Literature summary for 3.1.4.53 extracted from

Alvarez, R.; Sette, C.; Yang, D.; Eglen, R.M.; Wilhelm, R.; Shelton, E.R.; Conti, M.
Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3 (1995), Mol. Pharmacol., 48, 616-622.

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Cloned(Commentary)

Cloned (Comment)	Organism
cloned and expressed in Sf9 cells with recombinant baculovirus infection	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
RS-25344	phosphorylation of PDE-4D3 increases the sensitivity of the enzyme to inhibition by RS-25344 about 100fold	Homo sapiens
RS-33793	phosphorylation of PDE-4D3 increases the sensitivity of the enzyme to inhibition by RS-33793 about 330fold	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	the concentration-response curve for Mg2+ is biphasic and ranges from 0.1 to 100 mM. Phosphorylation of PDE-4D3 by protein kinase A produces a monophasic Mg2+ response curve	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	phosphorylation of PDE-4D3 by protein kinase A produces a monophasic Mg2+ response curve. Phosphorylation of PDE-4D3 increased the sensitivity of the enzyme to inhibition by RS-25344 (about 100fold) and RS-33793 (about 330fold). Phosphorylation of PDE-4D3 induces an apparent conformation change that increases maximum velocity and sensitivity to inhibition by some analogues of nitraquazone	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
adenosine 3',5'-cyclic phosphate + H2O	the enzyme is specific for cAMP	Homo sapiens	adenosine 5'-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
PDE-4D3	-	Homo sapiens

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Release 2023.1 (January 2023)