Literature summary for 3.2.1.28 extracted from

Pedreno, Y.; Maicas, S.; Arguelles, J.C.; Sentandreu, R.; Valentin, E.
The ATC1 gene encodes a cell wall-linked acid trehalase required for growth on trehalose in Candida albicans (2004), J. Biol. Chem., 279, 40852-40860.

Search for more literature for 3.2.1.28

Cloned(Commentary)

Cloned (Comment)	Organism
gene ATC1, DNA and amino acid sequence determination and analysis, expression pattern, subcloning in Escherichia coli, in vitro transcription and translation of HA-tagged enzyme using an Escherichia coli-derived system	Candida albicans

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of enzyme-deficient mutants by gene disruption at two ATC chromosomal alleles	Candida albicans

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	reaction product D-glucose suppresses enzyme expression	Candida albicans

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell wall	bound to	Candida albicans	5618	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
alpha,alpha-trehalose + H2O	Candida albicans	the enzyme is essential for growth on trehalose as carbon source, regulation by D-glucose repression	2 D-glucose	-	?

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	gene ATC1	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	Atc1p contains 20 potential N-glycosylation sites	Candida albicans

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	expression pattern in presence or absence of D-glucose	Candida albicans	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
alpha,alpha-trehalose + H2O	-	Candida albicans	2 D-glucose	-	?
alpha,alpha-trehalose + H2O	the enzyme is essential for growth on trehalose as carbon source, regulation by D-glucose repression	Candida albicans	2 D-glucose	-	?

Synonyms

Synonyms	Comment	Organism
acid trehalase	-	Candida albicans
Atc1p	-	Candida albicans

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Candida albicans

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6	-	assay at	Candida albicans

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Release 2023.1 (January 2023)