Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apremilast | CC-10004, i.e. (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]acetamide, oral phosphodiesterase-4 inhibitor, apremilast shows no marked selectivity among PDE4 isozymes | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | Homo sapiens | - |
5'-AMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
peripheral blood mononuclear cell | - |
Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Homo sapiens | 5'-AMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cAMP phosphodiesterase-4 | - |
Homo sapiens |
PDE4 | - |
Homo sapiens |
PDE4A4 | isoform | Homo sapiens |
PDE4B2 | isoform | Homo sapiens |
PDE4C2 | isoform | Homo sapiens |
PDE4D3 | isoform | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000068 | - |
apremilast | PDE4 purified from U-937 cells, using 0.001 mM cAMP as substrate, pH and temperature not specified in the publication | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00002 | - |
recombinant isoform PDE4A4, using 0.001 mM cAMP as substrate, pH and temperature not specified in the publication | Homo sapiens | apremilast | |
0.00003 | - |
recombinant isoform PDE4D3, using 0.001 mM cAMP as substrate, pH and temperature not specified in the publication | Homo sapiens | apremilast | |
0.000049 | - |
recombinant isoform PDE4B2, using 0.001 mM cAMP as substrate, pH and temperature not specified in the publication | Homo sapiens | apremilast | |
0.00005 | - |
recombinant isoform PDE4C2, using 0.001 mM cAMP as substrate, pH and temperature not specified in the publication | Homo sapiens | apremilast | |
0.000074 | - |
PDE4 purified from U-937 cells, using 0.001 mM cAMP as substrate, pH and temperature not specified in the publication | Homo sapiens | apremilast |