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Literature summary for 3.1.4.53 extracted from
- Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity (2004), J. Biol. Chem., 279, 13095-13101.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| hanging drop method, PDE4D2 in complex with the nonselective inhibitor 3-isobutyl-1-methylxanthine | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-isobutyl-1-methylxanthine | the inhibitor binds to a subpocket that comprises key residues Ile336, Phe340, Gln369 and Phe372 of PDE54D2. This subpocket may be a common site for binding nonselective inhibitors | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cAMP-specific PDE4D2 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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