Information on EC 2.7.11.25 - mitogen-activated protein kinase kinase kinase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
2.7.11.25
-
RECOMMENDED NAME
GeneOntology No.
mitogen-activated protein kinase kinase kinase
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (MAPKKKK-activated)
This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) but requires MAPKKKK for activation. Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway [2]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
(JNK)/stress-activated protein kinase-associated protein 1
P53349
-
apoptosis signal-regulated kinase 1
-
-
apoptosis signal-regulating kinase
-
-
apoptosis signal-regulating kinase 1
-
-
apoptosis signal-regulating kinase 1
-
-
apoptosis signal-regulating kinase 2
-
-
B-Raf
-
-
B-Raf kinase
-
-
c-mos
-
-
-
-
C-Raf
-
-
cancer osaka thyroid
-
-
COT
Q6VAB6
-
COT30-397
-
-
COT30-467
-
-
DLK
-
-
-
-
Dual leucine zipper bearing kinase
-
-
-
-
Dual leucine zipper bearing kinase
-
-
dual leucine zipper-bearing kinase
-
-
extracellular signal-regulated kinase kinase kinase-1
-
-
fertilization-related kinase 1
Q6EE09
-
fertilization-related kinase 2
Q6EE08
-
Frk1
Q6EE09
-
Frk2
Q6EE08
-
germinal center kinase-related enzyme
-
-
HsNIK
-
-
-
-
JSAP1
P53349
-
Jun N-terminal kinase kinase kinase
-
-
Jun N-terminal protein kinase
P53349
-
Leucine-zipper protein kinase
-
-
-
-
M3Kalpha
Q75PK5
-
MAP kinase kinase kinase
-
-
MAP kinase kinase kinase
-
-
MAP kinase kinase kinase
Q75PK5
-
MAP kinase kinase kinase
-
-
MAP kinase kinase kinase
-
-
MAP kinase kinase kinase
-
-
MAP kinase kinase kinase
-
-
MAP kinase kinase kinase 1
-
-
MAP kinase kinase kinase 3
Q6VAB6
-
MAP kinase kinase kinase mkh1
Q10407
-
MAP kinase kinase kinase SSK2
P53599
-
MAP kinase kinase kinase win1
O74304
-
MAP kinase kinase kinase wis4
O14299
-
MAP/ERK kinase kinase 1
-
-
MAP3K
Q6VAB6
-
MAP3K
Q62073
-
MAP3K1
-
-
MAP3K6
-
-
MAP3Ka
Q6RFY4
-
MAP3Ka
Q6RFY3
-
MAPK kinase kinase
-
-
MAPK kinase kinase
-
-
MAPK-upstream kinase
-
-
-
-
MAPK/ERK kinase kinase 1
-
-
MAPK/ERKkinase kinase 3
-
-
MAPKK kinase
-
-
MAPKKK
-
-
MAPKKK
Q6VAB6
-
MAPKKK
Q75PK5
-
MAPKKK
Q7XTK4
-
MAPKKK
Q6EE08, Q6EE09
-
MAPKKK6
-
-
MAPKKK6
O95382
-
MAPKKK6
-
-
MAPKKKalpha
Q6RFY4
-
MAPKKKalpha
Q6RFY3
-
MEK kinase 1
-
-
MEK kinase 1
-
-
MEK kinase 3
-
-
MEKK1
Q39008
-
MEKK1
Q7XTK4
-
MEKK3
Q6VAB6
-
MEKK3
Q99759
-
MEKK3
-
belongs to the family of serine/threonine kinases
MEKK4
Q6VAB6
-
MEKK5
-
-
MEKK8
-
-
mitogen activated protein kinase kinase kinase
-
-
mitogen-activated protein kinase kinase kinase
-
-
mitogen-activated protein kinase kinase kinase
-
-
mitogen-activated protein kinase kinase kinase
-
-
mitogen-activated protein kinase kinase kinase
-
-
mitogen-activated protein kinase kinase kinase
-
-
mitogen-activated protein kinase kinase kinase
-
-
mitogen-activated protein kinase kinase kinase 1
-
-
mitogen-activated protein kinase kinase kinase 1
-
-
mitogen-activated protein kinase kinase kinase 1
P53349
-
mitogen-activated protein kinase kinase kinase 1
-
-
mitogen-activated protein kinase kinase kinase 3
Q99759
-
mitogen-activated protein kinase kinase kinase 4
O08648
-
mitogen-activated protein kinase kinase kinase 6
O95382
-
mitogen-activated protein kinase kinase kinase kinase
-
-
mitogen-activated protein kinase kinase kinase-1
-
-
mitogen-activated protein kinase/extracellular-regulated kinase kinase kinase-3
-
-
mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase kinase 1
-
-
mitogen-activated protein/ERK kinase kinase 3
-
-
Mixed Lineage Kinase
-
five characterized forms
MKL3
-
-
MLK
-
five characterized forms termed MLK1, 2, 3, 4 or 7
MLK-like mitogen-activated protein triple kinase
-
-
MLK1
-
-
MLK2
-
-
MLK4
-
-
MTK1
-
-
MUK
-
-
-
-
NF-kappa beta-inducing kinase
-
-
-
-
OMTK1
Q7XTK4
-
oxidative stress-activated MAP triple-kinase 1
Q7XTK4
-
protein kinase byr2
P28829
-
putative mitogen-activated protein kinase 1
Q7XTK4
-
Serine/threonine protein kinase NIK
-
-
-
-
serine/threonine-protein kinase STE11
P23561
-
SSk2 MAPK kinase kinase
-
-
TAK1
Q6VAB6
-
TAK1
-
belongs to the family of serine/threonine kinases
TAK1
Q62073
-
TAK1 (three isoforms termed A,B and C)
-
-
TAO kinase
-
three different forms
TAO1-2
-
-
TAO2-1
-
-
TGF-beta-activated kinase-1
Q62073
-
TGFalpha activated kinase
-
-
TGFbeta activated kinase 1
-
-
Thousand And One kinase
-
-
Tlp2
-
-
TPL-2
-
-
transforming growth factor beta-activated kinase 1
-
-
tumor progression locus-2
-
-
tumour progression locus 2
-
-
ZPK
-
-
-
-
MLTKalpha
-
-
additional information
-
MEKK2 and MEKK3 belong to the MEKK/Ste11 subfamily of the MAP3K family of enzymes
additional information
-
MAP kinase cascade is homologous to the Saccharomyces cerevisiae Slt2p pathway
additional information
Q6RFY4
MAPKKKalpha belongs to the A2 subgroup of the MEKK enzyme family
additional information
-
the enzyme belongs to the MEK family
additional information
Q6RFY3
MAPKKKalpha belongs to the A2 subgroup of the MEKK enzyme family
additional information
-
the enzyme belongs to the MLK family of mitogen activated protein kinase kinase kinases
CAS REGISTRY NUMBER
COMMENTARY
146702-84-3
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Col ecotype
Swissprot
Manually annotated by BRENDA team
Col-0 ecotype
-
-
Manually annotated by BRENDA team
Columbia ecotype
-
-
Manually annotated by BRENDA team
ecotype Columbia
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
gene BRAF
-
-
Manually annotated by BRENDA team
MEKK3 isozyme 1
SwissProt
Manually annotated by BRENDA team
disruption of MCK1 resulted in the fungus undergoing autolysis and showing hypersensitivity to cell-wall-degrading enzyme, mutant strain produces significantly reduced numbers of conidia and developed appressoria in a slightly retarded manner compared with the wild type, mutant is unable to penetrate into plant tissues
-
-
Manually annotated by BRENDA team
; activity requires TAB1 (TAK1 binding protein), binding of TAB1 promotes autophosphorylation of TAK1
-
-
Manually annotated by BRENDA team
; native and mutant mice, mutant embryos are growth retarded and die in utero; normal and mutant mice, mutant mice appear normal at birth but die 7-21 days postpartum due to neurological and intestinal problems; normal and mutant mice, mutant mice die in utero due to severe vascular abnormalities
-
-
Manually annotated by BRENDA team
C57BL/6 mice
-
-
Manually annotated by BRENDA team
wild type embryonic fibroblast and cells with a MAP3K deletion used for experiments
-
-
Manually annotated by BRENDA team
strains ORS-SL6a and 74-OR23-IVA and deletion mutants
-
-
Manually annotated by BRENDA team
single copy gene MAPKKKalpha
SwissProt
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Schizosaccharomyces pombe (strain 972 / ATCC 24843)