Reference on EC 3.1.4.53 - 3',5'-cyclic-AMP phosphodiesterase and Organism(s) Homo sapiens and UniProt Accession Q08499
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
O'Grady, S.M.; Jiang, X.; Maniak, P.J.; Birmachu, W.; Scribner, L.R.; Bulbulian, B.; Gullikson, G.W.
Cyclic AMP-dependent Cl secretion is regulated by multiple phosphodiesterase subtypes in human colonic epithelial cells
J. Membr. Biol.
185
137-144
2002
Homo sapiens
Richter, W.; Hermsdorf, T.; Kronbach, T.; Dettmer, D.
Refolding and Purification of Recombinant Human PDE7A: Expressed in Escherichia coli as Inclusion Bodies
Protein Expr. Purif.
25
138-148
2002
Homo sapiens
Ahlstrom, M.; Pekkinen, M.; Huttunen, M.; Lamberg-Allardt, C.
Cyclic nucleotide phosphodiesterases (PDEs) in human osteoblastic cells; the effect of PDE inhibition on cAMP accumulation
Cell. Mol. Biol. Lett.
10
305-319
2005
Homo sapiens
Bischoff, E.
Potency, selectivity, and consequences of nonselectivity of PDE inhibition
Int. J. Impot. Res.
16
S11-S14
2004
Homo sapiens
Huai, Q.; Liu, Y.; Francis, S.H.; Corbin, J.D.; Ke, H.
Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity
J. Biol. Chem.
279
13095-13101
2004
Homo sapiens
Xu, R.X.; Rocque, W.J.; Lambert, M.H.; Vanderwall, D.E.; Luther, M.A.; Nolte, R.T.
Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram
J. Mol. Biol.
337
355-365
2004
Homo sapiens
Card, G.L.; Blasdel, L.; England, B.P.; Zhang, C.; Suzuki, Y.; Gillette, S.; Fong, D.; Ibrahim, P.N.; Artis, D.R.; Bollag, G.; Milburn, M.V.; Kim, S.H.; Schlessinger, J.; Zhang, K.Y.
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design
Nat. Biotechnol.
23
201-207
2005
Homo sapiens
Oelke, M.; Hedlund, P.; Albrecht, K.; Ellinghaus, P.; Stief, C.G.; Jonas, U.; Andersson, K.E.; Uckert, S.
Expression of cAMP and cGMP-phosphodiesterase isoenzymes 3, 4, and 5 in the human clitoris: immunohistochemical and molecular biology study
Urology
67
1111-1116
2006
Homo sapiens
Waldkirch, E.; Uckert, S.; Yildirim, H.; Sohn, M.; Jonas, U.; Stief, C.G.; Andersson, K.E.; Hedlund, P.
Cyclic AMP-specific and cyclic GMP-specific phosphodiesterase isoenzymes in human cavernous arteries--immunohistochemical distribution and functional significance
World J. Urol.
23
405-410
2005
Homo sapiens
Murray, F.; Patel, H.H.; Suda, R.Y.; Zhang, S.; Thistlethwaite, P.A.; Yuan, J.X.; Insel, P.A.
Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1
Am. J. Physiol. Lung Cell Mol. Physiol.
292
L294-L303
2007
Homo sapiens
Bolger, G.B.; Baillie, G.S.; Li, X.; Lynch, M.J.; Herzyk, P.; Mohamed, A.; Mitchell, L.H.; McCahill, A.; Hundsrucker, C.; Klussmann, E.; Adams, D.R.; Houslay, M.D.
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5
Biochem. J.
398
23-36
2006
Homo sapiens
Baillie, G.S.; Adams, D.R.; Bhari, N.; Houslay, T.M.; Vadrevu, S.; Meng, D.; Li, X.; Dunlop, A.; Milligan, G.; Bolger, G.B.; Klussmann, E.; Houslay, M.D.
Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays
Biochem. J.
404
71-80
2007
Homo sapiens, Homo sapiens (Q08499)
Wang, H.; Peng, M.S.; Chen, Y.; Geng, J.; Robinson, H.; Houslay, M.D.; Cai, J.; Ke, H.
Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors
Biochem. J.
408
193-201
2007
Homo sapiens, Homo sapiens (P27815), Homo sapiens (Q08499)
Mackenzie, K.F.; Topping, E.C.; Bugaj-Gaweda, B.; Deng, C.; Cheung, Y.F.; Olsen, A.E.; Stockard, C.R.; Mitchell, L.H.; Baillie, G.S.; Grizzle, W.E.; Devivo, M.; Houslay, M.D.; Wang, D.; Bolger, G.B.
Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change
Biochem. J.
411
361-369
2007
Homo sapiens (P27815), Homo sapiens
Xiong, Y.; Lu, H.T.; Li, Y.; Yang, G.F.; Zhan, C.G.
Characterization of a catalytic ligand bridging metal ions in phosphodiesterases 4 and 5 by molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations
Biophys. J.
91
1858-1867
2006
Homo sapiens
Smith, K.J.; Baillie, G.S.; Hyde, E.I.; Li, X.; Houslay, T.M.; McCahill, A.; Dunlop, A.J.; Bolger, G.B.; Klussmann, E.; Adams, D.R.; Houslay, M.D.
1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1
Cell. Signal.
19
2612-2624
2007
Homo sapiens, Homo sapiens (Q08499)
Uckert, S.; Oelke, M.; Stief, C.G.; Andersson, K.E.; Jonas, U.; Hedlund, P.
Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate
Eur. Urol.
49
740-745
2006
Homo sapiens
Wang, H.; Robinson, H.; Ke, H.
The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10
J. Mol. Biol.
371
302-307
2007
Homo sapiens
Cheung, Y.F.; Kan, Z.; Garrett-Engele, P.; Gall, I.; Murdoch, H.; Baillie, G.S.; Camargo, L.M.; Johnson, J.M.; Houslay, M.D.; Castle, J.C.
PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6)
J. Pharmacol. Exp. Ther.
322
600-609
2007
Mus musculus, Homo sapiens (Q07343), Homo sapiens
Spoto, G.; della Malva, M.; Rubini, C.; Fioroni, M.; Piattelli, A.; Serra, E.; Di Nicola, M.; Santoleri, F.
cAMP phosphodiesterase activity evaluation in human carcinoma of salivary glands
Nucleosides Nucleotides Nucleic Acids
25
1113-1117
2006
Homo sapiens
Narita, M.; Murata, T.; Shimizu, K.; Nakagawa, T.; Sugiyama, T.; Inui, M.; Hiramoto, K.; Tagawa, T.
A role for cyclic nucleotide phosphodiesterase 4 in regulation of the growth of human malignant melanoma cells
Oncol. Rep.
17
1133-1139
2007
Homo sapiens
Brown, D.M.; Hutchison, L.; Donaldson, K.; MacKenzie, S.J.; Dick, C.A.; Stone, V.
The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4
Toxicol. Lett.
168
1-6
2007
Homo sapiens, Mus musculus
Fisher, D.A.; Smith, J.F.; Pillar, J.S.; Denis, S.H.St.; Cheng, J.B.
Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase
Biochem. Biophys. Res. Commun.
246
570-577
1998
Homo sapiens (O60658), Homo sapiens
Sasaki, T.; Kotera, J.; Yuasa, K.; Omori, K.
Identification of human PDE7B, a cAMP-specific phosphodiesterase
Biochem. Biophys. Res. Commun.
271
575-583
2000
Homo sapiens
Gardner, C.; Robas, N.; Cawkill, D.; Fidock, M.
Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase
Biochem. Biophys. Res. Commun.
272
186-192
2000
Homo sapiens (Q9NP56), Homo sapiens, Mus musculus (Q9QXQ1), Mus musculus
Bian, H.; Zhang, J.; Wu, P.; Lori, A.; Varty, Y.J.; Maywood, T.; Hey, J.A.; Wang, P.
Differential type 4 cAMP-specific phosphodiesterase (PDE4) expression and functional sensitivity to PDE4 inhibitors among rats, monkeys and humans
Biochem. Pharmacol.
68
2229-2236
2004
Rattus norvegicus (P14270), Rattus norvegicus (P14646), Rattus norvegicus (P54748), Homo sapiens (P27815), Homo sapiens (Q07343), Homo sapiens (Q08493), Homo sapiens (Q08499), Homo sapiens
Lynch, M.J.; Baillie, G.S.; Houslay, M.D.
cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling
Biochem. Soc. Trans.
35
938-941
2007
Homo sapiens
Amegadzie, B.Y.; Hanning, C.R.; McLaughlin, M.M.; Burman, M.; Cieslinski, L.B.; Livi, G.P.; Torphy, T.J.
Characterization of two human cAMP-specific phosphodiesterase subtypes expressed in baculovirus-infected insect cells
Cell Biol. Int.
19
477-484
1995
Homo sapiens
Richter, W.; Unciuleac, L.; Hermsdorf, T.; Kronbach, T.; Dettmer, D.
Identification of substrate specificity determinants in human cAMP-specific phosphodiesterase 4A by single-point mutagenesis
Cell. Signal.
13
159-167
2001
Homo sapiens
Houslay, M.D.; Baillie, G.S.; Maurice, D.H.
cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling
Circ. Res.
100
950-966
2007
Homo sapiens (P27815), Homo sapiens (Q07343), Homo sapiens (Q08499), Mus musculus (Q01063)
Horvath, A.; Giatzakis, C.; Tsang, K.; Greene, E.; Osorio, P.; Boikos, S.; Libe, R.; Patronas, Y.; Robinson-White, A.; Remmers, E.; Bertherat, J.; Nesterova, M.; Stratakis, C.A.
A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex
Eur. J. Hum. Genet.
16
1245-1253
2008
Homo sapiens, Homo sapiens (O95263), Mus musculus
McLaughlin, M.M.; Cieslinski, L.B.; Burman, M.; Torphy, T.J.; Livi, G.P.
A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA
J. Biol. Chem.
268
6470-6476
1993
Homo sapiens (Q07343), Homo sapiens
Huston, E.; Pooley, L.; Julien, P.; Scotland, G.; McPhee, I.; Sullivan, M.; Bolger, G.; Houslay, M.D.
The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram
J. Biol. Chem.
271
31334-31344
1996
Homo sapiens
Persani, L.; Borgato, S.; Lania, A.; Filopanti, M.; Mantovani, G.; Conti, M.; Spada, A.
Relevant cAMP-specific phosphodiesterase isoforms in human pituitary: effect of Gs(alpha) mutations
J. Clin. Endocrinol. Metab.
86
3795-3800
2001
Homo sapiens (P27815), Homo sapiens (Q07343), Homo sapiens (Q08493), Homo sapiens (Q08499), Homo sapiens
Xin, W.; Tran, T.M.; Richter, W.; Clark, R.B.; Rich, T.C.
Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signaling
J. Gen. Physiol.
131
349-364
2008
Homo sapiens
Verghese, M.W.; McConnell, R.T.; Lenhard, J.M.; Hamacher, L.; Jin, S.L.C.
Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isoenzymes in human monocytic cells
Mol. Pharmacol.
47
1164-1171
1995
Homo sapiens
Alvarez, R.; Sette, C.; Yang, D.; Eglen, R.M.; Wilhelm, R.; Shelton, E.R.; Conti, M.
Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3
Mol. Pharmacol.
48
616-622
1995
Homo sapiens
Rena, G.; Begg, F.; Ross, A.; Mackenzie, C.; McPhee, I.; Campbell, L.; Huston, E.; Sullivan, M.; Houslay, M.D.
Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic AMP-specific phosphodiesterase PDE4A10
Mol. Pharmacol.
59
996-1011
2001
Homo sapiens
Zhu, S.; Gan, Z.; Li, Z.; Liu, Y.; Yang, X.; Deng, P.; Xie, Y.; Yu, M.; Liao, H.; Zhao, Y.; Zhao, L.; Liao, F.
The measurement of cyclic nucleotide phosphodiesterase 4 activities via the quantification of inorganic phosphate with malachite green
Anal. Chim. Acta
636
105-110
2009
Homo sapiens
Wang, H.; Yan, Z.; Yang, S.; Cai, J.; Robinson, H.; Ke, H.
Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity
Biochemistry
47
12760-12768
2008
Homo sapiens (O60658), Homo sapiens
Nanda, K.; Chatterjee, M.; Arya, R.; Mukherjee, S.; Saini, K.S.; Dastidar, S.; Ray, A.
Optimization and validation of a reporter gene assay for screening of phosphodiesterase inhibitors in a high throughput system
Biotechnol. J.
3
1276-1279
2008
Homo sapiens
Herget, S.; Lohse, M.J.; Nikolaev, V.O.
Real-time monitoring of phosphodiesterase inhibition in intact cells
Cell. Signal.
20
1423-1431
2008
Homo sapiens (P27815)
Goldhoff, P.; Warrington, N.M.; Limbrick, D.D.; Hope, A.; Woerner, B.M.; Jackson, E.; Perry, A.; Piwnica-Worms, D.; Rubin, J.B.
Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression
Clin. Cancer Res.
14
7717-7725
2008
Homo sapiens
Santos-Silva, A.J.; Cairrao, E.; Morgado, M.; Alvarez, E.; Verde, I.
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries
Eur. J. Pharmacol.
582
102-109
2008
Homo sapiens (P27815), Homo sapiens (Q07343), Homo sapiens (Q08493), Homo sapiens (Q08499), Homo sapiens (Q13946), Homo sapiens
Maschi, O.; Cero, E.D.; Galli, G.V.; Caruso, D.; Bosisio, E.; DellAgli, M.
Inhibition of human cAMP-phosphodiesterase as a mechanism of the spasmolytic effect of Matricaria recutita L
J. Agric. Food Chem.
56
5015-5020
2008
Homo sapiens
Togo, S.; Liu, X.; Wang, X.; Sugiura, H.; Kamio, K.; Kawasaki, S.; Kobayashi, T.; Ertl, R.F.; Ahn, Y.; Holz, O.; Magnussen, H.; Fredriksson, K.; Skold, C.M.; Rennard, S.I.
PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-beta1-stimulated fibroblasts
Am. J. Physiol. Lung Cell Mol. Physiol.
296
L959-L969
2009
Homo sapiens
Guo, J.; Watson, A.; Kempson, J.; Carlsen, M.; Barbosa, J.; Stebbins, K.; Lee, D.; Dodd, J.; Nadler, S.G.; McKinnon, M.; Barrish, J.; Pitts, W.J.
Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation
Bioorg. Med. Chem. Lett.
19
1935-1938
2009
Homo sapiens
Kagayama, K.; Morimoto, T.; Nagata, S.; Katoh, F.; Zhang, X.; Inoue, N.; Hashino, A.; Kageyama, K.; Shikaura, J.; Niwa, T.
Synthesis and biological evaluation of novel phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors
Bioorg. Med. Chem.
17
6959-6970
2009
Homo sapiens
Schafer, P.H.; Parton, A.; Gandhi, A.K.; Capone, L.; Adams, M.; Wu, L.; Bartlett, J.B.; Loveland, M.A.; Gilhar, A.; Cheung, Y.F.; Baillie, G.S.; Houslay, M.D.; Man, H.W.; Muller, G.W.; Stirling, D.I.
Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis
Br. J. Pharmacol.
159
842-855
2010
Homo sapiens
Hatzimouratidis, K.; Hatzichristou, D.G.
Phosphodiesterase type 5 inhibitors: unmet needs
Curr. Pharm. Des.
15
3476-3485
2009
Homo sapiens
Zhang, L.; Murray, F.; Zahno, A.; Kanter, J.R.; Chou, D.; Suda, R.; Fenlon, M.; Rassenti, L.; Cottam, H.; Kipps, T.J.; Insel, P.A.
Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia
Proc. Natl. Acad. Sci. USA
105
19532-19537
2008
Homo sapiens
Rampersad, S.; Ovens, J.; Huston, E.; Umana, M.; Wilson, L.; Netherton, S.; Lynch, M.; Baillie, G.; Houslay, M.; Maurice, D.
Cyclic AMP phosphodiesterase 4D (PDE4D) tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability
J. Biol. Chem.
285
33614-33622
2010
Homo sapiens
Chen, X.; Zhao, X.; Xiong, Y.; Liu, J.; Zhan, C.G.
Fundamental reaction pathway and free energy profile for hydrolysis of intracellular second messenger adenosine 3',5'-cyclic monophosphate (cAMP) catalyzed by phosphodiesterase-4
J. Phys. Chem. B
115
12208-12219
2011
Homo sapiens
Lakics, V.; Karran, E.H.; Boess, F.G.
Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues
Neuropharmacology
59
367-374
2010
Homo sapiens (O60658), Homo sapiens (O95263), Homo sapiens (P27815), Homo sapiens (Q07343), Homo sapiens (Q08493), Homo sapiens (Q08499), Homo sapiens (Q13946), Homo sapiens (Q9NP56)
Adderley, S.P.; Sprague, R.S.; Stephenson, A.H.; Hanson, M.S.
Regulation of cAMP by phosphodiesterases in erythrocytes
Pharmacol. Rep.
62
475-482
2010
Homo sapiens
Weninger, S.; Van Craenenbroeck, K.; Cameron, R.T.; Vandeput, F.; Movsesian, M.A.; Baillie, G.S.; Lefebvre, R.A.
Phosphodiesterase 4 interacts with the 5-HT4(b) receptor to regulate cAMP signaling
Cell. Signal.
26
2573-2582
2014
Homo sapiens
Lee, J.; Komatsu, K.; Lee, B.C.; Lim, J.H.; Jono, H.; Xu, H.; Kai, H.; Zhang, Z.J.; Yan, C.; Li, J.D.
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway
J. Biol. Chem.
287
22799-22811
2012
Homo sapiens
Garcia, A.M.; Brea, J.; Morales-Garcia, J.A.; Perez, D.I.; Gonzalez, A.; Alonso-Gil, S.; Gracia-Rubio, I.; Ros-Simo, C.; Conde, S.; Cadavid, M.I.; Loza, M.I.; Perez-Castillo, A.; Valverde, O.; Martinez, A.; Gil, C.
Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors
J. Med. Chem.
57
8590-8607
2014
Homo sapiens (Q07343), Homo sapiens (Q08499), Homo sapiens (Q13946), Homo sapiens
Wahlang, B.; McClain, C.; Barve, S.; Gobejishvili, L.
Role of cAMP and phosphodiesterase signaling in liver health and disease
Cell. Signal.
49
105-115
2018
Homo sapiens
Cai, Y.; Nagel, D.J.; Zhou, Q.; Cygnar, K.D.; Zhao, H.; Li, F.; Pi, X.; Knight, P.A.; Yan, C.
Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia
Circ. Res.
116
1120-1132
2015
Homo sapiens, Mus musculus, Rattus norvegicus
Cao, B.; Wang, K.; Liao, J.M.; Zhou, X.; Liao, P.; Zeng, S.X.; He, M.; Chen, L.; He, Y.; Li, W.; Lu, H.
Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation
eLife
5
e15978
2016
Homo sapiens (Q08499), Homo sapiens
Byrne, A.M.; Elliott, C.; Hoffmann, R.; Baillie, G.S.
The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus
FEBS Lett.
589
750-755
2015
Homo sapiens (Q08499)
