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Literature summary for 2.7.11.25 extracted from

  • Craig, E.A.; Stevens, M.V.; Vaillancourt, R.R.; Camenisch, T.D.
    MAP3Ks as central regulators of cell fate during development (2008), Dev. Dyn., 237, 3102-3114.
    View publication on PubMed
Search for more literature for 2.7.11.25

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
BAD + ATP Mus musculus activation of the proapoptotic protein BAD BAD-phosphate + ADP
-
 ?
additional information Mus musculus phosphorylates and activates MAP kinase kinase, activates ERK and JNK pathways in cells of the imune system in response to inflammatory mediators, knockout mice show normal development but defects in inflammatory response, involved in T-cell proliferation, probably involved in cardiac myocyte differentiation ?
-
 ?
additional information Mus musculus phosphorylates and activates MAP kinase kinase, activates ERK1/2 and possibly also ERK3, important function in vascular development, important physiological role in cell growth and development, related to oncogenesis ?
-
 ?
additional information Mus musculus phosphorylates and activates MAP kinase kinase, activates JNK and p38MAP kinases in response to stress stimuli, knockout mice usually dying shortly after birth due to neural tube and skeletal malformations, functions in regulation of apoptosis and cell migration, possibly acts as central regulator of calcium-mediated signaling ?
-
 ?
additional information Mus musculus phosphorylates and activates MAP kinase kinase, activates JNK during neuronal migration in cerebal cortex development ?
-
 ?
additional information Mus musculus phosphorylates and activates MAP kinase kinase, activates the p38 pathway in response to stress and DNA damage ?
-
 ?
additional information Mus musculus phosphorylates and activates MAP kinase kinase, appears to transduce signals for JNK and ERK1/2 activation by pro-inflammatory stimuli and growth factors, key regulator of cell migration, deletion mutants are viable and fertile but display altered migration of epithelial cells resulting in defective eyelid closure, enzyme interacts directly with MEK1, MEK2 and c-Raf, involved in oxidative stress induced apoptosis in cardiac myocytes, enzyme deficiency individuals have diminished B-cell numbers, directly and indirectly involved in cell migration ?
-
 ?
additional information Mus musculus phosphorylates and activates MAP kinase kinase, important for the transduction of survival signals, involved in the regulation of apoptosis, important for TGFbeta signalling, deletion mutation in adult mice results in bone marrow and liver failure due to increased apoptosis of hematopoetic cells and hepatocytes, embryonic deletion is lethal due to severe vascular defects and delayed growth ?
-
 ?
additional information Mus musculus phosphorylates and activates MAP kinase kinase, induces the activation of the MEK/ERK pathway, important physiological role in cell growth and development, related to oncogenesis ?
-
 ?
additional information Mus musculus phosphorylates and activates MAP kinase kinase, involved in cellular stress response and JNK and p38 pathway activation, MLK1, 2 and 3 knockout mice show no obvious abnormalities, MLK 7 is activated in response to stressors like anisomycin and UV radiation and activates pro-apoptotic pathways through p38 and JNK ?
-
 ?
additional information Mus musculus phosphorylates and activates MAP kinase kinase, regulates apoptosis in response to stress stimuli, knockout mice do not exhibit developmental defects, activates p38 and JNK pathways ?
-
 ?
additional information Mus musculus phosphorylates and activates MAP kinase kinase, regulates p38,ERK1/2 and JNK, knockout embryos dying in utero due to abnormalities in vessel development and heart development, key regulator of cardiovascular and nervous system formation ?
-
 ?
additional information Mus musculus phosphorylates and activates MAP kinase kinase, regulation of apoptosis, induction of the MEK/ERK pathway, promotes cell survival in the heart through modulation of MEKK5 activity, important physiological role in cell growth and development, related to oncogenesis ?
-
 ?
additional information Mus musculus phosphorylates and activates MAP kinase kinase, selctive for the activation of JNK and ERK5, knockout mutants are viable and fertile without apparent malformations, involved in T-cell receptor modulation and cytokine production in response to IgE ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus
-
 native and mutant mice, mutant embryos are growth retarded and die in utero
-
Mus musculus
-
 normal and mutant mice, mutant mice appear normal at birth but die 7-21 days postpartum due to neurological and intestinal problems
-
Mus musculus
-
 normal and mutant mice, mutant mice die in utero due to severe vascular abnormalities
-

Source Tissue

Source Tissue Comment Organism Textmining
gastrointestinal tract
-
 Mus musculus
-
heart cardiac myocytes Mus musculus
-
heart highly expressed in myocardium of embryonic heart Mus musculus
-
heart MLK3 and MLK7 Mus musculus
-
T-cell lymphoma cell overxpressed Mus musculus
-
urogenital system
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BAD + ATP activation of the proapoptotic protein BAD Mus musculus BAD-phosphate + ADP
-
 ?
additional information phosphorylates and activates MAP kinase kinase, activates ERK and JNK pathways in cells of the imune system in response to inflammatory mediators, knockout mice show normal development but defects in inflammatory response, involved in T-cell proliferation, probably involved in cardiac myocyte differentiation Mus musculus ?
-
 ?
additional information phosphorylates and activates MAP kinase kinase, activates ERK1/2 and possibly also ERK3, important function in vascular development, important physiological role in cell growth and development, related to oncogenesis Mus musculus ?
-
 ?
additional information phosphorylates and activates MAP kinase kinase, activates JNK and p38MAP kinases in response to stress stimuli, knockout mice usually dying shortly after birth due to neural tube and skeletal malformations, functions in regulation of apoptosis and cell migration, possibly acts as central regulator of calcium-mediated signaling Mus musculus ?
-
 ?
additional information phosphorylates and activates MAP kinase kinase, activates JNK during neuronal migration in cerebal cortex development Mus musculus ?
-
 ?
additional information phosphorylates and activates MAP kinase kinase, activates the p38 pathway in response to stress and DNA damage Mus musculus ?
-
 ?
additional information phosphorylates and activates MAP kinase kinase, appears to transduce signals for JNK and ERK1/2 activation by pro-inflammatory stimuli and growth factors, key regulator of cell migration, deletion mutants are viable and fertile but display altered migration of epithelial cells resulting in defective eyelid closure, enzyme interacts directly with MEK1, MEK2 and c-Raf, involved in oxidative stress induced apoptosis in cardiac myocytes, enzyme deficiency individuals have diminished B-cell numbers, directly and indirectly involved in cell migration Mus musculus ?
-
 ?
additional information phosphorylates and activates MAP kinase kinase, important for the transduction of survival signals, involved in the regulation of apoptosis, important for TGFbeta signalling, deletion mutation in adult mice results in bone marrow and liver failure due to increased apoptosis of hematopoetic cells and hepatocytes, embryonic deletion is lethal due to severe vascular defects and delayed growth Mus musculus ?
-
 ?
additional information phosphorylates and activates MAP kinase kinase, induces the activation of the MEK/ERK pathway, important physiological role in cell growth and development, related to oncogenesis Mus musculus ?
-
 ?
additional information phosphorylates and activates MAP kinase kinase, involved in cellular stress response and JNK and p38 pathway activation, MLK1, 2 and 3 knockout mice show no obvious abnormalities, MLK 7 is activated in response to stressors like anisomycin and UV radiation and activates pro-apoptotic pathways through p38 and JNK Mus musculus ?
-
 ?
additional information phosphorylates and activates MAP kinase kinase, regulates apoptosis in response to stress stimuli, knockout mice do not exhibit developmental defects, activates p38 and JNK pathways Mus musculus ?
-
 ?
additional information phosphorylates and activates MAP kinase kinase, regulates p38,ERK1/2 and JNK, knockout embryos dying in utero due to abnormalities in vessel development and heart development, key regulator of cardiovascular and nervous system formation Mus musculus ?
-
 ?
additional information phosphorylates and activates MAP kinase kinase, regulation of apoptosis, induction of the MEK/ERK pathway, promotes cell survival in the heart through modulation of MEKK5 activity, important physiological role in cell growth and development, related to oncogenesis Mus musculus ?
-
 ?
additional information phosphorylates and activates MAP kinase kinase, selctive for the activation of JNK and ERK5, knockout mutants are viable and fertile without apparent malformations, involved in T-cell receptor modulation and cytokine production in response to IgE Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
A-Raf
-
 Mus musculus
apoptosis signal-regulating kinase
-
 Mus musculus
ASK1
-
 Mus musculus
B-Raf
-
 Mus musculus
C-Raf
-
 Mus musculus
DLK
-
 Mus musculus
Dual leucine zipper bearing kinase
-
 Mus musculus
MAP3K
-
 Mus musculus
MAPKKK
-
 Mus musculus
MEKK1
-
 Mus musculus
MEKK2
-
 Mus musculus
MEKK3
-
 Mus musculus
MEKK4
-
 Mus musculus
MEKK5
-
 Mus musculus
MEKK8
-
 Mus musculus
Mixed Lineage Kinase five characterized forms Mus musculus
MLK five characterized forms termed MLK1, 2, 3, 4 or 7 Mus musculus
Raf-1
-
 Mus musculus
TAK1 (three isoforms termed A,B and C)
-
 Mus musculus
TAO kinase three different forms Mus musculus
TGFbeta activated kinase 1
-
 Mus musculus
Thousand And One kinase
-
 Mus musculus
Tlp2
-
 Mus musculus
tumor progression locus-2
-
 Mus musculus