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Literature summary for 2.7.11.25 extracted from

  • Di, Y.; Li, S.; Wang, L.; Zhang, Y.; Dorf, M.E.
    Homeostatic interactions between MEKK3 and TAK1 involved in NF-kappaB signaling (2008), Cell. Signal., 20, 705-713.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed as native and mutant FLAG-tag/HA-tag fusion protein in HEK293T cells, coexpression expreiments with TAK1 Mus musculus
expressed together with or without MEKK3 in HEK293T cells Mus musculus

Protein Variants

Protein Variants Comment Organism
S526A/K391M critical phosphorylation site and catalytic site Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information inactive in vivo when bound to MEKK3; inactive in vivo when bound to TAK1 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus induces activation of NF-kappaB reporter activity, deficiency cells show defects in TNFalpha signalling ?
-
 ?
additional information Mus musculus involved in the activation of NF-kappaB, negatively regulates MEKK3-induced activation of NF-kappaB reporter activity, able to autophosphorylate at multiple sites when bound to TAB1, deficiency cells show defects in TNFalpha signalling ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus
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 activity requires TAB1 (TAK1 binding protein), binding of TAB1 promotes autophosphorylation of TAK1
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein by tandem affinity purification Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information induces activation of NF-kappaB reporter activity, deficiency cells show defects in TNFalpha signalling Mus musculus ?
-
 ?
additional information involved in the activation of NF-kappaB, negatively regulates MEKK3-induced activation of NF-kappaB reporter activity, able to autophosphorylate at multiple sites when bound to TAB1, deficiency cells show defects in TNFalpha signalling Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
MEKK3 belongs to the family of serine/threonine kinases Mus musculus
mitogen-activated protein/ERK kinase kinase 3
-
 Mus musculus
TAK1 belongs to the family of serine/threonine kinases Mus musculus
TGFalpha activated kinase
-
 Mus musculus