Literature summary for 3.4.21.59 extracted from

Thongyoo, P.; Bonomelli, C.; Leatherbarrow, R.J.; Tate, E.W.
Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold (2009), J. Med. Chem., 52, 6197-6200.

Search for more literature for 3.4.21.59

Inhibitors

Inhibitors	Comment	Organism	Structure
ck-MCoEeTI	-	Homo sapiens
MCoEeTI	-	Homo sapiens
MCoEeTI[K10R]	-	Homo sapiens
MCoTI-I	-	Homo sapiens
MCoTI-II	-	Homo sapiens
MCoTI-II-DELTA[DG]	-	Homo sapiens
MCoTI-II-DELTA[GSDGV]	-	Homo sapiens
MCoTI-II-DELTA[SDGGV]	-	Homo sapiens
MCoTI-II-DELTA[SDGG]	-	Homo sapiens
MCoTI-II-DELTA[SDGG][K10R]	-	Homo sapiens
MCoTI-II[K10A]	-	Homo sapiens
MCoTI-II[K10F]	-	Homo sapiens
MCoTI-II[K10Q]	-	Homo sapiens
MCoTI-II[K10R]	-	Homo sapiens
MCoTI-II[K10V]	-	Homo sapiens
MCoTI-II[K10V]-[I11P]	-	Homo sapiens
MCoTI-II[PKI]-[AVP]	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
beta-tryptase	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000009	-	MCoTI-II-DELTA[SDGG]	-	Homo sapiens
0.00001	-	MCoTI-II-DELTA[SDGG][K10R]	-	Homo sapiens
0.000028	-	MCoEeTI[K10R]	-	Homo sapiens
0.000033	-	MCoEeTI	-	Homo sapiens
0.00011	-	ck-MCoEeTI	-	Homo sapiens
0.0006	-	MCoTI-II	-	Homo sapiens
0.0006	-	MCoTI-II-DELTA[DG]	-	Homo sapiens
0.0016	-	MCoTI-I	-	Homo sapiens
0.002	-	MCoTI-II-DELTA[GSDGV]	Ki above 0.002 mM	Homo sapiens
0.003	-	MCoTI-II-DELTA[SDGGV]	Ki above 0.003 mM	Homo sapiens
0.05	-	MCoTI-II[K10F]	IC50 above 0.05 mM	Homo sapiens
0.05	-	MCoTI-II[K10Q]	IC50 above 0.05 mM	Homo sapiens
0.05	-	MCoTI-II[K10A]	IC50 above 0.05 mM	Homo sapiens
0.05	-	MCoTI-II[K10V]	IC50 above 0.05 mM	Homo sapiens
0.05	-	MCoTI-II[PKI]-[AVP]	IC50 above 0.05 mM	Homo sapiens
0.05	-	MCoTI-II[K10V]-[I11P]	IC50 above 0.05 mM	Homo sapiens
0.085	-	MCoTI-II[K10R]	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)