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Literature summary for 3.4.21.59 extracted from

  • Melo, F.R.; Vita, F.; Berent-Maoz, B.; Levi-Schaffer, F.; Zabucchi, G.; Pejler, G.
    Proteolytic histone modification by mast cell tryptase, a serglycin proteoglycan-dependent secretory granule protease (2014), J. Biol. Chem., 289, 7682-7690.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine increased tryptase concentrations are a risk marker for the severity of reactions to Hymenoptera stings or venom immunotherapy Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol during the cell death process, tryptase relocalizes from granules into the cytosol and nucleus Mus musculus 5829
-
nucleus during the cell death process, tryptase relocalizes from granules into the cytosol and nucleus Mus musculus 5634
-
secretory granule
-
Mus musculus 30141
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
x * 35000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone 2B + H2O Mus musculus
-
?
-
?
histone 3 + H2O Mus musculus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell
-
Mus musculus
-
serum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone 2B + H2O
-
Mus musculus ?
-
?
histone 3 + H2O
-
Mus musculus ?
-
?

Subunits

Subunits Comment Organism
? x * 35000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
mast cell protease 6
-
Mus musculus
Mast cell tryptase
-
Mus musculus
Mast cell tryptase
-
Homo sapiens
MCP-6
-
Mus musculus

Expression

Organism Comment Expression
Homo sapiens serum tryptase levels are positively associated with beekeeping activities, Hymenoptera venom allergy, age, and male sex up

General Information

General Information Comment Organism
malfunction tryptase deficiency results in defective proteolytic modification of core histones Mus musculus