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Literature summary for 2.7.11.25 extracted from

  • Itoh, A.; Horiuchi, M.; Wakayama, K.; Xu, J.; Bannerman, P.; Pleasure, D.; Itoh, T.
    ZPK/DLK, a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons (2011), J. Neurosci., 31, 7223-7228.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine ZPK/DLK can become a strategic therapeutic target in motor neuron diseases in which aberrant activation of the apoptogenic cascade is involved Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information ZPK/DLK-deficient mice are derived from the gene-trap embryonic stem cell clone RRN366 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q60700
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-

Source Tissue

Source Tissue Comment Organism Textmining
nerve the enzyme is most abundantly expressed in developing nervous tissues Mus musculus
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Synonyms

Synonyms Comment Organism
DLK
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Mus musculus
MAP3K12
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Mus musculus
MUK
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Mus musculus
ZPK
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Mus musculus
ZPK/DLK
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Mus musculus

General Information

General Information Comment Organism
evolution the enzyme is a member of the MLK family Mus musculus
malfunction mice deficient in ZPK have twice as many spinal motoneurons as do their wild-type littermates. Nuclear HB9/MNX1-positive motoneuron pools are generated similarly in the spinal cord of both ZPK/DLK-deficient and wild-type embryos. Significantly less apoptotic motoneurons are found in ZPK/DLK-deficient embryos compared to wild-type embryos, resulting in retention of excess numbers of motoneurons after birth. The excess motoneurons remain viable without atrophic changes in the ZPK/DLK-deficient mice surviving into adulthood. Analysis of the diaphragm and the phrenic nerve reveals that clustering and innervation of neuromuscular junctions are indistinguishable between ZPK/DLK-deficient and wild-type mice, whereas the proximal portion of the phrenic nerve of ZPK/DLK-deficient mice contain significantly more axons than the distal portion. Some excess ZPK/DLK-deficient motoneurons survive without atrophy despite failure to establish axonal contact with their targets Mus musculus
physiological function activation of mitogen-activated protein kinase pathways is critically involved in naturally occurring programmed cell death of motoneurons during development. Enzyme ZPK, also called DLK, (ZPK/DLK), a mitogen-activated protein kinase kinase kinase, is a critical mediator of programmed cell death of motoneurons. The enzyme has a distinctive role in neural development and in naturally occurring programmed cell death Mus musculus