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Literature summary for 2.7.11.25 extracted from

  • Zhang, D.; Facchinetti, V.; Wang, X.; Huang, Q.; Qin, J.; Su, B.
    Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways (2006), EMBO J., 25, 97-107.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of HA-tagged active MEKK2 and inactive S519A MEKK2 mutant catalytic sites, expression of wild-type and mutant full length MEKK2s and of wild-type and mutant MEKK3s Mus musculus

Protein Variants

Protein Variants Comment Organism
S519A site-directed mutagenesis, MEKK2 phosphorylation site mutant, inactive mutant Mus musculus
S526A site-directed mutagenesis, MEKK3 phosphorylation site mutant, inactive mutant Mus musculus
T521A site-directed mutagenesis, MEKK2 phosphorylation site mutant, the mutant shows slightly reduced activity compared to the wild-type enzyme Mus musculus
T523A site-directed mutagenesis, MEKK2 phosphorylation site mutant, the mutant shows slightly reduced activity compared to the wild-type enzyme Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus MEKK2 and MEKK3 are involved in activation of signal transduction pathways via toll-like receptor TLR, mitogen-activated protein kinases MAPK, and NF-kappaB, overview ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein MEKK2 and MEKK3 are activated by phosphorylation, determination of phosphorylation sites, S519 is a key regulator phosphorylation site in MEKK2, other sites are Thr521 and Thr523 Mus musculus

Reaction

Reaction Comment Organism Reaction ID
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate molecular mechanism of MEKK2 and MEKK3 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MEKK2 and MEKK3 are involved in activation of signal transduction pathways via toll-like receptor TLR, mitogen-activated protein kinases MAPK, and NF-kappaB, overview Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
MAP3K
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Mus musculus
MEKK2
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Mus musculus
MEKK3
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Mus musculus
More MEKK2 and MEKK3 belong to the MEKK/Ste11 subfamily of the MAP3K family of enzymes Mus musculus