, S and K by hypervalent tellurium compounds
Biol. Chem.
390
1205-1212
2009
Homo sapiens
brenda
Pucer, A.; Castino, R.; Mirkovi?, B.; Falnoga, I.; Slejkovec, Z.; Isidoro, C.; Lah, T.T.
Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells
Biol. Chem.
391
519-531
2010
Homo sapiens
brenda
Song, G.; Bailey, D.W.; Dunlap, K.A.; Burghardt, R.C.; Spencer, T.E.; Bazer, F.W.; Johnson, G.A.
Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae
Biol. Reprod.
82
854-864
2010
Homo sapiens
brenda
Li, J.; Petrassi, H.; Tumanut, C.; Masick, B.; Trussell, C.; Harris, J.
Substrate optimization for monitoring cathepsin C activity in live cells
Bioorg. Med. Chem.
17
1064-1070
2009
Homo sapiens
brenda
Kenig, S.; Alonso, M.B.; Mueller, M.M.; Lah, T.T.
Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9
Cancer Lett.
289
53-61
2010
Homo sapiens
brenda
Colella, R.; Lu, G.; Glazewski, L.; Korant, B.; Matlapudi, A.; England, M.R.; Craft, C.; Frantz, C.N.; Mason, R.W.
Induction of cell death in neuroblastoma by inhibition of cathepsins B and L
Cancer Lett.
294
195-203
2010
Homo sapiens
brenda
Bhoopathi, P.; Chetty, C.; Gujrati, M.; Dinh, D.H.; Rao, J.S.; Lakka, S.
Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells
Cell Death Differ.
17
1529-1539
2010
Homo sapiens
brenda
Tomoo, K.
Development of cathepsin inhibitors and structure-based design of cathepsin B-specific inhibitor
Curr. Top. Med. Chem.
10
696-707
2010
Homo sapiens
brenda
Huryn, D.M.; Smith, A.B.
The identification, characterization and optimization of small molecule probes of cysteine proteases: experiences of the Penn center for molecular discovery with cathepsin B and cathepsin L
Curr. Top. Med. Chem.
9
1206-1216
2009
Homo sapiens
brenda
Spencer, J.; Casini, A.; Zava, O.; Rathnam, R.P.; Velhanda, S.K.; Pfeffer, M.; Callear, S.K.; Hursthouse, M.B.; Dyson, P.J.
Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles
Dalton Trans.
2009
10731-10735
2009
Bos taurus, Homo sapiens
brenda
Casini, A.; Edafe, F.; Erlandsson, M.; Gonsalvi, L.; Ciancetta, A.; Re, N.; Ienco, A.; Messori, L.; Peruzzini, M.; Dyson, P.J.
Rationalization of the inhibition activity of structurally related organometallic compounds against the drug target cathepsin B by DFT
Dalton Trans.
39
5556-5563
2010
Homo sapiens
brenda
Kolwijck, E.; Kos, J.; Obermajer, N.; Span, P.N.; Thomas, C.M.; Massuger, L.F.; Sweep, F.C.
The balance between extracellular cathepsins and cystatin C is of importance for ovarian cancer
Eur. J. Clin. Invest.
40
591-599
2010
Homo sapiens
brenda
Mirkovic, B.; Premzl, A.; Hodnik, V.; Doljak, B.; Jevnikar, Z.; Anderluh, G.; Kos, J.
Regulation of cathepsin B activity by 2A2 monoclonal antibody
FEBS J.
276
4739-4751
2009
Homo sapiens
brenda
Pungercar, J.R.; Caglic, D.; Sajid, M.; Dolinar, M.; Vasiljeva, O.; Pozgan, U.; Turk, D.; Bogyo, M.; Turk, V.; Turk, B.
Autocatalytic processing of procathepsin B is triggered by proenzyme activity
FEBS J.
276
660-668
2009
Homo sapiens
brenda
Moles, A.; Tarrats, N.; Fernandez-Checa, J.C.; Mari, M.
Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential
Hepatology
49
1297-1307
2009
Homo sapiens, Mus musculus, Mus musculus C57BL/6
brenda
Reich, M.; Wieczerzak, E.; Jankowska, E.; Palesch, D.; Boehm, B.O.; Burster, T.
Specific cathepsin B inhibitor is cell-permeable and activates presentation of TTC in primary human dendritic cells
Immunol. Lett.
123
155-159
2009
Homo sapiens
brenda
Beckham, S.A.; Piedrafita, D.; Phillips, C.I.; Samarawickrema, N.; Law, R.H.; Smooker, P.M.; Quinsey, N.S.; Irving, J.A.; Greenwood, D.; Verhelst, S.H.; Bogyo, M.; Turk, B.; Coetzer, T.H.; Wijeyewickrema, L.C.; Spithill, T.W.; Pike, R.N.
A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites
Int. J. Biochem. Cell Biol.
41
1601-1612
2009
Fasciola hepatica, Homo sapiens
brenda
Kolwijck, E.; Massuger, L.F.; Thomas, C.M.; Span, P.N.; Krasovec, M.; Kos, J.; Sweep, F.C.
Cathepsins B, L and cystatin C in cyst fluid of ovarian tumors
J. Cancer Res. Clin. Oncol.
136
771-778
2010
Homo sapiens
brenda
Duncan, J.A.; Gao, X.; Huang, M.T.; OConnor, B.P.; Thomas, C.E.; Willingham, S.B.; Bergstralh, D.T.; Jarvis, G.A.; Sparling, P.F.; Ting, J.P.
Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome
J. Immunol.
182
6460-6469
2009
Homo sapiens, Mus musculus
brenda
Zhou, Z.; Wang, Y.; Bryant, S.H.
QSAR models for predicting cathepsin B inhibition by small molecules - continuous and binary QSAR models to classify cathepsin B inhibition activities of small molecules
J. Mol. Graph. Model.
28
714-727
2010
Homo sapiens
brenda
Puissant, A.; Colosetti, P.; Robert, G.; Cassuto, J.P.; Raynaud, S.; Auberger, P.
Cathepsin B release after imatinib-mediated lysosomal membrane permeabilization triggers BCR-ABL cleavage and elimination of chronic myelogenous leukemia cells
Leukemia
24
115-124
2010
Homo sapiens
brenda
Joy, B.; Sivadasan, R.; Abraham T, E.; John, M.; Sobhan, P.K.; Seervi, M.; Santhoshkumar, T.R.
Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin-induced apoptosis
Mol. Carcinog.
49
324-336
2010
Homo sapiens
brenda
Gole, B.; Duran Alonso, M.B.; Dolenc, V.; Lah, T.
Post-translational regulation of cathepsin B, but not of other cysteine cathepsins, contributes to increased glioblastoma cell invasiveness in vitro
Pathol. Oncol. Res.
15
711-723
2009
Homo sapiens
brenda
Murata, R.M.; Yatsuda, R.; dos Santos, M.H.; Kohn, L.K.; Martins, F.T.; Nagem, T.J.; Alencar, S.M.; de Carvalho, J.E.; Rosalen, P.L.
Antiproliferative effect of benzophenones and their influence on cathepsin activity
Phytother. Res.
24
379-383
2010
Homo sapiens
brenda
Bien, S.; Rimmbach, C.; Neumann, H.; Niessen, J.; Reimer, E.; Ritter, C.A.; Rosskopf, D.; Cinatl, J.; Michaelis, M.; Schroeder, H.W.; Kroemer, H.K.
Doxorubicin-induced cell death requires cathepsin B in HeLa cells
Biochem. Pharmacol.
80
1466-1477
2010
Homo sapiens
brenda
Costa, M.G.; Batista, P.R.; Shida, C.S.; Robert, C.H.; Bisch, P.M.; Pascutti, P.G.
How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamics
BMC Genomics
11 Suppl 5
S5
2010
Homo sapiens (P07858)
brenda
Valadares, N.F.; Dellamano, M.; Soares-Costa, A.; Henrique-Silva, F.; Garratt, R.C.
Molecular determinants of improved cathepsin B inhibition by new cystatins obtained by DNA shuffling
BMC Struct. Biol.
10
30
2010
Homo sapiens
brenda
Asai, M.; Yagishita, S.; Iwata, N.; Saido, T.C.; Ishiura, S.; Maruyama, K.
An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model
FASEB J.
25
3720-3730
2011
Homo sapiens
brenda
Wisastra, R.; Ghizzoni, M.; Maarsingh, H.; Minnaard, A.J.; Haisma, H.J.; Dekker, F.J.
Isothiazolones; thiol-reactive inhibitors of cysteine protease cathepsin B and histone acetyltransferase PCAF
Org. Biomol. Chem.
9
1817-1822
2011
Homo sapiens
brenda
Gogiel, T.; Galewska, Z.; Romanowicz, L.
Differential distribution of cathepsin B in human umbilical cord tissues
Acta Biochim. Pol.
59
679-684
2012
Homo sapiens (P07858), Homo sapiens
brenda
Kim, C.J.; Lee, D.I.; Zhang, D.; Lee, C.H.; Ahn, I.S.
New strategy for selective and sensitive assay of cathepsin B using a dityrosine-based material
Anal. Biochem.
435
166-173
2013
Homo sapiens (P07858)
brenda
Wyczalkowska-Tomasik, A.; Plczek, L.
Cathepsin B and L activity in the serum during the human aging process: cathepsin B and L in aging
Arch. Gerontol. Geriatr.
55
735-738
2012
Homo sapiens
brenda
Morchang, A.; Panaampon, J.; Suttitheptumrong, A.; Yasamut, U.; Noisakran, S.; Yenchitsomanus, P.T.; Limjindaporn, T.
Role of cathepsin B in dengue virus-mediated apoptosis
Biochem. Biophys. Res. Commun.
438
20-25
2013
Homo sapiens (P07858), Homo sapiens
brenda
Sosic, I.; Mirkovic, B.; Arenz, K.; Stefane, B.; Kos, J.; Gobec, S.
Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives
J. Med. Chem.
56
521-533
2013
Homo sapiens
brenda
Edem, P.E.; Czorny, S.; Valliant, J.F.
Synthesis and evaluation of radioiodinated acyloxymethyl ketones as activity-based probes for cathepsin B
J. Med. Chem.
57
9564-9577
2014
Homo sapiens (P07858)
brenda
Bian, B.; Mongrain, S.; Cagnol, S.; Langlois, M.; Boulanger, J.; Bernatchez, G.; Carrier, J.; Boudreau, F.; Rivard, N.
Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis
Mol. Carcinog.
55
671-687
2015
Homo sapiens (P07858), Homo sapiens
brenda
Zhang, X.; Yang, X.; Wang, H.; Li, S.; Guo, K.; Jiang, D.; Xiao, J.; Liang, D.
Design, synthesis, and structure-activity relationship study of epoxysuccinyl-peptide derivatives as cathepsin B inhibitors
Biol. Pharm. Bull.
40
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Homo sapiens (P07858)
brenda
Schmitz, J.; Gilberg, E.; Loeser, R.; Bajorath, J.; Bartz, U.; Guetschow, M.
Cathepsin B Active site mapping with peptidic substrates and inhibitors
Bioorg. Med. Chem.
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2019
Homo sapiens (P07858), Homo sapiens
brenda
Sosic, I.; Mitrovic, A.; Curic, H.; Knez, D.; Brodnik Zugelj, H.; Stefane, B.; Kos, J.; Gobec, S.
Cathepsin B inhibitors Further exploration of the nitroxoline core
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28
1239-1247
2018
Homo sapiens (P07858), Homo sapiens
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Mijanovic, O.; Brankovic, A.; Panin, A.N.; Savchuk, S.; Timashev, P.; Ulasov, I.; Lesniak, M.S.
Cathepsin B A sellsword of cancer progression
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2019
Homo sapiens (P07858)
brenda
Chen, N.; Ou, Z.; Zhang, W.; Zhu, X.; Li, P.; Gong, J.
Cathepsin B regulates non-canonical NLRP3 inflammasome pathway by modulating activation of caspase-11 in Kupffer cells
Cell Prolif.
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2018
Homo sapiens (P07858), Homo sapiens, Mus musculus (P10605)
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Kryczka, J.; Papiewska-Pajak, I.; Kowalska, M.A.; Boncela, J.
Cathepsin B is upregulated and mediates ECM degradation in dolon adenocarcinoma HT29 cells overexpressing snail
Cells
8
203
2019
Homo sapiens (P07858)
brenda
Araujo, T.F.; Cordeiro, A.V.; Vasconcelos, D.A.A.; Vitzel, K.F.; Silva, V.R.R.
The role of cathepsin B in autophagy during obesity A systematic review
Life Sci.
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2018
Homo sapiens (P07858)
brenda
Ramalho, S.D.; de Sousa, L.R.; Burger, M.C.; Lima, M.I.; da Silva, M.F.; Fernandes, J.B.; Vieira, P.C.
Evaluation of flavonols and derivatives as human cathepsin B inhibitor
Nat. Prod. Res.
29
2212-2214
2015
Homo sapiens (P07858), Homo sapiens
brenda