Activating Compound | Comment | Organism | Structure |
---|---|---|---|
methylglyoxal | induces the PI3K/PKC/Raf-1-independent MEK/ERK signaling pathway by activation of MEKK1, accumulates in case of diabetes | Mus musculus | |
methylglyoxal | induces the PI3K/PKC/Raf-1-independent MEK/ERK signaling pathway by activation of MEKK1, accumulates in case of diabetes | Homo sapiens | |
additional information | no effect on enzyme activity by RAF-1 | Mus musculus | |
additional information | no effect on enzyme activity by RAF-1 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by LY294002 or bisindolylmaleimide | Homo sapiens | |
additional information | no inhibition by LY294002 or bisindolylmaleimide | Mus musculus | |
PD98059 | - |
Homo sapiens | |
PD98059 | - |
Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ERK | Mus musculus | PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway | ADP + phosphorylated ERK | - |
? | |
ATP + ERK | Homo sapiens | PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway | ADP + phosphorylated ERK | - |
? | |
ATP + MEK | Mus musculus | PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway | ADP + phosphorylated MEK | - |
? | |
ATP + MEK | Homo sapiens | PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway | ADP + phosphorylated MEK | - |
? | |
additional information | Mus musculus | alterations of the intracellular milieu induced by methylglyoxal through a MEKK1-mediated and PI3K/PKC/Raf-1-independent pathway results in the modification of cell response to IGF-I for the cyclin-dependent kinase inhibitor p21Waf1/Cip1-mediated growth arrest | ? | - |
? | |
additional information | Homo sapiens | alterations of the intracellular milieu induced by methylglyoxal through a MEKK1-mediated and PI3K/PKC/Raf-1-independent pathway results in the modification of cell response to IGF-I for the cyclin-dependent kinase inhibitor p21_Waf1/Cip1-mediated growth arrest, which may be one of the crucial mechanisms for methylglyoxal to promote the development of chronic clinical complications in diabetes in humans | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | embryonic kidney cell line | Homo sapiens | - |
NIH-3T3 cell | fibroblast cell line | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + ERK | - |
Mus musculus | ADP + phosphorylated ERK | - |
? | |
ATP + ERK | - |
Homo sapiens | ADP + phosphorylated ERK | - |
? | |
ATP + ERK | PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway | Mus musculus | ADP + phosphorylated ERK | - |
? | |
ATP + ERK | PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway | Homo sapiens | ADP + phosphorylated ERK | - |
? | |
ATP + MEK | - |
Mus musculus | ADP + phosphorylated MEK | - |
? | |
ATP + MEK | - |
Homo sapiens | ADP + phosphorylated MEK | - |
? | |
ATP + MEK | PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway | Mus musculus | ADP + phosphorylated MEK | - |
? | |
ATP + MEK | PI3K/PKC/Raf-1-independent activation of the MEK/ERK signaling pathway | Homo sapiens | ADP + phosphorylated MEK | - |
? | |
ATP + MKK4 | a MAPKK | Mus musculus | ADP + phosphorylated MKK4 | - |
? | |
ATP + MKK4 | a MAPKK | Homo sapiens | ADP + phosphorylated MKK4 | - |
? | |
additional information | alterations of the intracellular milieu induced by methylglyoxal through a MEKK1-mediated and PI3K/PKC/Raf-1-independent pathway results in the modification of cell response to IGF-I for the cyclin-dependent kinase inhibitor p21Waf1/Cip1-mediated growth arrest | Mus musculus | ? | - |
? | |
additional information | alterations of the intracellular milieu induced by methylglyoxal through a MEKK1-mediated and PI3K/PKC/Raf-1-independent pathway results in the modification of cell response to IGF-I for the cyclin-dependent kinase inhibitor p21_Waf1/Cip1-mediated growth arrest, which may be one of the crucial mechanisms for methylglyoxal to promote the development of chronic clinical complications in diabetes in humans | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MEK kinase 1 | - |
Mus musculus |
MEK kinase 1 | - |
Homo sapiens |
MEKK1 | - |
Mus musculus |
MEKK1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |