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Literature summary for 2.7.11.25 extracted from

  • Cuevas, B.D.; Abell, A.N.; Witowsky, J.A.; Yujiri, T.; Johnson, N.L.; Kesavan, K.; Ware, M.; Jones, P.L.; Weed, S.A.; DeBiasi, R.L.; Oka, Y.; Tyler, K.L.; Johnson, G.L.
    MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts (2003), EMBO J., 22, 3346-3355.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.25

Activating Compound

Activating Compound Comment Organism Structure
additional information MEKK1 forms complexes with FAK involved in regulation of cell migration, overview Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
transient co-expression of MEKK1 and FAK in HEK293 cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information MAPKK with mutated DVD docking sites are inhibitory for the MAPKKK, as well as synthetic DVD sequence oligopeptides in vitro and in vivo, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information the enzyme colocalizes with focal adhesions Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + MEK1 Mus musculus MEK1 activates the ERK2 signaling pathway ADP + phosphorylated MEK1
-
 ?
ATP + MKK4 Mus musculus MKK4 activates the JNK signaling pathway ADP + phosphorylated MKK4
-
 ?
additional information Mus musculus the MAPKKKs are part of the MAPK signaling cascade, overview, MEKK1 regulates calpain-dependent cell migration via regulation of th ERK2-dependent signaling pathway and binding to focal adhesions, actinin, and FAK, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + MEK1 MEK1 activates the ERK2 signaling pathway Mus musculus ADP + phosphorylated MEK1
-
 ?
ATP + MEK1 substrate is a MAPKK Mus musculus ADP + phosphorylated MEK1
-
 ?
ATP + MKK4 MKK4 activates the JNK signaling pathway Mus musculus ADP + phosphorylated MKK4
-
 ?
ATP + MKK4 substrate is a MAPKK Mus musculus ADP + phosphorylated MKK4
-
 ?
additional information the MAPKKKs are part of the MAPK signaling cascade, overview, MEKK1 regulates calpain-dependent cell migration via regulation of th ERK2-dependent signaling pathway and binding to focal adhesions, actinin, and FAK, overview Mus musculus ?
-
 ?
additional information the enzyme docks at the DVD docking site of MAPKK, a stretch of about 20 amino acids immediately on the C-terminal side of the catalytic domain, MAPKK with mutated DVD docking sites are inhibitory for the MAPKKK Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
More MEKK1 forms complexes with FAK involved in regulation of cell migration, overview Mus musculus

Synonyms

Synonyms Comment Organism
MAPKKK
-
 Mus musculus
MEKK1
-
 Mus musculus
MEKK2
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus