Reference on EC 2.7.11.25 - mitogen-activated protein kinase kinase kinase and Organism(s) Mus musculus and UniProt Accession P53349
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ito, M.; Yoshioka, K.; Akechi, M.; Yamashita, S.; Takamatsu, N.; Sugiyama, K.; Hibi, M.; Nakabeppu, Y.; Shiba, T.; Yamamoto, K.I.
JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway
Mol. Cell. Biol.
19
7539-7548
1999
Mus musculus (P53349), Mus musculus
Gerwins, P.; Blank, J.L.; Johnson, G.L.
Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway
J. Biol. Chem.
272
8288-8295
1997
Mus musculus (O08648), Mus musculus
Schweifer, N.; Valk, P.J.; Delwel, R.; Cox, R.; Francis, F.; Meier-Ewert, S.; Lehrach, H.; Barlow, D.P.
Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r gene
Genomics
43
285-297
1997
Mus musculus (O08648)
Lange-Carter, C.A.; Pleiman, C.M.; Gardner, A.M.; Blumer, K.J.; Johnson, G.L.
A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
Science
260
315-319
1993
Mus musculus (P53349), Mus musculus
Huang, J.; Tu, Z.; Lee, F.S.
Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity
Biochem. Biophys. Res. Commun.
303
532-540
2003
Mus musculus
Takeda, K.; Matsuzawa, A.; Nishitoh, H.; Ichijo, H.
Roles of MAPKKK ASK1 in stress-induced cell death
Cell Struct. Funct.
28
23-29
2003
Caenorhabditis elegans, Homo sapiens, Mus musculus
Cuevas, B.D.; Abell, A.N.; Witowsky, J.A.; Yujiri, T.; Johnson, N.L.; Kesavan, K.; Ware, M.; Jones, P.L.; Weed, S.A.; DeBiasi, R.L.; Oka, Y.; Tyler, K.L.; Johnson, G.L.
MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts
EMBO J.
22
3346-3355
2003
Mus musculus
Zhang, D.; Facchinetti, V.; Wang, X.; Huang, Q.; Qin, J.; Su, B.
Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways
EMBO J.
25
97-107
2006
Mus musculus
Witowsky, J.A.; Johnson, G.L.
Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways
J. Biol. Chem.
278
1403-1406
2003
Mus musculus
Tu, Z.; Lee, F.S.
Subdomain VIII is a specificity-determining region in MEKK1
J. Biol. Chem.
278
48498-48505
2003
Mus musculus
Cheng, J.; Yu, L.; Zhang, D.; Huang, Q.; Spencer, D.; Su, B.
Dimerization through the catalytic domain is essential for MEKK2 activation
J. Biol. Chem.
280
13477-13482
2005
Mus musculus
Fritz, A.; Brayer, K.J.; McCormick, N.; Adams, D.G.; Wadzinski, B.E.; Vaillancourt, R.R.
Phosphorylation of serine 526 is required for MEKK3 activity and association with 14-3-3 blocks dephosphorylation
J. Biol. Chem.
281
6236-6245
2006
Homo sapiens, Mus musculus, synthetic construct
Du, J.; Cai, S.; Suzuki, H.; Akhand, A.A.; Ma, X.; Takagi, Y.; Miyata, T.; Nakashima, I.; Nagase, F.
Involvement of MEKK1/ERK/p21Waf1/Cip1 signal transduction pathway in inhibition of IGF-I-mediated cell growth response by methylglyoxal
J. Cell. Biochem.
88
1235-1246
2003
Homo sapiens, Mus musculus
Stevens, M.V.; Parker, P.; Vaillancourt, R.R.; Camenisch, T.D.
MEKK4 regulates developmental EMT in the embryonic heart
Dev. Dyn.
235
2761-2770
2006
Mus musculus
Takeda, K.; Shimozono, R.; Noguchi, T.; Umeda, T.; Morimoto, Y.; Naguro, I.; Tobiume, K.; Saitoh, M.; Matsuzawa, A.; Ichijo, H.
Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1
J. Biol. Chem.
282
7522-7531
2007
Homo sapiens (O95382), Mus musculus (Q9WTR2)
Bettinger, B.T.; Amberg, D.C.
The MEK kinases MEKK4/Ssk2p facilitate complexity in the stress signaling responses of diverse systems
J. Cell. Biochem.
101
34-43
2007
Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Mus musculus
Chen, Z.; Cobb, M.H.
Activation of MEKK1 by Rho GTPases
Methods Enzymol.
406
468-478
2006
Homo sapiens, Mus musculus, synthetic construct
Deng, M.; Chen, W.L.; Takatori, A.; Peng, Z.; Zhang, L.; Mongan, M.; Parthasarathy, R.; Sartor, M.; Miller, M.; Yang, J.; Su, B.; Kao, W.W.; Xia, Y.
A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing
Mol. Biol. Cell
17
3446-3455
2006
Mus musculus
Shi, C.S.; Huang, N.N.; Harrison, K.; Han, S.B.; Kehrl, J.H.
The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes
Mol. Cell. Biol.
26
6511-6521
2006
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Cuevas, B.D.; Abell, A.N.; Johnson, G.L.
Role of mitogen-activated protein kinase kinase kinases in signal integration
Oncogene
26
3159-3171
2007
Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus sp.
Symons, A.; Beinke, S.; Ley, S.C.
MAP kinase kinase kinases and innate immunity
Trends Immunol.
27
40-48
2006
Drosophila melanogaster, Homo sapiens, Mus musculus
Winkel, A.; Stricker, S.; Tylzanowski, P.; Seiffart, V.; Mundlos, S.; Gross, G.; Hoffmann, A.
Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling
Cell. Signal.
20
2134-2144
2008
Mus musculus (Q62073)
Di, Y.; Li, S.; Wang, L.; Zhang, Y.; Dorf, M.E.
Homeostatic interactions between MEKK3 and TAK1 involved in NF-kappaB signaling
Cell. Signal.
20
705-713
2008
Mus musculus
Craig, E.A.; Stevens, M.V.; Vaillancourt, R.R.; Camenisch, T.D.
MAP3Ks as central regulators of cell fate during development
Dev. Dyn.
237
3102-3114
2008
Mus musculus
Mongan, M.; Tan, Z.; Chen, L.; Peng, Z.; Dietsch, M.; Su, B.; Leikauf, G.; Xia, Y.
Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury
Toxicol. Sci.
104
405-411
2008
Mus musculus
Itoh, A.; Horiuchi, M.; Wakayama, K.; Xu, J.; Bannerman, P.; Pleasure, D.; Itoh, T.
ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons
J. Neurosci.
31
7223-7228
2011
Mus musculus (Q60700)
