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Literature summary for 3.1.4.53 extracted from

  • Bian, H.; Zhang, J.; Wu, P.; Lori, A.; Varty, Y.J.; Maywood, T.; Hey, J.A.; Wang, P.
    Differential type 4 cAMP-specific phosphodiesterase (PDE4) expression and functional sensitivity to PDE4 inhibitors among rats, monkeys and humans (2004), Biochem. Pharmacol., 68, 2229-2236.
    View publication on PubMed
Search for more literature for 3.1.4.53

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
rolipram
-
 Homo sapiens
rolipram
-
 Rattus norvegicus
SB 207499
-
 Homo sapiens
SB 207499
-
 Rattus norvegicus
SCH 351591
-
 Homo sapiens
SCH 351591
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens P27815
-
-
Homo sapiens Q07343
-
-
Homo sapiens Q08493
-
-
Homo sapiens Q08499
-
-
Rattus norvegicus P14270 Sprague-Dawley, male
-
Rattus norvegicus P14646 Sprague-Dawley, male
-
Rattus norvegicus P54748
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Homo sapiens
-
adrenal gland
-
 Rattus norvegicus
-
adrenal gland weak activity Homo sapiens
-
aorta
-
 Homo sapiens
-
aorta
-
 Rattus norvegicus
-
aorta weak activity Homo sapiens
-
brain
-
 Homo sapiens
-
brain
-
 Rattus norvegicus
-
brain high activity Rattus norvegicus
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
liver weak activity Homo sapiens
-
additional information mRNA expression levels of PDEs 4A, 4B, 4C and 4D are significantly higher in rats than in humans. Higher PDE4 expression levels are correlated with a higher enzyme activity level in rat leukocytes Homo sapiens
-
additional information mRNA expression levels of PDEs 4A, 4B, 4C and 4D are significantly higher in rats than in humans. Higher PDE4 expression levels are correlated with a higher enzyme activity level in rat leukocytes Rattus norvegicus
-
renal artery
-
 Homo sapiens
-
renal artery
-
 Rattus norvegicus
-
renal artery high activity Rattus norvegicus
-
renal artery weak activity Homo sapiens
-
stomach
-
 Homo sapiens
-
stomach
-
 Rattus norvegicus
-
testis
-
 Rattus norvegicus
-
testis high activity Homo sapiens
-
testis high activity Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
PDE4A
-
 Homo sapiens
PDE4A
-
 Rattus norvegicus
PDE4B
-
 Homo sapiens
PDE4B
-
 Rattus norvegicus
PDE4C
-
 Rattus norvegicus
PDE4C
-
 Homo sapiens
PDE4D
-
 Homo sapiens
PDE4D
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000105
-
-
 Homo sapiens SCH 351591
0.000109
-
-
 Rattus norvegicus SCH 351591
0.000113
-
-
 Homo sapiens SB 207499
0.000117
-
-
 Rattus norvegicus SB 207499
0.000143
-
-
 Rattus norvegicus rolipram
0.000148
-
-
 Homo sapiens rolipram