Information on EC 3.2.1.28 - alpha,alpha-trehalase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
3.2.1.28
-
RECOMMENDED NAME
GeneOntology No.
alpha,alpha-trehalase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of O-glycosyl bond
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Metabolic pathways
-
Starch and sucrose metabolism
-
trehalose degradation II (trehalase)
-
trehalose degradation VI (periplasmic)
-
SYSTEMATIC NAME
IUBMB Comments
alpha,alpha-trehalose glucohydrolase
The enzyme is an anomer-inverting glucosidase that catalyses the hydrolysis of the alpha-glucosidic O-linkage of alpha,alpha-trehalose, releasing initially equimolar amounts of alpha- and beta-D-glucose. It is widely distributed in microorganisms, plants, invertebrates and vertebrates.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
acid (non regulatory) trehalase
-
-
acid (non regulatory) trehalase
Schizosaccharomyces pombe 968
-
-
-
acid non-regulatory trehalase
-
-
acid trehalase
A8J4S9
-
acid trehalase
-
-
acid trehalase
-
-
acid trehalase
-
-
acid trehalase
Candida albicans CAI4
-
-
-
acid trehalase
Q307Q4
-
acid trehalase
-
-
acid trehalase
Saccharomyces cerevisiae MCY1264
-
-
-
acid trehalase
-
-
acid trehalase
Scytalidium thermophilum 77.7.8
-
-
-
alkaline trehalase
-
-
alpha,alpha glucoside 1-glucohydrolase
-
-
alpha,alpha trehalase
A8J4S9
-
alpha,alpha trehalose glucohydrolase
A8J4S9
-
alpha,alpha'-trehalose 1-D-glucohydrolase
-
-
-
-
Alpha,alpha-trehalase
-
-
-
-
Alpha,alpha-trehalose glucohydrolase
-
-
-
-
Alpha,alpha-trehalose glucohydrolase
A1XBT9
-
Alpha,alpha-trehalose glucohydrolase
B5ATV4, Q0ZIF5
-
alpha-glucoside-1-glucohydrolase
-
-
Atc1p
-
isoform
Atc1p
Candida albicans CAI4
-
-
-
ATM1
Q307Q4
mature enzyme
GH37 trehalase
-
-
membrane-bound SfTre2
B5ATV4
-
MSMEG 4528
Mycobacterium smegmatis b11
-
-
-
neutral regulatory trehalase
-
-
neutral trehalase
-
-
neutral trehalase
Candida albicans CAI4
-
-
-
neutral trehalase
A4QMP6
-
neutral trehalase
Saccharomyces cerevisiae MCY1264
-
-
-
neutral trehalase
-
-
neutral trehalase
Scytalidium thermophilum 77.7.8
-
-
-
Ntc1p
-
isoform
Ntc1p
Candida albicans CAI4
-
-
-
NTH1
A1YQE2
-
SfTre1
Q0ZIF5
-
soluble P I type trehalase
-
-
soluble P II type trehalase
-
-
soluble trehalase
Q0ZIF5
-
Tre-2
A7XZC0
isoform
trehalase
-
-
-
-
trehalase
-
-
trehalase
-
-
trehalase
-
-
trehalase
Escherichia coli Mph2
-
-
-
trehalase
-
-
trehalase
-
-
trehalase
-
-
trehalase
-
-
trehalase
Mycobacterium smegmatis b11
-
-
-
trehalase
C0LZJ6, C0LZJ7
-
trehalase
B6ZIV1
-
trehalase
Nostoc punctiforme IAM M-15
B6ZIV1
-
-
trehalase
A1XBT9
-
trehalase
Scytalidium thermophilum 77.7.8
-
-
-
trehalase
-
-
trehalase
-
-
CAS REGISTRY NUMBER
COMMENTARY
9025-52-9
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
ecotype Columbia-0
-
-
Manually annotated by BRENDA team
Blastobotrys adeninivorans SBUG 724
SBUG 724
-
-
Manually annotated by BRENDA team
isozymes trehalase type 1 and 2
-
-
Manually annotated by BRENDA team
treh-1, soluble trehalase
UniProt
Manually annotated by BRENDA team
treh-2, integral membrane trehalase
UniProt
Manually annotated by BRENDA team
gene ATC1
-
-
Manually annotated by BRENDA team
isoform Atc1p; isoform Ntc1p
-
-
Manually annotated by BRENDA team
strain CAI4
-
-
Manually annotated by BRENDA team
Candida albicans CAI4
strain CAI4
-
-
Manually annotated by BRENDA team
var. coprophilum
-
-
Manually annotated by BRENDA team
strain Mph2
-
-
Manually annotated by BRENDA team
Escherichia coli K12
K12
-
-
Manually annotated by BRENDA team
Escherichia coli Mph2
strain Mph2
-
-
Manually annotated by BRENDA team
strain ArI3
-
-
Manually annotated by BRENDA team
strain ArI3
-
-
Manually annotated by BRENDA team
var. thermoidea
-
-
Manually annotated by BRENDA team
isolated from brazilian soil
-
-
Manually annotated by BRENDA team
termites
-
-
Manually annotated by BRENDA team
strain Y55
-
-
Manually annotated by BRENDA team
Komagataella pastoris Y55
strain Y55
-
-
Manually annotated by BRENDA team
Lobosphaera sp.
-
-
-
Manually annotated by BRENDA team
fragment; subspecies Metarhizium anisopliae acridum, strain CQMa102
UniProt
Manually annotated by BRENDA team
strain Ma2575; strain Ma473; strain TIB2-1ii
Uniprot
Manually annotated by BRENDA team
strain SCB1-2i
SwissProt
Manually annotated by BRENDA team
strain SCB2-2i
SwissProt
Manually annotated by BRENDA team
Metarhizium anisopliae Ma2575
strain Ma2575
Uniprot
Manually annotated by BRENDA team
Metarhizium anisopliae Ma473
strain Ma473
Uniprot
Manually annotated by BRENDA team
Metarhizium anisopliae SCB1-2i
strain SCB1-2i
SwissProt
Manually annotated by BRENDA team
Metarhizium anisopliae SCB2-2i
strain SCB2-2i
SwissProt
Manually annotated by BRENDA team
Metarhizium anisopliae TIB2-1ii
strain TIB2-1ii
Uniprot
Manually annotated by BRENDA team
strain SCB1-2i
-
-
Manually annotated by BRENDA team
Metarhizium flavoviride SCB1-2i
strain SCB1-2i
-
-
Manually annotated by BRENDA team
Mycobacterium smegmatis b11
strain B11
-
-
Manually annotated by BRENDA team
neutral trehalase
Uniprot
Manually annotated by BRENDA team
NlTre-1; brown planthopper, gene NlTre-1 encoding the soluble isozyme
UniProt
Manually annotated by BRENDA team
NlTre-2; brown planthopper, gene NlTre-2 encoding the membrane-bound isozyme
UniProt
Manually annotated by BRENDA team
strain IAM M-15, gene treH
UniProt
Manually annotated by BRENDA team
Nostoc punctiforme IAM M-15
strain IAM M-15, gene treH
UniProt
Manually annotated by BRENDA team
2 nonglycoprotein enzyme forms: A1 and B1 and 2 glycoprotein enzyme form A2 and B2
-
-
Manually annotated by BRENDA team
strain DSM 4252T
-
-
Manually annotated by BRENDA team
isoform Ath1
-
-
Manually annotated by BRENDA team
neutral Nth1 and Nth2 and acid Ath1, encoded by gene ath1
-
-
Manually annotated by BRENDA team
strain MCY1264, neutral trehalase and acid trehalase isozymes encoded by the NTH1 and ATH1 genes
-
-
Manually annotated by BRENDA team
strain S288c
-
-
Manually annotated by BRENDA team
two enzyme activities, C-trehalase and V-trehalase
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae MCY1264
strain MCY1264, neutral trehalase and acid trehalase isozymes encoded by the NTH1 and ATH1 genes
-
-
Manually annotated by BRENDA team
Schizosaccharomyces pombe 968
strain 968
-
-
Manually annotated by BRENDA team
intracellular and extracellular threhalase
-
-
Manually annotated by BRENDA team
strain 77.7.8, isolated from indian soil
-
-
Manually annotated by BRENDA team
Scytalidium thermophilum 77.7.8
strain 77.7.8, isolated from indian soil
-
-
Manually annotated by BRENDA team
genes SeTre-1 and SeTre-2
-
-
Manually annotated by BRENDA team
isoform Tre-2
UniProt
Manually annotated by BRENDA team
membrane-bound trehalase SfTre2; membrane-bound isozyme SfTre2
UniProt
Manually annotated by BRENDA team
soluble trehalase SfTre1; soluble isozyme SfTre1
UniProt
Manually annotated by BRENDA team
Thermomyces lanuginosus RM-B
RM-B
-
-
Manually annotated by BRENDA team
kcat/KM VALUE [1/mMs-1]
kcat/KM VALUE [1/mMs-1] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.008
-
alpha,alpha-trehalose
Q0ZIF5, -
mutant R222A/R287A, pH 7.0, 30C
6709
0.009
-
alpha,alpha-trehalose
Q0ZIF5, -
mutant R222A, pH 7.0, 30C
6709
0.027
-
alpha,alpha-trehalose
Q0ZIF5, -
mutant E520A, pH 7.0, 30C
6709
0.045
-
alpha,alpha-trehalose
Q0ZIF5, -
mutant R287A, pH 7.0, 30C
6709
0.18
-
alpha,alpha-trehalose
Q0ZIF5, -
mutant D322A, pH 7.0, 30C
6709
0.27
-
alpha,alpha-trehalose
Q0ZIF5, -
mutant R169A, pH 7.0, 30C
6709
2400
-
alpha,alpha-trehalose
Q0ZIF5, -
wild-type, pH 7.0, 30C
6709
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
4.7
-
-, Q307Q4
isoelectric focusing
4.7
-
Q307Q4
native enzyme, isoelectric focusing
4.75
-
-
SeTre-1, sequence calculation
4.9
-
Q307Q4
recombinant enzyme, isoelectric focusing
6
-
A7XZC0, -
calculated
PDB
SCOP
CATH
ORGANISM
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
EXPRESSION
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
diapause hormone stimulates expression of both soluble trehalase and integral membrane trehalase. The amount of treh-2 mRNA is approximately 1000fold higher than that of treh-1 mRNA. Trehalase activity enhanced by diapause hormone in developing ovaries is mostly induced by treh-2 protein depending on the transcriptional level; diapause hormone stimulates expression of both soluble trehalase and integral membrane trehalase. The amount of treh-2 mRNA is approximately 1000fold higher than that of treh-1 mRNA. Trehalase activity enhanced by diapause hormone in developing ovaries is mostly induced by treh-2 protein depending on the transcriptional level
P32358, Q3MV18
no induction by 20-hydroxyecdysone of the membrane-bound trehalase isozyme encoded by gene NlTre2
C0LZJ6, C0LZJ7, -
20-hydroxyecdysone induces the soluble trehalase isozyme encoded by gene NlTre1
C0LZJ6, C0LZJ7, -