Reference on EC 3.4.21.59 - Tryptase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Harvima, I.T.; Schechter, N.M.; Harvima, R.J.; Frki, J.E.
Human skin tryptase: purification, partial characterization and comparison with human lung tryptase
Biochim. Biophys. Acta
957
71-80
1988
Homo sapiens
Kido, H.; Fukusen, N.; Katunuma, N.
Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions
Arch. Biochem. Biophys.
239
436-443
1985
Rattus norvegicus
Tanaka, T.; McRae, B.J.; Cho, K.; Cook, R.; Fraki, J.E.; Johnson, D.A.; Powers, J.C.
Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates
J. Biol. Chem.
258
13552-13557
1983
Homo sapiens
Vanderslice, P.; Ballinger, S.M.; Tam, E.K.; Goldstein, S.M.; Craik, C.S.; Caughey, G.H.
Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family
Proc. Natl. Acad. Sci. USA
87
3811-3815
1990
Homo sapiens
Cromlish, J.A.; Seidah, N.G.; Marcinkiewicz, M.; Hamelin, J.; Jonson, D.A.; Chretien, M.
Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates
J. Biol. Chem.
262
1363-1373
1987
Homo sapiens
Schwartz, L.B.
Tryptase: a mast cell serine protease
Methods Enzymol.
244
88-100
1994
Bos taurus, Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Rest, R.F.
Human neutrophil and mast cell proteases implicated in inflammation
Methods Enzymol.
163
309-327
1988
Homo sapiens
Kido, H.; Yokogoshi, Y.; Katunuma, N.
Kunitz-type protease inhibitor found in rat mast cells. Purification, properties, and amino acid sequence
J. Biol. Chem.
263
18104-18107
1988
Rattus norvegicus
Kido, H.; Fukusen, N.; Katunuma, N.; Morita, T.; Iwanaga, S.
Tryptase from rat mast cells converts bovine prothrombin to thrombin
Biochem. Biophys. Res. Commun.
132
613-619
1985
Rattus norvegicus
Schechter, N.M.; Slavin, D.; Fetter, R.D.; Lazarus, G.S.; Frki, J.E.
Purification and identification of two serine class proteinases from dog mast biochemically and immunologically similar to human proteinases tryptase and chymase
Arch. Biochem. Biophys.
262
232-244
1988
Canis lupus familiaris
Alter, S.C.; Metcalfe, D.D.; Bradford, T.R.; Schwartz, L.B.
Regulation of human mast cell tryptase. Effects of enzyme concentration, ionic strength and the structure and negative charge density of polysaccharides
Biochem. J.
248
821-827
1987
Homo sapiens
Schwartz, L.B.; Bradford, T.R.
Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer
J. Biol. Chem.
261
7372-7379
1986
Homo sapiens
Powers, J.C.; Tanaka, T.; Harper, J.W.; Minematsu, Y.; Barker, L.; Lincoln, D.; Crumley, K.V.; Fraki, J.E.; Schechter, N.M.; Lazarus, G.G.; Nakajima, K.; Nakashino, K.; Neurath, H.; Woodbury, R.G.
Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors
Biochemistry
24
2048-2058
1985
Rattus norvegicus
Yoshida, N.; Everitt, M.T.; Neurath, H.; Woodbury, R.G.; Powers, J.C.
Substrate specificity of two chymotrypsin-like proteases from rat mast cells. Studies with peptide 4-nitroanilides and comparison with cathepsin G
Biochemistry
19
5799-5804
1980
Rattus norvegicus
Alter, S.C.; Schwartz, L.B.
Effect of histamine and divalent cations on the activity and stability of tryptase from human mast cells
Biochim. Biophys. Acta
991
426-430
1989
Homo sapiens
Alter, S.C.; Kramps, J.A.; Janoff, A.; Schwartz, L.B.
Interactions of human mast cell tryptase with biological protease inhibitors
Arch. Biochem. Biophys.
276
26-31
1990
Homo sapiens
Muramatu, M.; Itoh, T.; Takei, M.; Endo, K.
Tryptase in rat mast cells: properties and inhibition by various inhibitors in comparison with chymase
Biol. Chem. Hoppe-Seyler
369
617-625
1988
Rattus norvegicus
Remington, S.J.; Woodbury, R.G.; Reynolds, R.A.; Matthews, B.W.; Neurath, H.
The structure of rat mast cell protease II at 1.9-A resolution
Biochemistry
27
8097-8105
1988
Rattus norvegicus
Caughey, G.H.; Viro, N.F.; Ramachandran, J.; Lazarus, S.C.; Borson, D.B.; Nadel, J.A.
Dog mastocytoma tryptase: affinity purification, characterization, and amino-terminal sequence
Arch. Biochem. Biophys.
258
555-563
1987
Canis lupus familiaris
Fiorucci, L.; Erba, F.; Falasca, L.; Dini, L.; Ascoli, F.
Localization and interaction of bovine pancreatic trypsin inhibitor and tryptase in the granules of bovine mast cells
Biochim. Biophys. Acta
1243
407-413
1995
Bos taurus
Fiorucci, L.; Erba, F.; Ascoli, F.
Bovine tryptase: purification and characterization
Biol. Chem. Hoppe-Seyler
373
483-490
1992
Bos taurus
Walls, A.F.; Bennett, A.R.; Sueiras-Diaz, J.; Olsson, H.
The kininogenase activity of human mast cell tryptase
Biochem. Soc. Trans.
20
260S
1992
Homo sapiens
Braganza, V.J.; Simmons, W.H.
Tryptase from rat skin: purification and properties
Biochemistry
30
4997-5007
1991
Rattus norvegicus
Dietze, S.C.; Auerswald, E.A.; Fritz, H.
A new, highly sensitive enzymic assay for human tryptase and its use for identification of tryptase inhibitors
Biol. Chem. Hoppe-Seyler
371
65-73
1990
Homo sapiens
Schwartz, L.B.; Bradford, T.R.; Lee, D.C.; Chlebowski, J.F.
Immunologic and physicochemical evidence for conformational changes occurring on conversion of human mast cell tryptase from active tetramer to inactive monomer. Production of monoclonal antibodies recognizing active tryptase
J. Immunol.
144
2304-2311
1990
Homo sapiens
Sommerhoff, C.P.; Sllner, C.; Mentele, R.; Piechottka, G.P.; Auerswald, E.A.; Fritz, H.
A Kazal-type inhibitor of human mast cell tryptase: isolation from the medical leech Hirudo medicinalis, characterization, and sequence analysis
Biol. Chem. Hoppe-Seyler
375
685-694
1994
Homo sapiens
Sturzebecher, J.; Prasa, D.; Sommerhoff, C.P.
Inhibition of human mast cell tryptase by benzamidine derivatives
Biol. Chem. Hoppe-Seyler
373
1025-1030
1992
Homo sapiens
Schechter, N.M.; Eng, G.Y.; McCaslin, D.R.
Human skin tryptase: kinetic characterization of its spontaneous inactivation
Biochemistry
32
2617-2625
1993
Homo sapiens
Suzuki, K.; Lees, M.; Newlands, G.F.J.; Nagase, H.; Woolley, D.E.
Activation of precursors for matrix metalloproteinases 1 (interstitial collagenase) and 3 (stromelysin) by rat mast-cell proteinases I and II
Biochem. J.
305
301-306
1995
Rattus norvegicus
Pallaoro, M.; Gambacurta, A.; Fiorucci, L.; Mignogna, G.; Barra, D.; Ascoli, F.
cDNA cloning and primary structure of tryptase from bovine mast cells, and evidence for the expression of bovine pancreatic trypsin inhibitor mRNA in the same cells
Eur. J. Biochem.
237
100-105
1996
Bos taurus
Little, S.S.; Johnson, D.A.
Human mast cell tryptase isoforms: separation and examination of substrate-specificity differences
Biochem. J.
307
341-346
1995
Homo sapiens
Fiorucci, L.; Erba, F.; Coletta, M.; Ascoli, F.
Evidence for multiple interacting binding sites in bovine tryptase
FEBS Lett.
363
81-84
1995
Bos taurus
Osman, I.A.R.; Garrett, J.R.; Smith, R.E.
Enzyme histochemical discrimination between tryptase and chymase in mast cells of human gut
J. Histochem. Cytochem.
37
415-421
1989
Homo sapiens
Sakai, K.; Long, S.D.; Pettit, D.A.D.; Cabral, G.A.; Schwartz, L.B.
Expression and purification of recombinant human tryptase in a baculovirus system
Protein Expr. Purif.
7
67-73
1996
Homo sapiens
Lohi, J.; Harvima, I.; Keski-Oja, J.
Pericellular substrates of human mast cell tryptase: 72,000 dalton gelatinase and fibronectin
J. Cell. Biochem.
50
337-349
1992
Homo sapiens
Butterfield, J.H.; Weiler, D.A.; Hunt, L.W.; Wynn, S.R.; Roche, P.C.
Purification of tryptase from a human mast cell line
J. Leukocyte Biol.
47
409-419
1990
Homo sapiens
Millner, J.S.; Westin, E.H.; Schwartz, L.B.
Cloning and characterization of complementary DNA for human tryptase
J. Clin. Invest.
84
1188-1195
1989
Homo sapiens
Cregar, L.; Elrod, K.C.; Putnam, D.; Moore, W.R.
Neutrophil myeloperoxidase is a potent and selective inhibitor of mast cell tryptase
Arch. Biochem. Biophys.
366
125-130
1999
Homo sapiens
Hallgren, J.; Estrada, S.; Karlson, U.; Alving, K.; Pejler, G.
Heparin antagonists are potent inhibitors of mast cell tryptase
Biochemistry
40
7342-7349
2001
Homo sapiens, Mus musculus
Selwood, T.; Wang, Z.M.; McCaslin, D.R.; Schechter, N.M.
Diverse stability and catalytic properties of human tryptase alpha and beta isoforms are mediated by residue differences at the S1 pocket
Biochemistry
41
3329-3340
2002
Homo sapiens
Erba, F.; Fiorucci, L.; Sommerhoff, C.P.; Coletta, M.; Ascoli, F.
Kinetic and thermodynamic analysis of leech-derived tryptase inhibitor interaction with bovine tryptase and bovine trypsin
Biol. Chem.
381
1117-1122
2000
Bos taurus
Selwood, T.; Elrod, K.C.; Schechter, N.M.
Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor
Biol. Chem.
384
1605-1611
2003
Homo sapiens
Schaschke, N.; Matschiner, G.; Zettl, F.; Marquardt, U.; Bergner, A.; Bode, W.; Sommerhoff, C.P.; Moroder, L.
Bivalent inhibition of human beta-tryptase
Chem. Biol.
8
313-327
2001
Homo sapiens
Chen, Y.; Shiota, M.; Ohuchi, M.; Towatari, T.; Tashiro, J.; Murakami, M.; Yano, M.; Yang, B.; Kido, H.
Mast cell tryptase from pig lungs triggers infection by pneumotropic Sendai and influenza A viruses. Purification and characterization
Eur. J. Biochem.
267
3189-3197
2000
Sus scrofa
Peng, Q.; McEuen, A.R.; Benyon, R.C.; Walls, A.F.
The heterogeneity of mast cell tryptase from human lung and skin. Differences in size, charge and substrate affinity
Eur. J. Biochem.
270
270-283
2003
Homo sapiens
Fiorucci, L.; Erba, F.; Bolognesi, M.; Coletta, M.; Ascoli, F.
pH dependence of bovine mast cell tryptase catalytic activity and of its inhibition by 4',6-diamidino-2-phenylindole
FEBS Lett.
408
85-88
1997
Bos taurus
Stubbs, M.T.; Morenweiser, R.; Sturzebecher, J.; Bauer, M.; Bode, W.; Huber, R.; Piechottka, G.P.; Matschiner, G.; Sommerhoff, C.P.; Fritz, H.; Auerswald, E.A.
The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition
J. Biol. Chem.
272
19931-19937
1997
Homo sapiens
Huang, C.; Li, L.; Krilis, S.A.; Chanasyk, K.; Tang, Y.; Li, Z.; Hunt, J.E.; Stevens, R.L.
Human tryptases alpha and beta/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft
J. Biol. Chem.
274
19670-19676
1999
Homo sapiens
Huang, C.; De Sanctis, G.T.; O'Brien, P.J.; Mizgerd, J.P.; Friend, D.S.; Drazen, J.M.; Brass, L.F.; Stevens, R.L.
Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung
J. Biol. Chem.
276
26276-26284
2001
Homo sapiens, Mus musculus
Harris, J.L.; Niles, A.; Burdick, K.; Maffitt, M.; Backes, B.J.; Ellman, J.A.; Kuntz, I.; Haak-Frendscho, M.; Craik, C.S.
Definition of the extended substrate specificity determinants for b-tryptases I and II
J. Biol. Chem.
276
34941-34947
2001
Homo sapiens
Combrink, K.D.; Guelgeze, H.B.; Meanwell, N.A.; Pearce, B.C.; Zulan, P.; Bisacchi, G.S.; Roberts, D.G.; Stanley, P.; Seiler, S.M.
1,2-Benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase
J. Med. Chem.
41
4854-4860
1998
Homo sapiens
Costanzo, M.J.; Yabut, S.C.; Almond, H.R., Jr.; Andrade-Gordon, P.; Corcoran, T.W.; De Garavilla, L.; Kauffman, J.A.; Abraham, W.M.; Recacha, R.; Chattopadhyay, D.; Maryanoff, B.E.
Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone
J. Med. Chem.
46
3865-3876
2003
Homo sapiens
Marquardt, U.; Zettl, F.; Huber, R.; Bode, W.; Sommerhoff, C.
The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region
J. Mol. Biol.
321
491-502
2002
Homo sapiens
Qian, X.; Zheng, B.; Burke, B.; Saindane, M.T.; Kronenthal, D.R.
A stereoselective synthesis of BMS-262084, an azetidinone-based tryptase inhibitor
J. Org. Chem.
67
3595-3600
2002
Homo sapiens
Mori, S.; Itoh, Y.; Shinohata, R.; Sendo, T.; Oishi, R.; Nishibori, M.
Nafamostat mesilate is an extremely potent inhibitor of human tryptase
J. Pharm. Sci.
92
420-423
2003
Homo sapiens
Pereira, P.J.B.; Bergner, A.; Macedo-Ribeiro, S.; Huber, R.; Matschiner, G.; Fritz, H.; Sommerhoff, C.P.; Bode, W.
Human b-tryptase is a ring-like tetramer with active sites facing a central pore
Nature
392
306-311
1998
Homo sapiens
Sommerhoff, C.P.; Bode, W.; Pereira, P.J.; Stubbs, M.T.; Stuerzebecher, J.; Piechottka, G.P.; Matschiner, G.; Bergner, A.
The structure of the human betaII-tryptase tetramer: fo(u)r better or worse
Proc. Natl. Acad. Sci. USA
96
10984-10991
1999
Homo sapiens
Burgess, L.E.; Newhouse, B.J.; Ibrahim, P.; Rizzi, J.; Kashem, M.A.; Hartman, A.; Brandhuber, B.J.; Wright, C.D.; Thomson, D.S.; Vigers, G.P.; Koch, K.
Potent selective nonpeptidic inhibitors of human lung tryptase
Proc. Natl. Acad. Sci. USA
96
8348-8352
1999
Homo sapiens
Chan, H.; Elrod, K.C.; Numerof, R.P.; Sideris, S.; Clark, J.M.
Expression and characterization of recombinant mast cell tryptase
Protein Expr. Purif.
15
251-257
1999
Homo sapiens
Ma, Y.; Zhang, B.; Qian, R.; Lu, C.; Zhao, F.; Yin, L.
Tryptase activates PKB in inflammatory reaction in ECV304 cells
Biochim. Biophys. Acta
1763
313-321
2006
Homo sapiens
Wong, T.; Groutas, C.S.; Mohan, S.; Lai, Z.; Alliston, K.R.; Vu, N.; Schechter, N.M.; Groutas, W.C.
1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase
Arch. Biochem. Biophys.
436
1-7
2005
Homo sapiens
Sperandio, D.; Tai, V.W.; Lohman, J.; Hirschbein, B.; Mendonca, R.; Lee, C.S.; Spencer, J.R.; Janc, J.; Nguyen, M.; Beltman, J.; Sprengeler, P.; Scheerens, H.; Lin, T.; Liu, L.; Gadre, A.; Kellogg, A.; Green, M.J.; McGrath, M.E.
Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors
Bioorg. Med. Chem. Lett.
16
4085-4089
2006
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Vliagoftis, H.; Lacy, P.; Luy, B.; Adamko, D.; Hollenberg, M.; Befus, D.; Moqbel, R.
Mast cell tryptase activates peripheral blood eosinophils to release granule-associated enzymes
Int. Arch. Allergy Immunol.
135
196-204
2004
Homo sapiens
Yuan, J.; Beltman, J.; Gjerstad, E.; Nguyen, M.T.; Sampang, J.; Chan, H.; Janc, J.W.; Clark, J.M.
Expression and characterization of recombinant gamma-tryptase
Protein Expr. Purif.
49
47-54
2006
Homo sapiens
Caughey, G.H.
Mast cell tryptases and chymases in inflammation and host defense
Immunol. Rev.
217
141-154
2007
Homo sapiens, Mus musculus
Tatler, A.L.; Porte, J.; Knox, A.; Jenkins, G.; Pang, L.
Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis
Biochem. Biophys. Res. Commun.
370
239-242
2008
Homo sapiens
McGrath, M.E.; Sprengeler, P.A.; Hirschbein, B.; Somoza, J.R.; Lehoux, I.; Janc, J.W.; Gjerstad, E.; Graupe, M.; Estiarte, A.; Venkataramani, C.; Liu, Y.; Yee, R.; Ho, J.D.; Green, M.J.; Lee, C.S.; Liu, L.; Tai, V.; Spencer, J.; Sperandio, D.; Katz, B.A.
Structure-guided design of peptide-based tryptase inhibitors
Biochemistry
45
5964-5973
2006
Homo sapiens
Schechter, N.M.; Choi, E.J.; Selwood, T.; McCaslin, D.R.
Characterization of three distinct catalytic forms of human tryptase-beta: their interrelationships and relevance
Biochemistry
46
9615-9629
2007
Homo sapiens
Miyazaki, Y.; Kato, Y.; Manabe, T.; Shimada, H.; Mizuno, M.; Egusa, T.; Ohkouchi, M.; Shiromizu, I.; Matsusue, T.; Yamamoto, I.
Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors
Bioorg. Med. Chem. Lett.
16
2986-2990
2006
Homo sapiens
Palmer, J.T.; Rydzewski, R.M.; Mendonca, R.V.; Sperandio, D.; Spencer, J.R.; Hirschbein, B.L.; Lohman, J.; Beltman, J.; Nguyen, M.; Liu, L.
Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors
Bioorg. Med. Chem. Lett.
16
3434-3439
2006
Homo sapiens
Lee, C.S.; Liu, W.; Sprengeler, P.A.; Somoza, J.R.; Janc, J.W.; Sperandio, D.; Spencer, J.R.; Green, M.J.; McGrath, M.E.
Design of novel, potent, and selective human beta-tryptase inhibitors based on alpha-keto-[1,2,4]-oxadiazoles
Bioorg. Med. Chem. Lett.
16
4036-4040
2006
Homo sapiens
Costanzo, M.J.; Yabut, S.C.; Zhang, H.C.; White, K.B.; de Garavilla, L.; Wang, Y.; Minor, L.K.; Tounge, B.A.; Barnakov, A.N.; Lewandowski, F.; Milligan, C.; Spurlino, J.C.; Abraham, W.M.; Boswell-Smith, V.; Page, C.P.; Maryanoff, B.E.
Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives
Bioorg. Med. Chem. Lett.
18
2114-2121
2008
Homo sapiens
Dacre, K.J.; McAleese, S.M.; Knight, P.; McGorum, B.C.; Pemberton, A.D.
cDNA cloning and substrate specificity of equine tryptase, a possible mediator in equine heaves
Clin. Exp. Allergy
36
1303-1309
2006
Equus caballus (Q7YS62), Equus caballus
Hallgren, J.; Pejler, G.
Biology of mast cell tryptase. An inflammatory mediator
FEBS J.
273
1871-1895
2006
Homo sapiens, Mus musculus
Fukuoka, Y.; Schwartz, L.B.
Active monomers of human beta-tryptase have expanded substrate specificities
Int. Immunopharmacol.
7
1900-1908
2007
Homo sapiens
Pang, L.; Nie, M.; Corbett, L.; Sutcliffe, A.; Knox, A.J.
Mast cell beta-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities
J. Immunol.
176
3788-3795
2006
Homo sapiens
Rohr, K.B.; Selwood, T.; Marquardt, U.; Huber, R.; Schechter, N.M.; Bode, W.; Than, M.E.
X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha-beta-tryptase transition
J. Mol. Biol.
357
195-209
2006
Homo sapiens
Spichalska, B.; Lesner, A.; Wysocka, M.; Sledz, M.; Legowska, A.; Jaskiewicz, A.; Miecznikowska, H.; Rolka, K.
The influence of substrate peptide length on human beta-tryptase specificity
J. Pept. Sci.
14
917-923
2008
Homo sapiens
Storjord, E.; Nielsen, E.W.
Tryptase levels after suxamethonium administration and defibrillation
Acta Anaesthesiol. Scand.
52
838-840
2008
Homo sapiens
Coffman, L.G.; Brown, J.C.; Johnson, D.A.; Parthasarathy, N.; DAgostino, R.B.; Lively, M.O.; Hua, X.; Tilley, S.L.; Muller-Esterl, W.; Willingham, M.C.; Torti, F.M.; Torti, S.V.
Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin
Am. J. Physiol. Lung Cell Mol. Physiol.
294
L505-L515
2008
Mus musculus
McNeil, H.P.; Shin, K.; Campbell, I.K.; Wicks, I.P.; Adachi, R.; Lee, D.M.; Stevens, R.L.
The mouse mast cell-restricted tetramer-forming tryptases mouse mast cell protease 6 and mouse mast cell protease 7 are critical mediators in inflammatory arthritis
Arthritis Rheum.
58
2338-2346
2008
Mus musculus
Kim, M.S.; Kim, Y.K.; Lee, D.H.; Seo, J.E.; Cho, K.H.; Eun, H.C.; Chung, J.H.
Acute exposure of human skin to ultraviolet or infrared radiation or heat stimuli increases mast cell numbers and tryptase expression in human skin in vivo
Br. J. Dermatol.
160
393-402
2009
Homo sapiens
Gerdes, S.; Kurrat, W.; Mrowietz, U.
Serum mast cell tryptase is not a useful marker for disease severity in psoriasis or atopic dermatitis
Br. J. Dermatol.
160
736-740
2009
Homo sapiens
Ribatti, D.; Nico, B.; Finato, N.; Crivellato, E.; Beltrami, C.A.
Co-localization of tryptase and cathepsin-G in mast cells in cutaneous mastocytosis
Cancer Lett.
279
209-212
2009
Homo sapiens
Potier, A.; Lavigne, C.; Chappard, D.; Verret, J.L.; Chevailler, A.; Nicolie, B.; Drouet, M.
Cutaneous manifestations in Hymenoptera and Diptera anaphylaxis: relationship with basal serum tryptase
Clin. Exp. Allergy
39
717-725
2009
Homo sapiens
Masuko, K.; Murata, M.; Xiang, Y.; Nakamura, H.; Yudoh, K.; Nishioka, K.; Beppu, M.; Kato, T.
Tryptase enhances release of vascular endothelial growth factor from human osteoarthritic chondrocytes
Clin. Exp. Rheumatol.
25
860-865
2008
Homo sapiens
de Rossi, T.M.; Krauss, N.; Wilken, V.; Giera, B.; Konturek, P.C.; Kressel, J.; Hahn, E.G.; Raithel, M.
Mast cell tryptase in sera of patients with Crohns disease and mastocytosis
Eur. J. Gastroenterol. Hepatol.
21
273-277
2009
Homo sapiens
Bonadonna, P.; Perbellini, O.; Passalacqua, G.; Caruso, B.; Colarossi, S.; Dal Fior, D.; Castellani, L.; Bonetto, C.; Frattini, F.; Dama, A.; Martinelli, G.; Chilosi, M.; Senna, G.; Pizzolo, G.; Zanotti, R.
Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels
J. Allergy Clin. Immunol.
123
680-686
2009
Homo sapiens
Shin, K.; Watts, G.F.; Oettgen, H.C.; Friend, D.S.; Pemberton, A.D.; Gurish, M.F.; Lee, D.M.
Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection
J. Immunol.
180
4885-4891
2008
Mus musculus
Tsujii, K.; Andoh, T.; Ui, H.; Lee, J.B.; Kuraishi, Y.
Involvement of tryptase and proteinase-activated receptor-2 in spontaneous itch-associated response in mice with atopy-like dermatitis
J. Pharmacol. Sci.
109
388-395
2009
Mus musculus
Jiang, Y.F.; Zhao, F.D.; Li, X.B.; Ning, Y.X.; Zhi, X.L.; Qian, R.Z.; Yin, L.H.
Effects of RNA interference-induced tryptase down-regulation in P815 cells on IL-6 and TNF-alpha release of endothelial cells
J. Zhejiang Univ. Sci. B
9
656-661
2008
Mus musculus
McEuen, A.R.; Walls, A.F.
Purification and characterization of mast cell tryptase and chymase from human tissues
Methods Mol. Med.
138
299-317
2008
Homo sapiens
Rojas, I.G.; Martinez, A.; Brethauer, U.; Grez, P.; Yefi, R.; Luza, S.; Marchesani, F.J.
Actinic cheilitis: epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2
Oral Oncol.
45
284-290
2009
Homo sapiens
Carr, M.N.; Torres, S.M.; Koch, S.N.; Reiter, L.V.
Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin-2 in healthy dogs
Vet. Dermatol.
20
105-110
2009
Homo sapiens
Fineschi, V.; Riezzo, I.; Cantatore, S.; Pomara, C.; Turillazzi, E.; Neri, M.
Complement C3a expression and tryptase degranulation as promising histopathological tests for diagnosing fatal amniotic fluid embolism
Virchows Arch.
454
283-290
2009
Homo sapiens
Chang, E.H.; Lee, J.H.; Zabner, J.
Tryptase does not alter transepithelial conductance or paracellular permeability in human airway epithelial cells
Am. J. Rhinol. Allergy
24
126-128
2010
Homo sapiens
Yeong, P.; Ning, Y.; Xu, Y.; Li, X.; Yin, L.
Tryptase promotes human monocyte-derived macrophage foam cell formation by suppressing LXRalpha activation
Biochim. Biophys. Acta
1801
567-576
2010
Homo sapiens
Schaschke, N.; Sommerhoff, C.
Upgrading a natural product: Inhibition of human beta-tryptase by cyclotheonamide analogues
ChemMedChem
5
367-370
2010
Homo sapiens
Gonzalez-Quintela, A.; Vizcaino, L.; Gude, F.; Rey, J.; Meijide, L.; Fernandez-Merino, C.; Linneberg, A.; Vidal, C.
Factors influencing serum total tryptase concentrations in a general adult population
Clin. Chem. Lab. Med.
48
701-706
2010
Homo sapiens
Dugas-Breit, S.; Przybilla, B.; Dugas, M.; Arnold, A.; Pfundstein, G.; Kuechenhoff, H.; Rueff, F.
Serum concentration of baseline mast cell tryptase: evidence for a decline during long-term immunotherapy for Hymenoptera venom allergy
Clin. Exp. Allergy
40
643-649
2010
Homo sapiens
Ricci, G.; Zannoni, M.; Cigolini, D.; Caroselli, C.; Codogni, R.; Caruso, B.; Bonello, E.; Rocca, G.P.
Tryptase serum level as a possible indicator of scombroid syndrome
Clin. Toxicol. (Phila.)
48
203-206
2010
Homo sapiens
Lee, J.W.; Park, J.H.; Park, D.I.; Park, J.H.; Kim, H.J.; Cho, Y.K.; Sohn, C.I.; Jeon, W.K.; Kim, B.I.
Subjects with diarrhea-predominant IBS have increased rectal permeability responsive to tryptase
Digest. Dis. Sci.
55
2922-2928
2010
Homo sapiens
Sperr, W.R.; El-Samahi, A.; Kundi, M.; Girschikofsky, M.; Winkler, S.; Lutz, D.; Endler, G.; Rumpold, H.; Agis, H.; Sillaber, C.; Jaeger, U.; Valent, P.
Elevated tryptase levels selectively cluster in myeloid neoplasms: a novel diagnostic approach and screen marker in clinical haematology
Eur. J. Clin. Invest.
39
914-923
2009
Homo sapiens
Lee, S.H.; Lee, J.H.; Lee, J.H.; Kim, D.K.
Involvement of MITF-A, an alternative isoform of mi transcription factor, on the expression of tryptase gene in human mast cells
Exp. Mol. Med.
42
366-375
2010
Homo sapiens
Reimer, J.M.; Samollow, P.B.; Hellman, L.
High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution
Immunogenetics
62
369-382
2010
Mus musculus, Canis lupus familiaris (P15944), Canis lupus familiaris, Homo sapiens (P20231), Homo sapiens (Q15661), Homo sapiens, Meriones unguiculatus (P50342), Equus caballus (Q7YS62), Ovis aries (Q9XSM1), Ovis aries (Q9XSM2)
Bargagli, E.; Mazzi, A.; Mezzasalma, F.; Perrone, A.; Olivieri, C.; Prasse, A.; Bianchi, N.; Pieroni, M.G.; Rottoli, P.
The analysis of tryptase in serum of sarcoidosis patients
Inflammation
32
310-314
2009
Homo sapiens
Simon, M.R.; Jan, M.; Yee, J.; Nori, U.S.; Hu, J.; Akin, C.; Schwartz, L.B.
Tryptase is not cleared by the kidneys into the urine
Int. Arch. Allergy Immunol.
152
28-31
2010
Homo sapiens
Ranieri, G.; Ammendola, M.; Patruno, R.; Celano, G.; Zito, F.A.; Montemurro, S.; Rella, A.; Di Lecce, V.; Gadaleta, C.D.; Battista De Sarro, G.; Ribatti, D.
Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients
Int. J. Oncol.
35
115-120
2009
Homo sapiens
Trivedi, N.N.; Tamraz, B.; Chu, C.; Kwok, P.Y.; Caughey, G.H.
Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations
J. Allergy Clin. Immunol.
124
1099-105
2009
Homo sapiens (P20231), Homo sapiens (Q15661), Homo sapiens
Kaieda, S.; Shin, K.; Nigrovic, P.A.; Seki, K.; Lee, R.T.; Stevens, R.L.; Lee, D.M.
Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1)
J. Biol. Chem.
285
21478-21486
2010
Mus musculus
Schiemann, F.; Brandt, E.; Gross, R.; Lindner, B.; Mittelstaedt, J.; Sommerhoff, C.P.; Schulmistrat, J.; Petersen, F.
The cathelicidin LL-37 activates human mast cells and is degraded by mast cell tryptase: counter-regulation by CXCL4
J. Immunol.
183
2223-2231
2009
Homo sapiens
Ugajin, T.; Kojima, T.; Mukai, K.; Obata, K.; Kawano, Y.; Minegishi, Y.; Eishi, Y.; Yokozeki, H.; Karasuyama, H.
Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells
J. Leukoc. Biol.
86
1417-1425
2009
Mus musculus
Thongyoo, P.; Bonomelli, C.; Leatherbarrow, R.J.; Tate, E.W.
Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold
J. Med. Chem.
52
6197-6200
2009
Homo sapiens
Sommerhoff, C.P.; Avrutina, O.; Schmoldt, H.U.; Gabrijelcic-Geiger, D.; Diederichsen, U.; Kolmar, H.
Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase beta
J. Mol. Biol.
395
167-175
2010
Homo sapiens
Carson, H.J.; Cook, B.A.
Mast cell tryptase in a case of anaphylaxis due to repeat antibiotic exposure
Leg. Med.
11
234-236
2009
Homo sapiens
Xiang, M.; Gu, Y.; Zhao, F.; Lu, H.; Chen, S.; Yin, L.
Mast cell tryptase promotes breast cancer migration and invasion
Oncol. Rep.
23
615-619
2010
Homo sapiens
Neri, M.; DErrico, S.; Fiore, C.; Pomara, C.; Rabozzi, R.; Riezzo, I.; Turillazzi, E.; Greco, P.; Fineschi, V.
Stillborn or liveborn? Comparing umbilical cord immunohistochemical expression of vitality markers (tryptase, alpha1-antichymotrypsin and CD68) by quantitative analysis and confocal laser scanning microscopy
Pathol. Res. Pract.
205
534-541
2009
Homo sapiens
Noyan, T.; Kolusari, A.; Kamaci, M.
Serum mast cell tryptase, eosinophil cationic protein, endothelin-1 and cytokine levels in preeclampsia and healthy pregnancy
Turk. J. Biochem.
34
19-24
2009
Homo sapiens
-
Wich, P.; Schmuck, C.
Reversible and noncompetitive inhibition of ?-tryptase by protein surface binding of tetravalent peptide ligands identified from a combinatorial split-mix library
Angew. Chem. Int. Ed. Engl.
49
4113-4116
2010
Homo sapiens
Santos, P.P.; Nonaka, C.F.; Pinto, L.P.; de Souza, L.B.
Immunohistochemical expression of mast cell tryptase in giant cell fibroma and inflammatory fibrous hyperplasia of the oral mucosa
Arch. Oral Biol.
56
231-237
2011
Homo sapiens
Yamagishi, H.; Mochizuki, Y.; Hamakubo, T.; Obata, K.; Ugajin, T.; Sato, S.; Kawano, Y.; Minegishi, Y.; Karasuyama, H.
Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner
Biochem. Biophys. Res. Commun.
415
709-713
2011
Mus musculus
Janke, D.; Sommerhoff, C.P.; Schaschke, N.
The arginine mimicking beta-amino acid beta3hPhe(3-H2N-CH2) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors
Bioorg. Med. Chem.
19
7236-7243
2011
Homo sapiens
Ribatti, D.; Ranieri, G.; Nico, B.; Benagiano, V.; Crivellato, E.
Tryptase and chymase are angiogenic in vivo in the chorioallantoic membrane assay
Int. J. Dev. Biol.
55
99-102
2011
Homo sapiens
Spinnler, K.; Froehlich, T.; Arnold, G.J.; Kunz, L.; Mayerhofer, A.
Human tryptase cleaves pro-nerve growth factor (pro-NGF): hints of local, mast cell-dependent regulation of NGF/pro-NGF action
J. Biol. Chem.
286
31707-31713
2011
Homo sapiens
Murray, D.; McLarty-Williams, J.; Nagalla, K.; Janicki, J.
Tryptase activates isolated adult cardiac fibroblasts via protease activated receptor-2 (PAR-2)
J. Cell Commun. Signal.
6
45-51
2011
Homo sapiens
Yang, X.P.; Li, Y.; Wang, Y.; Wang, Y.; Wang, P.
beta-Tryptase up-regulates vascular endothelial growth factor expression via proteinase-activated receptor-2 and mitogen-activated protein kinase pathways in bone marrow stromal cells in acute myeloid leukemia
Leuk. Lymphoma
51
1550-1558
2010
Homo sapiens
Hamilton, M.J.; Sinnamon, M.J.; Lyng, G.D.; Glickman, J.N.; Wang, X.; Xing, W.; Krilis, S.A.; Blumberg, R.S.; Adachi, R.; Lee, D.M.; Stevens, R.L.
Essential role for mast cell tryptase in acute experimental colitis
Proc. Natl. Acad. Sci. USA
108
290-295
2011
Mus musculus
Zhang, X.; Zheng, H.; Ma, W.; Wang, F.; Zeng, X.; Liu, C.; He, S.
Tryptase enzyme activity is correlated with severity of chronic obstructive pulmonary disease
Tohoku J. Exp. Med.
224
179-187
2011
Homo sapiens
Li, Q.; Jie, Y.; Wang, C.; Zhang, Y.; Guo, H.; Pan, Z.
Tryptase compromises corneal epithelial barrier function
Cell Biochem. Funct.
32
183-187
2014
Homo sapiens
Zhang, S.; Zeng, X.; Yang, H.; Hu, G.; He, S.
Mast cell tryptase induces microglia activation via protease-activated receptor 2 signaling
Cell. Physiol. Biochem.
29
931-940
2012
Rattus norvegicus
Matos, N.A.; Silva, J.F.; Matsui, T.C.; Damasceno, K.A.; Duarte, I.D.; Lemos, V.S.; Cassali, G.D.; Klein, A.
Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2
Inflammation
36
1260-1267
2013
Mus musculus
Melo, F.R.; Vita, F.; Berent-Maoz, B.; Levi-Schaffer, F.; Zabucchi, G.; Pejler, G.
Proteolytic histone modification by mast cell tryptase, a serglycin proteoglycan-dependent secretory granule protease
J. Biol. Chem.
289
7682-7690
2014
Homo sapiens, Mus musculus
Wang, Y.; Zheng, Q.C.; Kong, C.P.; Tian, Y.; Zhan, J.; Zhang, J.L.; Zhang, H.X.
Heparin makes differences: a molecular dynamics simulation study on the human betaII-tryptase monomer
Mol. Biosyst.
11
252-261
2015
Homo sapiens
Jiang, Q.Q.; Bartsch, L.; Sicking, W.; Wich, P.R.; Heider, D.; Hoffmann, D.; Schmuck, C.
A new approach to inhibit human beta-tryptase by protein surface binding of four-armed peptide ligands with two different sets of arms
Org. Biomol. Chem.
11
1631-1639
2013
Homo sapiens
Pereira, B.A.; Lister, N.L.; Hashimoto, K.; Teng, L.; Flandes-Iparraguirre, M.; Eder, A.; Sanchez-Herrero, A.; Niranjan, B.; Niranjan, B.
Tissue engineered human prostate microtissues reveal key role of mast cell-derived tryptase in potentiating cancer-associated fibroblast (CAF)-induced morphometric transition in vitro
Biomaterials
197
72-85
2019
Homo sapiens
de Souza Junior, D.A.; Santana, A.C.; da Silva, E.Z.; Oliver, C.; Jamur, M.C.
The role of mast cell specific chymases and tryptases in tumor angiogenesis
BioMed Res. Int.
2015
142359
2015
Homo sapiens, Mus musculus
Ribatti, D.; Ranieri, G.
Tryptase, a novel angiogenic factor stored in mast cell granules
Exp. Cell Res.
332
157-162
2015
Homo sapiens
Atiakshin, D.; Buchwalow, I.; Samoilova, V.; Tiemann, M.
Tryptase as a polyfunctional component of mast cells
Histochem. Cell Biol.
149
461-477
2018
Homo sapiens
Wongrattanakamon, P.; Ampasavate, C.; Sirithunyalug, B.; Jiranusornkul, S.
An integrated molecular modeling approach for the tryptase monomer-curcuminoid recognition analysis conformational and bioenergetic features
J. Bioenerg. Biomembr.
50
447-459
2018
Homo sapiens (Q15661), Homo sapiens
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