Literature summary for 3.1.4.53 extracted from

Garcia, A.M.; Brea, J.; Morales-Garcia, J.A.; Perez, D.I.; Gonzalez, A.; Alonso-Gil, S.; Gracia-Rubio, I.; Ros-Simo, C.; Conde, S.; Cadavid, M.I.; Loza, M.I.; Perez-Castillo, A.; Valverde, O.; Martinez, A.; Gil, C.
Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors (2014), J. Med. Chem., 57, 8590-8607.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-[(2-chloro-4-nitrophenyl)thio]-pyridine	-	Homo sapiens
N-[2-(5-chloro-2-nitrophenylthio)phenyl]acetamide	10% inhibition at 0.01 mM; 11% inhibition at 0.01 mM; lead compound for Parkinson's disease treatment	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q07343	-	-
Homo sapiens	Q08499	-	-
Homo sapiens	Q13946	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuroblastoma cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PDE4B	-	Homo sapiens
PDE4D	-	Homo sapiens
PDE7A	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00018	-	pH not specified in the publication, 30°C	Homo sapiens	4-[(2-chloro-4-nitrophenyl)thio]-pyridine
0.0021	-	pH not specified in the publication, 30°C	Homo sapiens	N-[2-(5-chloro-2-nitrophenylthio)phenyl]acetamide
0.0066	-	pH not specified in the publication, 30°C	Homo sapiens	4-[(2-chloro-4-nitrophenyl)thio]-pyridine
0.0073	-	pH not specified in the publication, 30°C	Homo sapiens	4-[(2-chloro-4-nitrophenyl)thio]-pyridine

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Release 2023.1 (January 2023)