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Literature summary for 3.1.4.53 extracted from
- cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling (2007), Circ. Res., 100, 950-966.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | PDE4D deficiency may contribute to heart failure and arrhythmias by promoting defective regulation of the RyR2 channel in humans | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P27815 | - |
- |
| Homo sapiens | Q07343 | - |
- |
| Homo sapiens | Q08499 | - |
- |
| Mus musculus | Q01063 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cardiomyocyte | - |
Homo sapiens | - |
| cardiomyocyte | - |
Mus musculus | - |
| vascular smooth muscle cell | - |
Homo sapiens | - |
| vascular smooth muscle cell | numerous PDE4D gene-derived variants including PDE4D3, PDE4D5, PDE4D7, PDE4D8, and PDE4D9 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | PDE4D deficiency may contribute to heart failure and arrhythmias by promoting defective regulation of the RyR2 channel in humans | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDE4A | - |
Homo sapiens |
| PDE4B | - |
Homo sapiens |
| PDE4D | - |
Homo sapiens |
| PDE4D | - |
Mus musculus |
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Release 2023.1 (January 2023)
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